Aim To study the Visualization design and development of African Material culture heritage in northern Anhui from the perspective of new media. Methods From the perspective of cultural protection and inheritance and innovation, the relationship between Intangible cultural heritage and Visualization design in northern Anhui was analyzed. Combined with the practice of Visualization design of Sizhou Opera, the ways of Visualization design and the development of Intangible cultural heritage of Sizhou Opera were discussed, trying to build an effective bridge of modern visual expression between cultural protection and inheritance and innovation. Conclusion The Visualization expression of Sizhou Opera's Intangible cultural heritage is an inevitable choice to solve its survival problems, and is also an effective means to promote its development. Visualization design and development can be carried out through three ways: symbolic image, cultural and creative products, and interactive interface. This has important theoretical and practical significance for inheriting Sizhou Opera's intangible cultural heritage, demonstrating excellent cultural and construction achievements, and enhancing local cultural self-confidence. At the same time, only through such creative transformation can the contemporary value of Sizhou Opera's intangible cultural heritage be realized.