In a reality that combines the virtual with the physical and in a context of information saturation, there are consumers who are more critical, demanding, and less loyal. In this context, it is timely to know the new habits of the Centennials, so as to understand their behaviors and consumption trends, aligning future communication strategies to their personality and interests. The Centennials or Generation Z are digital natives, concerned with technology, and complex to understand (Alonso-López; Terol-Bolinches, 2020). Generation Z –analyzed in this study– is composed of those born between 2000 and 2008, which corresponds to the youth currently between 14 and 22 years old (Vilanova; Ortega, 2017; Hernández; Andrade-del-Cid, 2020). The main objective of this research is to determine the patterns of consumption and online behavior exhibited by this generation in Mexico, Colombia, Chile, and Panama, with a focus on the characteristics of communication processes, online consumption patterns, and the cultural traits they possess. To achieve this, a mixed method is proposed consisting of a Twitter conversation analysis, survey application (n=550), in-depth interviews (n=36), and focus groups (n=2); all of which have been applied in the four selected countries. The main conclusions are that the preferred content of Centennials is humor (75%), with Instagram and TikTok being the most used networks. For they, the most important thing is to take care of their image and 40% are not interested in technological topics. Furthermore, cultural characteristics are shared among countries; however, language is the main difference between countries.