Background: Exfoliative cytology considered as one of the best technique to obtain the epithelial cells lining buccal mucosa in oral cavity. Diabetes mellitus type 2 is one of the most distributed disorder wild world which cause deferent histological and cytological defects in all body organs. Aim: To realize the histological changes in oral epithelium (of buccal and gingival mucosa) in patients suffering from type 2 diabetic mellitus. Material and methods: Sample composed of two groups, the study group represented by ten male diabetic patients, their age between (50-65) years attending the teaching hospital of college of Dentistry/ Tikrit university, and the control group (10 male 50-65 years old), the smear taken from oral epithelia from buccal mucosa, gingiva and saliva using cotton swab. The samples were carried on glass slides and stained by using Giemsa dye.Results: The microscopical examination revealed a number of histological changes, as presence of binucleated cells, budding in nuclei and decay (karyolysis) of other nuclei with the observation of fragmentation (karyorrhexis) of others, besides, some of vasicular degeneration seen with the cytoplasm of number of cells and hypertrophy in others.Conclusion: Diabetes mellitus type 2 cause many histological changes in oral epithelia of buccal mucosa and gingiva which detected by exfoliative cytology.
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