Dental Gel Research Articles

Complex Procedure of Orthopedic Rehabilitation of Patients with Pathology of The Oral Mucosa

Topicality: Removаble orthopedic struсtures of dentures in the сourse of time irritate the оral mucosa. Competent mаnufacturing, timely cоrrection, recommendаtions for professional and individual hygiene of the оral cavity and the dentures themselves do nоt аlways guarantee the absence of аn inflammatory reаction of the prosthetiс bed tissues. During orthopedic treаtment, a dentist fаces the challenge of preventing dysbiotic аnd inflammatory complicаtions. The Purpose: of this reseаrch is to study the influenсe of the basiс mаterial of removable orthоpedic structures on the stаte of prosthetiс bed tissues and to prоve the effectiveness оf the comprehensive method of оral dysbiosis prevention prоposed by the аuthors. Material and Methods of Reseаrch: Pаtients needed removable prosthetiсs were allocated to 3 equivаlent study groups, each wаs offered specific therаpeutic and preventive mеasures. The method of mаcrohistochemical reaction enabled to assess the muсous membrаne condition under the bases of removablе dentures made of acrylic polymer in a day, 7 and 14 days of applying a removable dеnture. The quantitative and quаlitative compоsition of the oral mucosa micrоbiocinosis was alsо studied. Results оf the Study: The results of clinicаl and microbiolоgical mucоus membrane examinatiоn of the prоsthetic bed indicаte the expedience of using the оrthopedic rehаbilitation method prоposed by the authоrs for the prevention of oral dysbiоsis. Conclusion: Studying these prоblems is especially significаnt for imprоving the effectiveness of orthоpedic rehabilitatiоn due to reducing inflammatory and dysbiotic dental complicatiоns. MeSH words: removаble dentures, oral mucоsa, acrylic base plаstic, dysbiоsis, synbiоtics, probiоtics, dental gel, disinfectant sоlution.

The market study of medicines used for the prevention and treatment of hyperesthesia of dental hard tissues

The purpose of the work is to study the structure of the Ukrainian market of medicines, cosmetics and dental products for the prevention and treatment of hyperesthesia of dental hard tissues in order to determine marketing opportunities for domestic pharmacy.
 Materials and methods. The study was conducted using structural analysis, logical and graphical methods, methods of marketing analysis.
 The results. Determined the state of the Ukrainian market of medicines of the specified group with their distribution on means of mass market and specialized means, which are usually used by dentists in professional activity, with allocation of separate groups, namely: toothpastes for sensitive teeth, rinses, dental gels, pastes, creams, varnishes, solutions, films. The market is studied by the number of items, by form of release, country of origin, brand, composition. The dynamics of import and export of oral and dental hygiene products in the context of commodity items according to Foreign Economic Activity Codes has been studied.
 Conclusions. The composition of desensitizing agents is analyzed, the most popular APIs used to eliminate the manifestations of dental hyperesthesia with their distribution on plant medicinal raw materials, mineral-biological and synthetic are identified. Recently, there is a popularity of the use of calcium hydroxyapatite in dental products for the prevention and treatment of dental hyperesthesia, which is primarily characterized by safety and high biocompatibility with body tissues. The results of research show that the market is 90% import-dependent, and in the group of dental films 100% of the market belongs to Russian manufacturers, the range is unstable, there are no positions for a long time. It should be noted that for the domestic producer, the domestic Ukrainian market is promising, it is stable in terms of consumption, almost completely import-dependent. In this regard, the development of new drugs for the prevention and treatment of hyperesthesia with innovative composition, high biocompatibility, complex action, possibly with controlled access of drugs and with minimal side effects is a promising area of further research.

Fluorinated Agents Effects on Orthodontic Alloys: A Descriptive In Vitro Study.

Fluoride-based mouthwashes and gels are preventive measures in countering demineralization and caries but, modifying environmental acidity, can reduce the wet corrosion resistance of orthodontic alloys. To evaluate chemical stability, in vitro experiments were conducted on stainless steel and nickel–titanium wires, weighed before and after immersion in household fluorinated mouthwashes and gels, measuring weight variations and elution of metal ions from acid corrosion phenomena. Elution samples were analyzed by inductively coupled plasma mass spectrometry, detecting residual ion concentration, while surface changes were analyzed under scanning electron microscopy. Results showed stainless steel wires do not undergo significant erosion when exposed to most fluorinated mouthwashes but, at prolonged exposure, alloys elute gradually greater amounts of metals and Ni–Ti wires become more sensitive to some mouthwashes. Ions’ elution varies considerably, especially for Ni–Ti wires, if exposed to household fluorinated gels, for which significant negative values were obtained. Changes, affecting wires’ outer layer, negatively act on shiny appearance and luster, reducing corrosion resistance. Although examined orthodontic wires showed good chemical stability and low toxicity, surface corrosion from exposure to fluorinated agents was observed. Home use must be accompanied by clinician prescription and, for household dental gels, must follow manufacturers’ recommendations, ensuring prophylactic action without damaging alloys surfaces.

Formulation and Evaluation of Antimicrobial Mucoadhesive Dental Gel of Aerial Root of Ficus Benghalensis L to Enhance the Therapeutic Activity using Clove Oil

Formulation and Evaluation of Antimicrobial Mucoadhesive Dental Gel of Aerial Root of Ficus Benghalensis L to Enhance the Therapeutic Activity using Clove Oil

Effectiveness of Experimental Whitening Toothpastes Containing Colorants on the Optical Properties of Enamel.

Objective This in vitro study investigated the whitening potential of experimental toothpastes containing optical colorants in their formulations in comparison with commercial products. The chemical and physical characteristics of the toothpastes, the morphology, and elemental analysis of the enamel surface after treatment were also analyzed. Materials and Methods One hundred twenty-five bovine incisor teeth were randomly divided into five groups according to the treatment: (i) experimental PHTALOX dental gel (PHT); (ii) experimental blue silica dental gel (SDG); (iii) Sensodyne Whitening Repair & Protect (WRP); (iv) Sensodyne True White (STW); (v) Snow White Toothpaste (SWS). The whiteness index differences (ΔWID) and color alteration (CIELab-ΔE, CIEDE2000-ΔE00) were calculated after color change analysis using a spectrophotometer before and after the enamel treatment (n = 25). The surface and cross-sectional micromorphology were assessed using scanning electron microscopy. The elemental analyses were determined with energy-dispersive X-ray spectroscopy (EDS). The pH, particle size, zeta potential, and polydispersity index of toothpaste were evaluated. Data was statistically analyzed (ANOVA/Tukey, 5%). Results Whitening toothpastes containing optical colorants were effective for whitening the enamel, as whiter teeth were observed following treatment (higher means of ΔWID). In addition, when the parameters ΔEab and ΔE00 were evaluated, these toothpastes were graded as very good effectiveness (grade 4). Other toothpastes were graded as 3 (good effectiveness). PHT had a neutral pH and a larger mean particle size (412.8 nm). Elemental analysis demonstrated enamel with a silicon-enriched mineral layer on the enamel surface treated with SDG. The Ca/P ratio after enamel treatment varied from 1.74 (SWS) to 2.04 (SDG and WRP). Conclusions Experimental whitening toothpastes containing optical colorants are effective at bleaching the enamel. The synergism among the different parameters analyzed seems to positively affect the color change after brushing with whitening toothpastes containing optical colorants.

DEVELOPMENT OF COMPOSITION AND ANALYSIS OF DENTAL GEL BASED ON PERILLA FRUTESCENS. L. LIQUID EXTRACT

Abstract: The aim of the study was to develop and substantiate the optimal composition, as well as methods for analyzing dental gel based on perilla grass of shrub extract of liquid. Based on the results of the studies, optimal adjuvants and compositions of dental gels on composite ointment bases were determined. Process parameters of gels, organoleptic properties, pH index, homogeneity, rheological characteristics, biopharmaceutical and microbiological indices, authenticity and quantitative content of active substances were studied. According to all indicators, the developed dental gels meet the requirements of GF XIV. However, the best structural and mechanical properties and high release kinetics (87%) have composition No.1, which includes PEO 400, PEO 4000, tween-80 and perillas shrub extract liquid, which allowed for subsequent studies with this gel. By TLC, rosemary and coffee acids, as well as tannins, flavonoids, saponins and chlorophyll were identified. The presence of shrub extract with liquid flavonoids in a perilla grass-based gel was confirmed by a cyanidine sample (red staining) and chalkone formation (yellow-orange staining appeared in the presence of alkali when heated). In addition, qualitative reactions were carried out, as a result of which tannins, saponins and chlorophyll were identified. A method of quantifying the sum of flavonoids using differential spectrophotometry in terms of rutin has been developed. As analytical wavelength it is chosen λmax = 395nm. It was found that the content of flavonoids in the gel in terms of rutin is 0,0123 ± 0,0002%. The relative error of the technique does not exceed ± 2,24%.

Avaliação da ação profilática de gel odontológico veterinário a base de Aloe vera e chá verde na formação de cálculos dentários em cães submetidos a tratamento periodontal

The aim of this study was to evaluate the effect of veterinary dental gel containing Aloe vera and green tea, with and without a water additive in preventing calculus formation in dogs after all animals were initially submitted to periodontal treatment. The preventive treatment was performed on 72 dogs, which 24 received treatment with the veterinary dental gel (G1), 24 received treatment with the gel associated with a water additive (G2), and 24 dogs did not receive any treatment (G3). The animals also were subdivided into three groups according to their diet. The gel was applied directly to the dogs’ teeth and 500 ml of the additive was added to the water, three times a week. The animals’ teeth were photographed every 30 days to observe the time of new deposition of dental calculus. The images were analyzed by MATLAB. The dogs in G1 showed average of new accumulation of dental calculus of 254.8 days, those in G2 also showed an average return of 258.6 days, and G3 showed an average return of 156.7 days. There was a statistical difference between G1 - G3 (p-value = 0,000007885) and G2 - G3 (p-value = 0,00004568). There was no statistical difference between the different food groups. We concluded that the gel used in this study, associated or not with the water additive, was effective in helping to maintain the dental health of the animals for a prolonged period after the surgical procedure to prevent the calculus return.

CLINICAL AND LABORATORY EVALUATION OF A NOVEL DENTAL GEL FOR TREATMENT OF CHRONIC CATARRHAL GINGIVITIS

This article presents the study of a dental gel developed by us, containing, as an active ingredient, sanguitrithrin and oil extract from calendula flowers and yarrow grass. As a result of our studies of the dental gel on 1,844 children and adolescents, we revealed that it has antiinflammatory and wound-healing activities and produces anti-inflammatory, reparative, hemostatic and trophic effects. The results of the study make it possible to use the dental gel in clinical practice for treatment of inflammatory periodontal diseases in children. We substantiated the prospects of using the phytocomplex in the form of a dental gel and proved it as effective and safe. Besides, its dosage form is convenient for use in dental practice and even provides advantages over known domestic analogues.

The effect of astaxanthin on the adaptation of the oral mucosa to a removable denture

Of this study was the evaluation of the effect of the antioxidant gel on the oral mucosa and reduction of the time of adaptation to a removable denture in patients with partial adentia. The study comprised 105 patients aged 30-65 years divided into three groups: the main group of 45 patients, the comparison group of 35 patients, the control group of 25 patients. The main group was given a prophylactic gel with natural astaxanthin after the delivery of a removable prosthesis. The patients of the control group and the comparison group do not received an antioxidant gel. Patients of all three groups underwent a study of the hygienic state of the oral mucosa and oral fluid to assess the state of oral microbiocenosis. The main group and the comparison group underwent visual examination and photoplanimetric control after the placement of a removable denture. A positive preventive and anti-inflammatory effect of astaxanthin gel was found in patients who received an immediate and a partial removable dentures. The use of the gel for 7 days helps to reduce the values of hygiene indices, concentrations of bacterial plasmalogen and endotoxin in the oral fluid in the short-term perspective. Preventive dental gel with astaxanthin decreases the time of adaptation to removable dentures by 1.7-2 times and reduces the risk of prosthetic stomatitis due to its wound-healing, anti-inflammatory and antimicrobial actions.

Formulation and evaluation of dental gels and pastilles containing xylitol for dental caries

Impact of teaching on dental knowledge in fifth standard of MCD primary school children of south DelhiFatima Chaudhary, Khalid Umer Khayyam, Mohd. Junaid Siddiqui, Rubi Anjum, Sazina Muzammil

Creation and technological research of dental gel with tizol and L-arginine

Creation and technological research of dental gel with tizol and L-arginine

Antimicrobial properties of the new combined dental gel

Given the role of the microbial factor in the development of infectious-inflammatory processes in the oral mucosa, the research aim was to study the antimicrobial action of a new combined dental gel containing Rotocan® (10%) and triclosan (0.4%) in vitro and in the traumatic stomatitis in albino rats. Rotrin- Denta® exhibited strong antimicrobial activity against etalon strains of gram-positive (S. aureus ATTC 6538, S. pyogenes DICK 1, B. subtilis ATCC 6633) and gramnegative (E. coli ATCC 25922) bacteria, which exceeded the action of the reference drug Camident-Zdorovia® and weak effects on pseudomonads (P. aeruginosa ATCC 27853) and fungi (C. albicans CCV 885-653), which is less to the reference preparation. Rotrin- Denta® reduced microbial insemination and eliminated oral dysbiosis in albino rats with traumatic stomatitis, exceeding the effect of Kamident-Zdorov’ya®. The results open up the prospect of its clinical testing and further implementation in the dentistry practice.

Anti-inflammatory activity of a dental gel based on Origanum vulgare raw material

Inflammatory and destructive diseases of parodontosis are one of the most complex and common forms of the teeth diseases of human population. Search of the herbal preparation with anti-inflammatory activity is a prospect way for development of new drugs on the base of local raw material. A prerequisite for this study has been the presence of a high antimicrobial and anti-caries activity of the essential oil of medicinal plant Origanum vulgare. The article presents for the first time the results on the anti-inflammatory activity of dental anti-caries gel with essential oil and ethanol extract of oregano. A sample of dental gel at a dose of 25 mg / kg has anti-inflammatory activity, which was expressed in a significant decrease by 41.4 % in the amount of inflammatory lymph in the abdominal teeth in rats compared to controls. The anti-inflammatory activity of this sample is comparable to the reference drug diclofenac sodium.

ОЦЕНКА КОМПЛЕКСНОГО ЛЕЧЕНИЯ C ИСПОЛЬЗОВАНИЕМ СТОМАТО-ЛОГИЧЕСКОГО ГЕЛЯ ОРИГИНАЛЬНОГО СОСТАВА НА ПОКАЗАТЕЛИ ПСИХОЭМОЦИОНАЛЬНОГО И СТОМАТОЛОГИЧЕСКОГО ЗДОРОВЬЯ КУР-САНТОВ ВЕДОМСТВЕННОГО ИНСТИТУТА

Subject. Dental diseases are a frequent companion of distress, since the negative impact of psychoemotional stress on the immune status of cadets is reflected in changes in the microflora of the oral cavity and periodontal [4, 9]. 
 The aim of the study is to evaluate the results of using the developed gel for the preven-tion and treatment of inflammatory periodontal diseases in cadets who are under psychoemotional stress.
 Methodology. The group of examined persons consisted of 245 people-cadets of 1–4 courses of the Ministry of Internal Affairs of the Russian Federation. After the dental exami-nation, the cadets were divided into 2 groups: 26 cadets were found to have gingivi-tis/periodontitis of mild severity (group I), and 45 cadets without periodontal lesions (group II) served as a comparison group. The study included psychological testing, clarification of the state of their vegetative reactions and cortisol content in saliva, molecular genetic deter-mination of the composition of the most common periodontal pathogenic bacteria of the dentoalveolar furrow and enzyme immunoassay of the content of pro-inflammatory cytokines in saliva, cell-regulatory and immunosuppressive effects. 
 Results.The application of the gel helps to correct the phenomena of depression, while it affects the frequency of relapses of diseases.The effect of the application on the frequency of detection of periodontal pathogenic bacteria in cadets is manifested in relation to Tanerella forsythia and Aggregatibacter actinomycetemcomitans in the absence of depression, but in the presence of periodontal lesions. When the phenomena of gingivitis/periodontitis of mild se-verity occurred against the background of depression, the effects of using dental gel were in the form of a decrease in the occurrence of these bacteria. There was a significant drop in the oral fluid of IL-12 in the group with depression and periodontal disease, as well as IL-10 in the group without depression, but with mild gingivitis/periodontitis.
 Conclusions. The developed dental gel is recommended both for the phenomena of de-pression and in cases of mild gingivitis/periodontitis against the background of psychoemotional stress.

Comprehensive treatment of glossodynia using vacuum therapy

Relevance. This article evaluates the effectiveness of vacuum therapy in the comprehensive treatment of glossodynia by assessing tongue tissue oxygen saturation and oral fluid noradrenaline content.Materials and methods. 65 patients with glossodynia, aged from 42 to 70 years old, comprised control (n = 32) and comparison (n = 33) groups. The control group received only medication therapy, while the comparison group also received vacuum therapy. Medication therapy included antianxiety drugs, antidepressants, vitamins and dental gel. The study used a CAP-“Periodontist” unit for physiotherapy treatment. Vacuum acted upon painful tongue areas with pressure 0.35-0.45 atm during 1.5-8 min daily (time and vacuum gradually increased within the specified range). The treatment cycle consisted of 7 sessions. We assessed the pain level by VAS (visual analogue scale). We evaluated parameters of peripheral oxygen saturation by pulse oximetry. We checked noradrenaline in the oral fluid by high-performance liquid chromatography using a liquid chromatograph with an electrochemical detector.Results. In the control group, values of peripheral oxygen saturation, noradrenaline content in the oral fluid and pain level after treatment differed from the corresponding values in the comparison group (p < 0,001).Conclusion. Comprehensive treatment of glossodynia, with vacuum therapy, is effective and significantly decreases tingling and numbness, improves microcirculation and patient psychoemotional condition due to pain relief.

APPROACHES TO THE SELECTION OF EXCIPIENTS FOR DENTAL GEL WITH CETYLPYRIDINIUM CHLORIDE

The aim of the study was to determine the excipients influence on the characteristics of gels with cetylpyridinium chloride and to select the dental gel formulation gelation agents promising for the development of dental gel compositions. Hereby, the properties of the active pharmaceutical ingredient, characteristics of the specific gelation agents, as well as their influence on stability, biopharmaceutical and application properties of gels, were taken into account. Materials and methods. In this study, polymers with various gelation mechanisms were considered. Their compatibility with cetylpyridinium chloride as well as storing kinetic and colloid kinds of stability, pH of aqueous solutions, spreadability and textural properties, a penetration ability by the agar diffusion method, an osmotic activity and rheological properties of the gels, were examined. For a complex evaluation of gel compositions study results, a desirability function was used.Results. Stable homogenous dental gels with cetylpyridinium chloride can be obtained by using 25% poloxamer 407 and 5.0% high molecular weight chitosan as the basis.The addition of poloxamer 188 to high molecular weight chitosan gels can produce stable systems with improved textural characteristics as well as increase their osmotic activity. Agar and low molecular weight chitosan addition significantly decrease, whereas poloxamer188 and various molecular weight polyethyleneglycol increase the osmotic activity of 25 % poloxamer 407 gels which are also characterized by a high penetration ability.Conclusion. A complex evaluation of biopharmaceutical, physicochemical and application properties of the gels made it possible to establish that combinations of poloxamer 407 with polyvinylpyrrolidone, agar, and low molecular weight chitosan, can be recommended as a base for a dental gel with cetylpyridinium chloride.

Baking Soda and Peroxide Formulation as Dental Whitening Gel

Indonesian society began to make appearance as a primary need. Appearance becomes important for middle and upper social classes which reaches 60-70% in Indonesia. Researchers are trying to find a combination formula of two teeth whitening ingredients (Baking Soda and Peroxide). The study uses an experimental method, which is to make a dental gel with variety of gradient constituent formulas, including F1, F2, F3, F4, and F5. F5 is the most optimal formula with best stability test results among other. F5 with Peroxide concentration of 30% had teeth whitening activity of 38% by two months in vitro test on adult teeth samples.

Formulation of an Origanum vulgare based dental gel with antimicrobial activity

ObjectivesThis study aims to formulate a new Origanum vulgare anti-caries dental gel with high antimicrobial activity. MethodsO. vulgare essential oil was extracted using hydro-distillation, ethanol extraction, gas chromatography/mass spectrometry, and high-performance liquid chromatography methods. Antimicrobial activity of the produced gels with oregano oil and extract was determined through the disco-diffusion method. The effectiveness of O. vulgare essential oil was tested in vitro for Streptococcus mutans biofilm using colorimetric analysis. ResultsO. vulgare essential oil inhibited the growth of S. mutans biofilm by 98% compared with unexposed control bacteria (p <0.05). Five samples of anti-caries gel (ACDG1, ACDG2, ACDG3, ACDG4, ACDG5) were formulated using the obtained oregano essential oil and extract. Based on the microbiological study results, the ACDG1 and ACDG3 gel samples exhibited high antimicrobial activity against the gram-positive bacterial strains of Staphylococcus aureus and Bacillus subtilis and the yeast fungus Candida albicans and moderate antimicrobial activity against the gram-negative strains of Escherichia coli and Pseudomonas aeruginosa. ConclusionBased on the results of this study, the ACDG3 sample may be considered an anti-caries gel owing to its high antimicrobial activity. This sample has good organoleptic properties compared to other samples, produces relatively high antimicrobial activity, and guards against cariogenic biofilms of S. mutans.

Virucidal Activity of the Antiseptic Mouthwash and Dental Gel Containing Anionic Phthalocyanine Derivative: In vitro Study.

AimThis research suggested an in vitro virucidal action of a dental gel and a mouthwash with phthalocyanine derivative.PurposeThe aim of this study was to report an in vitro study evaluating the virucidal capacity of mouthwash and dental gel containing anionic phthalocyanine derivate (APD).MethodsThe research followed the recommendations of the National Health Surveillance Agency (ANVISA) and adapted methodology, described in the standards EN14776: 2015; ASTM E1053-11 and the Robert Koch Institute – RKI, in addition to good laboratory practices (GLP). The determination of the percentage of inactivation of the SARS-CoV-2 virus particles was carried out by imposing the viral solution in contact with the respective tested products, with intervals of 30 seconds, 1 and 5 minutes, with subsequent submission of the aliquots, recovered in cell culture microplates following virus titration using the TCID50 (50% Median Tissue Culture Infectious Dose).ResultsThe Mouthwash APD presented 90% of viral inactivation percentage, while the dental gel APD demonstrated 99.99% of viral inactivation.ConclusionIn vitro analyses showed that mouthwash and dental gel APD can reduce the viability of SARS-CoV-2 virus particles.

Development of the simultaneous analysis of choline salicylate, lidocaine hydrochloride and preservatives in a new dental gel by HPLC method

A new high-performance liquid chromatography (HPLC) method for the simultaneous quantitative determination of active pharmaceutical substances and preservatives in a new dental medication has been developed. The optimization of HPLC method parameters was done through studies of a mobile phase composition and a detection wavelength. Our developing method uses an ACE C18 column (250 × 4.6 mm, 5 µm) and a gradient mode for separation with the acetonitrile and phosphate buffer solution (adjusted to pH 3.0) as mobile phases. The flow rate is 1 ml/ min, and the detection was set at 260 nm (DAD). The method was evaluated according to the ICH guidelines and the State Pharmacopoeia of Ukraine in terms of specificity, accuracy, linearity and precision (repeatability and intermediate precision). The limit of detection and the limit of quantification were also calculated. The developed method was put in place for the analysis of a combined dental gel to a quantitative determination of the APIs (choline salicylate, lidocaine hydrochloride) and preservatives (methylparaben, propylparaben).