Construction industry is a crucial sector of a country’s economy, but faces continuing problems such as low productivity, labor intensity, and fragmented processes. Design for Manufacturing and Assembly (DfMA) has been identified as an important strategy for solving this problem. Despite its potential, the adoption of DfMA in Indonesian construction industry has been slow. Therefore, this study aimed to (1) investigate barriers to the adoption of DfMA and (2) propose effective drivers to promote the adoption of DfMA. To achieve these objectives, a comprehensive literature review and structured interviews were conducted with DfMA experts. A questionnaire survey was then carried out with 100 respondents, and after applying purposive sampling criteria, 71 respondents were considered eligible. Following this discussion, the primary data was analyzed using descriptive and inferential statistics. The collected data was processed using structural equation modelling (SEM) application known as SMARTPLS. The result showed that the main obstacle faced was the organizational mindset, while the most effective strategy was the contribution and support of the government. This study provided a better understanding of the constraints faced and driving factors that could be considered effective by industry practitioners. Additionally, there was an expectation that the results of this exploration would be an important starting point for developing a roadmap to encourage the wider adoption of DfMA in construction industry in Indonesia.