Diagnostic and Comparative Therapeutic Study on Treatment of Gastroenteritis in Dogs Without and With Histamine H2 Receptor Antagonist

Abstract

This study was applied to investigate the effect of Antodine® (Famotidine, 40 mg PO BID/~25 kg dog twice daily) supplement for 5 days in dogs suffering from gastro-enteritis. Twenty seven dogs enrolled in this study, their ages ranged between 6-8 month and their bodyweight ranged between 20-27 kg. Dogs divided into two groups, first group (Gp) included nine (n=9) clinically healthy dogs considered as control group, second group (Gp 2) included eighteen (n=18) dogs suffering from gastro-enteritis, kept in Dog Kennel and divided into two subgroups: (Gp2 A) included 9 dogs given the traditional regimen of treatment (GIT protectant, Anti-emetic, and fluid therapy); and (Gp 2 B) included 9 dogs treated with same regimen plus the addition of famotidine. Whole blood examined for changes in CBC and serum for selected biochemical constituents levels. Abdominal ultrasonography applied to detect changes in stomach and duodenum which revealed that gastritis, can produce a diffuse, mild to moderate thickening of wall with preservation of the wall layering. Early recovery and return of appetite, vital signs to normal occur at 3-5 days in dogs treated with famotidine while cases treated without famotidine recovery gained at 5-7 days of treatment.