Mastitis is one of the most common diseases of dairy cattle that appreciates the enormous losses of farm worldwide. Current treatment and prevention developed at the moment does not guarantee the reliable protection of animals from the disease, given the polyethological nature of mastitis. An important method of combating this problem may be a selection aimed at improving the immunity of livestock to the inflammation of the breast.The purpose of the article was to search and systematize information on genes associated with the sustainability of dairy cattle towards the development of clinical mastitis and SCS in milk, mainly among the Holstein breed. Also, the publication presents data on the genomic assessment of the bull leader 395, obtained on the basis of St. Petersburg University of Veterinary Medicine, in terms of indicators related to the sustainability of the offspring to the Master.The relationship between the markers of high milk productivity and is low-resistant to the mastel, the protein composition of milk and the frequency of the inflammatory processes of udder. The general mechanisms for the formation of immunity, nonspecific resistance and stability to the mastel are illustrated. A correlation is indicated between allele variants of genes regulating cell cycle or modulating autoimmune processes, and the SCS level in milk. When implementing a genomic estimate of the bull, the leader 395 was identified by its potential as an improved indicators such as SCS, mastotustability, the form of udder, the fatness of milk in daughters.