Complementary and alternative medicine involves medical practices rooted in traditional methods such as herbal remedies and spiritual beliefs. Historical factors influence the practice of alternative medicine in Nigeria. This study examines cultural perceptions, practices, challenges, and integration strategies for alternative medicine in the Nigerian healthcare system. Nigeria, with a population of over 200 million, faces significant health challenges, necessitating robust healthcare systems. Despite having over 80,000 registered doctors, there is a low doctor-to-population ratio of 4,000 to 5,000 people per doctor. Traditional healers practicing under partial regulation significantly contribute to healthcare delivery by using indigenous herbal and spiritual therapies. Challenges in integrating alternative medicine include standardization, limited scientific evidence, stigma, funding constraints, and barriers to access of services . Integration efforts involve creating inclusive healthcare systems that combine traditional and modern approaches, prioritize equitable access, and respect for cultural diversity, developing standardized training, generating scientific evidence, and increasing public awareness. Collaboration among stakeholders, such as healers, healthcare providers, policymakers, researchers, and communities, is essential for successful integration and improved healthcare outcomes. The Nigerian healthcare system can benefit from integrating alternative medicine and promoting holistic and culturally sensitive practices. Overcoming these challenges requires cooperation, evidence-based strategies, and investments in research, leading to more effective healthcare delivery, improved health outcomes, and reduced disparities nationwide. Countries on integration journeys should prioritize collaboration, establish clear regulations, raise public awareness, and invest in research to support the effectiveness and safety of alternative medicine.