Destructive Procedures Research Articles

Protocols for Culturing and Imaging a Human Ex Vivo Osteochondral Model for Cartilage Biomanufacturing Applications.

Cartilage defects and diseases remain major clinical issues in orthopaedics. Biomanufacturing is now a tangible option for the delivery of bioscaffolds capable of regenerating the deficient cartilage tissue. However, several limitations of in vitro and experimental animal models pose serious challenges to the translation of preclinical findings into clinical practice. Ex vivo models are of great value for translating in vitro tissue engineered approaches into clinically relevant conditions. Our aim is to obtain a viable human osteochondral (OC) model to test hydrogel-based materials for cartilage repair. Here we describe a detailed step-by-step framework for the generation of human OC plugs, their culture in a perfusion device and the processing procedures for histological and advanced microscopy imaging. Our ex vivo OC model fulfils the following requirements: the model is metabolically stable for a relevant culture period of 4 weeks in a perfusion bioreactor, the processing procedures allowed for the analysis of 3 different tissues or materials (cartilage, bone and hydrogel) without compromising their integrity. We determined a protocol and the settings for a non-linear microscopy technique on label free sections. Furthermore, we established a clearing protocol to perform light sheet-based observations on the cartilage layer without the need for tedious and destructive histological procedures. Finally, we showed that our OC system is a clinically relevant in terms of cartilage regeneration potential. In conclusion, this OC model represents a valuable preclinical ex vivo tool for studying cartilage therapies, such as hydrogel-based bioscaffolds, and we envision it will reduce the number of animals needed for in vivo testing.

3D pore analysis of gasoline particulate filters using X-ray tomography: impact of coating and ash loading

Since particulate emissions control technologies are dependent on filtration technologies, development of porous materials with optimized pore structures is crucial to improve filtration efficiency and pressure drop across filters. Despite increasing attention to 3D measurements of porous materials, there are few reports of pore structure investigations of diesel/gasoline particulate filters (D/GPFs) using 3D visualization techniques. In this work, GPF 3D pore structures were examined using X-ray tomography (XRT) to identify the impacts of catalyst coating or ash loading. Voxel resolution of 2.93 µm made it impossible to distinguish coating or ash materials from the cordierite substrate or to recognize smaller pores than the voxel resolution. However, pores up to 200 µm, which are responsible for the most pore volume, were successfully analyzed. Coating and ash loading resulted in lowering average pore diameter, total porosity, and open porosity, as the peak density of pore diameter at 60 µm decreased, while pores below 20 µm increased. Also, the visualized closed pores, which were homogeneously distributed throughout the bare filter, tended to get larger from inlet to outlet sides and more likely to be on the surface inlet due to coating and ash loading, indicating gas pathways originally existing in open pores were blocked due to coating and ash loading, leading to increased pressure drop. The ash impact was found to be more noticeable on mid and back positions than on front position. In addition, the investigation of areal porosity along the direction of gas flow suggested that while ash penetration could reach the outlet side as noted from increased closed pore population, most ash particles would be contained up to 150 µm. The 2D crosscut microscopic analysis that requires destructive procedures with the limited examination area could provide underestimation of ash penetration, whereas the 3D XRT analysis seems to provide more accurate information of pore structure changes due to ash loading at different locations.

Rapid detection of cadmium and its distribution in Miscanthus sacchariflorus based on visible and near-infrared hyperspectral imaging

Monitoring the effectiveness of Miscanthus sacchariflorus to meet the basic requirements for environmental remediation projects is an important step in determining its use as a productive bioenergy crop for phytoremediation. Conventional chemical methods for the determination of cadmium (Cd) contents involve time-consuming, monotonous and destructive procedures and are not suitable for high-throughput screening. In the present study, visible and near-infrared hyperspectral imaging technology combined with chemometric methods was used to assess the Cd concentrations in M. sacchariflorus. The total Cd concentrations in different plant tissues were measured using an inductively coupled plasma-mass spectrometer. Partial least-squares regression and least-squares support vector machine were implemented to estimate Cd contents from spectral reflectance. Successive projections algorithm and competitive adaptive reweighted sampling (CARS) methodology were used for selecting optimal wavelength. The CARS-partial least-squares regression model resulted in the most accurate predictions of Cd contents in M. sacchariflorus leaves, with a determination coefficient (R2) of 0.87 and a root mean square error (RMSE) value of 97.78 for the calibration set, and an R2 value of 0.91 and a RMSE value of 75.95 for the prediction set. The CARS-least-squares support vector machine model resulted in the most satisfactory predictions of Cd contents in roots, with R2 values of 0.95 (RMSE, 0.92 × 103) for the calibration set and 0.90 (RMSE, 1.64 × 103) for the prediction set. Finally, the Cd concentrations in different plant tissues were visualized on the prediction maps by predicted spectral features on each hyperspectral image pixel. Thus, visible and near-infrared imaging combined with chemometric methods produces a promising technique to evaluate M. sacchariflorus' Cd phytoremediation capability in high-throughput metal-contaminated field applications.

Experimental study of the influence of crack width due to corrosion behaviour using different measurement methods and different exposures

Corrosion of reinforcing steel has a great influence in reducing the lifetime of concrete structures; Carbonation of the concrete pore solution causes surface corrosion on the steel and diffusion of chloride ions through the capillary system of the concrete cover causes pitting corrosion on the steel surface. Corrosion of metals is highly dependent on the environmental conditions. Exposure to chloride ions can be critical to the service life of reinforced concrete structures. The durability of reinforced concrete structures exposed to deicing salt or marine environments can be affected by impact of chloride ions. Detection methods for the rate of corrosion of non-destructive and destructive procedures were analysed. The potential mapping applied on the concrete surface was discussed as a standard method for corrosion detection and will be explained in detail including the application boundaries of the method. It is assumed that the corrosion behaviour of reinforcing steel depends on crack widths. To analyse that, 8 coated and 8 uncoated test samples with different concrete strength classes were used. The concrete objects were exposed to a 3% sodium chloride solution. The corrosion behaviour of reinforcing steel is analysed by using potential mapping with different reference electrodes (Ag/AgCl and Cu/CuSO4). The results show a significant correlation between crack size and protection system on the surface. The maximum crack width with a low indication of corrosion was found to be 0.1 mm.

Experimental study of the influence of crack width due to corrosion behaviour using different measurement methods and different exposures

Corrosion of reinforcing steel has a great influence in reducing the lifetime of concrete structures; Carbonation of the concrete pore solution causes surface corrosion on the steel and diffusion of chloride ions through the capillary system of the concrete cover causes pitting corrosion on the steel surface. Corrosion of metals is highly dependent on the environmental conditions. Exposure to chloride ions can be critical to the service life of reinforced concrete structures. The durability of reinforced concrete structures exposed to deicing salt or marine environments can be affected by impact of chloride ions. Detection methods for the rate of corrosion of non-destructive and destructive procedures were analysed. The potential mapping applied on the concrete surface was discussed as a standard method for corrosion detection and will be explained in detail including the application boundaries of the method. It is assumed that the corrosion behaviour of reinforcing steel depends on crack widths. To analyse that, 8 coated and 8 uncoated test samples with different concrete strength classes were used. The concrete objects were exposed to a 3% sodium chloride solution. The corrosion behaviour of reinforcing steel is analysed by using potential mapping with different reference electrodes (Ag/AgCl and Cu/CuSO4). The results show a significant correlation between crack size and protection system on the surface. The maximum crack width with a low indication of corrosion was found to be 0.1 mm.

Importance of Cryotherapy for Eyelid Papillomas

Cryotherapy as a destructive procedure is an important alternative to the surgical excision of eyelid tumors. We report our own experiences in the cryotherapy of large upper eyelid papillomas using spray- and contact-freezing. Cryotherapy gave excellent results in the treatment of unusually large papillomas. The preservation of collagen structures during cryotherapy provides a good aesthetic and functional outcome.

An iterated greedy algorithm with variable neighborhood descent for the planning of specialized diagnostic services in a segmented healthcare system

In this paper, a problem arising in the planning of specialized diagnostic services in a segmented public healthcare system is addressed. The problem consists of deciding which hospitals will provide the service and their capacity levels, the allocation of demand in each institution, and the reallocation of uncovered demand to other institutions or private providers, while minimizing the total equivalent annual cost of investment and operating cost required to satisfy all the demand. An associated mixed-integer linear programming model can be solved by conventional branch and bound for relatively small instances; however, for larger instances the problem becomes intractable. To effectively address larger instances, a hybrid metaheuristic framework combining iterated greedy (IGA) and variable neighborhood descent (VND) components for this problem is proposed. Two greedy construction heuristics are developed, one starting with an infeasible solution and iteratively adding capacity and the other starting with a feasible, but expensive, solution and iteratively decrease capacity. The iterated greedy algorithm includes destruction and reconstruction procedures. Four different neighborhood structures are designed and tested within a VND procedure. In addition, the computation of local search components benefit from an intelligent exploitation of problem structure since, when the first-level location variables (hospital location and capacity) are fixed, the remaining subproblem can be solved efficiently as it is very close to a transshipment problem. All components and different strategies were empirically assessed both individually and within the IGA-VND framework. The resulting metaheuristic is able to obtain near optimal solutions, within 3% of optimality, when tested over a data base of 60- to 300-hospital instances.

On the application of principles of artificial intelligence for eigenstrain reconstruction of volumetric residual stresses in non-uniform Inconel alloy 740H weldments

The eigenstrain theory provides a range of fruitful concepts for advanced modelling of the behaviour of materials and components obtained using sophisticated manufacturing routes, their response to thermal and mechanical loading, and deformation under fatigue and creep conditions. In recent years the method has been shown to be able to provide predictions of residual stresses for a limited range of processing and simulated service conditions for which experimental data is available. The authors recently presented advances in the use of eigenstrain-based analysis to include accurate determination of the domain and boundaries of eigenstrain fields in the weld zone. This approach allowed effective modelling of large-scale components and the determination of volumetric distributions of residual stresses through the use of additional model coefficients that need to be determined. Due to the non-linear dependence of the prediction on these parameters, the algorithm of the decision-making process has a profound influence on the cost of the simulation, and the reliability of its output. To address this challenge, the principles of Artificial Intelligence were adopted for use in the eigenstrain contour method to develop fuzzy Finite Element Model (fFEM) for the eigenstrain the reconstruction of residual stresses in large structures. The deterministic finite element eigenstrain model uses contour measurements for reconstruction process, and the developed fFEM behaves as an artificial agent to determine the coefficients of the deterministic finite element eigenstrain model. As an example application, as-welded and post-weld heat-treated specimens of non-uniform weldments of Inconel Alloy 740H were investigated using the proposed model. The results were verified using displacement measurements and residual stress calculations of the contour method. The determination of model coefficients by artificial agent allowed effective reconstruction of volumetric residual stresses in complex shaped components using limited data without the requirement of costly and destructive multi-cut experimental procedures.

Empirical Relationship between Hardness and Tensile Properties of High Pressure Torsion-processed Al 6061

Improved strength is the ultimate goal of advanced material processing technique, including high-pressure torsion (HPT). To evaluate this goal, it requires determination of strength properties of the processed sample. While tensile test involves destructive test procedures, hardness is a closely related mechanical property in evaluating strength. This illustrates the need for a reliable hardness-tensile properties relationship. This paper determined an empirical relationship between hardness and several tensile properties i.e. ultimate tensile strength, Young modulus and tangent modulus, of HPT-processed Al 6061 samples. As results, an acceptable linear correlation for each property was obtained with a unique relationship. The degree of agreement between the studied properties and hardness was discussed. With recent advanced in computational method, the derived empirical relationships could optimise the HPT processing and aid the sample behaviour control and prediction.

Quality-of-Life Outcomes following Surgical Treatment of Ménière's Disease: A Systematic Review and Meta-analysis.

Several surgical interventions are offered to patients with Ménière's disease (MD) who fail medical management. Although outcomes have historically been reported according to American Academy of Otolaryngology-Head and Neck Surgery guidelines, patient-reported outcome measures (PROMs) are increasingly used to evaluate treatments. This study reviews PROMs used to assess surgical treatments for MD and compares the effect of each intervention based on PROM scores. PubMed, EMBASE, CINAHL, and Web of Science. This is a systematic review and meta-analysis of English-language studies that reported PROMs for surgical treatments of MD. Two independent investigators assessed study eligibility, rated the quality using Methodological Index for Non-Randomized Studies (MINORS), and abstracted data for comparative analysis. A random-effects model was used for meta-analysis of pooled data. Of 148 unique studies identified, 11 satisfied inclusion criteria. The Ménière's Disease Outcome Questionnaire (MDOQ) was the most commonly used survey. Interventions included intratympanic gentamicin, vestibular nerve section, endolymphatic sac surgery, and labyrinthectomy. Pooled analysis of 8 studies that used the MDOQ instrument demonstrated statistically significant improvements in quality of life but did not identify a difference between destructive and nondestructive procedures. Although our review shows significant improvements in PROM scores for both destructive and nondestructive interventions, there was no significant difference noted between treatment types. We cannot draw conclusions regarding the comparative effectiveness of specific interventions, and the results do not account for placebo effects or the natural history of the disease. Further investigation with randomized controlled trials should be considered in future studies.

Retinoblastoma in Developing Country

Background: Retinoblastoma is the most common intraocular malignancy of childhood occurring in children below five years of age. Its worldwide incidence is one in 10,000 live births. Mortality rate in developed world is 5%, in developing countries is 50% while it can reach 99% if not treated. The etiology of high mortality in developing world is multifactorial like late presentation due to lack of knowledge or poor health care facility, limited knowledge about the severity of the disease among health care workers, fewer centers for its treatment and lack of modern day treatment facilities in the hospitals. Aim: To describe the profile of retinoblastoma presentation and management in a tertiary care hospital in a developing country. Methods: A retrospective data analysis of all diagnosed retinoblastoma patients who received treatment at a tertiary care hospital since last 12 years. Results: Mortality and morbidity due to retinoblastoma has improved in last 12 years due to earlier presentation when we can still save life as well as globe in many patients. Destructive procedures like exenteration and enucleation can be avoided by going for conservative treatment like chemotherapy if they present early. Conclusion: Early presentation and proper diagnosis of retinoblastoma significantly improves the outcome of its management. Awareness campaigns among parents as well as primary health care personnel is crucial for early detection of disease so that life and globe saving measures can be done to improve mortality and morbidity.

Description and Thermoluminescence (Tl) Dating of An Alleged Hopewell Mobiliary Clay Human Figurine from Hopeton Earthworks, Ross County, Ohio

Abstract During a reorganization of the collections at Kent State University (KSU), a fired-clay human figurine was discovered. Beyond the fact that KSU obtained the specimen from a collector, and the alleged origin was the Ohio Hopewell site of Hopeton Earthworks, information on the specimen’s provenience and chain of custody was lacking or ambiguous. To determine whether the artifact was consistent in style and age with Hopewell, we conducted a comparative study, as well as a direct chronometric assessment using thermoluminescence (TL) dating. The comparative study was equivocal: The figurine possessed some attributes consistent with Hopewell, but other features were not consistent or missing. TL dating revealed an age of 4590 ± 270, exceeding the Hopewell period by over 2,000 years. These results suggest two mutually exclusive hypotheses, neither of which is relevant to Hopewell: Either the figurine is one of the earliest examples of ceramic technology in eastern North America or it is a “fake,” perhaps from the Old World, and the object entered the KSU collections under pretense. More broadly, we suggest that archaeologists take a much more circumspect approach to collector-acquired objects and perform their due diligence in verifying the stories associated with them, even if that means increased use of destructive testing procedures.

Fundal Rupture with Breech Expulsion through it in Primigravida: Role of Destructive Procedure (Decapitation) in Modern Obstetrics

Fundal Rupture with Breech Expulsion through it in Primigravida: Role of Destructive Procedure (Decapitation) in Modern Obstetrics

Comparison between Hemiarthroplasty in the First Proximal Phalanx and Keller's Arthroplasty. A Finite Element Study

Hallux valgus and hallux rigidus are the most common pathologies in the first ray of the foot. Arthroplasty can restore the mobility of the joint but is a destructive procedure. This paper presents three finite element analysis of the foot studying two different kinds of arthroplasty.

Chronic pudenal neuralgia treatment with method of pulsed radio frequency (PRF)

Pudendal neuralgia is a pronounced pain in pudendal nerve dermatomes, most often aggravated in the sitting position. This condition is characterized by such symptoms as pain in the perineum, genitals, anus. The onset of pudendal nerve neuralgia can occur after surgery, cycling, trauma or without a provocative factor. Today, there is no ideal method for treating pudendal neuralgia. Treatment includes medication, blockade, decompressive surgery, or radiofrequency intervention. The article presents the clinical case of a patient who received a stable positive result due to radiofrequency pulse ablation (PRF) of the pudendal nerves after unsuccessful long-term conservative treatment. 44 years age patient complained of a pronounced pulling and throbbing pain in the perineum from the anus to the pubis, which was strengthened in the sitting position. The manifestation of the disease occurred several years ago for no apparent reason. Over time, the pain acquired signs of neuropathic, that is, burning and baking, sometimes unbearable. Conservative treatment included non-steroidal, anti-inflammatory drugs, physiotherapy procedures, massage and antidepressants. But it turned out to be ineffective: the patient’s condition worsened, she was forced to resign from the work (office clerk). After a comprehensive examination (MRI, SCT, ultrasound, physical examination), a diagnosis was established: chronic neuropathy of the pudendal nerves. Under the fluoroscopic and ultrasound-guided treatment-diagnostic block of the pudendal nerves. Received a positive result – for the duration of the action of the anesthetic pain was stopped. After this a pulse radiofrequency ablation of the pudendal nerves was performed at a frequency of 2 Hz (20 millisecond pulses) at 42°C, duration 120 seconds. Observation for 2 months confirmed the correctness of the chosen strategy. The pain significantly decreased, reaching a level of temporary discomfort, the patient returned to professional activity. The success of the treatment in such way: from medical-diagnostic block under X-rays and ultrasound-control to destructive radio-frequency procedures.

Applications of non‐destructive 3D data acquisition and processing for biomechanical computation, soft tissue visualization, and 4D real‐life animation

3D imaging, based mostly on data from x‐ray CT and MRI, has become part of the tool box for the visual representations of morphological data sensu lato. While the basic methodology continues to be refined at the acquisition and data processing levels, the time has come to explore how specific research questions can be solved by creating 3D models that are accurate and testable, and, therefore, realistic (realitätsgetreu, i.e., faithful to reality) based on nondestructive 3D data acquisition techniques that allow a particular specimen to be used subsequently for other, possibly destructive procedures, such as dissection, histology, or electron microscopy. Three different 3D modeling approaches for answering specific questions exemplify the range of possible applications and can be adapted to analogous biological systems. (1) 3D modeling of a human skeleton based on x‐ray CT data allows the depiction of the three‐dimensional orientation of muscle and external forces and the calculation of their relative magnitude as a baseline for evaluating the effects of (A) healthy versus unhealthy postures on the body as a whole; and (B) bilateral asymmetry due to preferential use of a particular side or to congenital conditions (e.g., torticollis, scoliosis). Such a 3D model allows the resolution of forces without invoking limiting preconditions in contrast to 2D models, which require certain unrealistic assumptions for flattening a 3D specimen into a 2D plane. (2) 3D modeling of soft tissue structures and organisms that lack a mineralized skeleton (e.g., lampreys, soft‐bodied invertebrates) by using MRI data to avoid the shrinkage and deformation of soft tissues associated with contrast‐stained x‐ray CT data, and by using special acquisition and visualization procedures to deal with the inherent trade‐off between tissue contrast and image resolution in MRI. (3) 4D modeling of the movement patterns of a complex organism with a multitude of moving skeletal elements, such as the simultaneous movements of the thorax, neck, skull, jaw, tongue, and larynx of a vocalizing bird, requires a combination of several techniques. First, a segmented 3D model based on x‐ray CT data is created, in which all skeletal elements are marked as independent units. This structural 3D model is then transformed into a dynamic 3D model by matching its configuration to the configuration shown in individual frames of an x‐ray video of a singing bird, which is synchronized with an audio‐recording of the bird's vocalizations to calibrate particular skeletal positions with particular notes sung by the bird. This approach transforms a 2D x‐ray video into a 3D video that can be observed from any angle. Furthermore, it controls the exposure of live organisms to radiation and, therefore, is applicable to humans, as well as to rare and valuable live specimens, in fundamental and clinical research. The principles involved in the presented 3D data processing techniques are preparing the ground for applications to emerging 3D data acquisition modes, such as x‐ray phase‐contrast, or phase‐sensitive, imaging and neutron grating interferometry.Support or Funding InformationLSU Foundation support and National Institute of Neurological Disorders and Strokes subcontract IN‐4683010‐LSU to Dominique G. Homberger; Sigma Xi Grant‐in‐Aid to Bradley M. Wood.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.

Thermal shock resistance of refractory composites with Zirconia and Silicon-Carbide inclusions and alumina binder

With the goal of designing a castable refractory for an aerospace application with optimum resistance to thermal shock, three different particle-reinforced ceramic composites are designed and compared. Different volume fractions of Silicon Carbide (SiC) particles, Zirconia (ZrO2) bubbles, and Zirconia solid particles dispersed in an alumina (Al2O3) matrix are used in the fabrication of these castables. Destructive and nondestructive testing procedures are implemented to evaluate their thermomechanical properties, both before and after a custom designed thermal shock cycle. After demonstrating the applicability of thermal shock indices, the variation of these indices due to thermal shock is measured experimentally and utilized as a design tool. Multiple micro-scale damage mechanisms were observed, all of which are various forms of structural deformation.

Adaptive tabu search with strategic oscillation for the bipartite boolean quadratic programming problem with partitioned variables

The bipartite boolean quadratic programming problem with partitioned variables (BQP-PV) is an NP-hard combinatorial optimization problem that accommodates a variety of real-life applications. We propose an adaptive tabu search with strategic oscillation (ATS-SO) approach for BQP-PV, which employs a multi-pass search framework where each pass consists of an initial constructive phase, an adaptive tabu search phase and a frequency-driven strategic oscillation phase. In particular, the adaptive tabu search phase combines different move operators to collectively conduct neighborhood exploration and an adaptive tabu tenure management mechanism that obviates the task of determining a proper tabu tenure. The frequency-driven strategic oscillation phase diversifies the search when the search reaches a critical solution, drawing on a destructive procedure to unassign some variables by reference to frequency memory and a constructive procedure to re-assign these variables utilizing both frequency memory and problem specific knowledge. Computational experiments on five classes of problem instances indicate that the proposed ATS-SO algorithm is able to find improved solutions for 14 instances and match the best known solutions for all remaining instances, whereas no previous method has succeeded in finding the previous best solutions for all instances. Statistical tests indicate that ATS-SO significantly outperforms the state-of-the-art algorithms in the literature.

Iterated Greedy methods for the distributed permutation flowshop scheduling problem

Large manufacturing firms operate more than one production center. As a result, in relation to scheduling problems, which factory manufactures which product is an important consideration. In this paper we study an extension of the well known permutation flowshop scheduling problem in which there is a set of identical factories, each one with a flowshop structure. The objective is to minimize the maximum completion time or makespan among all factories. The resulting problem is known as the distributed permutation flowshop and has attracted considerable interest over the last few years. Contrary to the recent trend in the scheduling literature, where complex nature-inspired or metaphor-based methods are often proposed, we present simple Iterated Greedy algorithms that have performed well in related problems. Improved initialization, construction and destruction procedures, along with a local search with a strong intensification are proposed. The result is a very effective algorithm with little problem-specific knowledge that is shown to provide demonstrably better solutions in a comprehensive and thorough computational and statistical campaign.

Current issues of trigeminal neuralgias of compressive origin. Results of surgical treatment regarding the iatrogenias influence

Objective. To study the results of surgical treatment of classical and symptomatic trigeminal prosopalgias of compressive origin; to define the influence of iatrogenias and thus to improve the treatment provided for this cohort of patients.Materials and methods. Retrospective case series assay of 43 patients with trigeminal neuralgia of compressive origin was performed. The groups were formed regarding the sequence of treatment procedures. Group 1 included 15 patients with TN (3 patients with symptomatic TN and 12 persons with classic TN) who had undergone trigeminal nerve decompression as a primary measure. Group 2 consisted of 28 patients with TN (5 symptomatic and 23 classic) operated after destructive procedures performed previously.Results. Treatment outcomes were significantly worse in the 2nd group where destructive procedures were primary treatment options. Mean BNI PS on the 1st postoperative day were 1.2 vs 2.2 for groups 1 and 2, respectively (Р=0.01; 95% CI 0.25–1.78). At one-year of follow-up period the parameters were 1.13 vs 2.43 (P=0.0006; 95% CI 0.59–2). Average BNI NS score after one year was significantly worse in group 2 — 2.43 vs 1.27 in group 1 (P < 0.0001; 95% CI 0.67–1.65). 100% of group 2 and only 27% of group 1 had clinically significant neuropathy at one-year follow-up period after surgery with RR=3.75 (P=0.002; 95% CI 1.62–8.68).Conclusions. We suggest that destructive procedures as a primary measure for treatment of trigeminal neuralgias of compressive origin lead to worse long-term outcomes and reduce effectiveness of reconstructive technique of microsurgical decompression option.