Anyi Mazo-Vargas received the first place for a Graduate Poster Presentation at the 2019 meeting of the Pan-American Society for Evolutionary Developmental Biology. She is also a recipient of a Cozzarelli Prize from the National Academy of Science, a GRFP-NSF and Cornell Provost Diversity Fellowship, and the LaMont C. Cole Award from the Department of Ecology and Evolutionary Biology at Cornell University. What got you interested in Biology? In a lot of ways, I got into biology by mere luck. I am a low income, first-generation college student. My mother finished high school when I was a teenager, and my father only went to elementary school. Hence, the goal set for me was to finish high school. When I did, I wanted to keep studying, and I loved the TV documentaries about wildlife, nature and medicine. I applied for a Biology degree because I did not see myself in anything else. I later discovered EvoDevo, and I knew it was for me during my PhD. What drew you to EvoDevo for your graduate degree? I applied to graduate school thinking more about the population genetics field. I joined a laboratory with a history of working with Heliconius butterflies. At that time, studies in Heliconius speciation and population evolution were coming out. From those studies, we learned that few candidate loci are driving the divergence between these mimetic populations. Then I got curious, what are these genes doing, what about the other species and genera of butterflies? What are the molecular mechanisms behind these fantastic phenotypical changes we see in nature? Then, it became evident to me that EvoDevo was the realm where I could approach these questions, especially with the implementation of CRISPR-Cas9 and the acquisition of epigenomic data from developing wings in Lepidoptera. How did you find your PhD advisor? I wanted to work with insects, for which a necessary amount of natural history was known. Using those parameters as a starter, I looked for papers, I developed a spreadsheet with faculty that I was interested in and then emailing them until I reduced my list to two people, including my current advisor, Dr. Robert Reed. Is your PhD proposal anything like your thesis? No, the proposal was in gene regulation, specifically cis-regulation between populations of Heliconius. However, I switched to work with distantly related species and the evolution of the cis-regulation architecture of the WntA gene. What leads your research: an experimental tool, the organism, or a question? It is a mix between the questions and the organism. I wonder all the time about the “how” and “why” questions that resulted in the phenotype. A lot of it is related to the developmental repatterning and evolution of novel traits. Then, there are moths and butterflies (Lepidoptera), a megadiverse group of insects, with many fascinating morphological features (e.g., color patterns, wing tails, tympanate ears) with known ecological functions and selective pressures driving their diversification. They do have their limitations, but colleagues and I are working on getting genetic tools in the system to do more sophisticated experiments.
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