Dog Days Research Articles

Rabacfosadine for relapsed canine B-cell lymphoma: Efficacy and adverse event profiles of 2 different doses.

Rabacfosadine (RAB), a novel double prodrug of the acyclic nucleotide phosphonate PMEG, preferentially targets neoplastic lymphocytes with reduced off target toxicity. Historical studies have suggested that every 21-day dosing is effective with acceptable toxicity. The purpose of this study was to evaluate RAB's safety and efficacy at 2 different doses every 21 days in dogs with relapsed B-cell lymphoma. Dogs that had failed 1 doxorubicin-based chemotherapy protocol were eligible for inclusion in this prospective trial. Once enrolled, dogs were randomized to receive RAB at either 0.82 mg/kg or 1.0 mg/kg as a 30-minute IV infusion every 21 days for up to 5 treatments. Response assessment and adverse event (AE) evaluation were performed every 21 days via VCOG criteria. Fifty dogs were enrolled, with 16 treated at 0.82 mg/kg and 34 treated at 1.0 mg/kg. The overall response rate was 74%, with 45% of dogs experiencing a complete response (CR). The median progression free intervals (PFIs) were 108 days, 172 days and 203 days for all dogs, all responders, and all CRs, respectively. Response rates and PFIs were similar in both treatment groups. The incidence of AEs, dose delays, dose reductions and withdrawals were not statistically different between the 2 groups. The AEs observed were similar to those previously reported and included hematologic, gastrointestinal, dermatologic and pulmonary AEs. One dog had grade 5 pulmonary fibrosis; otherwise, AEs resolved with supportive treatment. Rabacfosadine is a generally well tolerated, effective chemotherapy option for dogs with relapsed B-cell lymphoma.

Evaluation of clinical and histologic factors associated with survival time in dogs with stage II splenic hemangiosarcoma treated by splenectomy and adjuvant chemotherapy: 30 cases (2011-2014).

OBJECTIVE To determine histologic and clinical factors associated with survival time in dogs with stage II splenic hemangiosarcoma treated by splenectomy and a chemotherapy protocol in which an anthracycline was alternated with lomustine. DESIGN Retrospective case series. ANIMALS 30 dogs with stage II splenic hemangiosarcoma. PROCEDURES Medical records of 3 facilities were reviewed to identify dogs treated for stage II splenic hemangiosarcoma between June 2011 and October 2014. Information collected included signalment, disease staging data, whether anemia was present, date of splenectomy, chemotherapy protocol, adverse effects, and date of death or last follow-up. Histologic slides were reviewed and scored by pathologists. Associations between variables of interest and survival data were evaluated statistically. RESULTS Median survival time for all dogs was 158 days (range, 55 to 560 days), and the 1-year survival rate was 16%. On multivariate analysis, only the histologically determined mitotic score was significantly associated with survival time. The median survival time of 292 days for dogs with a mitotic score of 0 (< 11 mitoses/10 hpf; n = 9) was significantly longer than that for dogs with higher scores (indicating higher mitotic rates); the 1-year survival rate for these dogs was 42%. CONCLUSIONS AND CLINICAL RELEVANCE Results suggested that future studies should take histologic factors, particularly mitotic rate, as well as tumor stage into account when assessing treatment effects on survival time of dogs with splenic hemangiosarcoma.

Clinical therapeutic effect on bronchial asthma in children of different body constitutions treated with sanfu pingchuan plaster and sanjiu zhichuan plaster

To observe the difference in the clinical therapeutic effects on bronchial asthma in children of different body constitutions treated with sanfu pingchuan plaster and sanjiu zhichuan plaster. One hundred and twenty-two children of bronchial asthma were divided into three groups according to TCM body constitutions, 42 cases in the qi deficiency constitution group, 40 cases in the yang deficiency constitution group and 40 cases in the phlegm damp constitution group. From 2011 to 2013, the acupoint plaster was applied to all of the children in the three groups during the dog days and the third nine-day period after the winter solstice each year. The average attack frequency and onset days of bronchial asthma and relevant immune function indicators were observed during treatment and 1 year after treatment in the children and the therapeutic effects were evaluated. ①In 2014, the acute attacks of bronchial asthma were (1.2±0.9) times and (1.4±0.4) times in the qi deficiency constitution group and the yang deficiency constitution group, all lower than (3.0±0.5) times in the phlegm damp constitution group (both P<0.05) separately. ②After treatment, in the qi deficiency constitution group and yang deficiency constitution group, the values of IgG, IgA and IgM were all increased as compared with those before treatment (all P<0.05). ③The total effective rate was over 95% in the children of the three groups. The clinical control rates in the qi deficiency constitution group and the yang deficiency constitution group were higher apparently than that in the phlegm damp constitution group, indicating the significant difference statistically (both P<0.05). The combined treatment of sanfu pingchuan plaster and sanjiu zhichuan plaster are effective on bronchial asthma in the children of different body constitutions. The therapeutic effects for the qi deficiency constitution and the yang deficiency constitution are more apparent than that for the phlegm damp constitution.

Eficácia da ivermectina comprimido no tratamento da sarna sarcóptica em cães naturalmente infestados

RESUMO: O objetivo deste trabalho foi avaliar a eficácia da ivermectina comprimido administrada por via oral no tratamento de Sarcoptes scabiei em cães naturalmente infestados. Foram selecionados 14 cães com raspados cutâneos positivos para o ácaro S. scabiei, idade de 1-5 anos, sem raça definida, distribuídos na mesma proporção de ambos os sexos, em dois grupos experimentais, compondo 7 animais por grupo. Todos os animais foram tratados a cada 7 dias, totalizando quatro tratamentos em cada cão (Dias 0,7,14 e 21). No grupo I foi administrada a ivermectina5 comprimido na dosagem de 0,2mg/kg e no grupo controle positivo (Grupo II) foi administrado um produto comercial a base de ivermectina comprimido na mesma dosagem do grupo I. Raspados cutâneos, avaliações clinicas e laboratoriais complementares dos cães foram realizadas durante o período de estudo. Clinicamente, não houve diferença significativa entre as avaliações antes e após o tratamento entre os dois grupos. Raspados negativos foram observados em ambos os grupos a partir do dia D+14, mantendo-se negativos até o final do período experimental. As lesões dermatológicas iniciais observadas no acompanhamento clínico regrediram e a partir do dia D+14 a melhora clínica era evidente em ambos os grupos. A ivermectina (Ivermectan Pet, UCBVET Saúde Animal) administrada por via oral foi eficaz no tratamento de S. scabiei em cães naturalmente infestados.

The Dog Days of Winter: Indigenous Dogs, Indian Hunters, and Wintertime Subsistence in the Northeast

Abstract Prior to European settlement, indigenous members of the species Canis lupus familiaris (Domestic Dog) was, aside from humans, the most common large predator in the North American northeast. Dogs served Indian communities throughout the year, but their value increased over the winter. Light enough to run over packed snow, Domestic Dogs chased down Alces alces (Moose) and Odocoileus virginianus (White-tailed Deer). They protected food stores from vermin, provided warmth at night, and acted as a meat source during times of dearth. Domestic Dogs facilitated the fur trade by sniffing out the frozen lodges of Castor canadensis (Beaver). Although they often hunted and scavenged autonomously, it was through their symbiotic partnership with humans that indigenous Dogs helped to define the Northeast's early modern ecology.

Whole-Body Counter Evaluation of Internal Radioactive Cesium in Dogs and Cats Exposed to the Fukushima Nuclear Disaster.

As a result of the 2011 nuclear incident that occurred at the Fukushima Nuclear Power Plant, a large number of abandoned dogs and cats were left within the disaster zone. A small number of these animals were rescued and cared for at shelters. Prior to the dispersal of these animals to their owners or fosterers, we evaluated the degree of internal radiocesium contamination using a specially designed whole-body counter. We conducted 863 non-invasive measurements of gamma rays due to internal radioactive cesium for 68 dogs and 120 cats at one shelter. After plotting graphs of 137Cs density we generated exponential functions of decay from seven dogs and six cats. From the regression formulae, we were able to determine the biological half-lives as 38.2 days for dogs and 30.8 days for cats. We found that in dogs there was a correlation between the biological half-life of radioactive cesium and age. Using our data, we estimated whole-body densities for each cat and dog at the time when they were rescued. We found that there were deviations in the data distributions among the different species, likely due to the timing of rescue, or living habits prior to rescue. A significant correlation was found when extracted feline reproductive organs were analyzed; the coefficients for the estimation of whole-body densities were approximately 7-fold higher than those based on the extracted feline reproductive organs. This may be due to the fact that majority of the radioactive cesium accumulates within muscular tissue with less distribution in other organs. It is possible to plan the appropriate management period in an animal shelter based on the use of the biological half-life of radioactive cesium calculated in this study. We believe that the correlations we uncovered in this work would be of great use for the management of companion animals in the event of a future nuclear accident.

Significance of clonal rearrangements of lymphocyte antigen receptor genes on the prognosis of chronic enteropathy in 22 Shiba dogs

Shiba dogs are predisposed to chronic enteropathy (CE) and have poorer prognosis than other dog breeds. The objective of this study was to investigate the significance of polymerase chain reaction for antigen receptor rearrangement (PARR) results on clinical findings and prognosis of Shiba dogs with CE. We retrospectively collected data on 22 Shiba dogs diagnosed as having CE. Fifty-nine percent of the dogs had clonality-positive results on PARR analysis. Furthermore, on histopathology, epitheliotropic behavior of small lymphocytes of the intestinal mucosa was observed significantly more frequently in dogs with clonal rearrangement of antigen receptor genes (P=0.027). The median overall survival time of clonality-positive dogs was 48 days (range, 4–239 days), compared to 271 days (range, 45–1,316+ days) in clonality-negative dogs. The median overall survival time of epitheliotropism-positive dogs was 76 days (range, 30–349 days) compared to 239 days (range, 4–1,316+ days) for epitheliotropism-negative dogs. Statistical analysis revealed that the clonality-positive result was associated with significantly shorter survival time (P=0.036). In contrast, presence or absence of epitheliotropism had no statistically significant effect on survival time (P=0.223). These cases might appropriately be diagnosed as small T-cell intestinal lymphoma; there are some common clinical and pathogenic features with human enteropathy-associated T-cell lymphoma type 2. The pathogenesis and poor prognosis for Shiba dogs with CE seem to be associated with this type of lymphoma, although further investigation is warranted.

Comment s’en sortir dans les « sous-quartiers » de Yaoundé ?

Dans Temps de chien, Patrice Nganang ecrit et donne a lire les sous-quartiers de Yaounde, megapole postcoloniale. Ceux-ci constituent un espace de sociabilite, de parole, de theâtre, d’illusion et de rumeur, mais egalement un espace de violence, de chaos, de danger et de tragedie ; un espace voue a la survie deshumanisante, potentiellement genocidaire. Le narrateur subalterne, le chien au nom d’homme, Mboudjak, cherche a repondre a la question : « Ou est l’homme ? » et l’ecrivain esquisse des pistes pour « s’en sortir » par le recours a l’humour, l’imagination, la philosophie, la parole, l’etre ensemble, le combat politique, l’humanisme et l’art engage.

A randomized controlled trial of the effect of prednisone omission from a multidrug chemotherapy protocol on treatment outcome in dogs with peripheral nodal lymphomas.

OBJECTIVE To determine the effect of prednisone omission from a multidrug chemotherapy protocol on outcome in dogs with peripheral nodal lymphomas. DESIGN Single-center, nonblinded, parallel-group, randomized, controlled trial. ANIMALS 40 client-owned dogs with a histopathologically confirmed diagnosis of peripheral nodal lymphoma and an expected survival time of > 4 weeks with treatment. PROCEDURES Treatment consisted of a combination of L-asparaginase, cyclophosphamide, doxorubicin, vincristine, and prednisone (L-CHOP) or an identical protocol except for the omission of prednisone (L-CHO). The primary outcome of interest was progression-free survival time. Veterinary caregivers and assessors of outcome were not blinded to treatment assignment. Treatment assignment was concealed from the owners of study dogs prior to enrollment, but was revealed after written informed consent was provided. RESULTS The trial was terminated early because of slow enrollment. The 40 dogs successfully enrolled in the study were randomly assigned to the L-CHOP (n = 18) or L-CHO (22) group; results for all 40 dogs were analyzed with respect to the primary outcome. Median progression-free survival time was 142.5 days for dogs receiving L-CHO and 292 days for dogs receiving L-CHOP (hazard ratio, 1.79; 95% confidence interval, 0.85 to 3.75). Serious adverse events were more common among dogs receiving L-CHO. However, this difference was not significant. CONCLUSIONS AND CLINICAL RELEVANCE The exclusion of prednisone from the L-CHOP protocol did not appear to result in improved progression-free survival time for dogs with peripheral nodal lymphomas. However, the present trial was likely underpowered to detect a clinically meaningful difference in progression-free survival time between groups.

The Ante-Closet: Figurability, Sexual Modernity, and Dog Day Afternoon

Sidney Lumet’s 1975 film Dog Day Afternoon represents sexual identity in the early 1970s in terms of an “ante-closet” temporally and spatially located “ahead” of or “before” more familiar closet epistemologies.

Successful response to imatinib in two dogs with inoperable grade III infiltrating mast cell tumours: a case report

Two dogs were presented owing to sudden rapid growth of cutaneous masses greater than 10 cm on the neck and axillary region, respectively. Based on history and results of physical examinations, blood work, fine needle aspiration, histopathological examination, and computed tomography, inoperable grade III infiltrating mast cell tumours were diagnosed. After the initiation of imatinib treatment, the masses markedly shrank and became undetectable within 10 days in both dogs, although none of the tumour specimens showed evidence of mutations in sequencing of c-kit exons 8 and 11. These results suggest that imatinib could be a therapeutic option in patients with surgically inoperable canine mast cell tumours, even those that are histopathologically high grade without c-kit exon 8 or 11 mutations.

Dog days of summer: influences on decision of wolves to move pups

For animals that forage widely, protecting young from predation can span relatively long time periods due to the inability of young to travel with and be protected by their parents. Moving relatively immobile young to improve access to important resources, limit detection of concentrated scent by predators, and decrease infestations by ectoparasites can be advantageous. Moving young, however, can also expose them to increased mortality risks (e.g., accidents, getting lost, predation). For group-living animals that live in variable environments and care for young over extended time periods, the influence of biotic factors (e.g., group size, predation risk) and abiotic factors (e.g., temperature and precipitation) on the decision to move young is unknown. We used data from 25 satellite-collared wolves ( Canis lupus ) in Idaho, Montana, and Yellowstone National Park to evaluate how these factors could influence the decision to move pups during the pup-rearing season. We hypothesized that litter size, the number of adults in a group, and perceived predation risk would positively affect the number of times gray wolves moved pups. We further hypothesized that wolves would move their pups more often when it was hot and dry to ensure sufficient access to water. Contrary to our hypothesis, monthly temperature above the 30-year average was negatively related to the number of times wolves moved their pups. Monthly precipitation above the 30-year average, however, was positively related to the amount of time wolves spent at pup-rearing sites after leaving the natal den. We found little relationship between risk of predation (by grizzly bears, humans, or conspecifics) or group and litter sizes and number of times wolves moved their pups. Our findings suggest that abiotic factors most strongly influence the decision of wolves to move pups, although responses to unpredictable biotic events (e.g., a predator encountering pups) cannot be ruled out.

Dung Beetle1Community Response to Vegetation Type and Season in an Arid Zone of the Mexican Plateau

Abstract. Faunistical and ecological studies are lacking on dung beetles in the xerophytic scrublands at Villa de Cos, Zacatecas, of the Mexican Plateau Province. This study analyzed the effect of season and vegetation type on community structure. Pitfall traps baited with human dung were sampled at six sites on three dates (early rainy season, dog days, and late rainy season). In total, 4,040 beetles in 17 species were trapped. Vegetation type and sampling season affected average dung beetle abundance, species richness, and Simpson diversity index. Scrublands had more abundance and richness but least diversity than grasslands. Abundance diminished during dog days but richness increased during this season and the rains after it. Diversity had an inverse pattern with more during early rains than during the dog days or late rains. The community structure was determined by microhabitats for nesting provided by the combination of vegetation type and soil compaction. Telecoprids like Canthon humectus (Say) wer...

Influence of glucocorticoids on a time-of-day-dependent variation in intradermal reactivity to histamine in dogs

The objectives of this study were to determine daily variation in intradermal reactivity to histamine in dogs and to evaluate a potential influence of glucocorticoids on reactivity. Wheal sizes formed after intradermal injections of histamine were measured every 6 h during a single 24 h period in six healthy dogs. To determine whether glucocorticoids were implicated in daily variation, intradermal reactivity to histamine was evaluated at 9:00 h and at 21:00 h during a single day in dogs that received oral prednisolone (a synthetic glucocorticoid) or oral trilostane (an inhibitor of endogenous glucocorticoid synthesis). Finally, the time required for the histamine reaction to diminish after an intravenous injection of hydrocortisone was also assessed.A significant time-of-day-dependent variation in intradermal reactivity to histamine was detected in dogs, with a larger wheal size observed at 9:00 h than at 21:00 h. Administration of prednisolone or trilostane disrupted this variation. Intradermal reactivity to histamine was significantly reduced 6 h after an intravenous injection of hydrocortisone. These results suggest that glucocorticoid secretion from the adrenal glands could be involved in the regulation of daily variation in histamine-mediated reactions in dogs.

Opera for the Domestic Apocalypse

“America's house of cards is crumbling,” sings one of the inhabitants of the homestead at the center of Dog Days, a new chamber opera featured at the 2016 Prototype Festival. “Well, you can only be on top for so long, I guess,” he shrugs. Set in the middle of a total war of unknown origins, Dog Days places a small cross-section of society under the microscope, and we watch as it dissolves before our eyes. A seemingly typical nuclear family, complete with mother, father, daughter, two sons, and a dog makes up the heart of the work. It is the kind of traditional middle-class family unit exemplary of what politicians refer to as the “real America,” save for the fact that the pet dog is actually a homeless man in a dog costume.

0263 : Effects of anti- -adrenoceptors autoantibodies from dogs suffering from degenerative mitral valve disease on cardiovascular response to-adrenoceptors agonists in rats: preliminary results

In numerous cardiac diseases leading to heart failure, involvement of anti-β-adrenoceptors autoantibodies (β-aAb) has been demonstrated. However, to date no link has been made between degenerative mitral valve disease (DMVD) and those β-aAb. In order to evaluate their possible involvement in the disease development, King Charles spaniel dog was chosen as a study model, owing to its particular predisposition for this affection. Thus, aims of this study were to detect β1 – and β3-aAb presence in the sera of diseased dogs and to assess their impact on cardiovascular response to different β-adrenoceptors agonists in rats by acute passive immunization. Blood samples were collected from 15 dogs, including 6 females and 9 males. Total immunoglobulins G (IgG) were purified and an ELISA assay was performed. Male SD rats were then passively immunized with the IgG (25μg IgG/kg/day for 3 days) of diseased dogs. A concentration-response curve to isoproterenol (10-10 to 10-6 M), a non-selective β-adrenergic agonist, was carried on isolated perfused rat hearts and dose-response curves to dobutamine (5 to 20 μg/kg/min), a selective β1-adrenergic agonist, and SR58611A (5 to 40μg/kg/min), a preferential β3-adrenergic agonist, were performed on anaesthetized catheterized rats. β1 – and β3-aAb were detected in all dogs sera. A strong trend to lower baseline values was observed for all parameters in isolated hearts of immunized rats, without any modification of the concentration-response curve to isoproterenol. In contrast, baseline values as well as dobutamine response remained unchanged for all parameters in anaesthetized immunized animals. However, response to SR58611A was attenuated in immunized rats, especially for arterial pressure parameters. These preliminary results highlight the presence of β1 – and β3-aAb in the sera of dogs suffering from DMVD and suggest that β-aAb can exert functional effects within this pathological context. The author hereby declares no conflict of interest

Treatment of canine meningoencephalomyelitis of unknown aetiology with mycophenolate mofetil and corticosteroids: 25 cases (2007-2012).

The use of mycophenolate mofetil (MMF) for a variety of immune‐mediated diseases in veterinary medicine has been described. However, there is only a small number of cases documenting its use in dogs with meningoencephalomyelitis of unknown aetiology (MUE). We hypothesized that the use of MMF and corticosteroids in dogs with MUE results in comparable survival data to other published treatment protocols and is associated with limited adverse effects. A retrospective study of medical case records of dogs clinically diagnosed with MUE recorded signalment, neuroanatomic localization, magnetic resonance imaging findings, cerebrospinal fluid analysis results, medications administered, follow‐up neurologic examinations, survival and adverse events. Variables were compared between dogs which were treated with MMF within 30 days of diagnosis (immediate group) vs. dogs in which MMF therapy was started >30 days after diagnosis (delayed group). Twenty‐five cases of MUE were identified. The overall median survival time from diagnosis was 731 days (range 43–1672 days). After 1 month of MMF treatment, 92% of dogs showed improvement on a neurological examination. There was no significant effect of any recorded parameter on survival, including delayed vs. immediate initiation of MMF treatment. Dogs with delayed treatment had significantly lower clinical remission rates than dogs with immediate treatment at 6 months after starting MMF. Adverse events were identified in two cases (8%) and were characterized by mild gastrointestinal signs (vomiting and decreased appetite). Administration of MMF appears safe in dogs with MUE. The use of MMF results in comparable survival times to alternate immunosuppressive protocols.

Presence of Systemic Inflammatory Response Syndrome Predicts a Poor Clinical Outcome in Dogs with a Primary Hepatitis.

Primary hepatopathies are a common cause of morbidity and mortality in dogs. The underlying aetiology of most cases of canine hepatitis is unknown. Consequently, treatments are typically palliative and it is difficult to provide accurate prognostic information to owners. In human hepatology there is accumulating data which indicates that the presence of systemic inflammatory response syndrome (SIRS) is a common and debilitating event in patients with liver diseases. For example, the presence of SIRS has been linked to the development of complications such as hepatic encephalopathy (HE) and is associated with a poor clinical outcome in humans with liver diseases. In contrast, the relationship between SIRS and clinical outcome in dogs with a primary hepatitis is unknown. Seventy dogs with histologically confirmed primary hepatitis were enrolled into the study. Additional clinical and clinicopathological information including respiratory rate, heart rate, temperature, white blood cell count, sodium, potassium, sex, presence of ascites, HE score, alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin and red blood cell concentration were available in all cases. The median survival of dogs with a SIRS score of 0 or 1 (SIRS low) was 231 days compared to a median survival of 7 days for dogs with a SIRS score of 2, 3 or 4 (SIRS high) (p<0.001). A Cox proportional hazard model, which included all other co-variables, revealed that a SIRS high score was an independent predictor of a poor clinical outcome. The effect of modulating inflammation on treatment outcomes in dogs with a primary hepatitis is deserving of further study.

SEM characterization of anatomical variation in chitin organization in insect and arthropod cuticles

The cuticles of insects and arthropods have some of the most diverse material properties observed in nature, so much so that it is difficult to imagine that all cutciles are primarily composed of the same two materials: a fibrous chitin network and a matrix composed of cuticle proteins. Various factors contribute to the mechanical and optical properties of an insect or arthropod cuticle including the thickness and composition. In this paper, we also identified another factor that may contribute to the optical, surface, and mechanical properties of a cuticle, i.e. the organization of chitin nanofibers and chitin fiber bundles. Self-assembled chitin nanofibers serve as the foundation for all higher order chitin structures in the cuticles of insects and other arthropods via interactions with structural cuticle proteins. Using a technique that enables the characterization of chitin organization in the cuticle of intact insects and arthropod exoskeletons, we demonstrate a structure/function correlation of chitin organization with larger scale anatomical structures. The chitin scaffolds in cuticles display an extraordinarily diverse set of morphologies that may reflect specific mechanical or physical properties. After removal of the proteinaceous and mineral matrix of a cuticle, we observe using SEM diverse nanoscale and micro scale organization of in-situ chitin in the wing, head, eye, leg, and dorsal and ventral thoracic regions of the periodical cicada Magicicada septendecim and in other insects and arthropods. The organization of chitin also appears to have a significant role in the organization of nanoscale surface structures. While microscale bristles and hairs have long been known to be chitin based materials formed as cellular extensions, we have found a nanostructured layer of chitin in the cuticle of the wing of the dog day annual cicada Tibicen tibicens, which may be the scaffold for the nanocone arrays found on the wing. We also use this process to examine the chitin organizations in the fruit fly, Drosophila melanogaster, and the Atlantic brown shrimp, Farfantepenaeus aztecus. Interestingly many of the homologous anatomical structures from diverse arthropods exhibit similar patterns of chitin organization suggesting that a common set of parameters, govern chitin organization.

Splenic liposarcoma in dogs: 13 cases (2002–2012)

To describe the clinical signs, diagnostic findings, surgical management, and outcome in dogs with splenic liposarcoma. Retrospective case series. 13 client-owned dogs with splenic liposarcoma. Medical and pathology records of dogs with a histopathologic diagnosis of splenic liposarcoma from 2002 to 2012 were reviewed for the following data: clinical signs, CBC, biochemical profile, thoracic and abdominal imaging, surgical management, histologic grade, and outcome (local recurrence, distant metastasis, and survival time). Telephone interviews were conducted with referring veterinarians. The median survival time (MST) was 623 days (range, 1 to 1,283 days). In 5 dogs that died of splenic liposarcoma, survival times ranged from 42 to 369 days. Metastasis at the time of surgery was a negative prognostic indicator: the MST was 45 days for dogs with metastasis and 767 days for dogs without metastasis. Dogs with grade 1 splenic liposarcoma had a significantly greater MST (1,009 days), compared with dogs with grade 2 or 3 splenic liposarcoma (MST, 206 and 74 days, respectively). Results confirmed that splenic liposarcoma is a rare differential diagnosis in dogs with a splenic mass. Survival time was influenced by preoperative clinical stage and histologic grade.