The calculation of volumes for irregular bodies holds significant relevance across various production processes. This spans tasks such as evaluating the growth status of crops and fruits, conducting morphological analyses of spatial objects based on volume parameters, and estimating quantities for earthwork and excavation. While methods like drainage, surface reconstruction, and triangulation suffice for smaller irregular bodies, larger ones introduce heightened complexity. Technological advancements, such as UAV photogrammetry and LiDAR, have introduced efficient point cloud data acquisition methods, bolstering precision and efficiency in calculating volumes for substantial irregular bodies. Notably, open-pit mines, characterized by their dynamic surface alterations, exemplify the challenges posed by large irregular bodies. Ensuring accurate excavation quantity calculations in such mines is pivotal, impacting operational considerations, acceptance, as well as production cost management and project oversight. Thus, this study employs UAV-acquired point cloud data from open-pit mines as a case study. In practice, calculating volumes for substantial irregular bodies often relies on the point cloud slicing method. However, this approach grapples with distinguishing multi-contour boundaries, leading to inaccuracies. To surmount this hurdle, this paper introduces an enhanced point cloud slicing method. The methodology involves segmenting point cloud data at fixed intervals, followed by the segmentation of slice contours using the Euclidean clustering method. Subsequently, the concave hull algorithm extracts the contour polygons of each slice. The final volume calculation involves multiplying the area of each polygon by the spacing and aggregating these products. To validate the efficacy of our approach, we employ model-derived volumes as benchmarks, comparing errors arising from both the traditional slicing method and our proposed technique. Experimental outcomes underscore the superiority of our point cloud volume calculation method, manifesting in an average relative error of 1.17%, outperforming the conventional point cloud slicing method in terms of accuracy.