Cultural Profile Research Articles

Host-virus interactions during infection with a wild-type ILTV strain or a glycoprotein G deletion mutant ILTV vaccine strain in an ex vivo system.

Previous studies have demonstrated the safety and efficacy of a live-attenuated glycoprotein G (gG) deletion mutant vaccine strain of ILTV (∆gG-ILTV). In the current study, transcriptional profiles of chicken tracheal organ cultures (TOCs), 24 h post inoculation with ∆gG-ILTV or the gG-expressing parent wild-type strain, CSW-1 ILTV were explored and compared with the mock-infected TOCs using RNA-seq analysis. Transcriptomes of the vaccine and wild-type ILTV were also compared with each other. Although no viral genes (except for gG) were differentially regulated between the two ILTV-infected TOCs, pair-wise comparison of the transcriptomes of the ∆gG-ILTV or the CSW-1 ILTV-infected TOCs (each compared with mock-infected TOCs) identified the similarities and differences in host gene transcription between them. Several immune checkpoint inhibitors with likely roles in ILTV-mediated immune augmentation, and gene ontologies indicating cytokine response, and cytokine signaling were upregulated in both TOCs. Additionally, several other biological processes, molecular functions, and cellular components were enriched uniquely in the ∆gG-ILTV-infected TOCs, including those that indicated modifications to tracheal extracellular matrix (ECM) structural components, which may have a role in immune modulation in vivo. This study has revealed that the modifications of transcription of host genes during the early stages of ILTV infection are not limited to changes in cytokine or chemokine gene transcription, but several other immune-related genes and ECM components. Moreover, their differential regulation in the ex vivo system appears to be influenced by gG expression, potentially affecting the outcome of ILTV infection in vivo.IMPORTANCEInfectious laryngotracheitis virus (ILTV) remains a serious threat to poultry industries worldwide, causing significant economic losses. The glycoprotein G (gG) of ILTV is a virulence factor and a chemokine-binding protein with immunoregulatory functions. The influence of gG on the transcription of select host chemokine and cytokine genes has been demonstrated previously. This study extends our understanding of the early and localized host-ILTV interactions using genome-wide transcriptome analysis of ILTV-infected chicken tracheal organ cultures, and the role of gG during the process. Differential regulation of genes encoding immune checkpoint inhibitors observed in this study may have a role in ILTV-induced inhibition of type I interferon response, or negative regulation of T cell responses, bringing clarity to these ILTV immune-evasion mechanisms. Furthermore, differential regulation of genes encoding certain structural components and receptors with roles in cell migration, in the absence of gG, is consistent with the immunomodulatory role of ILTV gG.

Elastic properties of the cell surface and metabolic profile of an embryonic primary mixed culture of hippocampal neurons under conditions of P2X3 receptor blockade

Elastic properties of the cell surface and metabolic profile of an embryonic primary mixed culture of hippocampal neurons under conditions of P2X3 receptor blockade

OSTEOMIELITE RELACIONADA A IMPLANTES EM HOSPITAL REFERÊNCIA DE TRAUMA DO CEARÁ: PERFIL CLÍNICO, RADIOLÓGICO E MICROBIOLÓGICO DAS CULTURAS DE FRAGMENTO ÓSSEO

Osteomyelitis remains a major challenge in medical practice and has growing importance in the national public health scenario by increasing the number of orthopedic surgeries with implant use and, mainly due to the increase in the number of high energy traumas associated with exposed fractures. Failure to identify the correct microorganism can result in potentially toxic and expensive treatments, as well as possible failure to eradicate the pathogen and increase the length of hospitalization. Implant-related osteomyelitis is considered a serious and difficult to treat complication, representing a challenge for all professionals involved in patient care, as it significantly increases the time needed for recovery, In addition to also raising the cost of treatment and causing impairment in long-term functional results. It is known that, although infection occurs less frequently than mechanical loss of the prosthesis, it is considered the most devastating of complications, leading to long-term hospitalization, repeated surgical interventions and even permanent with shortening of the affected limb and significant permanent deformities. Therefore, it is of great importance the recognition of clinical, radiological and surgical aspects of patients hospitalized with diagnosis of implant-related osteomyelitis in reference centers such as the Instituto José Frota (IJF). The study aimed to characterize patients with diagnosis of implant-related osteomyelitis in a trauma referral hospital in Ceará. At the end of the study, we recognized the microbiological and sensitivity profile of the bone fragment cultures, as well as the main risk factors related to infection.

Industrial diversity, formal, and informal institutions: a configurational moderation of the innovation input-output relationship

ABSTRACT This study seeks to uncover configurations of industrial diversity and institutions that act as boundary conditions in the conversion of innovation inputs into outputs. Specifically, we analyse how industrial diversity, rule of law, open markets, power distance, and individualism combine to influence countries’ transformation of innovation inputs into innovation outputs. A novel, two-stage fuzzy-set qualitative comparative analysis is used to identify configurational moderation on panel data from 66 countries. Results revealed three distinct equifinal combinations of conditions that moderate the innovation input-output relationship: (1) the presence of open markets and individualism, coupled with the absence of power distance; (2) the presence of industrial diversity, open markets, and individualism; and (3) the presence of rule of law and power distance. These configurations support the presence of high innovation outputs, even when innovation inputs lose importance. This study reconciles the literature on industrial structure with institutional theory and embeds them in the NSI approach. Furthermore, it helps to clarify the current discussions of whether innovation benefits more from industrial diversity or specialisation, or through one cultural profile or another. Thus, the study sheds light on previous inconsistencies in the literature by harmonising different approaches to innovation.

Cultural Dimensions and Consumption Values of Cross-Border Electronic Commerce: A Canonical Analysis

The purpose of this research is to explore the fitting models for cross-border e-commerce by developing localized business strategies tailored to cultural factors. The study adopts Hofstede’s five cultural dimensions along with Sheth et al.’s five consumption value dimensions. A canonical correlation analysis is employed to identify the fitting relationships between cultural dimensions and consumer values. The targeting samples focus on the rapidly growing Southeast Asian economy. The results indicate differences in cultural dimensions among countries like Taiwan, Vietnam, Malaysia, Indonesia, and Myanmar. The canonical correlation analysis reveals fitting combinations for each region: Taiwan’s higher individualism, masculinity, and long-term orientation align with demands for functional, conditional, and emotional values in e-commerce. Vietnam’s high risk-taking propensity fits demands for conditional and epistemic values. Malaysia and Indonesia, with similar cultural profiles, are highly correlated with consumer demands in functional and emotional values, with Malaysia additionally emphasizing epistemic value. Myanmar’s high masculinity and long-term orientation correlate with demands for functional, emotional, and conditional values, while its low power distance links to demands for social and epistemic values. Overall, the study shows that there is no fixed correspondence between cultural dimensions and consumption values in e-commerce. Optimal configurations vary, emphasizing the importance of tailored strategies to promote e-commerce development across different regions.

Life satisfaction and the variety and intensity of cultural participation in Italy: disentangling the individual and regional dimensions

ABSTRACT This paper proposes a novel approach to explore the relation between cultural participation and subjective well-being, and to dig into the relation between the individual and regional dimensions. Using the Italian Multipurpose survey, we derive major cultural consumer profiles that combine the variety and intensity of engagement through latent class analysis. We then investigate how heterogeneity in cultural profiles at the national and regional levels relates to overall life satisfaction and relevant domains (leisure and friendship relationships). The results indicate a positive relation with diversity in consumption becoming more significant in specific domains. At the same time, we find patterns of regional variation in the relation, which is only partly explained by indicators of cultural supply at the regional level. The findings shed light on the role of habits of cultural consumption in individual well-being and inform the policy debate on culture-led interventions.

The Interplay of Happiness and Sustainability: A Multidimensional Scaling and K-Means Cluster Approach

This study examines the intricate relationship between national happiness and sustainability by analyzing data from the 2024 World Happiness Report (WHR) and the Sustainable Development Goal (SDG) Index across 74 countries. Employing multidimensional scaling (MDS) and K-means clustering, we investigate the interplay of economic, social, and environmental factors that contribute to subjective well-being. Our results indicate that high-income countries, particularly those characterized by secular–rational values, tend to achieve elevated scores in both happiness and sustainability. In contrast, lower-income nations exhibit diverse cultural value systems that significantly influence their happiness and sustainability outcomes. This analysis identifies distinct clusters of countries with unique governance and cultural profiles, underscoring the inadequacies of traditional economic indicators in measuring societal well-being. By integrating sustainability metrics into happiness assessments, we propose a comprehensive framework for understanding and promoting human happiness. These findings offer critical insights for policymakers aiming to address pressing global challenges, including inequality and health disparities.

Parallel Analyses by Mass Spectrometry (MS) and Reverse Phase Protein Array (RPPA) Reveal Complementary Proteomic Profiles in Triple-Negative Breast Cancer (TNBC) Patient Tissues and Cell Cultures.

High-plex proteomic technologies have made substantial contributions to mechanism studies and biomarker discovery in complex diseases, particularly cancer. Despite technological advancements, inherent limitations in individual proteomic approaches persist, impeding the achievement of comprehensive quantitative insights into the proteome. In this study, we employed two widely used proteomic technologies, mass spectrometry (MS) and reverse phase protein array (RPPA) to analyze identical samples, aiming to systematically assess the outcomes and performance of the different technologies. Additionally, we sought to establish an integrated workflow by combining these two proteomic approaches to augment the coverage of protein targets for discovery purposes. We used 14 fresh frozen tissue samples from triple-negative breast cancer (TNBC: seven tumors versus seven adjacent non-cancerous tissues) and cell line samples to evaluate both technologies and implement this dual-proteomic strategy. Using a single-step protein denaturation and extraction protocol, protein samples were subjected to reverse-phase liquid chromatography (LC) followed by electrospray ionization (ESI)-mediated MS/MS for proteomic profiling. Concurrently, identical sample aliquots were analyzed by RPPA for profiling of over 300 proteins and phosphoproteins that are in key signaling pathways or druggable targets in cancer. Both proteomic methods demonstrated the expected ability to differentiate samples by groups, revealing distinct proteomic patterns under various experimental conditions, albeit with minimal overlap in identified targets. Mechanism-based analysis uncovered divergent biological processes identified with the two proteomic technologies, capitalizing on their complementary exploratory potential.

Multi–class cyanobacterial toxin analysis using hydrophilic interaction liquid chromatography–mass spectrometry

Cyanobacteria produce diverse classes of toxins including microcystins, nodularins, anatoxins, cylindrospermopsins and saxitoxins, encompassing a range of chemical properties and mechanisms of toxicity. Comprehensive analysis of these toxins in cyanobacterial, environmental and biological samples generally requires multiple methods of extraction and analysis.In this work, a method was developed for the major classes of cyanotoxins, which comprised of a three-step liquid-solid extraction method using 75 % CH3CN with 0.1 % HCOOH and a hydrophilic interaction liquid chromatography (HILIC) elution gradient that provided retention of the less polar microcystins through to the highly polar saxitoxins. Detection was performed by tandem mass spectrometry in selected reaction monitoring mode with positive and negative polarity switching. Identification criteria included matching retention times and product ion ratios with available standards. In-house validation demonstrated good performance of the method including precision ranging from 1.5 (microcystin-LA) to 5.8 (gonyautoxin-2) % RSDs, and detection limits ranging from 0.01 (cylindrospermopsin) to 0.99 (gonyautoxin-3) µg/g in freeze dried material cyanobacteria. Recovery was assessed using spiked non-toxic cyanobacterial samples (Aphanizomenon sp.) and ranged from 83 (neosaxitoxin) to 107 % ([Dha7]microcystin-LR).As a demonstration of application, toxin profiles in cyanobacterial cultures, benthic and planktonic cyanobacteria field samples, and shellfish reference materials were successfully evaluated. The procedure is also amenable for extension to other polar toxin classes including domoic acid and guanitoxin. With increasing reports of cyanobacterial blooms globally, the method represents a powerful quantitative screening tool for measuring cyanotoxins across a broad range of samples.

Flood-induced mobility in rural and urban coastal jurisdictions: a homeowner’s perspective

AbstractCoastal flooding often exceeds homeowners’ capacity to cope with repetitive damages and profoundly disrupts their livelihoods. Permanent relocation has been proposed as a solution for some coastal areas experiencing recurrent flooding and anticipating acceleration of impacts. However, it is unclear if homeowners living in such areas would support this strategy, where they would choose to go, and why. This study evaluates the willingness to relocate and the reasoning behind it among rural and urban homeowners residing in coastal high-risk areas. The rural versus urban comparison explores how attitudes toward relocation differ between these settings with distinct sociodemographic, economic, and cultural profiles. A mail survey administered on the Eastern Shore, Maryland, and in the Hampton Roads metropolitan area, Virginia, measured how willingness to relocate differs across the socioeconomic spectrum, prior flood exposure, concerns with flood impacts, and preferences for relocation destination. The survey responses were analyzed using descriptive and inferential statistics. The results show that more than one-third of respondents would consider relocating. The willingness to relocate was marginally influenced by socioeconomic factors and flood experiences and instead was significantly correlated with the risk of disastrous flooding, inadequate insurance compensation, and worsening crime. However, data show a clear shift in relocation support and the distance of the preferred destination from minor to significant flooding. Rural respondents are slightly less likely to relocate than urban ones. Descriptive statistics indicate nuanced differences in flood experiences, reasons to relocate, and preferences for a new destination between rural and urban populations.

Cultural profiles evaluation and their impact on the performance of production systems in Colombian companies using data analytics

Strategically managing production systems is crucial for creating value and enhancing the competitive capabilities of companies. However, research on organizational culture within these systems is scarce, particularly in the Colombian context. This research aims to evaluate cultural profiles and their impact on the performance of production systems in Colombian firms. The regional focus is vital as cultural and contextual factors can vary significantly between regions, influencing organizational behavior and performance outcomes. To achieve this, we make a study in a sample of Colombian companies, with participation from working students of the Universidad Nacional Abierta y a Distancia (UNAD). We used a data analytics approach to collected data. The results will be relevant to both the scientific community and business practitioners. This research seeks to determine whether the perception of the work environment within a company influences the perceived performance of the company. The findings will provide a deeper understanding of the relationship between organizational culture and production system performance, offering a foundation for business decision-making and enhancing competitiveness in Latin American context.

Exploring organisational culture: assessing readiness for lean production implementation – an empirical study

Purpose Studies emphasise the critical role of a suitable organisational culture (OC) in successfully implementing lean production (LP) and argue that failure to consider OC can hinder organisations from fully benefiting and sustaining the success of LP. It is also observed that consensus regarding the suitable OC required for implementing LP remains elusive, with existing research predominantly theoretical and in developed economies. Using a systematic approach, this study aims to evaluate organisational readiness for LP implementation from the OC point of view by identifying the suitable OC for LP implementation, examining the existing OC to determine the most dominant (primary OC) and evaluating the suitability of the current OC for LP implementation. The paper uses empirical data collected from Pakistan’s textile sector as a case study. Design/methodology/approach The study used the competing values framework of OC and a quantitative approach. The data was collected by surveying 162 textile professionals, including first-level supervisors, middle managers and top management. Data analysis included quantitative techniques such as testing of hypotheses and multiple regression analysis techniques. SPSS, Minitab and SmartPLS 4.0 were used for data analysis. Findings The study revealed that characteristics of developmental and rational culture profiles are the most suitable for implementing LP in Pakistan’s textile industry. However, the group and hierarchy culture profiles do not significantly impact the implementation of LP. Moreover, the group culture profile (GCP) is the most dominant (primary OC) within the selected sector and the hierarchy culture profile is the least dominant. As a result, the current prevailing OC profile i.e. GCP is unsuitable for lean deployment. Research limitations/implications Although this study provides valuable insights, it is important to acknowledge its limitations. Data could not be collected from the employees with low education. Its applicability to other countries or industries may be limited due to its specific context. However, the approach used to assess organisational readiness regarding OC is both innovative and practical. Additionally, this research fills a gap in the literature by including a case study from a developing economy. Despite these contributions, future research could further validate and refine the proposed framework through comparative studies across diverse contexts. Practical implications The study’s findings emphasise the significance of OC in driving lean transformation and offer valuable recommendations and approaches for management, consultants and academicians to enhance lean deployment. By realising the significance of OC, stakeholders can effectively tailor strategies and interventions to align OC with lean principles. Originality/value This research is novel in terms of the structured approach and the selected case for evaluating the preparedness of organisations concerning OC for implementing LP. This approach can be used for other sectors and contexts.

Bacterial Profile in Urine Culture and Amikacin Sensitivity and Emergence of Carbapenem-Resistant Pathogens in Tertiary Medical College Hospital, Bangladesh

Background: Urinary tract infection (UTI) is one of the most common encounters both in the outpatient department and inpatient department. It is important to know the bacteriological etiology according to urine culture and to know the antibiotic sensitivity. Objective: Our study was carried out to observe the urine culture and sensitivity pattern to commonly used injectable antibiotics such as amikacin and to look for the emergence of carbapenem-resistant uropathogens.Materials and methods: A total of 150 patients of UTI being culture-positive were isolated and identified by random selection. Samples were collected throughout January 2022 to March 2022. Standard microbiological techniques were used to identify the bacteria and test for susceptibility to various antibiotics. Data were entered into MS Office Excel 2016 for analysis and visualization.Results: The most common urine culture positive was E. coli, 108 (72%) followed by Pseudomonas sp., 16 (11%) and staphylococcus saprophyticus, 15 (10%). The rest of 7% urine culture was positive were other bacterial species. Around 90% of the total cultured E. coli was sensitive to amikacin. Staphylococcus saprophyticus 8 cases (53%), E. coli 15 cases (14%) and Pseudomonas sp. single cases (6%) were resistant to carbapenem. Resistance to vancomycin was common among most of the pathogens, with 88 cases (81%) of E. coli and 12 cases (75%) of Pseudomonas sp. being resistant. In contrast, Staphylococcus saprophyticus had a higher sensitivity to vancomycin, with only 3 cases (20%) being resistant and 12 cases (80%) being sensitive.Conclusion: The study focused on the commonest uropathogens causing UTI and antibiotic resistance in urine isolates may be useful guidelines for clinicians initiating empirical antibiotic therapy as well as help in the formulation of antibiotic therapy strategy. KYAMC Journal Volume: 15, No: 01, April 2024: 16-19.

A Kinetic Study on Chronic Response of Activated Sludge to Diclofenac by Respirometry

The present study investigated the chronic response of activated sludge to the emerging pollutant diclofenac as well as its aerobic biodegradation potential at different sludge retention times (SRTs). The impact of prolonged exposure to diclofenac on microbial process kinetics was explored with respirometric modelling. The long-term operation of lab-scale reactors revealed that continuous feeding of diclofenac at relevant concentrations observed in municipal wastewaters did not affect carbon removal efficiency independentl of SRT. However, in case of diclofenac removal, 34% efficiency could be achieved at a higher SRT of 20 days. Kinetic evaluation showed that the increment in diclofenac dosing resulted in no adverse effect on the microbial growth rate except that high concentrations of diclofenac exposure decreased the growth rate at SRT of 10 days. A significant increase in hydrolysis rate was determined in the diclofenac-acclimated biomass for both SRTs; even at high concentrations of diclofenac exposure, the hydrolysis rate remained unchanged. Long-term acclimation to diclofenac had a progressive impact on the hydrolysis kinetics, which could be attributed to an alteration in the microbial culture profile. Overall, the results suggest that the operation with diclofenac-acclimated biomass at higher SRTs could enrich a microbial culture capable of overcoming the adverse effect of the pollutant and improve the biodegradation potential as well.

Identifying Culturally Relevant School Support Profiles and Links to Academic Functioning in Adolescents.

There is limited knowledge about patterns of adolescents' experiences of general teacher support and support for critical consciousness and cultural competence development in school settings, which are key experiences proposed to promote academic functioning. Furthermore, less is known about potential developmental and ethnic-racial differences in these patterns. Using a person-centered approach, this study examined culturally relevant school support profiles in a sample of sixth and ninth grade students (N = 717; 49.9% girls) from the U.S. Southwest. Participants were aged 10 to 18 years (M = 13.73; SD = 1.54) and were ethnoracially diverse (31.8% Hispanic/Latinx, 31.5% Multiethnic, 25.7% White, 7.3% Black or African American, 1.4% Asian American or Pacific Islander, 1.4% American Indian or Alaska Native, and 1% Arab, Middle Eastern, or North African). Four culturally relevant school support profiles were identified: (1) low general, devoid cultural & critical support; (2) moderate general, moderate cultural, & devoid critical support; (3) high general, moderate cultural & critical support; and (4) high general, cultural, & critical support. Youth in the high general, cultural, & critical support profile had higher concurrent emotional and behavioral engagement. No significant differences were found between early (6th grade) and middle adolescent (9th grade) youth, pointing to the relevance and associations of the identified profiles across development. One significant difference emerged when comparing White and ethnoracially minoritized youth; among White youth, those in the high general, cultural, & critical support and high general, moderate cultural & critical support profiles had higher academic expectations than those in the low general, devoid cultural & critical support profile. The discussion focuses on characterizing heterogeneous and culturally relevant school support profiles, the associations between these profiles and indicators of academic functioning for ethnoracially diverse youth to advance developmental theory and the importance of promoting culturally relevant school support practices to foster developmental competencies among youth.

Chromatin Accessibility Plays an Important Epigenetic Role on Antibody Expression From CMV Promoter and DNA Elements Flanking the CHO TI Host Landing-Pad.

Targeted integration (TI) Chinese hamster ovary (CHO) platforms are commonly used for protein expression. However, the impact of epigenetic modifications on protein expression in TI cell lines remains elusive since almost all the epigenetic studies focus on random integration (RI) of the gene of interest and only within the promoter region. To address the impact of epigenetic modifications on TI CHO cells, we utilized a standard mAb-1 to identify and characterize TI clones with the same transgene copy numbers but different levels of transgene transcription and titer. Surprisingly, while CMV promoters were not methylated and histone acetylation/methylation was present, these epigenetic markers did not trend with mRNA transcription and protein expression in our TI model. Instead, ATAC-seq data analysis revealed that differences in chromatin accessibility within the TI site could be a major factor impacting these observed differences. However, neither chromatin accessibility nor histone acetylation/methylation profiles in early cultures were predictive of high-expressing clones early during the CLD process. Finally, modulation of the histone profiles (H3K27ac and H3K4me3) at the CMV promoters within the TI integration site using dCas9 fusion proteins was not effective in further increasing mAb titers which could have been likely due to interference of the dCas9 fusion proteins with transcription from the CMV promoters. Overall, our data suggests increasing chromatin accessibility at the TI site is the most effective way to increase mRNA transcription and hence, productivity in TI cell lines.

The double pandemic: Examining cultural stress among Asian Americans during the COVID-19 pandemic.

To investigate patterns of cultural stress (racial discrimination and COVID stress) and their impact on ethnic identity and civic engagement among Asian American college students. 491 undergraduate students who self-identify as Asian American (female = 63.50%; Mage = 20.40, SD = 3.64) were recruited from seven college campuses. We identified four distinct cultural stress profiles: COVID-related stress, discrimination stress, double pandemic stress (high in both), and low combined COVID-discrimination stress. Double pandemic profile members were more likely to be immigrants and reported higher ethnic identity, civic behaviors, and belief in civic participation, whereas low combined COVID-discrimination stress participants reported significantly lower beliefs in civic participation compared to those in the double pandemic profile. Findings reaffirm the need to focus on Asian Americans' experiences and expand current conceptualizations of cultural stress to include macrolevel structural processes (COVID stress and racial discrimination) and its implications for identity and civic engagement. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Analysis of the Influence of Organizational Culture on Employee Job Satisfaction in Multinational Companies

Organizational culture has long been recognized as one of the factors that greatly influences employee performance and job satisfaction in companies, especially on a global scale such as multinational companies (Garnida, 2011; Santoso, 2020). In the era of globalization, multinational companies are often faced with unique challenges related to cultural diversity, cross-border human resource management, and adaptation to different values (Nurfatmala et al., 2023; Sesariza, 2020). This study aims to analyze the influence of organizational culture on employee job satisfaction in multinational companies. Research Design This study uses a quantitative design with a correlational survey approach. In the organizational culture profile, the teamwork aspect scored the highest, with an average score of 4.5, indicating that teamwork and collaboration are very important in the organization. The level of employee performance shows that Job Quality received the highest average score (4.3), indicating that employees produce high-quality work. From the results of the analysis, it can be seen that the leadership aspect has the strongest influence with a regression coefficient of 0.40 and a significant value of p = 0.0000. Based on data analysis, the influence of organizational culture on employee job satisfaction in the context of this multinational company is very relevant to various theories of motivation, leadership, and management

Exploring the nexus of organisational culture and sustainability for green innovation

ABSTRACT Organisations have embraced green innovation, but the desired environmental impacts remain unrealised. We approach this problem by focusing on how a driver of green innovation, sustainability, relates to organisational culture. Prior research suggests that understanding culture is fundamental to managing sustainability, but empirical research relating the two concepts is lacking. Global Reporting Initiative documents and annual reports to shareholders from 197 organisations were examined via content analysis to measure their sustainability strength with the Stages of Sustainability model and to quantify their organisational culture profiles on the Competing Value Framework. Expectedly, organisations oriented towards Hierarchy, and Market typologies were purveyors of weak sustainability. Unexpectedly, Clan organisations were found to reduce weak sustainability while Adhocracy types had no significant effect on sustainability strength. These findings result in implications for shifting organisational culture for strong sustainability. This knowledge can be leveraged in future research to cultivate impactful green innovation.

Moderation of OM practice effectiveness by organizational culture profile: contingency vs paradox perspective

PurposeThis paper investigates how a firm’s organizational culture profile (configuration of organizational culture types) influences the effectiveness of operations management (OM) practices in improving their targeted outcomes.Design/methodology/approachWe developed alternative hypotheses based on contingency and paradox perspectives to predict the effectiveness of OM practices in dominant (one prevalent organizational culture type) vs eclectic (opposing organizational culture types at a similar level) organizational culture profiles. They were tested using data from over 7,000 respondents across 330 manufacturing plants in 15 countries.FindingsConsistent with contingency theory, OM practices oriented toward innovation are more efficacious in plants with an adhocracy-dominant organizational culture profile and practices targeting supply chain (SC) control are less effective in a clan-dominant organizational culture profile. Consistent with paradox theory, OM practices oriented toward efficiency or SC control are more effective in plants with an eclectic organizational culture profile.Practical implicationsThis study offers relevant practical implications regarding the effectiveness of various OM practices, whether they are used in an aligned dominant organizational culture profile or in an eclectic organizational culture profile.Originality/valuePrevious research on organizational culture provides a limited understanding of the effectiveness of OM practices in the presence of strategic tensions, such as opposing organizational cultures or opposing targeted outcomes. This research concludes that the validity of the contingency or paradox perspective depends on strategic tensions faced, with important implications for research and practice.