Current Trends In Development Research Articles

Capillary electrophoresis in the analysis of therapeutic peptides-A review.

Therapeutic peptides are a growing class of innovative drugs with high efficiency and a low risk of adverse effects. These biomolecules fall within the molecular mass range between that of small molecules and proteins. However, their inherent instability and potential for degradation underscore the importance of reliable and effective analytical methods for pharmaceutical quality control, therapeutic drug monitoring, and compliance testing. Liquid chromatography-mass spectrometry (LC-MS) has long time been the "gold standard" conventional method for peptide analysis, but capillary electrophoresis (CE) is increasingly being recognized as a complementary and, in some cases, superior, highly efficient, green, and cost-effective alternative technique. CE can separate peptides composed of different amino acids owing to differences in their net charge and size, determining their migration behavior in an electric field. This review provides a comprehensive overview of therapeutic peptides that have been used in the clinical environment for the last 25 years. It describes the properties, classification, current trends in development, and clinical use of therapeutic peptides. From the analytical point of view, it discusses the challenges associated with the analysis of therapeutic peptides in pharmaceutical and biological matrices, as well as the evaluation of CE as a whole and the comparison with LC methods. The article also highlights the use of microchip electrophoresis, nonaqueous CE, and nonconventional hydrodynamically closed CE systems and their applications. Overall, the article emphasizes the importance of developing new CE-based analytical methods to ensure the high quality, safety, and efficacy of therapeutic peptides in clinical practice.

Mapping the intellectual structure and landscape of nano-drug delivery systems in colorectal cancer.

Background: Colorectal cancer (CRC) is a prevalent malignancy affecting the digestive tract, and its incidence has been steadily rising over the years. Surgery remains the primary treatment modality for advanced colorectal cancer, complemented by chemotherapy. The development of drug resistance to chemotherapy is a significant contributor to treatment failure in colorectal cancer. Nanodrug delivery systems (NDDS) can significantly improve the delivery and efficacy of antitumor drugs in multiple ways. However, there is a lack of visualization of NDDS research structures and research hotspots in the field of colorectal cancer, and the elaboration of potential research areas remains to be discovered. Objective: To comprehensively explore the current research status and development trend of NDDS in CRC research. Methods: Bibliometric analysis of articles and reviews on NDDS for CRC published between 2002 and 2022 using tools including CiteSpace, VOSviewer, R-bibliometrix, and Microsoft Excel was performed. Results: A total of 1866 publications authored by 9,870 individuals affiliated with 6,126 institutions across 293 countries/regions were included in the analysis. These publications appeared in 456 journals. Abnous Khalil has the highest number of publications in this field. The most published journals are the International Journal of Nanomedicine, International Journal of Pharmaceutics, and Biomaterials. Notably, the Journal of Controlled Release has the highest citation count and the third-highest H-index. Thematic analysis identified "inflammatory bowel disease"," "oral drug delivery," and "ulcerative colitis" as areas requiring further development. Keyword analysis revealed that "ulcerative colitis," "exosomes," and "as1411"have emerged as keywords within the last 2years. These emerging keywords may become the focal points of future research. Conclusion: Our findings reveal the current research landscape and intellectual structure of NDDS in CRC research which helps researchers understand the research trends and hot spots in this field.

Analysis on the Development Prospect of Low-altitude Tourism in Hunan Province

As one of China's popular tourist provinces, Hunan has a unique geographical environment and rich tourism resources, as well as colorful landscapes and sufficient product portfolio. With the improvement of people's living conditions, the ways people choose to travel are also diversified. People are no longer satisfied with the conventional road tourism, at this time, low-altitude tourism is driven by policies and needs, began to develop rapidly, all over the country began to promote the development of low-altitude tourism, and the aviation industry is booming, China's low-altitude tourism in recent years began to prevail. However, under the prevalence of low-altitude tourism, it is still necessary to proceed from the actual situation, according to the geographical environment and cultural needs of their own province to develop, otherwise it will face huge risks. In the face of the current development trend of low-altitude tourism, Hunan Province began to comply with the requirements of The Times, rapidly develop low-altitude tourism, constantly optimize the corresponding service environment, explore the construction of pilot bases, and thus enrich the types of tourism products. Based on the current changes in Hunan's tourism transportation mode and local tourism resources, this paper discusses and analyzes the status quo and trend of low-altitude tourism in Hunan through literature method, questionnaire analysis and swot analysis, and then puts forward targeted marketing development strategies.

Research on the Chinese Enterprise Environmental Information Disclosure System

Green development is the trend of current international economic development, and achieving green development is an inevitable requirement for a country to integrate into the international economic society. The enterprise environmental information disclosure system is an important means to urge enterprises to assume environmental responsibility and promote the green development of China's economy. In recent years, Chinese government has issued a series of regulations on environmental information disclosure to alleviate environmental problems, but these regulations have not achieved the expected regulatory effect. Research has found that the reasons for this problem include shortcomings in government environmental audits, limitations of environmental policies, and poor media oversight. Further research has found that China can currently improve the regulatory effect of corporate environmental information disclosure through some measures. Measures including improving the relevant laws and regulations of enterprise environ-mental audit, making up for the deficiencies of green credit policies, and establishing corporate environmental information sharing mechanism should be taken.

Chinese Manufacturing Industry in the Context of Industry 4.0

The fourth industrial revolution, more popular known as Industry 4.0, has been developed for nearly 10 years since it was proposed, and has gradually evolved into a new revolution in manufacturing on a global scale. It is an era of opportunities for comprehensive digitalization. Through continuous exploration and development, the core technology of Industry 4.0 is constantly being explored and improved. China has written a manufacturing legend in the past 30 years, but its productivity still behind developed countries. If China wants to grow from the world's largest manufacturing country to a manufacturing powerhouse, it must grasp the general trend of Industry 4.0. Therefore, this paper explores the characteristics, core technologies and current global development trends of industry 4.0. And by analyzing the development data of Chinese manufacturing in the past ten years combined with Chinese government policies, the development status of Chinese Industry 4.0 and the problems encountered, some solutions and suggestions are put forward. Help enterprises understand the general environment and the technical characteristics of Industry 4.0, to formulate digital transformation and upgrading strategies based on their own characteristics and development needs.

Bibliometric Analysis of Research Progress and Perspectives of Deep Underground Rockburst Using Knowledge Mapping Method

In order to ensure the successful construction and stable operation of deep engineering projects, significant progress has been made in researching deep underground rockburst issues from various perspectives. However, there have been few systematic analyses of the overall research status of deep rockburst to date. In this study, a bibliometric approach using CiteSpace software (version 6.2.R3) was employed to visualize and analyze knowledge maps of 353 research articles on deep rockburst collected from the Web of Science core database from 1996 to 2022. The results show that the number of publications experienced exponential growth after an initial stage of budding and peaked in 2016. In terms of collaboration, China plays an absolute central role. The top three highly cited journals were the International Journal of Rock Mechanics and Mining Sciences, Rock Mechanics and Rock Engineering, and Tunneling and Underground Space Technology. In the keyword co-occurrence analysis, the keyword “prediction” had the highest frequency of occurrence in the past two decades, indicating it as the major research focus in deep rockburst studies. The keyword co-occurrence clustering analysis revealed eight clusters, including conventional criteria, acoustic emission, geology, seismic velocity tomography, dynamic disturbance, and others, representing the primary research topics. This study provides a comprehensive analysis of the current research progress and development trends of deep underground rockburst, helping to understand the key areas of focus in this field and providing potential prospects for future investigations for researchers and practitioners.

Undergraduate students’ modular experiences in learning mathematics in the new normal education

<span lang="EN-US">The modular approach has been proven to be an effective tool in mathematics learning. However, this approach presents challenges regarding students’ learning. Hence, this study was conducted to determine and compare the modular experiences of 55 Bachelor of Secondary Education (BSED) Math students of Eastern Samar State University (ESSU) Salcedo based on gender, age, and year level. The study utilized a descriptive-comparative design and a survey questionnaire. Percentage, mean, t-test, and </span><span lang="EN-US">analysis of variance </span><span lang="EN-US">(</span><span lang="EN-US">ANOVA) were used to treat the data. The study revealed that respondents were satisfied with their modular experience in learning mathematics in the new normal education. Specifically, the respondents rated their experience satisfactory in good teaching, high in clear outcomes, manageable in appropriate workload, moderate in appropriate assessment, and average in generic skills. Furthermore, the study found a significant difference in good teaching, clear outcomes, appropriate workload, appropriate assessment, generic skills, and satisfaction with modular learning across the respondents’ year level, but insignificant across age and gender. Based on the findings, it is recommended that teachers should attend intensive seminars and training on current trends in math teaching and module development. Modules’ quality must be improved considering the workload, assessment, outcomes, and skills development.</span>

Analysis of the Research Hotspot of Exosomes in Cardiovascular Disease: A Bibliometric-based Literature Review.

To investigate the current status and development trend of research on exosomes in cardiovascular disease (CVD) using bibliometric analysis and to elucidate trending research topics. Research articles on exosomes in CVD published up to April 2022 were retrieved from the Web of Science database. Data were organized using Microsoft Office Excel 2019. CiteSpace 6.1 and VOSviewer 1.6.18 were used for bibliometric analysis and result visualization. Overall, 256 original research publications containing 190 fundamental research publications and 66 clinical research publications were included. "Extracellular vesicle" was the most frequent research keyword, followed by "microrna," "apoptosis," and "angiogenesis." Most publications were from China (187, 73.05%), followed by the United States (57, 22.27%), the United Kingdom (7, 2.73%), and Japan (7, 2.73%). A systematic review of the publications revealed that myocardial infarction and stroke were the most popular topics and that exosomes and their contents, such as microRNAs (miRNAs), play positive roles in neuroprotection, inhibition of autophagy and apoptosis, promotion of angiogenesis, and protection of cardiomyocytes. Research on exosomes in CVD has attracted considerable attention, with China having the most published studies. Fundamental research has focused on CVD pathogenesis; exosomes regulate the progression of CVD through biological processes, such as the inflammatory response, autophagy, and apoptosis. Clinical research has focused on biomarkers for CVD; studies on using miRNAs in exosomes as disease markers for diagnosis could become a future trend.

Current situation and development trend of design methods for subgrade structure of high speed railways

PurposeThis method will become a new development trend in subgrade structure design for high speed railways.Design/methodology/approachThis paper summarizes the structural types and design methods of subgrade bed for high speed railways in China, Japan, France, Germany, the United States and other countries based on the study and analysis of existing literature and combined with the research results and practices of high speed railway subgrade engineering at home and abroad.FindingsIt is found that in foreign countries, the layered reinforced structure is generally adopted for the subgrade bed of high speed railways, and the unified double-layer or multi-layer structure is adopted for the surface layer of subgrade bed, while the simple structure is adopted in China; in foreign countries, different inspection parameters are adopted to evaluate the compaction state of fillers according to their respective understanding and practice, while in China, compaction coefficient, subsoil coefficient and dynamic deformation modulus are adopted for such evaluation; in foreign countries, the subgrade top deformation control method, the subgrade bottom deformation control method, the subsurface fill strength control method are mainly adopted in subgrade bed structure design of high speed railways, while in China, dynamic deformation control of subgrade surface and dynamic strain control of subgrade bed bottom layer is adopted in the design. However, the cumulative deformation of subgrade caused by train cyclic vibration load is not considered in the existing design methods.Originality/valueThis paper introduces a new subgrade structure design method based on whole-process dynamics analysis that meets subgrade functional requirements and is established on the basis of the existing research at home and abroad on prediction methods for cumulative deformation of subgrade soil.

Current Situation and Development Trend of Fresh Ground Coffee Market in China

Freshly ground coffee is coffee that is ground into coffee powder on site and then made by different extraction methods. Nowadays, with the acceleration of global economization, China's coffee industry is also booming, there are many chain cafes. Through consumer analysis in this paper, it is found that new coffee products have little impact on the overall brand store sales, and coffee needs to meet functional needs, so basic coffee is the choice of the public. In the past two years, the trend of increasing is obvious. It is estimated that fresh ground coffee will be more and more popular in the future to better meet people's needs for daily health.

Exploring The Possibilities of Enhanced Mobility A Review of Hand Glove Controlled Wheelchair Design and Development

This research review article provides an overview of the current design and development of hand glove controlled wheelchairs. It examines the benefits of such devices, including improved mobility for those with disabilities, and the challenges in designing and implementing them. The article then looks at the design considerations for hand glove controlled wheelchairs and the current development trends in the field. Furthermore, it discusses potential applications of such devices and provides possible directions for their future development. Finally, the article concludes by highlighting the importance of hand glove controlled wheelchairs and the need to continue researching and developing them. By exploring the possibilities of enhanced mobility through this review article, the reader is able to gain a better understanding of the current state of hand glove controlled wheelchairs and the potential for future development.

Rural tourism service design based on collaborative filtering algorithm after epidemic normalization

Abstract In the epidemic, normalized tertiary and rural tourism service industries are in the economic depression stage. Under the epidemic, combined with big data technology to improve the economic income and development scale of rural tourism services become the current development trend of the tourism industry. This paper first proposes a collaborative filtering recommendation algorithm based on big data technology to study the design of rural tourism services under the new epidemic normalization. Then the basic principle of the content-based recommendation algorithm is to obtain the interests of tourists based on their historical behaviors and recommend rural tourism similar to their interest preferences, and choosing the appropriate similarity function can improve the accuracy of the neighborhood-based CF method. Finally, to meet the tourists’ demand for a full range of tourism experience services and build a rural tourism service system, the psychological demand of rural tourism tourists’ consumption is analyzed based on a collaborative recommendation algorithm. The results show that among the main factors attracting tourists, 75.54% are natural scenery, 54.68% are folk culture, 51.08% are unique flavors and food, 43.17 are experiencing rural life, and 41.73% are promoting relationships with friends. This study plays an important role in accelerating rural revitalization by attracting urban tourists back to the countryside and driving the transfer of consumer groups and the rural economy to increase income; thus, rural tourism plays an important role in accelerating rural revitalization.

The Relationship between Rural Sustainability and Land Use: A Bibliometric Review

Faced with substantial environmental, societal, and economic challenges, the matters of rural sustainability and land use have emerged as pivotal global concerns. Amidst the rapid phenomenon of urbanization, the escalating requisites for sustenance, energy, and natural resources have engendered profound pressure upon rural landscapes and ecosystems. The attainment of sustainability within rural regions assumes a paramount role, encompassing not only the advancement of these rural domains but also holding pivotal significance in addressing critical global concerns such as climate change, biodiversity depletion, and the eradication of poverty. In order to gain a thorough understanding of the implications associated with rural sustainability and land use, this study undertakes a bibliometric analysis of 1746 articles sourced from the Web of Science database. The analysis unveils a multitude of pivotal revelations. Primarily, the domain exhibits a conspicuous trajectory of expansion in publications spanning the period from 1990 to 2023, thereby alluding to a substantial reservoir of potential for subsequent advancement. Secondly, high-frequency keywords encompass sustainability, land use, agriculture, ecosystem services, and China. Thirdly, the field encompasses four primary research directions, namely the impact of rural land use and land cover changes on biodiversity, adaptive capacity, and vulnerability in rural sustainable development; the interplay between rural land use changes and rural agricultural development; and land management for rural sustainability. Fourthly, the evolution of research hotspots focuses on three main areas: rural sustainability and biodiversity conservation and ecosystem services, rural sustainability and land management and impacts, and the impacts of climate change and human activities on rural sustainability. Finally, future research should focus on sustainable multifunctional agriculture and rural land management, continue to pay attention to the social dimensions of rural sustainability, and emphasize the role of ecosystem services and natural capital in sustainable rural development. The results of this study can provide a reference for grasping the current situation, research directions, and development trends in the field of rural sustainability and land use.

A Review on Predictive Control Technology for Switched Reluctance Motor System

The significance of employing control strategies on a switched reluctance motor (SRM) is that they can reduce vibration noise and torque ripple. With the rapid development of digital system processors, predictive control (PC), as a modern control approach, is increasingly applied to enhance the dynamic performance and operational efficiency of SRMs. This review provides a comprehensive overview of the current state of research on PC strategies of SRMs and classifies PC technologies, such as generalized predictive control (GPC), hysteresis predictive control (HPC), deadbeat predictive control (DPC), and model predictive control (MPC). It summarizes the PC schemes from the aspects of predictive current control (PCC), predictive torque control (PTC), and other PC, and it discusses the current trends in technology development, as well as potential research directions. The insights presented herein aim to facilitate further investigations into predictive control techniques for SRM.

Exploring the Current Status and Development of Condition Monitoring and Fault Diagnosis for Power Machinery of Engineering Ships

With the continuous progress of science and technology, modern engineering ships are also moving towards large-scale and high-speed development. Due to the fact that the power propulsion system is one of the most important parts of the entire ship, its operational status will directly affect navigation safety and operational efficiency, etc. Therefore, real-time monitoring of it is of great significance. Based on this, this article mainly explores the current status and development trends of condition monitoring and fault diagnosis of engineering ship power machinery, aiming to enable technical personnel to quickly and better grasp and apply these advanced technologies, and promote the healthy and sustainable development of China's shipbuilding industry.

A Survey of Side-Channel Leakage Assessment

As more threatening side-channel attacks (SCAs) are being proposed, the security of cryptographic products is seriously challenged. This has prompted both academia and industry to evaluate the security of these products. The security assessment is divided into two styles: attacking-style assessment and leakage detection-style assessment. In this paper, we will focus specifically on the leakage detection-style assessment. Firstly, we divide the assessment methods into Test Vector Leakage Assessment (TVLA) and its optimizations and summarize the shortcomings of TVLA. Secondly, we categorize the various optimization schemes for overcoming these shortcomings into three groups: statistical tool optimizations, detection process optimizations, and decision strategy optimizations. We provide concise explanations of the motivations and processes behind each scheme, as well as compare their detection efficiency. Through our work, we conclude that there is no single optimal assessment scheme that can address all shortcomings of TVLA. Finally, we summarize the purposes and conditions of all leakage detection methods and provide a detection strategy for actual leakage detection. Additionally, we discuss the current development trends in leakage detection.

Current State and Development Trends of Regulative and Methodological Support of the Activities of Nuclear-Medicine Centers

Current State and Development Trends of Regulative and Methodological Support of the Activities of Nuclear-Medicine Centers

Current Trends in Vaccine Development for Hereditary Colorectal Cancer Syndromes.

The coming of age for cancer treatment has experienced exponential growth in the last decade with the addition of immunotherapy as the fourth pillar to the fundamentals of cancer treatment-chemotherapy, surgery, and radiation-taking oncology to an astounding new frontier. In this time, rapid developments in computational biology coupled with immunology have led to the exploration of priming the host immune system through vaccination to prevent and treat certain subsets of cancer such as melanoma and hereditary colorectal cancer. By targeting the immune system through tumor-specific antigens-namely, neoantigens (neoAgs)-the future of cancer prevention may lie within arm's reach by employing neoAg vaccines as an immune-preventive modality for hereditary cancer syndromes like Lynch syndrome. In this review, we discuss the history, current trends, utilization, and future direction of neoAg-based vaccines in the setting of hereditary colorectal cancer.

The Green Dimension of a Compact City: Temperature Changes in the Urban Area of Banja Luka

Responsible and rational urban planning is reflected in an integral and multidimensional approach to city development. Contemporary theories of sustainable and resilient urban planning support a clear vision and strategy for city development, emphasizing its identity, specifics, and values. Through its vision and action plans, the city of Banja Luka protects its default identity as a green city while recognizing the current development trend toward a compact city. The paper deals with two theories: green and compact cities, both motivated by ecological and energy planning. The paper aims to show the importance of the green dimension of a compact city and the adoption of the principles of compactness in the green city in order to examine its contribution through synergistic action. Through the comparative analysis of the green structure change toward a compact urban area and temperature rise in the last fifty years and on different scales, it is possible to question the set green goals and effects of environmental urban (non) planning.

ANALYSIS OF ADMISSIONS AND MARKETING OPTIMIZATION STRATEGY OF YUNNAN VOCATIONAL COLLEGE OF ECONOMICS AND FOREIGN AFFAIRS

This research takes the Yunnan Vocational College of Economics, Trade and Foreign Affairs as the research object, and conduct in-depth study in combination with the current development trend of private education and the specific reality of the school. The background, meaning, writing methods and ideas of the topic selection are expounded in detail in the introductory part, and then the relevant theories of marketing are analyzed as well as the macro- and micro- environment faced by the Yunnan Vocational College of Economics, Trade and Foreign Affairs. The recruitment and marketing concept of the Yunnan Vocational College of Economics, Trade and Foreign Affairs are also summarized in this article. PEST and SWOT analysis are used to analyze the career of the Yunnan Economics, Trade and Foreign Affairs. The article also looks into the political environment, economic environment, social environment, and scientific environment in which the college is located, as well as the advantages, disadvantages, opportunities and challenges it faces, and the usage of relevant marketing strategies, such as market segmentation, market positioning, and selection of target markets, etc. Finally, it studies the college's admissions marketing strategy, and puts forward a series of solutions to promote the optimization of the college's marketing strategy.