Total tooth loss and its treatment with removable dentures: features of the microbiota and mucosal immunity

Abstract

The prevention of denture stomatitis is an important measure in the clinic of orthopedic dentistry, because at present, in spite of the availability of dentures on artificial supports, full removable dentures are still widely in demand. The study of oral microbiome and mucosal immunity in persons using full removable acrylic dentures was carried out, as it is important for scientifically substantiated development of ways to prevent denture stomatitis. Sixty-seven elderly patients with total tooth loss were examined and divided into 3 study groups. Patients in Group 1 (19 people) did not use any dentures. Patients in group 2 (25 people) had full removable acrylic dentures and from the first day of the adaptation period were offered to use the domestic denture fixation cream Acepta Parodontal. Patients of group 3 (23 people) were also made full removable acrylic dentures, but their adaptation period took place without the use of denture fixation cream. During the clinical-laboratory study it was established that the use of domestic Acepta Parodontal denture fixation cream in patients with full removable acrylic dentures during the adaptation period leads to a decrease in the level of inflammation in the oral cavity, contributes to an increase in mucosal immunity of its mucous membranes, as evidenced by the increased synthesis of secretory immunoglobulin A. At the same time, improvement of oral microbiota was noted, including reduction of detectability of Candida albicans as the main pathogen associated with denture stomatitis.