Analytical Cross-sectional Study Research Articles

HUBUNGAN ASUPAN MAKAN, DURASI TIDUR DAN AKTIVITAS FISIK DENGAN STATUS GIZI KARYAWAN TOKO RITEL KOTA BATAM TAHUN 2023

Background: Nutritional status remains a global issue, including in Indonesia. Nutritional status is influenced by several factors, namely food intake, sleep duration, and unbalanced physical activity, which can lead to either excessive or insufficient nutritional status. This study aims to investigate the relationship between dietary intake, sleep duration, and physical activity with the nutritional status of retail store employees in Batam City in 2023. Methods: This research is a cross-sectional analytical study with accidental sampling technique involving 60 samples. Food intake is measured using a semi-qualitative Food Frequency Questionnaire (FFQ), sleep duration is measured using a questionnaire on average weekly sleep duration, physical activity is measured using the Global Physical Activity Questionnaire (GPAQ), and nutritional status is measured using the Body Mass Index (BMI) by measuring weight and height. Data analysis using correlation gamma test. Results: The correlation gamma test results indicate a significant relationship between food intake and nutritional status with a p-value of 0.000 (p ≤ 0.05)(r=0,919). However, the relationship between sleep duration and nutritional status resulted in a p-value of 0.137 (p > 0.05)(r = -0,284), and the relationship between physical activity and nutritional status resulted in a p-value of 0.758 (p>0.05)(r = -0,067). Conclusion: There is a significant relationship between food intake and the nutritional status of retail store employees in Batam City in 2023. However, there is no significant relationship between sleep duration, physical activity, and the nutritional status of retail store employees in Batam City in 2023. Keywords: Nutritional Status, Food Intake, Sleep Duration, Physical Activity

Is double-J stent mandatory in complete supine percutaneous nephrolithotomy for adult patients with staghorn renal stones?

It is controversial whether double-J (DJ) stent insertion is necessary in tubeless percutaneous nephrolithotomy (PCNL) for patients with staghorn stones. We compared the outcomes of using ureteral catheters and double-J stents in tubeless complete supine PCNL (csPCNL) of staghorn stones. In this analytical cross-sectional study, from May 2008 to August 2022, 123 patients who underwent tubeless csPCNL were assessed. Patients were divided into two groups by either tubeless csPCNL with DJ stent (Group I; n = 23) or totally tubeless just with perioperative ureteral stent (Group II; n = 100). Demographic characteristics, stone-related factors, perioperative and postoperative parameters were compared in groups. Baseline characteristics were comparable in groups. The operative time in group I was significantly longer than group II (68.26 vs. 55.25min, P = 0.05). However, the duration of hospitalization in Group I was shorter than the other group (1.81 vs. 2.37 days, P = 0.03). Stone free rate was notably higher in Group I (90.5% vs. 79.8.0%) with no statistically significant difference. No significant differences were found in major complications. Patients in Group II had a significantly shorter time to return to normal life (6.48 vs. 7.91day; P = 0.043). Multivariable linear regression showed the preoperative creatinine level and stone size can affect the operative time (P = 0.02). In addition, stone number and underlying disease can affect the length of hospital stay (P = 0.007 & 0.030, respectively). Although not inserting a double J stent after csPCNL has acceptable results, because of higher residual rate in staghorn stone which cause more incidence of renal colic, longer time of hospital stay and return to normal life, inserting DJ stent is recommended.

HUBUNGAN ANTARA DERAJAT HIPERTENSI DENGAN KUALITAS TIDUR PADA PASIEN HIPERTENSI DI RUMAH SAKIT PMI KOTA BOGOR

Background: According to the Ministry of Health (2021), Hypertension or high blood pressure is characterized by an increase in systolic blood pressure exceeding 140 mmHg and diastolic blood pressure exceeding 90 mmHg in two measurements taken five minutes apart in a sufficiently rested/quiet state. Poor sleep quality occurs due to increased cortisol hormone, caused by the activation of the sympathetic nervous system, which enhances vasoconstrictor effects (epinephrine and norepinephrine) that influence the increase in blood pressure. Individuals with good sleep quality tend to experience a better quality of life. This study aims to determine the relationship between the degree of hypertension and sleep quality in hypertensive patients at PMI Hospital Bogor City in 2023. Method: This is a quantitative study with a cross-sectional analytical study design. The sampling technique used in this study is non-probability sampling with a sample size of 82 individuals using accidental sampling. Sleep quality was measured using the PSQI questionnaire. Data analysis employed univariate and bivariate analyses with the chi-square statistical test. Results: The Chi-square test analysis for the relationship between the degree of hypertension and sleep quality in hypertensive patients yielded a p-value of 0.115 (p > 0.05). Conclusion: Based on the results of this research, it is concluded that there is no significant relationship between the degree of hypertension and sleep quality in hypertensive patients at PMI Hospital Bogor City in 2023. Keywords: Hypertension Severity; Sleep Quality; PSQI

Factors associated with the perception of university social responsibility among dental students from two universities in the Peruvian capital: a multivariable regression analysis

Students play a key role in university social responsibility (USR), as they are the protagonists of change and the fundamental axis in the teaching-learning process. This study aims to assess the factors associated with the perception of university social responsibility among dental students from two universities in the Peruvian capital. This analytical cross-sectional study assessed 754 students from two Peruvian universities between May and July 2023. The study utilized a validated 51-item questionnaire to assess sociodemographic factors and dental students’ perception of USR. A Poisson regression model with robust variance and prevalence ratio (PR) was used to assess the influence of variables such as age, sex, marital status, type of university, academic year, and awareness of taking subjects related to USR. The significance was set at p < 0.05. The perception of USR was rated as poor, fair, and good by 16%, 67%, and 17% of the participants, respectively. According to the study, dental students from public universities were 68% more likely to perceive their USR education as poor than those from private universities (APR = 1.68, 95% CI: 1.06–2.66), and those who were aware of taking MSR-related courses were 37% less likely to perceive their USR education as poor (APR = 0.63, 95% CI: 0.40–0.98). Similarly, dental students attending public universities were 2.28 times more likely to perceive poor organizational management in USR compared to their counterparts at private universities (APR = 2.28, 95% CI: 1.51–3.44). Additionally, students in their first and second academic years were 62% and 57% less likely to perceive poor organizational management in USR compared to those in their sixth year (APR = 0.38, 95% CI: 0.19–0.79 and APR = 0.43, 95% CI: 0.20–0.95; respectively). Furthermore, students from public universities were 2.31 times more likely to perceive social participation in USR poorly compared to their counterparts from private universities (APR = 2.31, 95% CI: 1.63–3.26). Lastly, it was observed that students from public universities were 2.51 times more likely to have a poor overall perception of USR compared to students from private universities (APR = 2.51, 95% CI: 1.67–3.78). Acknowledging the diverse contexts and challenges inherent in public and private institutions, it can be concluded that more than half of the dental students had a fair perception of USR. Additionally, attending a public university was found to be a risk factor for having a poor perception of USR. However, taking a course related to USR and being in the early years of the program were identified as protective factors against a poor perception of organizational training and management in USR. It is recommended that students be involved in USR activities, including the Sustainable Development Goals, from the first years of their university education, especially in public universities.

8102 Hyperandrogenism and its Influence on Emotional and Social Development in Adolescent Daughters of Women with Polycystic Ovary Syndrome

Abstract Disclosure: J.P. del Rio: None. R. Gonzalo: None. M. Maliqueo: None. B. Echiburu: None. A. Ladron de Guevara: None. P. Gaspar: None. M. Alejandro: None. N.R. Crisosto: None. Introduction: Polycystic Ovarian Syndrome (PCOS) is the most prevalent endocrine disorder in adolescents. PCOS is characterized by hyperandrogenism, which can modulate brain maturation, especially in highly neuronal plasticity periods, such as intra-uterine life and adolescence. Daughters of women with PCOS (dPCOS) will probably be exposed to hyperandrogenism during these two periods. However, the effects of hyperandrogenism on psychosocial development have not yet been fully characterized. Objectives: To characterize the consequences of hyperandrogenism in the emotional status and social cognition (SC) on dPCOS. Methods/Design: Analytical cross-sectional study. dPCOS and controls between 12 to 25 years old were recruited. Participants underwent a complete clinical evaluation, serum hormone determinations (including total testosterone, SHBG, androstenedione, 17-OH-progesterone, and OGTT-I with 4 collections (0’-30’-90’-120´)) and ovarian ultrasound characterization. Emotional status and SC were estimated by measurements of affects (PANAS), strength and difficulties (SDQ), self-reported empathy (EQ/SQ and AQ), and gaze patterns measurement via Eye-Tracking (while completing an emotional recognition task). Results: 33 participants were recruited, 15 cases and 18 controls. Median age was 17 and 18 years, respectively. The dPCOS presented a larger anogenital distance (cm) (9.7 vs 7.8; p=0.014), Ferryman-Gallwey score mean (13.0 vs 2.0; p=&amp;lt;0.001) and free androgen index value (7.5 vs 4.1; p=0.004), suggesting hyperandrogenism exposure during intrauterine and adolescence periods. Regarding emotional status and SC, dPCOS exhibited a predominantly negative affective status (PANAS 8.0 vs 2.0, p=0.049) and a higher score in socio-emotional problems (SDQ 2,5 vs 1,5; p=0,047). The eye-tracking registration showed that dPCOS presented a longer time to first fixation in areas of interest (s) (0,35 vs 0,28; p=0,037), which was associated with a worse endpoint in emotional recognition (aR2=-0,920; f=19,48; Pr &amp;gt;|t|=&amp;lt;0,049). Furthermore, the 2D:4D ratio (intrauterine marker of androgen exposure) and insulin levels at 60’ were correlated with a predominance of negative affects (rho=0,51; p=0,019 and rho= -0,48; p=0,035), and 2D:4D ratio was also correlated with less prosocial behaviors (coef=-2,39; P&amp;gt;|t|=0,049). Conclusions: Clinical and hormonal markers suggest that dPCOS are exposed to hyperandrogenism during the most critical neuroplasticity periods. This exposure is associated with a predominance of negative affects, more social-emotional difficulties and worse performance on emotional recognition and prosocial behavior. Considering PCOS patient’s elevated psychiatric comorbidity, early mental health intervention becomes crucial, underscoring the necessity for in-depth study on hyperandrogenism's impacts on psychosocial development. Presentation: 6/3/2024

7796 The Profile And Associated Risk Factors Of Diabetic Foot Disease Among Patients With Type 2 Diabetes Mellitus Seen At Outpatient Clinics In A Tertiary Private Hospital In Quezon City, Philippines

Abstract Disclosure: D.C. Lopez: None. K.T. Lim: None. B.C. S.: None. O.C. Dampil: None. The Profile and Associated Risk Factors of Diabetic Foot Disease Among Patients with Type 2 Diabetes Mellitus Seen at Outpatient Clinics in a Tertiary Private Hospital in Manila, Philippines. Background: Diabetic foot disease is a debilitating complication of diabetes mellitus and is a major source of morbidity, mortality, and reduced quality of life. Determining the risk factors of diabetic foot ulcer is important to prevent the devastating consequences among patients with diabetes. This study aims to determine the profile and associated risk factors of diabetic foot disease among patients diagnosed with type 2 diabetes mellitus being seen in private specialty clinics. Methodology: A single center, analytical cross-sectional study was conducted among patients with type 2 diabetes mellitus at outpatient clinics in a tertiary private hospital in the Philippines. Clinical information and laboratory results were obtained during the time of consult; and patients were classified as either low risk, moderate risk, high risk for diabetic foot disease or in active foot disease. Interaction between various risk factors was explored by multivariate analysis. Results: A total of 129 adult patients with diabetes mellitus were evaluated using the Diabetes Foot Screening and Risk Stratification Tool from January to May 2021. The demographic and clinical profile of the study showed that proportion of patients with neuropathy (χ2=60.66, p=0.001), long duration of diabetes (F=5.92, p=0.004), and low estimated glomerular filtration rate (eGFR) (F=3.70, p=0.023) was significantly higher in patients with moderate to high risk for diabetic foot disease. Univariate polynomial logistic regression analyses showed that neuropathy greatly increased the odds of having moderate (OR=115.63, p=0.001) and high risk stratification (OR=166.50, p=0.001). Other factors were also noted to affect the risk stratification for diabetic foot disease such as duration of diabetes (OR=1.09, p=0.004) and hypertension (OR=2.45, p=0.027). On the other hand, normal eGFR (OR=–1.02, p=0.011), left normal ankle brachial pressure index (OR=–4.32, p=0.042), and good glycemic control (OR=–5.41, p=0.050) significantly decrease the likelihood of having high risk stratification for diabetic patients. Conclusion: Those most susceptible to developing high risk for diabetic foot disease were patients with neuropathy, hypertension, and long duration of diabetes. High-risk patients with the given profile should be followed closely in order to prevent complications brought by diabetes. Keywords:Diabetes mellitus, Diabetic foot disease, Foot ulcer Presentation: 6/3/2024

8102 Hyperandrogenism and its Influence on Emotional and Social Development in Adolescent Daughters of Women with Polycystic Ovary Syndrome

Abstract Disclosure: J.P. del Rio: None. R. Gonzalo: None. M. Maliqueo: None. B. Echiburu: None. A. Ladron de Guevara: None. P. Gaspar: None. M. Alejandro: None. N.R. Crisosto: None. Introduction: Polycystic Ovarian Syndrome (PCOS) is the most prevalent endocrine disorder in adolescents. PCOS is characterized by hyperandrogenism, which can modulate brain maturation, especially in highly neuronal plasticity periods, such as intra-uterine life and adolescence. Daughters of women with PCOS (dPCOS) will probably be exposed to hyperandrogenism during these two periods. However, the effects of hyperandrogenism on psychosocial development have not yet been fully characterized. Objectives: To characterize the consequences of hyperandrogenism in the emotional status and social cognition (SC) on dPCOS. Methods/Design: Analytical cross-sectional study. dPCOS and controls between 12 to 25 years old were recruited. Participants underwent a complete clinical evaluation, serum hormone determinations (including total testosterone, SHBG, androstenedione, 17-OH-progesterone, and OGTT-I with 4 collections (0’-30’-90’-120´)) and ovarian ultrasound characterization. Emotional status and SC were estimated by measurements of affects (PANAS), strength and difficulties (SDQ), self-reported empathy (EQ/SQ and AQ), and gaze patterns measurement via Eye-Tracking (while completing an emotional recognition task). Results: 33 participants were recruited, 15 cases and 18 controls. Median age was 17 and 18 years, respectively. The dPCOS presented a larger anogenital distance (cm) (9.7 vs 7.8; p=0.014), Ferryman-Gallwey score mean (13.0 vs 2.0; p=&amp;lt;0.001) and free androgen index value (7.5 vs 4.1; p=0.004), suggesting hyperandrogenism exposure during intrauterine and adolescence periods. Regarding emotional status and SC, dPCOS exhibited a predominantly negative affective status (PANAS 8.0 vs 2.0, p=0.049) and a higher score in socio-emotional problems (SDQ 2,5 vs 1,5; p=0,047). The eye-tracking registration showed that dPCOS presented a longer time to first fixation in areas of interest (s) (0,35 vs 0,28; p=0,037), which was associated with a worse endpoint in emotional recognition (aR2=-0,920; f=19,48; Pr &amp;gt;|t|=&amp;lt;0,049). Furthermore, the 2D:4D ratio (intrauterine marker of androgen exposure) and insulin levels at 60’ were correlated with a predominance of negative affects (rho=0,51; p=0,019 and rho= -0,48; p=0,035), and 2D:4D ratio was also correlated with less prosocial behaviors (coef=-2,39; P&amp;gt;|t|=0,049). Conclusions: Clinical and hormonal markers suggest that dPCOS are exposed to hyperandrogenism during the most critical neuroplasticity periods. This exposure is associated with a predominance of negative affects, more social-emotional difficulties and worse performance on emotional recognition and prosocial behavior. Considering PCOS patient’s elevated psychiatric comorbidity, early mental health intervention becomes crucial, underscoring the necessity for in-depth study on hyperandrogenism's impacts on psychosocial development. Presentation: 6/3/2024

Control and elimination of Schistosoma mansoni infection in adult individuals on Ukerewe island, northwestern Tanzania: baseline results before implementation of intervention measures

BackgroundCommunities living along the shoreline and on the islands of Lake Victoria in northwestern Tanzania remain endemic for schistosomiasis and suffer from the life-threatening morbidities associated with the disease. Nevertheless, the control measures particularly the mass drug administration do not cover the adult population. The current project on Ukerewe island aims to close this gap by involving adult community members in the control program. Here we report the baseline results of S. mansoni infection and associated hepatosplenic morbidities and factors before implementing the project activities.MethodsA cross-sectional analytical study was conducted with 4,043 participants aged ≥ 18 years living in 20 villages on Ukerewe island, northwestern Tanzania. Individual stool and urine samples were collected and examined using the Kato-Katz (KK) technique and point-of-care circulating cathodic antigen testing(POC-CCA) to identify S. mansoni eggs and antigens, respectively. All study participants underwent ultrasound evaluation of S. mansoni hepatosplenic morbidities using the Niamey protocol. Rapid diagnostic tests were used to diagnose HIV infection, hepatitis C and chronic hepatitis B. A questionnaire was used to collect demographic data and reported clinical symptoms of study participants.ResultsA total of 4,043 participants took part in the study, of which 49.7% (n = 2,009) and 50.3% (n = 2,035) were male and female, respectively. The overall prevalence of S. mansoni infection was 30.4% (95%CI:29.0-31.9%) and 84.7% (95%CI:83.3–85.9%), respectively, based on the KK technique and the POC-CCA test. The geometrical mean eggs per gram of faeces (GMepg) was 105.3 (95%CI:98.7-112.3% GMepg) with 53.9%, 32.4% and 13.7% of the participants having mild, had moderate and severe intensity of infection. The prevalence of hepatitis C, HIV, and hepatitis B was 0.4%, 2.2% and 4.7%, with 0.2%, 2.2% and 5.4% of the infected individuals coexisting with S. mansoni infection. The prevalence of splenomegaly, periportal fibrosis, hepatomegaly, and portal vein dilatation was 40.5%(95%CI: 38.8–42.1%), 48.1%(95%CI:64.4–49.7%), 66.2%(95%CI:4.6–67.7%) and 67.7%(95%CI:66.2–69.2%), with their prevalence varying depending on the demographic information and infection status of the participants. Other detectable ultrasound-related morbidities included ascites (1.7%), collateral veins (18.3%) and gall bladder wall thickness (40.4%). Age groups, gender, reported clinical characteristics, reported non-use of the drug praziquantel, liver imaging pattern, and place of residence remained independently associated with hepatosplenic morbidities.ConclusionThe current study setting is endemic for S. mansoni infection and the population has a high prevalence of the disease associated hepatosplenic morbidities characterized by hepatomegaly, splenomegaly, ascites, gall bladder wall thickening, periportal fibrosis and portal vein dilatation. Several demographic, clinical and epidemiological circumstances remained independently associated with S. mansoni infection and associated morbidities. These findings call for integrative intervention efforts, starting with whole community MDA that includes all out of schools community members.

Dietary pattern and menstrual disorders among female university students.

Assessment of the relationship between dietary patterns and menstrual disorders among female medical and paramedical students at Beni-Suef University, Egypt. Beni-Suef University conducted a cross-sectional analytical questionnaire-based study. Three hundred fifty two female medical and paramedical students agreed to participate in the study. The collected data about demographics, physical activity, menstrual history, and dietary assessment were transferred to SPSS version 26 for statistical analysis. A p value≤0.05 was considered statistically significant. The prevalence of irregular cycles, heavy blood flow, severe dysmenorrhea, and premenstrual syndrome (PMS) was found to be (21.9 %), (13.1 %), (35.5 %), and (68.9 %), respectively. Poor adherence to the Mediterranean diet (40.1 %) and physical activity (69.9 %) was present. Females with irregular cycles (p=0.472), heavy menstrual blood flow (p=0.007), and severe dysmenorrhea (p=0.029) reported lower adherence to the Mediterranean diet. Mothers' educational level (p=0.034), family income (p=0.005), and family size (p=0.009) were significantly associated with dietary adherence. Poor adherence to regular physical activity and the Mediterranean diet is highly prevalent in our research and is highly associated with menstruation disorders. So, it is critical to support health education programs emphasizing healthy dietary habits and regular physical activity to improve menstrual health and women's quality of life.

Prevalence of unplanned extubation in a tertiary care neonatal intensive care unit.

Orotracheal intubation and mechanical ventilation (MV) have become routine practices in intensive care units. Unplanned extubation (UE) is one of the most important complications, particularly in premature infants and critically ill newborns. The objective of this study was to determine the prevalence of UE in a tertiary care neonatal intensive care unit (NICU). In this analytical cross-sectional retrospective study, all data, including perinatal data, indications for ventilatory support, days of MV at the time of UE, work shift, month of the event, reintubation, and postextubation complications, were obtained from the manual review of clinical charts. In total, 151 neonates, who received invasive MV, were included in this study. The prevalence of UE was 2.0/100 days of ventilation. The most affected were premature infants, with a gestational age of ≤ 32 weeks (54.7%) and a birth weight of ≤ 1500 g. The main cause for UE was deficient fixation of the endotracheal tube (ETT) (27.7%). Most UE events occurred during night shifts (48.1%). Reintubation was required in 83.3% of newborns. Immediate complications developed in 96.3% of the UE events, including desaturation (57.7%) and bradycardia (36.5%). The prevalence of UE was high, particularly in premature infants, with a high rate of reintubation and immediate complications. Standardized protocols for ETT care must be implemented to reduce these events.

Gender dynamics in nursing profession: impact on professional practice and development in Tanzania

BackgroundGender disparity has long been noted in nursing, a predominantly female-dominated profession. However, recently the increase in the number of male nurses disproves the existing belief that nursing is exclusively a female profession. Even though the studies have reported changing gender trends in nursing, the information is not sufficient and the effects of the changing trend on professional practice and professional development have not been explored. Therefore this study aims to assess the influence of gender in nursing on professional practice and development in Tanzania.MethodsThis was an analytical Hospital-Based Cross-sectional Study Design, conducted at four hospitals in Dar es Salaam, with 580 nurses between 20th May and 20th June 2024. Proportionate sampling was used to determine the required number of participants from each of the four facilities. Moreover, systematic random sampling was used to recruit participants from each facility. The validated questionnaire was used to obtain data, which were analyzed through descriptive and inferential statistics.ResultsAmong seventy items that measured professional practices, sixty three items indicated good professional practices among female nurses compared with their male counterparts male. On the association of gender in nursing to professional practice and development, the findings revealed no significant association between gender in nursing and professional practice (χ2 = 1.384; P = 0.239). Moreover, the item analysis revealed that male nurses have professional development in three items similar to female nurse who had shown professional development on other three items. Through binary logistic regression, male nurses were 0.528 (OR) times less likely to have good professional development than their female counterpart (P < 0.001; 95% CI: 0.379, 0.737). Several social demographic factors were found to be associated with professional practice and development.ConclusionIt was found that professional practice does not depend on gender in nursing, because the practice was optimal across both genders. Nurse’s self-image of nursing, facility factors, and professional development influence their professional practice. Moreover, gender in nursing is associated with professional development, indicating the existence of gender stereotypes in the distribution of opportunities between male and female nurses. The study recommends extending this cross-sectional study to nonclinical settings such as training institutions.

Investigating Vitamin D Status: A Key Factor in Gestational Diabetes among Pregnant Women

Background: Vitamin D deficiency within the general population suggests the emergence of glucose intolerance. The relationship between insufficient vitamin D levels and gestational diabetes mellitus remains a subject of ongoing discussion. Objectives: The investigation looked into the connection between vitamin D levels and the chances of developing gestational diabetes mellitus. Methodology: This cross-sectional analytic study includes 262 pregnant women who attended the Gestational Diabetes Center and Antenatal Counseling Center at the Maternity Teaching Hospital in Sulaimani City. The study used convenience sampling, and the data was collected from November 1st, 2021, to October 1st, 2022. The study used a specific questionnaire divided into four sections: demographics, medical, and obstetric. Simultaneously, the Roche Elecsys vitamin D3 assay determined serum vitamin D status. Results: Women with gestational diabetes mellitus had a significantly higher prevalence of vitamin D inadequate levels (p =0.000), Significant variance in residency (p =0.000), education (p =0.000), body mass index (p =0.038), age at marriage (p =0.023), history of using the contraceptive pill (p-value =0.000), parity (p =0.001), and gravidity (p =0.014) were additionally identified between the two groups of gestational diabetes mellitus and non-gestational diabetes mellitus. Conclusion: Women with gestational diabetes mellitus had higher rates of vitamin D deficiency than those without, but the differences were not statistically significant.

Factors influencing adherence to antiretroviral treatment among people living with HIV aged 15 – 60 years at Cité des Palmiers District Hospital, Cameroon

Antiretroviral therapy (ART), essential for halting the progression of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) infection and restoring immunity, should be taken regularly to be effective. This study aimed to assess the factors that may affect adherence to ART among people living with HIV (PLHIV) aged between 15 and 60 years at the Cit&amp;eacute; des Palmiers District Hospital. Thus, we conducted a descriptive and analytical cross-sectional study using a non-probabilistic, convenience survey. Data were collected using a questionnaire administered to PLHIV aged between 15 and 65 years (n = 309). These factors affecting adherence were established by determining relative and absolute frequencies, and associations were estimated by calculating the odds ratios, confidence intervals, and P-values. Subsequently, 48.5% of participants were found to comply with ART and 51.5% were not. The independent predictors of poor adherence to ART were missed appointments at the HIV unit, occasional use of excitants/cigarettes, fear of disclosing HIV status, perceived limited opening hours of HIV-related services, discomfort with medication, recent initiation of treatment, and use of therapy reminders. Our study results are essential to orient public health policies and measures toward PLHIV non-adherents to ART treatment and mitigate the social, economic, and health impact of HIV threats on developing countries by focusing on good adherence.

Assessment of screen time and its correlates among adolescents in selected rural areas of Puducherry.

To assess screen time and its correlates among adolescents in selected rural areas of Puducherry. This cross-sectional analytical study was conducted among adolescents aged 10-19 years visiting the Pediatrics and other departments at Sri Lakshmi Narayana Institute of Medical Sciences (SLIMS), Puducherry. The sample size of 164 was determined based on previous studies, with a systematic random sampling technique used for participant selection. Data collection involved a semi-structured questionnaire covering sociodemographic factors, screen time, sleep, dietary, and physical activity patterns. Increased screen time was defined as more than 2 h per day, and adequate physical activity was considered as at least 60 min of moderate-to-vigorous intensity exercises. Statistical analysis was performed using Stata version 17, with associations tested using Chi-square analysis and a significance level set at p<0.05. The mean age of the participants was 18.2 (0.9) years, with 86 % in the 16-19 years age group. Males comprised 53.7 %, and 66.5 % were from rural areas. The mean screen time was 4.4 (1.5) hours per day, with 79.1 % exceeding the recommended limit. Mobile phones were the most frequently used devices (92.7 %), primarily for watching movies (51.8 %) and videos (23.8 %). Increased screen time was significantly associated with younger age (10-15 years), urban residence, and school-going status. Adolescents with increased screen time exhibited lower physical activity and inadequate sleep. Additionally, increased consumption of packaged foods was observed among those with higher screen time. More than three-fourths of the adolescents exceeded the recommended screen time, negatively impacting their physical activity and sleep. These findings underscore the need for targeted interventions to promote healthier lifestyle choices among adolescents in rural Puducherry.

Knowledge, attitudes and support practices related to breastfeeding promotion of doctors and nurses in Motheo district, Free State province, South Africa

Background: Breastfeeding is widely acknowledged as the optimal method of infant feeding. However, the percentage of South African mothers who exclusively breastfeed remains alarmingly low. Healthcare workers (HCWs) are pivotal in promoting breastfeeding; however, a deficiency in their knowledge, negative attitudes, and unfavourable practices can impede the promotion and support of breastfeeding. Aim: To assess the knowledge, attitudes, and support practices related to breastfeeding promotion of HCWs in the Motheo district, Free State province, compared with the 2016 WHO Guideline updates on HIV and infant feeding and 2018 Mother-Baby Friendly initiative guidelines. Methods: A quantitative analytical cross-sectional study involving paediatricians, obstetricians, general practitioners (GPs), and midwives was conducted using a self-administered questionnaire. Results: Over half of the HCWs (59%) were able to define exclusive breastfeeding (EBF), with a significant majority of GPs (76.1%) and midwives (78.6%) recommending EBF up to six months, compared with only 10% of paediatricians and 25% of obstetricians (p < 0.001). Some 11.1% of the total group of HCWs reported that breastfeeding is contraindicated for HIV-infected mothers, while 15.4% were unsure of the recommendation for breastfeeding among HIV-infected mothers. A higher proportion of midwives, compared with other HCWs, felt highly confident in providing breastfeeding advice (p < 0.001). Additionally, more than half (56%) of HCWs had not completed the 20-hour WHO Lactation Management Training, and 55% believed their prior breastfeeding training was not sufficient to support and educate breastfeeding mothers. Conclusion: Regular breastfeeding training of HCWs on the latest breastfeeding guidelines is necessary to equip HCWs with the knowledge and competence to successfully promote, protect, and support breastfeeding.

Caregivers’ perceptions of feeding practices and diet diversity among children aged 12–59 months in a rural district of South India: an analytical cross-sectional study

ObjectiveThe primary objective of this study was to assess caregivers’ perceptions of feeding practices (breastfeeding and complementary feeding) and diet diversity among children aged 12–59 months in a rural district...

Correlation of nutritional status with transplantation outcomes in adult patients who underwent hematopoietic stem cell transplantation: A cross-sectional analytical study

Correlation of nutritional status with transplantation outcomes in adult patients who underwent hematopoietic stem cell transplantation: A cross-sectional analytical study

Serum MicroRNA-126-3p and Serum Vascular Endothelial Growth Factor for Vision Threatening Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients

Purpose: To investigate the precise function of miRNA-126-3p in controlling the expression of the VEGF gene and the signalling cascade that it is linked to in patients with type 2 diabetes Mellitus (DM). Study Design: Cross-sectional analytical study. Place and Duration of Study: Prof Ngoerah General Hospital as a tertiary hospital in Bali, Indonesia from January-April 2022 Methods: This study involved 35 vision-threatening diabetic retinopathy (VTDR) and 30 non-VTDR patients of type 2 DM. After diagnosis of DR by vitreoretinal specialist, blood samples were drawn. Real-time polymerase chain reaction assays were performed to examine miRNA-126-3p and ELISA to detect VEGF. Continuous data were analyzed using median (minimum-maximum range) and categorical data were analyzed using percentages. The statistical analysis was conducted using SPSS for Windows version 25.0.Thedifference and relationship between the proportions were tested by the Chi-square test and logistic regression test. Results: In case group, there were 23 subjects (65.7%) with low serum miRNA-126-3p expression, while in the control group, there were 7 subjects (23.3%) with low serum miRNA-126-3p expression (OR=6.3; 95% CI 2.1-18.86). In the case group, 20 individuals (57.1%) had high serum VEGF levels of 71.6 ng/L, whereas in the control group, there were 6 individuals (20.0%) with high serum VEGF levels. There was a statistically significant difference between the two groups (OR=5.33; 95% CI 1.75-16.3). Conclusion: The miRNA-126-3p expression and serum VEGF levels are the risk factors for VTDR development in patients with type 2 diabetes.

Association between medication adherence and health-related quality of life among type 2 diabetic adults in Mexico

ABSTRACT Purpose: Previous evidence suggests that non-adherence to medication among patients with chronic diseases might negatively affect their health-related quality of life (HRQoL); however, the evidence in adults with type 2 diabetes (T2D) is not conclusive, and information is scarce in the Mexican context. Therefore, this study aimed to evaluate the association between medication adherence and HRQoL among Mexican adults with T2D. Methods: A cross-sectional analytical study was conducted on a sample of 320 adults with T2D. Participants were recruited from two community health centers in Hidalgo, Mexico. The four-item Morisky Green Levine Medication Adherence Scale and the Short Form 36 Health Survey Questionnaire (SF-36) were used to assess medication adherence and HRQoL, respectively. The associations between the variables of interest were evaluated using logistic regression models. Results: It was found that 78.4% of the participants were non-adherent to medication. After adjusting for confounders, we observed that non-adherent adults were more likely to have poor HRQoL in six domains of SF-36: physical functioning (adjusted odds ratio [ORa] =2.02; 95% confidence interval [95% CI] =1.06, 3.80); physical role (ORa = 2.37; 95% CI = 1.13, 4.96); bodily pain (ORa = 2.71; 95% CI = 1.45, 5.06); general health (ORa = 2.57; 95% CI = 1.37, 4.80); vitality (ORa = 3.30; 95% CI = 1.70, 6.39); social functioning (ORa = 2.97; 95% CI = 1.56, 5.65); and mental health (ORa = 2.66; 95% CI = 1.42, 4.98). Conclusion: Non-adherence to medication was independently associated with HRQoL in Mexican adults with T2D. Therefore, it is necessary to plan awareness interventions to encourage adherence to therapeutic recommendations during routine clinical consultations in primary care.

Depression and its Association with Insomnia among Geriatric Population of Selected Slums of Bankura Municipality, West Bengal

Background: While depression is a major health concern among older people, sleep disorders are also very common among them and often persist simultaneously. The study was conducted to assess the prevalence of depression and insomnia, and any correlation of association between them, in the geriatric people living in study area. Methodology: A cross-sectional analytical study was conducted among 186 older people living in three selected slums of Bankura Municipality, West Bengal, India. A pre-tested, structured interviewer-administered-questionnaire including Geriatric Depression Scale-Short form and Insomnia Severity Index were used for data collection. Results: The prevalence of geriatric depression and insomnia in the study setting were 54.3% and 37.6% respectively. While illiteracy, complete financial dependency and taking sedative were associated with geriatric depression, history of smoking was associated with insomnia among participants. Geriatric depression was significantly associated with insomnia. There was statistically significant positive correlation between GDS-S score and ISI score. Conclusions: A significant proportion of elderly population suffers from depressive disorders and sleep disorders. Early detection and management of these conditions will provide the society with healthy ‘senior citizens.