Analytical Design Method Research Articles

Human rights in education implication schema based on the study of the UN Economic and Social Council’s 2030 agenda

Human rights in education are an essential area that needs to be the highest priority for improving almost the entire world, especially for the 2030 agenda. This research analyzed the human rights in education values inside the UN Economic and Social Council’s declaration goal 4 of the official document entitled “Building back better from the coronavirus disease (COVID-19) while advancing the full implementation of the 2030 Agenda for Sustainable Development”. The data are analyzed through a critical discourse approach in qualitative design and discourse organization analysis method. There are nine main human rights in education found inside the declaration including ensuring and protecting education equality, education, and learning development acceleration, preparing and providing sufficient education funding, cultural diversity in education, providing a safe environment for physical and mental health, providing safe, modern and convenient infrastructure and teaching-learning facilities, gender equality in education, internet literacy in education, involving every country as to the world’s global meeting and cooperation of education. The focus of improvement on human rights in education is concluded to be dynamic, which is influenced by economic, welfare, politics, IT, and other integral aspects of development and depends on the world’s and a country’s needs and future desire.

Association between Stress Levels and Functional Dyspepsia among Medical Students During the COVID-19 Pandemic: A Study of Indonesian Christian University

Background: Stress is a problem that often occurs among students. The high incidence of stress in students can interfere with students' effectiveness in carrying out their lecture activities. Stress in students not only affects the quality of learning but can also affect the physical condition of students, one of which is the occurrence of gastrointestinal disorders, one example of which is dyspepsia. Aims: This study aims to determine whether there is a relationship between stress levels and functional dyspepsia in students at the Faculty of Medicine, Indonesian Christian University class of 2020. Study Design: This research uses an observational analytical research design method with a cross-sectional approach. The main data source is primary data obtained through questionnaires taken online via Google Forms. Place and Duration of Study: The research was conducted at the Indonesian Christian University located in Cawang, East Jakarta. Time of research in September 2022. Methodology: The population in this study was 137 students from the Faculty of Medicine, Indonesian Christian University class of 2020. The sample was taken using a simple random sampling technique totaling 103 people determined using the Slovin formula with an uncertainty percentage of 5%. Results: From the results of data collection on 103 respondents who were FK UKI students Class of 2020, around 65% or 67 respondents were identified as having normal stress levels and as many as 64 students (62%) had symptoms of functional dyspepsia. Based on the results of the bivariate analysis, it was found that there was a relationship between the level of stress and the incidence of dyspepsia experienced by FK UKI students class of 2020 with the results of the chi-square test, namely p = 0.003 < sig 0.05 Conclusion: There is a significant relationship between stress levels and functional dyspepsia. This certainly cannot be taken lightly because the incidence of functional dyspepsia can have fatal consequences which can disrupt the sufferer's activities and productivity. Therefore, it is very necessary to manage emotions (stress levels) both by the sufferer himself and with professional help.

Comparison of stability analysis methods for safe design of volcanic rock slope

The performance of the stability chart (SC), limit equilibrium (LE), and finite element (FE) methods for stability analysis of weathered volcanic rock slopes under static and earthquake loads is not fully understood. This research aimed to evaluate the performance of the SC, LE, and FE methods for slope stability analyses by studying a case of a weathered volcanic rock slope at the Leuwikeris Dam diversion tunnel in Indonesia. Site characterisations were carried out to obtain the input parameters for the static and pseudostatic slope stability analyses. The results showed that using various search methods of failure surface and the suggested optimum number of finite elements, multiple non-circular failure surfaces were predicted from the LE and FE methods that were not anticipated in the initial slope design based on the SC method. The location and shape of the failure surfaces from the LE method agreed with those from the FE method. The difference between the Fs values from the static LE analysis and those from the static FE analyses was less than 14%, but the discrepancy increased up to 78% in the pseudostatic analyses. This study highlights the importance of validating the results from one method with the other methods to prevent slope failures.

Quantitative analysis of transferrin uptake into living cells at single-molecule level

Endocytosis, apart from providing a mechanism for cells to take up nutrients, is the principal route of entry for many nanomedicines. The evaluation of therapeutic delivery efficiency without providing quantitative parameters, like the number of molecules entering the cell and the time of their entry, is very limited. Despite advances in single-molecule methods for in-cell quantitative measurements, they have not become widely used in the study of endocytosis. Their application, however, is challenging owing to the appropriate experimental design and applicable analysis methods. Here, by using an integrated approach based on the multidimensional time-correlated single-photon counting (TCSPC) technique, we demonstrate the quantitative method to measure the time- and concentration-dependent uptake of TRITC-transferrin into living cells with single-molecule sensitivity. The methodology opens possibilities for quantitatively assessing the delivery efficiency of fluorescent molecules into living cells.

Core Concepts in Pharmacoepidemiology: Quantitative Bias Analysis.

Pharmacoepidemiological studies provide important information on the safety and effectiveness of medications, but the validity of study findings can be threatened by residual bias. Ideally, biases would be minimized through appropriate study design and statistical analysis methods. However, residual biases can remain, for example, due to unmeasured confounders, measurement error, or selection into the study. A group of sensitivity analysis methods, termed quantitative bias analyses, are available to assess, quantitatively and transparently, the robustness of study results to these residual biases. These approaches include methods to quantify how the estimated effect would be altered under specified assumptions about the potential bias, and methods to calculate bounds on effect estimates. This article introduces quantitative bias analyses for unmeasured confounding, misclassification, and selection bias, with a focus on their relevance and application to pharmacoepidemiological studies.

Development and Design Validation of an Inflow-Settling Chamber for Turbomachinery Test-Benches

At Leibniz University of Hannover, Germany, a new turbomachinery test facility has been built over the last few years. A major part of this facility is a new 6 MW compressor station, which is connected to a large piping system, both designed and built by AERZEN. This system provides air supply to several wind tunnel and turbomachinery test rigs, e.g., axial turbines and axial compressors. These test rigs are designed to conduct high-quality aerodynamic, aeroelastic, and aeroacoustic measurements to increase physical understanding of steady and unsteady effects in turbomachines. One primary purpose of these investigations is the validation of aerodynamic and aeroacoustic numerical methods. To provide precise boundary conditions for the validation process, extremely high homogeneity of the inflow to the investigated experimental setup is imminent. Thus, customized settling chambers have been developed using analytical and numerical design methods. The authors have chosen to follow basic aerodynamic design steps, using analytical assumptions for the inlet section, the “mixing” area of a settling chamber, and the outlet nozzle in combination with state-of-the-art numerical investigations. In early 2020, the first settling chamber was brought into operation for the acceptance tests. In order to collect high-resolution flow field data during the tests, Leibniz University and AERZEN have designed a unique measurement device for robust and fast in-line flow field measurements. For this measurement device, total pressure and total-temperature rake probes, as well as traversing multi-hole probes, have been used in combination to receive high-resolution flow field data at the outlet section of the settling chamber. The paper provides information about the design process of the settling chamber, the developed measurement device, and measurement data gained from the acceptance tests.

Nurse-Patient Communication: An Examination of Student-Nurses of Post Basic Nursing Anesthesia (PBNA) and Peri-Operative Nursing (PON) of Jos University Teaching Hospital (JUTH), Plateau State, Nigeria

Effective nurse-patient communication is essential for providing high-quality healthcare and ensuring patient safety and satisfaction. Proficiency in English is crucial for nurses to effectively interact with patients, families, and other healthcare professionals. However, many nurses face challenges in using correct grammar and language, which can impact communication and care delivery. This paper explores the relevance of English proficiency in nurse-patient communication, examines the grammar challenges nurses face, and suggests potential strategies to overcome these challenges. A total of 35 student-nurses were randomly selected from the Post Basic Nursing Anesthesia (PBNA) and Peri-Operative Nursing (PON) program at JUTH. The study adopted a mixed-methods research design, combining both qualitative and quantitative data collection and analysis methods. Among other challenges, the study discovered that nurses face problems in the areas of tenses, choice of words, sentence construction, and patients’ poor grasp of English. The study suggests that language training and support, and continuous professional development, etc. can help improve the communication among nurses and with patients. The study thus concludes that proficiency in English and proper grammar usage are essential for effective nurse-patient communication, and overcoming language and grammar challenges can improve patient safety, satisfaction, and healthcare outcomes.

Tailored guidance to apply the Estimand framework to Trials within Cohorts (TwiCs) studies

Objective: The estimand framework offers a structured approach to define the treatment effect to be estimated in a clinical study. Defining the estimand upfront helps formulating the research question and informs study design, data collection and statistical analysis methods. Since the Trials within Cohorts (TwiCs) design has unique characteristics, the objective of this study is to describe considerations and provide guidance for formulating estimands for TwiCs studies.Methods: The key attributes of an estimand are the target population, treatments that are compared, the endpoint, intercurrent events and their handling, and the population-level summary measure. The estimand framework was applied retrospectively to two TwiCs studies: the SPONGE and UMBRELLA Fit trial. The aim is to demonstrate how the estimand framework can be implemented in TwiCs studies, thereby focusing on considerations relevant for defining the estimand. Three estimands were defined for both studies. For the SPONGE trial, estimators were derived.Results: Intercurrent events considered to occur exclusively or more frequently in TwiCs studies compared to conventional randomized trials included intervention refusal after randomization, misalignment of timing of routine cohort measurements and the intervention period, and participants in the control arm initiating treatments similar to the studied intervention. Considerations for handling refusal after randomization related to decisions on whether the target population should include all eligible participants or the subpopulation that would accept (or undergo) the intervention when offered. Considerations for handling treatment initiation in the control arm and misalignments of timing related to decisions on whether such events should be considered part of treatment policy or whether interest is in a hypothetical scenario where such events do not occur.Conclusion: The TwiCs study design has unique features that pose specific considerations when formulating an estimand. The examples in this study can provide guidance in the definition of estimands in future TwiCs studies.

Accurate statistical methods to cover the aspects of the increase in the incidence of kidney failure: A survey study in Ha'il -Saudi Arabia.

Chronic kidney disease (CKD) has become more common in recent decades, putting significant strain on healthcare systems worldwide. CKD is a global health issue that can lead to severe complications such as kidney failure and death. The purpose of this study was to investigate the actual causes of the alarming increase of kidney failure cases in Saudi Arabia using the supersaturated design analysis and edge design analysis. A cross-sectional questionnaire was distributed to the general population in the KSA, and data were collected using Google Forms. A total of 401 responses were received. To determine the actual causes of kidney failure, edge and supersaturated designs analysis methods were used, which resulted in statistical significance. All variables were studied from factor h1 to factor h18 related to the causes of kidney failure. The supersaturated analysis method revealed that the reasons for the increase in kidney failure cases are as follows: h9(Bad diet), h8(Recurrent urinary tract infection), h1 (Not drinking fluids), h6 (Lack of exercise), h14 (drinking from places not designated for valleys and reefs), h18 (Rheumatic diseases), h10 (Smoking and alcohol consumption), h13 (Direct damage to the kidneys), h2 (take medications), h17 (excessive intake of soft drinks), h12 (Infection), h5 (heart disease), h3 (diabetes), h4 (pressure disease), h15 (Dyes used in X-rays), and h11 (The presence of kidney stones) are all valid. The design analysis method by edges revealed that the following factors contributed to an increase in kidney failure cases: h8 (Recurrent urinary tract infection), h6 (Lack of exercise), h7 (Obesity), and h11. The findings showed that there were causes of kidney failure that led to the statistical significance, which is h8 (Recurrent urinary tract infection) and h11 (The presence of kidney stones).

Design of nonlinear locking mechanism for shape memory alloy archwire of miniature orthodontic device

The locking mechanism between bracket and shape memory alloy (SMA) archwire in the newly developed domestic orthodontic device is the key to controlling the precise alignment of the teeth. To meet the demand of locking force in clinical treatment, the tightening torque angle of the locking bolt and the required torque magnitude need to be precisely designed. For this purpose, a design study of the locking mechanism is carried out to analyze the correspondence between the tightening torque angle and the locking force and to determine the effective torque value, which involves complex coupling of contact, material and geometric nonlinear characteristics. Firstly, a simulation analysis based on parametric orthogonal experimental design is carried out to determine the SMA hyperelastic material parameters for the experimental data of SMA archwire with three-point bending. Secondly, a two-stage fine finite-element simulation model for bolt tightening and archwire pulling is established, and the nonlinear analysis is converged through the optimization of key contact parameters. Finally, multiple sets of calibration experiments are carried out for three tightening torsion angles. The comparison results between the design analysis and the calibration experiments show that the deviation between the design analysis and the calibration mean value of the locking force in each case is within 10%, and the design analysis method is valid and reliable. The final tightening torque angle for clinical application is determined to be 10° and the rated torque is 2.8 N∙mm. The key data obtained can be used in the design of clinical protocols and subsequent mechanical optimization of novel orthodontic devices, and the research methodology can provide a valuable reference for force analysis of medical devices containing SMA materials.

Experiences of Parents of Children with Cancer in the Diagnosis Process: A Qualitative Study.

This study aimed to describe the experiences of parents of children with cancer in the diagnosis process. A descriptive qualitative research design and content analysis method were used. Eleven parents participated in the study. Three main themes emerged, each with related sub-themes: encountering a cancer diagnosis, changes in the lives of those affected by the diagnosis, and coping strategies. Upon their children's diagnosis, parents reported feelings of guilt, regret, helplessness, devastation, constant thoughts of death, and changes in their lives, with some siblings displaying negative reactions. Some children felt their freedom was restricted, and some refused treatment. Parents coped by distracting their attention, praying, receiving support from their family, relatives or health professionals, and maintaining hope for their children's recovery. The study concludes that parents of children diagnosed with cancer require support to manage and adapt to the diagnosis process and meet their needs effectively throughout this difficult journey.

A laminar spray group combustion experiment (LSGCE) with in situ image diagnostic methods and image analysis algorithms.

Spray combustion is important for different engines. The understanding of spray combustion should be further promoted especially in the non-dilute region, and there is lack of well-defined spray experiments. In this study, an experimental platform was developed. Using this platform, a cylindrical quasi-laminar spray can be formed and ignited by a thin and straight hot wire, making it a simple configuration. Two image diagnostic methods were also developed to capture in situ microscopic droplet images and macroscopic droplet-flame images synchronously. Different image analysis algorithms were developed to obtain droplet statistics (diameter, velocity, and number density) and flame information (size, location, and flame propagation speed) from the raw images. The design, diagnostic methods, and image analysis methods are detailedly presented. This experimental platform can cover a wide range of operating conditions, with Gig in a range of 0.01-0.06 and temperature in a range from room temperature to 1400K. In addition, this platform is small in size and is capable of further implanting into a ground-based microgravity facilitaty. The whole experimental system can be applied in spray ignition and combustion studies and can provide legitimate data for further model development.

Analytical modeling of cylindrical eddy current brakes and multi-objective optimization based on game theory

With the research and development of eddy current brake (ECB), today ECBs have been applied in a variety of fields including vibration control and braking of strong impact loads.The application of a new cylindrical structure eddy current brake (ECB) for strong impact braking of large machinery has been discussed recently. Its high-speed and high-kinetic-energy braking conditions require different analytical and optimization design models and methods from what has been addressed in previous studies. For subsequent more engineering-oriented research and optimization, modeling methods are needed, as well as analysis and optimization studies for braking forces and critical speeds of interest. In this work, a magnetic equivalent circuit model is established, and the influence of eddy current induced during application is taken into account by considering it as a magnetomotive force in the model. The braking force is calculated with the MEC model and an approximate electric field cross-section method. A small prototype experiment is carried out and proves the correctness of the proposed model. Using the proposed and FEM model, parameters of the ECB are analyzed. Then, aiming at design objectives of the ECB that are somewhat competitive under this special braking condition, a multi-objective optimization model is established using the Stackelberg game strategy. An FEM model is built and assessed based on optimization results. The results indicate that the multi-objective optimization model based on the Stackelberg game is effective for the design of this ECB structure.

The Extent of Implementation and Influence of Boys and Girls Brigade Philippines (BGBP) Programs

This study examines the extent of implementation and influence of the Boys and Girls Brigade Philippines (BGBP) programs. Its objectives are twofold: first, to assess the extent of implementation of its programs and determine their impact on its recipients; and second, to introduce a quality program for other institutions to adopt in addressing current societal challenges and preparing students for the VUCA world. The research employs a descriptive comparative design, utilizing both quantitative and qualitative data analysis methods. The quantitative data analysis used mean scores, frequency count, Kruskal-Wallis H Test, and Post-Hoc Analysis (Dwass-Steel-Critchlow-Fligner Pairwise Comparison). Qualitative data were analyzed using thematic analysis. The study involved 144 respondents, including administrators, teachers, students, and alumni of BGBP. Key findings reveal that all the BGBP programs are highly implemented. Also, all the BGBP programs are highly influential. There is a highly significant difference in the perception of administrators, teachers, and students on the implementation and influence of the programs. The program offers numerous benefits, such as spiritual growth, learning to live and lead for Christ, and developing leadership skills. Challenges faced include leadership issues, financial constraints, inconsistency in implementation, students’ attitudes, and parental support. To enhance the program, recommendations include strengthening the set standard, elevating the mentoring system, reinforcing parental involvement, and seeking financial support. Additionally, policymakers and curriculum makers may consider adopting BGBP as a benchmark, as it addresses current challenges and prepares students for the rapidly changing world.

Flexoelectric and surface effects on bending deformation and vibration of piezoelectric nanolaminates: Analytical solutions

In this paper, a model of double-layer rectangular piezoelectric nanolaminates with different upper and lower surface properties is established. The bending and vibration behavior of the piezoelectric nanolaminates are evaluated and analyzed, taking into consideration the flexoelectric and surface effects. Utilizing the surface piezoelectric model, flexoelectric theory, and Kirchhoff plate theory, this study provides analytical solutions for the bending deflection and natural frequency of rectangular piezoelectric nanolamination materials under various boundary conditions. The results indicate that the effects of flexoelectric and surface influences on piezoelectric nanolaminates are associated with residual surface stress and flexoelectric coefficients. These effects can enhance the bending stiffness and decrease the natural frequency of the piezoelectric nanolaminates. Furthermore, altering the residual stress on the upper and lower surfaces of the laminates separately will result in different trends in bending deflection, while causing a consistent trend in natural frequency change. When the electric potential direction of piezoelectric nanolaminates is different, the bending deflection of piezoelectric nanolaminates will change accordingly. The natural frequency of piezoelectric nanolaminates is determined by the absolute value of the flexoelectric coefficients, and is independent of their positive or negative values. Both the surface effect and the flexoelectric effect are influenced by size-dependent behaviors. When the thickness of the laminates is sufficiently large, both the surface effect and flexoelectric effect can be disregarded. This paper's research methods and results provide theoretical models and analytical methods for the microstructure design, multi-physical field characterization, and bending deformation behavior of intelligent components containing rectangular piezoelectric nanolaminates.

Research on Sea Trial Techniques for Motion Responses of HDPE Floating Rafts Used in Aquaculture

The innovative aquaculture equipment known as high-density polyethylene (HDPE) floating rafts has gained popularity among fishermen in the southeast coastal regions of China. Compared to deep-water anti-wave fish cages, the construction costs of HDPE floating rafts are 50% to 75% less. There is a dearth of comprehensive publicly available records of HDPE floating rafts sea trial data, despite substantial numerical studies on the motion response of aquaculture fish cages and scale model experiments under controlled-wave conditions. This study involves sea trial techniques under operational and extreme environmental conditions for motion responses of HDPE floating rafts, presents a comprehensive procedure for sea trials of HDPE floating rafts, summarizes the issues encountered during the trials, and suggests solutions. Using MATLAB for independent programming, motion videos and photos collected from the sea trials are processed for image capture, yielding the original time history curve of vertical displacement. Based on the sea trials’ data, including motion displacement, acceleration, mooring line force, overall deformation patterns, and current and wave data, recommendations are provided for the design and layout of HDPE floating rafts. Based on the Fast Fourier Transform (FFT) method for spectral analysis, the influence of interference items on the observational data is eliminated; the rationality of the observational data is verified in conjunction with the results of the Gabor Transform. This study offers a scientific analytical method for the structural design and safe operation of HDPE floating rafts and provides a reference for subsequent numerical simulations.

Event-triggered [formula omitted]-fault-tolerant consistency control for multi-agent systems

This paper investigates the issue of active fault-tolerant control for multi-agent systems using an event-triggered mechanism, aiming to achieve state-consistency control under a leader–follower framework. The proposed control protocol consists of two main components: leader input estimation and fault tolerant controller design under an event-triggered mechanism. Firstly, a leader–follower error system is constructed, where the leader’s input is considered as a supplementary vector for the system state, resulting in an augmented error system. Then, a distributed state observer is designed for this augmented error system to transform the leader’s input estimation problem into an augmented state estimation issue. Furthermore, an event-triggered mechanism is designed to optimize network communication resources by updating the control law only when specific triggered conditions are met. Next, taking into account the errors introduced by the distributed observer and event-triggered mechanism, the problem of determining the state error feedback gain matrix is transformed into a linear matrix inequality problem using H∞ robustness design and Lyapunov stability analysis methods. Finally, the effectiveness of this theoretical framework is validated through a practical example involving several VTOLs.

Сравнительный анализ вариантов построения алгоритмов управления температурой в химическом реакторе

In conditions of increased demand for the quality and efficiency of control systems for objects of various nature, for example, chemical reactors, it is advisable to apply the principle of state vector control, and not only the principle of output coordinate control. Application of modern methods of synthesis of control algorithms encounters difficulties associated with the multidimensionality and nonlinearity of objects, the parametric uncertainty of models and noncomplete measurability of the state vector. To synthesize the temperature control algorithms in a chemical reactor, the method of analytical design of aggregated regulators and the method of modal control based on a state controller have been used. The problem of noncomplete measurability of the state vector has been solved by decomposition, reduction of the object model. The authors have synthesized two nonlinear algorithms of temperature control using the method of the analytical design of aggregated regulators and two algorithms based on state controller using a reduced linearized object model. The properties of invariance, covariance, and robustness of the control system with various algorithms are investigated by modeling the control system using the initial nonlinear model of the object. The best quality indicators of transient control processes are demonstrated by a nonlinear algorithm with an integral component synthesized by the method of analytical design of aggregated regulators.

한국 여성노인의 저작불편감과 영양소 섭취의 연관성

Objectives: The purpose of this study was to determine the relationship between chewing discomfort and nutrient intake in elderly Korean women. Methods: A complex sample design analysis method was applied using data from the 2022 National Health and Nutrition Examination Survey to confirm the relationship between chewing discomfort and nutrient intake, nutrient density, nutritional quality index, and nutrient intake ratio. Results: In both groups, the nutritional performance index and various optimal intake ratios for vitamin A, vitamin C, niacin, and lumps were in the range of 1.0 or less, which were relevant to the variation in chewing discomfort. Conclusions: To manage masticatory function for balanced nutrient intake in elderly women, interest in and management of oral health is necessary.

Seismic performance of underground subway station structure near the strike-slip fault by the developed hybrid IBE-FEM method

To investigate the influence of strike-slip faults on the seismic responses of underground structures, based on the single-layer potential theory of the boundary element concept and the fault-site-underground structure coupling mechanisms, we proposed a hybrid indirect boundary element-finite element numerical method (IBE-FEM) to simulate efficiently the seismic response of the entire process from the near seismogenic-fault to the underground structure. Initially, based on the kinematic finite-fault model, the seismic wavefield of an overlying soft-soil sedimentary-layer site subjected to strike-slip faults with source parameters, such as rupture velocity, dip-angle, and upper-boundary burial depth, was solved using the indirect boundary element method (IBE). Subsequently, the accuracy of the IBE-FEM in predicting the site seismic wavefield was verified. On this basis, the influence laws of the source parameters and the fault-site coupling effects on the seismic performance of the structure were preliminarily investigated by establishing a numerical model of the nonlinear dynamic interaction system of a soil-underground structure. The results showed that the seismic responses of the underground structure located in the footwall far-fault region were more strongly affected by variations in the rupture velocity. The lateral deformation of the structure under the rupture velocity condition of bedrock shear-wave velocity (vs) was dramatically increased compared to sub-vs, and the lowest amplification is 59 %. Furthermore, the hanging wall and seismic damage concentration effects significantly impacted the structure located in a strike-slip fault site with a shallow-burial. This study provides a reliable and efficient analytical method for the seismic design of underground structures in complex near-fault regions.