Abstract
Parasitic diseases of dogs remain quite common throughout the Russian Federation, which creates the need for constant monitoring, prevention and treatment.
 The drug ExpressTabs developed by NVC Agrovetzashchita LLC is complex and multicomponent. Available in four modifications containing as active ingredients: spinosad, praziquantel, moxidectin and excipients.
 The aim of the study was to study the tolerability of ExpressTabs with its repeated daily use for 5 days in dogs at therapeutic and double therapeutic doses.
 Materials and methods. To study the tolerance of ExpressTabs, 3 groups of dogs were formed, 10 animals each (2 experimental and 1 control), (outbred individuals, average weight 23 kg.)
 Results and conclusions. The conducted studies allow us to conclude that daily multiple oral administration of the drug for 5 days to dogs in a therapeutic dose does not adversely affect the general condition of the animals, does not change the body temperature, morphological composition and biochemical parameters of the blood of animals.
 Repeated administration of the drug to dogs at a twice increased therapeutic dose daily for 5 days in 30% of cases has a toxic effect, expressed by signs of poisoning, which completely disappear without medical intervention within 24…48 hours.
 Based on the results of the conducted studies, it can be concluded that the drug ExpressTabs for dogs is safe when administered in therapeutic doses.
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