Research and development objectives: measure the effectiveness of analytical thinking skills through guided inquiry-based modules. Data analysis used during research and development is descriptive analysis, percentage techniques and anacova tests. Research and development of teaching modules uses the Borg Gall procedural model which has been modified into nine stages: 1) research and information gathering stage, 2) planning stage, 3) initial product design development stage, 4) initial field trial stage, 5) initial first stage product revision, 6) limited field test stage, 7) second stage product revision stage, 8) operational field test stage, 9) final product revision stage. The results of research and development show: the guided inquiry-based module is effective in training analytical thinking skills, because based on the results of the Anakova test, it shows that there are differences in post-test results between the experimental, control and model classes. teaching material on the structure and function of plant tissues with F Table (0.05) = 2.37 F Calculate (0.05: 2) = 6.35.