Dental Fixation Research Articles

Development of Elements of a Risk Management Methodology and Evaluation of the Effectiveness of the Choice of Material for Fixation of Dentures

Development of Elements of a Risk Management Methodology and Evaluation of the Effectiveness of the Choice of Material for Fixation of Dentures

Influence of using a domestic adhesive cream for fixation of removable dentures with plantain extract on mucosal microbiome and secretory immunity of the mouth

Relevance. Denture stomatitis, including fungal infection, which affects many wearers of removable dental prostheses, has a multifactorial etiology with poor oral hygiene as the main predisposing factor. Therefore, the search for means that contribute to the prevention of occurrence and elimination of denture stomatitis in persons using removable dental prostheses remains relevant.Objective. The effect of the adhesive cream for fixation of dentures Asepta Рarodontal with plantain extract on the mucosal microbiome and secretory immunity of the mouth of patients using removable dentures was evaluated.Materials and Methods. The content of secretory immunoglobulin A (sIgA) in saliva was studied by enzyme-linked immunosorbent assay and microbiological examination for periodontopathogens (Prevotella intermedia, Bacteroides forsythus, Treponema denticola, Actinobacillus actinomycetemcomitans, Porhyromonas gingivalis), as well as Streptococccus spp, Staphylococcus spp and Candida spp in 3 groups of patients who did not use any dental prostheses (1 control group, 30 people). ), as well as those who were made partial removable acrylic dentures from the first day of application were offered to use domestic adhesive cream for fixation of dentures Asepta Рarodonta (2 main group, 30 people) and who were made partial removable acrylic dentures, but their adaptation period and subsequent use of dentures passed without the use of any adhesive means for fixation of dentures (3 comparison group, 30 people).Results. It was found that after 6 months of application of adhesive cream for fixation of dentures with plantain extract there was a significant decrease in detection of Bacteroides forsythus and Porphyromonas gingivalis in comparison with the control group, as well as a significant increase in the level of sIgA, which was noted 1 month after the beginning of application of Asepta Carodontal denture fixation agent and continued after 6 months. This indicates the strengthening of secretory immunity, which leads to increased binding of microbes in saliva with their further excretion, inhibition of adhesion of C. albicans to the walls of the denture and epithelial cells of the oral mucosa, which ultimately contributes to a decrease in colonization of the oral mucosa epithelium by fungi and a decrease in the incidence of stomatitis.Conclusion. Prevention of denture stomatitis by optimizing the microbiome of the oral mucosa and mucosal immunity is possible due to the use of adhesive cream for fixation of dentures Asepta Carodontal, as it creates the possibility of preserving and optimizing the microbiocenosis and immune balance in the oral cavity after dental prosthetics, which allow us to recommend the use of adhesive agents for fixation of removable dental prostheses, including cream Asepta Carodontal.

Impact of chemical surface treatment of samples made of domestic zirconium dioxide on adhesive strength

To study the impact of various methods of surface treatment of ZD-based ceramic on adhesive strength. Sandblasting with Al2O3 particles sized 50 μm and application of primers with 10-MDP phosphate monomer were used. Adhesive strength values for following 4 groups of samples were obtained: 1st group - RelyX U200 + sandblasting + Compofix new primer (n=9); 2nd group - Compofix + sandblasting + Compofix new primer (n=9); 3rd group - Panavia F 2.0 + sandblasting (n=9); 4th group (control) - Variolink Esthetic DC + sandblasting + Monobond Plus primer (n=9). The highest strength of adhesion was in the 4th group - 48.71±5.71MPa, the smallest in the 3rd group - 9.49±35.24 MPa. Fully domestic components used in the 2nd group allowed to obtain values of 42.50±9.79 MPa. Adhesive strength in the 1st group was 34.11±4.78 MPa. The absence of the 10-MDP-based primers application in the preparation of ZD ceramic reduces the adhesive strength between resin cement and its surface. The domestic set for fixation of dentures can be effectively used for ZD on the same basis as European analogue.

Finite Element Analysis (FEA) for the Evaluation of Retention in a Conometric Connection for Implant and Prosthesis

Today, dental implantology represents a reliable technique for treating both partial and total edentulism. The fixation of dentures on dental implants can be achieved using various techniques, where the choice of a specific technique depends on the patient’s individual needs, the jawbone’s condition, and the prosthesis design. Currently, the two most common types of prosthetic abutment connections are cemented and screwed, each with its own set of advantages and disadvantages. This study aimed to analyze a novel Morse cone connection system between the prosthesis and implant using finite element analysis (FEA). The analysis of connection retention was conducted using three different approaches: analytical, in vitro, and FEA. Three-dimensional models were created for systems comprising an abutment, healing cap, and crown under three inclination conditions: 0°, 15°, and 30°. Using Ansys finite element software (R1 2023), the impact of the tilt on the system retention was examined. The FEA showed results comparable with the in vitro studies regarding the retention strength for an abutment cap system with a 4° taper, obtaining 66.6 N compared with the 68 N calculated in our in vitro study. The inclination of the abutment affected the system retention due to the hole made in the abutment’s surface, decreasing the contact area between components. The Morse cone prosthesis–implant connection system was found to be the most stable and efficient compared with threaded or cemented systems. The retention was influenced by factors such as the abutment conicity, insertion strength, and the contact surface between components.

Morphologic alterations in the mucosa of the denture site in patients with full removable dentures from acrylic plastics

Relevance. Currently, many new agents have appeared on the market for users of removable dentures to improve adhesion, i.e. fixation and stabilization of dentures. It is important to evaluate the effect of such agents on the denture bed mucosa.Objective. Morphological substantiation of the effectiveness of the use of adhesive cream for fixation of prostheses Asepta Рarodontalu patients with removable dentures made of acrylic plastic.Materials and methods. The study involved 49 patients (12 men and 37 women) of elderly age (62–75 years) who suffered complete loss of teeth on both jaws. All patients were divided into 3 study groups: 1 (control) group, who had previously refused to have full removable acrylic dentures made for them; 2 (comparison) group, patients to whom removable acrylic dentures were made and who did not use any means to improvetheir fixation; 3 (main) group, patients to whom full removable acrylic dentures were made and who during the adaptation period and subsequently for a year used a domestic adhesive cream for fixation; 3 (main) group, patients to whom full removable acrylic dentures were made. In order to solve the realization of the set goal of the study, a number of clinical and histological studies with the use of immunohistochemical method were carried out, outpatient charts of dental patients were analyzed.Results. It was found that dystrophic and chronic inflammatory changes in the soft tissues of the denture bed were most pronounced in the case of using dentures without means to improve their fixation. At use of domestic adhesive cream for fixation of dentures Asepta Рarodontal the process of keratinization of the oral mucous membrane epithelium was minimal, there was no fibrosis of the own lamina of the mucous membrane, scattered infiltration was less expressed than in people not using acrylic dentures or using them without adhesive means, and was represented at the expense of lymphocytes, single neutrophilic granulocytes on the background of single leukostases. The immunohistochemical study showed that T-lymphocytes and mast cells were predominant in the preparations of group 2 patients, and they appeared in the preparations of this group of patients comparatively more than in the 1st control and 3rd main groups of the study, which confirmed the presence of the most pronounced chronic inflammatory infiltration in group 2 patients.Conclusion. The most optimal condition of the denture bed mucosa was observed in patients who used removable acrylic dentures for a year and simultaneously applied an adhesive agent for their fixation (domestic adhesive cream for denture fixation Asepta Рarodontal). It is obviously connected with the protection of the mucous membrane of the prosthetic bed by the adhesive cream from the mechanical impact of a dense acrylic plastic prosthesis, as well as with the reduction of contact with food products aggressive in temperature and structure.

Characteristics of speech function in the process of patients getting used to removable dentures

Relevance. The study of the attitude to the disease of dental patients during the adaptation period with the use of conventional clinical research methods is relatively rarely covered in the available domestic and foreign literature. Objective. To study the changes of internal disease pattern after the adaptation period completion in rehabilitation of patients with full tooth loss by full removable acrylic dentures, including the use of such orthopedic dental prosthesis together with the adhesive agent, designed to improve their fixation. Materials and methods. 48 (15 men and 33 women) elderly patients (61–74 years old) with a total loss of teeth were examined and were divided into 2 study groups: 1 – comparison group; 2 – main group. There were also examined 17 elderly people who had no defects of dental rows and formed a control group. The defects of dental rows in the patients of the 1st and 2nd groups were eliminated by making removable dentures. At the same time, during the adaptation period the patients of the second group of the study used a new domestic adhesive cream Aceptа Рarodontal with an extract of medicinal herbs for fixation of dentures. Before treatment and during the adaptation period the types of patients’ relation to the disease were investigated; for this purpose the clinical technique «Type of relation to the disease» (TORD) was usedResults. It was found that while preserving the integrity of dental rows in elderly people the types of attitude to the disease included in the conditionally adaptive block were mainly marked. At the end of adaptation period if all patients of the main group 2 had the types of attitude towards the disease included in the first conditionally adaptive block, then the patients of the comparison group 1 in only 39.1% of people revealed similar types of attitude towards the disease, which testified to the problems in adaptation to new removable acrylic dentures made for the treatment of complete tooth loss. Conclusion. The use of ASEPTA РARODONTAL adhesive cream with herbal extracts by patients provides a positive correction of the internal picture of the disease and the patient’s personal reaction to the treatment. On the basis of the carried out research it is possible to recommend to patients the domestic adhesive cream ASEPTA РARODONTAL for denture fixation in order to optimize the adaptation period to removable acrylic dentures as well as for permanent use, which will improve not only fixation and stabilization of dentures, condition of denture bed mucosa, but also quality of speech function.

АДГЕЗИВНЫЕ СРЕДСТВА ДЛЯ ФИКСАЦИИ ЗУБНЫХ ПРОТЕЗОВ

The loss of natural teeth and, especially, the complete loss of teeth, is an urgent problem of domestic and foreign dentistry, in the solution of which a significant place is given to prosthetics with full removable plate dentures. To improve the fixation and stabilization of complete removable plate dentures, dentists often consider it appropriate to use adhesive agents, the use of which also gives the patient psychological confidence, ensuring the success of orthopedic dental treatment. The purpose of the literature analysis is to summarize and analyze the literature data for the period 2012-2023 on modern adhesive means for fixing complete removable plate prostheses, their composition, main characteristics and properties. The analysis of scientific articles allows us to come to the conclusion that it is advisable for dentists-orthopedists to recommend adhesive agents to their patients and assist them in selecting a fixing agent taking into account individual characteristics, which will improve the quality and effectiveness of dental treatment.

СРАВНИТЕЛЬНЫЙ АНАЛИЗ ИСПОЛЬЗОВАНИЯ НОВОГО КРЕМА ДЛЯ ФИКСАЦИИ ЗУБНЫХ ПРОТЕЗОВ

One of the main difficulties in the rehabilitation of patients with a complete absence of teeth using removable lamellar dentures is the problem of adaptation to dentures and the full restoration of chewing function. This is often associated with insufficient fixation and stabilization of the prosthesis due to unfavorable anatomical conditions of the prosthetic bed. Improving the fixation and stabilization of removable lamellar dentures in the complete absence of teeth is facilitated by the use of special fixing creams, the mechanism of action is to create a viscous adhesive film between the prosthesis and the mucous membrane of the prosthetic bed, which contributes to a tighter closure of the valve zone. A large number of creams for fixing prostheses are freely available and are in great demand. As part of a research project with grant support at Volgograd University, a new cream for this purpose has been developed. This study is a comparative analysis of the effectiveness of the use of new and already known creams for fixing prostheses and was carried out by assessing the course of the adaptation process.

Protective periodontitis: the possibility of prevention

Relevance. The isolation of prosthetic periodontitis among inflammatory periodontal pathology has significantly supplemented the generally accepted notions of dentists concerning the etiology and progression of dental prosthetics complications. Improving the methods of preventing inflammatory periodontal lesions caused by the presence of denture structures in the oral cavity is very relevant nowadays, especially in persons using removable dental prostheses. This applies to older age groups, which for financial reasons are more accessible removable acrylic dentures, which they have the opportunity to get at the expense of the budget of the region.Aim. This applies to those in the older age groups who, for financial reasons, have more access to removable acrylic dentures because of the possibility of obtaining dentures at the expense of the regional budget. Therefore, the aim of the study was to assess the possibility of using a new domestic denture fixation cream for the prevention of prosthetic periodontitis in patients using removable dentures.Materials and methods. 63 (18 male and 45 female) elderly patients (61-74 years old) with partial tooth loss on both jaws were examined. Partial removable acrylic dentures were made for patients 1st group (n = 30) and 2nd group (n = 33). The patients of the second group constantly used the domestic ASEPTA РARODONTAL denture fixation cream with herbal extract for 9 months of the study. Assessment of the impact of dentures on the oral tissues and periodontium was carried out on the basis of clinical examination and by studying the antimicrobial potential of saliva.Results. The use of partial removable acrylic dentures has been found to contribute to the occurrence of prosthetic periodontitis, which is associated with the technology used in their manufacture. It is possible to reduce the incidence of prosthetic periodontitis not only by timely correction of prosthesis but also by using adhesive means for fixation of prosthesis, the application of which permitted to reduce the occurrence of prosthetic periodontitis by 47,58% and to reduce the occurrence of inflammatory changes of gingiva in the restored teeth area by 16,06%. The research of the antimicrobial potential of saliva in persons who constantly used ASEPTA РARODONTAL denture fixation cream with herbal extract showed that the immune balance achieved before dental prosthetics can be maintained in the oral cavity.Conclusion. The results of the clinical and laboratory study allow us to recommend more widely the use of adhesive means for fixation of removable dentures, including the ASEPTA PARODONTAL cream with herbal extracts.

Characteristics of speech function in the process of patients getting used to removable dentures

Relevance. The majority of elderly and senile patients in the Russian Federation still use removable acrylic dentures, which is associated with the economic problems of the elderly. However, there are few studies devoted to the study of the effect of such dentures on the quality of speech function. Objective. Evaluation of quality of speech function in the patients with partial and complete tooth loss during the adaptation to the removable dentures including using by patients new home-made adhesive cream for denture fixation. Materials and methods. Overall 111 (33 male and 78 female) elderly patients with partial (63) and complete (48) tooth loss were examined and were divided into 4 study groups. Groups 1 and 2 included patients with partial tooth loss and groups 3 and 4 included patients with total tooth loss. There were also examined 17 elderly people who had no defects of dentition and formed a control group. The defects of dental rows in the patients of groups 1–4 were eliminated by making removable dentures. At the same time, during the adaptation period, patients in groups 2 and 4 of the study used a new domestic adhesive cream for fixing dentures. Before treatment and during the adaptation period, the quality of speech function of the patients was studied. Results. It was found that with preservation of the integrity of the dental rows in the elderly people a high quality of speech is observed. Loss of teeth leads to a decrease in the quality of speech function, especially in patients with partial loss of teeth in the anterior part of the jaw or front teeth on both jaws. By the middle of the adaptation period, the quality of speech function had improved in all patients examined, both with partial and total tooth loss. Use of the adhesive cream by patients provided a reliably better quality of speech function with partial and full removable acrylic dentures, which was characterised as «high» at the end of the adaptation period. Conclusion. On the basis of the conducted research, home-made adhesive cream for denture fixation can be recommended to patients with the purpose of optimization of the adaptation period to removable acrylic dentures as well as for permanent use, which will improve not only fixation and stabilization of dentures, state of the prosthetic bed mucosa, but also the quality of speech function.

Effects of acrylic dentures on oral mucosa and salivary antimicrobial peptide content in denture wearers

Relevance. Aging of the body leads to the development of an imbalance in the secretory immunity of the oral mucosa, with the loss of natural teeth leading to an even more rapid decline in the host’s oral defense reactions. However, studies on salivary antimicrobial peptides in denture users and their potential role in protecting against the development of inflammation are still scarce at this time.Purpose. To evaluate the effects of full removable acrylic dentures on the oral mucosa and analyze the content of antimicrobial peptides in the saliva of wearers of such dentures.Materials and methods. Sixty-seven (21 men and 46 women) elderly patients (61 to 74 years old) with complete tooth loss were examined and divided into 3 study groups. In the 1st control group the patients did not use any dentures. Patients in groups 2 and 3 were made full removable acrylic dentures for the upper and lower jaws, and in group 2 from the first day of the adaptation period was used domestic denture fixation cream ASEPTA PARODONTAL. Assessment of the denture bed on the hard palate was performed visually using the Schiller – Pisarev test. Microbiological examination for Candida albicans was performed by PCR-diagnostics. The content of antimicrobial peptides in saliva was assessed using ELISA kits by Hycult Biotech.Results. The use of the adhesive cream was found to improve the condition of the palatal mucosa by 25% on the 15th day and by 50% on the 30th day of the adaptation period. Candida albicans was detected in oral material in more than 55% of patients in all groups during their initial examination. In the group of patients using denture fixation cream, a significant decrease in Candida albicans carriage was noted, while an increase in Candida albicans detection of up to 70% was noted in those not using the cream. There was also an increase in the level of cathelicidin LL-37 in the saliva of patients without the use of the cream and with a marked increase in inflammation. One month after dentures in patients without cream use the content of alpha-defensins (HNP 1-3) was significantly lower than that of the group with cream and the control group.Conclusion. On the basis of the carried out clinical and laboratory study, the domestic ACEPTA adhesive cream should be recommended for optimization of the adaptation period to removable acrylic dentures as well as for their permanent use.

Analysis of the level of optopedical rehabilitation in studying the microbiome and evaluation of the degree of fixation of removable plated prosthesis.

The widespread use of traditional removable prosthetics is explained by the relative simplicity of the technological stages of manufacture and determines its availability. The development of prosthetic stomatitis of the oral cavity is facilitated by poor fixation and stabilization of removable orthopedic structures. Microbiome biofilms formed on the surface of dental orthopedic structures can help reduce their service life and cause an inflammatory process of the oral cavity of microbial etiology during dental prosthetics in the process of orthopedic rehabilitation. The purpose of the study: to assess the level of adaptation of patients during orthopedic rehabilitation based on the study of the microbiome and the assessment of the degree of fixation of removable lamellar dentures. Qualitative and quantitative characteristics of the microbiome of prostheses at the stages of orthopedic pealitation were assessed; facultative anaerobic species belonging to the genera Staphylococcus, Micrococcus, Enterococcus, Streptococcus, Klebsiella prevailed;noted the elimination of microorganisms of the genera Bifidobacterium and Lactobacterium, yeast-like fungi of the species Candida albicans were isolated. An analysis of the index of fixation of prostheses showed an increase depending on the duration of use; a good level of fixation of prostheses was established in groups of patients.

Changes in the Oral Microbiocenosis in the Process of Different Adhesive Agents Use for Fixation of Complete Removable Laminar Dentures

The use of adhesives to improve the fixation of complete removable laminar dentures, along with numerous benefits for the patient, creates additional risks of imbalance in some representatives of the oral microflora and, consequently, may cause or maintain the development of prosthetic stomatitis and worsen oral hygiene. Therefore, it is important to study the prevention of disorders of the normobiocenosis of the oral cavity due to the differentiated choice of adhesives based on their antimicrobial activity. The study represents the peculiarities of changes in the oral normomicrobiocenosis in the process of the prescribed adhesives’ use for fixing complete removable laminar dentures.
 The aim of the study – is to study the changes in the oral microbiocenosis in the process of adhesives use for fixing complete removable laminar dentures and to assess the effectiveness of their choice based on the results.
 Materials and methods of the study. There were examined 120 people, who used full removable laminar dentures, 90 of them used adhesive means prescribed by a dentist for three weeks to improve fixation. All patients were sampled for bacteriological examination. Based on the analysis of culture results for microorganisms in each Group, the constancy index was determined – sowing frequency in percent and population level – colonization mass in lg CFU/ml.
 Results of the study. In comparison with persons who did not use adhesives to improve the fixation of removable dentures and data before the study it was determined that the adhesive “Corega” had a preservative effect on the normoflora, reduced the population level of pathogenic coccal microflora, yeasts; adhesive “Laсalut” had an inhibitive effect on all representatives of the normal microflora, reduced sowing frequency and population level of β-hemolytic streptococci, but did not affect the pathogenic activity of Staphylococcus aureus, yeasts and gram-negative bacteria; adhesive “Protefix” had a suppressive effect on the normoflora, did not affect the population level of pathogenic microorganisms and even increased the massiveness of colonization by gram-negative bacteria.
 Conclusions. Taking into account the determined changes in the oral microbiocenosis in persons who used adhesives to improve the fixation of complete removable laminar dentures, we can talk about the effectiveness of the adhesive “Сorega” for long-term use in the absence of complications in prosthetic bed tissues and with proper hygienic care of the oral cavity; adhesives “Laсalut” and “Protefix” in patients with existing dysbiotic disorders and with subsequent control of the impact on the resident microflora of the oral cavity.

Psychological state of patients during adaptation to removable dentures and methods of optimization

BACKGROUND: Optimized use of removable dental prosthesis and enhancement of the adaptation period to such orthopedic substituting dental constructions in the oral cavity are the actual aims of practical stomatology.
 AIM: This study aimed to estimate the psychological state of patients in the process of adaptation to removable dental prostheses and to assess the influence of dental prosthesis fixation on the optimization of adaptation for them.
 MATERIALS AND METHODS: In the case of psychosensoryanatomicalfunctional maladaptation syndrome, the psychological states of 35 people with partial and 38 with complete tooth loss before and during the adaptation period of their dental rehabilitation for removable acrylic dentures were assessed. The study groups were divided into two subgroups, depending on the method used to improve the fixation of dentures.
 RESULTS: During the initial examination, all study patients with partial or complete tooth loss had impaired adaptability to these conditions, mainly due to anatomical and functional disorders of the masticatory apparatus. During the adaptation period, an improvement in the psychological status of the patients was noted, especially in those who used the cream for fixation of dentures for domestic production.
 CONCLUSION: During their adaptation to the removable partial and full dentures, patients are recommended to use the prescribed cream to improve their fixation and thereby allow the reduction of painful symptoms from the prosthetic bed tissues and significantly improve the psychological status of the patients during the adaptation period.

Effect of a new domestic remedy for fixation of removable dentures on oral mucosal immunity

BACKGROUND: The persisting high incidence of complications in removable acrylic dentures should convince the researchers to understand the consequences of denture use on the oral health and whole organism.
 AIM: To examine the peculiarities of the oral mucosal immunity in patients with partial removable acrylic dentures and to evaluate the efficacy of the application of Asepta Prodontal denture fixation agent.
 MATERIAL AND METHODS: Mucosal immunity was studied in 93 (24 men and 69 women) elderly patients (aged 61 74 years) with partial tooth loss who were divided into three study groups. Patients in the control group 1 (n=30) did not use any dentures. Group 2 (n=33) had partial removable acrylic dentures and from the first day of the adaptation period were offered to use the domestic denture fixation cream Asepta Parodontal (ZAO VERTEX, Saint Petersburg, Russia). Partial removable acrylic dentures were also made for group 3 (n=30), but their adaptation period was conducted without the application of domestic Asepta Parodontal denture fixation cream.
 RESULTS: On day 15 of the adaptation period in groups 2 and 3, inflammatory changes in the denture bed mucosa were revealed in 9.1% and 56.7% of the cases, respectively. On day 30 of dynamic observation in groups 2 and 3, inflammatory changes in the prosthetic bed mucosa were noted in 6.1% and 40.0% of the cases, respectively. The average numbers of visits to the doctor for denture correction in groups 2 and 3 were 1.33 and 2.76, respectively. A significant increase was found in the levels of pro-inflammatory cytokines on day 15 of the study in the saliva of patients with removable dentures, who used them without the denture fixation agent Asepta Parodontal, whereas patients using Asepta Parodontal showed an increase only in interleukins (IL) 6 and 8. Moreover, on day 30 of the study, no differences from the control group were observed in the concentration of pro-inflammatory cytokines compared with the group using domestic denture fixation cream, and in the group without using the cream, no decrease in the level of pro-inflammatory cytokines was noted. The concentration of RAIL and IL-10 increased in group 3 on both day 15 and 30, whereas no significant differences were observed in the group using the cream.
 CONCLUSION: Better prosthetic bed condition, decreased concentration of pro-inflammatory cytokines with a simultaneous elevation of secretory IgA in the oral cavity, testifying to the decrease in inflammation, and an increase in the immunity of the oral mucosa was noted in patients using Asepta Parodontal denture fixation agent.

Total tooth loss and its treatment with removable dentures: features of the microbiota and mucosal immunity

The prevention of denture stomatitis is an important measure in the clinic of orthopedic dentistry, because at present, in spite of the availability of dentures on artificial supports, full removable dentures are still widely in demand. The study of oral microbiome and mucosal immunity in persons using full removable acrylic dentures was carried out, as it is important for scientifically substantiated development of ways to prevent denture stomatitis. Sixty-seven elderly patients with total tooth loss were examined and divided into 3 study groups. Patients in Group 1 (19 people) did not use any dentures. Patients in group 2 (25 people) had full removable acrylic dentures and from the first day of the adaptation period were offered to use the domestic denture fixation cream Acepta Parodontal. Patients of group 3 (23 people) were also made full removable acrylic dentures, but their adaptation period took place without the use of denture fixation cream. During the clinical-laboratory study it was established that the use of domestic Acepta Parodontal denture fixation cream in patients with full removable acrylic dentures during the adaptation period leads to a decrease in the level of inflammation in the oral cavity, contributes to an increase in mucosal immunity of its mucous membranes, as evidenced by the increased synthesis of secretory immunoglobulin A. At the same time, improvement of oral microbiota was noted, including reduction of detectability of Candida albicans as the main pathogen associated with denture stomatitis.

Mesoporous Silk-Bioactive Glass Nanocomposites as Drug Eluting Multifunctional Conformal Coatings for Improving Osseointegration and Bactericidal Properties of Metal Implants.

Endowing metal implants with multifunctional traits to prevent implant-associated infections and improve osseointegration has become a pivotal facet in orthopedics and dental fixation. Herein, we report the synthesis of mesoporous 70S bioactive glass-silk fibroin nanocomposites inspired by the biomimetic organo-apatites of mineralized collagen. The mesoporous, biomimetic nanocomposites enabled loading of antibiotics (gentamicin and doxycycline) and favored their release in a rapid manner while preserving their bioactivity. Ease in modification of the mesoporous nanocomposites enabled tailoring of 3-(aminopropyl)-triethoxysilane to the silanol network of bioactive glass, which improved the loading capacity of the hydrophobic drug (dexamethasone). The modification favored the slow and sustained release of dexamethasone from the modified mesoporous nanocomposites, which is desired for mediating osteogenesis and immunomodulation. Conformal coatings of these drug-loaded nanocomposites were materialized on stainless-steel implants through a facile electrophoretic deposition (EPD) technique, wherein the deposition yield can be controlled by applied parameters. Antibiotic coatings exhibited antibacterial efficacy with bioactivity retained up to 28 days, while dexamethasone-loaded coatings favored mesenchymal stem cell adhesion and osteoinduction. The immunomodulatory roles were also ascertained, wherein M2 macrophage biasness was favored in dexamethasone-loaded coatings. The versatility of these mesoporous biomimetic nanocomposites guarantee the loading of scenario-specific drugs to aid their local delivery through the conformal EPD coatings developed over metal implants toward improving implant patency.

A MODIFIED METHOD FOR RAPID PALATAL EXPANSION ANCHORED ON MINI-IMPLANTS

In modern orthodontic practice, a narrow upper jaw is often corrected using teeth-anchored expanders. As a result of skeletal expansion, dental orthodontic appliances have an adverse effect both on the teeth and on the supporting tissues. An analysis of the issues associated with dental fixation devices, as well as the results of combined orthodontic & surgical treatment with Surgically Assisted Rapid Palatal Expansion (SARPE), has allowed us to develop a palatal expander anchored on miniimplants. This method has been tested through the upper jaw expansion in patients in their post-pubertal period. The article offers a view at the changes in the skeletal and dental parameters during rapid maxillary expansion with the proposed expander. Skeletal expansion of the upper dentition in this case is achieved with minor changes in the lateral teeth inclination, thus allowing to minimize the risk of side effects typical for teeth-anchored expanders: root resorption, alveolar bone buccal thickness reduction, marginal bone reduction, and gum recession. The method proposed for upper jaw skeletal narrowing treatment with a palatal expander supported by mini-implants improves the upper airway.

Характеристика силовых взаимоотношений челюстей при реабилитации пациентов с полной утратой зубов съемными протезами: клиническое и патофизиологическое исследование

At the present time the complete loss of teeth is frequent, especially in older age groups, and their rehabilitation with the use of full removable acrylic dentures is not always effective. Objective: to estimate the peculiarities of patients adaptation to the full removable dentures taking into account the jaw strength characteristics and application of adhesive agents to improve denture fixation. Materials and methods. 34 elderly women suffering from the total loss of teeth were under observation. Group 1 consisted of 15 patients, who after fabrication of full removable dentures, during the whole adaptation period did not use any adhesive means for improvement of fixation of removable dentures and group 2 used ASEPTA parodontal cream for fixation of dentures. Indexes of gnathodinamometry and indexes of test with nucleus according to I.S. Rubinov were evaluated in all patients after fitting and application of prosthesis. Results. It has been established, that good jaw strength characteristics (81-105 N), as well as good fixation and stabilization of new dental restorations are determined during rehabilitation of patients with full tooth loss using removable dentures. The study has shown that to optimize the force characteristics of the jaws while using the full removable acrylic dentures and to increase their stability it is possible to use adhesive means for fixing dentures, thus reducing the number of visits for denture correction to 1.25±0.41 and improving gnathodinamometry parameters by 7.21-29.1%. Conclusion. Dental rehabilitation of complete tooth loss with full removable acrylic dentures is quite effective, especially when using removable denture fixation means. The use of the latter requires increased oncological vigilance due to the presence of chronic traumatic lesions of the oral mucosa, proceeding without painful symptoms and being facultative precancer.

Clinical classification of torus and effectiveness of two-layer bases in removable dentures.

To study and systematize the complaints of patients with removable prostheses, paying attention to the clinical manifestation of the torus and its sensitivity, and to determine the effectiveness of the use of two-layer bases in removable prosthetics. In the clinic of orthopedic dentistry, 104 people were examined and received orthopedic treatment, including 37 patients in the comparison group. The main number of patients up to 55.3, complained of poor fixation and violation of the chewing process. In order to improve the functional efficiency of the removable prosthesis, two-layer bases using soft linings, Gossil (Russia), Furji (Japan), and Mucopren (Germany), are proposed. Clinical and laboratory studies were conducted (Estesmary, gattingeri, physico-mechanical studies of soft linings). The effectiveness of using soft pads in removable prosthetics is shown. The conducted research allowed creating a clinical classification of the torus depending on the pain sensitivity of the oral mucosa-type I-painless torus, type II-moderately painful, and type III-painful when touched. The features of the technology for manufacturing two-layer bases for type II and type III of torus are recommended. It was found that 47.9% of patients in the comparison group and 55.3% of those examined in the main group complained about impaired chewing and poor fixation of dentures on the upper and lower jaws, depending on the condition of oral tissues. The patients did not always objectively assess the condition of their dentures. Patients complained about lack of stabilization, poor-quality dentures, and the need to replace the old denture with a new one in 13.8% of cases in the control group and 31.9% in the main group of patients examined. In the case of removable denture wearers with a total lack of teeth, there were 55.3% complaints of chewing disorders and poor fixation of dentures, and in the case of partially removable denture wearers, the greatest number of complaints of clasp fixation disorders were found in 42.1% of cases. Physico-mechanical study of soft linings from different countries, Gossil (Russia), Fuji (Japan), Mukopren (Germany), showed their effectiveness and the possibility of their use orthopedic dentistry.