A sustainable and green approach to concrete mix design is fundamental for the construction sector in terms of reducing carbon dioxide ( CO 2 ) emissions and conserving non-renewable natural resources. This article proposes a novel mix design method for sustainable high-strength self-compacting concrete (HSSCC) based on rheological and mechanical properties with the aim of reducing cement content in such mixes. HSSCC mixes were designed using ground granulated blast furnace slag (GGBS) and fly ash to replace up to 40% of the cement content and tested for target compressive strengths ranging between 70 and 100 MPa. The proposed design method was numerically programmed to provide straightforward and realistic guidance in the form of design charts and verified through the design and production of sixteen HSSCC mixes consisting of varying sand-to-aggregate ratios (S/A). All mixes satisfied the self-compacting concrete criteria in the fresh state and achieved the targeted viscosity and compressive strength values. The effects of S/A and paste-to-solid (P/S) ratios on the rheological properties were evaluated. The experimental results demonstrated that the proposed mix design method could produce HSSCC with excellent fresh and mechanical characteristics while being eco-efficient with respect to CO 2 emissions and cement consumption.