Safety Criteria Research Articles

Ryegrass uptake behavior and forage risk assessment after exposing to soil with combined polycyclic aromatic hydrocarbons and cadmium

Internalization of chemicals and the forage risks of ryegrass under the combined exposure to PAHs and Cd at environmental concentrations were studied here. The effect of soil pH was also concerned due to the widely occurred soil acidification and general alkali remediation for acidification soil. Unexpectedly, as same as the acid-treated group (pH 6.77), the alkali-treatment (pH 8.83) increased Cd uptake compared with original soil pH group (pH 7.92) for the reason of CdOH+ and CdHCO3+ formed in alkali-treated group. Co-exposure to PAHs induced more oxidative stress than Cd exposure alone due to PAHs aggregated in young root regions, such as root tips, and consequently, affecting the expression of Cd-transporters, destroying the basic structure of plant cells, inhibiting the energy supply for the transporters, even triggering programmed cell death, and finally resulting in decreased Cd uptake. Even under environmental concentrations, combined exposure caused potential risks derived from both PAHs and Cd. Especially, ryegrass grown in alkali-treated soil experienced an increased forage risks despite the soil meeting the national standards for Cd at safe levels. These comprehensive results reveal the mechanism of PAHs inhibiting Cd uptake, improve the understanding of bioavailability of Cd based on different forms, provide a theoretical basis to formulate the safety criteria, and guide the application of actual soil management.

An Approach of Multi Criteria Decision Making in Analyzing Rural Road Safety in Nashik District

Abstract: Rural road safety evaluations play a significant role in the transportation industry, and most fatal accidents happen on these types of roads. Road Safety Analysis (RSA), a process to evaluate a road's safety criteria and support overall road management decision-making, ensures the avoidance of loss of life and property damage. The "Pradhan Mantri Gram Sadak Yojana," which is primarily utilized in rural areas, is the main emphasis of this. In order to identify the most vulnerable roadways and implement mitigation measures, roads must be prioritized depending on safety ratings. This document presents the results of a study conducted to rank the safety criteria of Pradhan Mantri Gram Sadak Yojana (PMGSY) roads, a particular category of rural roads. A questionnaire survey was used for the study's analysis, and three MCDM methods were used to examine the relationships and interactions between the various factors. The study's findings indicated that the based on input from PMGSY engineers and contractors. From the perspective of the engineers in the Nashik area, we can determine the safety impact factor that influences the safety assessment of the PMGSY route.

The Impact of Food Safety Criteria on Fruit and Vegetable Exports from Türkiye to The European Union

Food safety has become an increasingly important issue as people become more concerned about access to healthy food. Particularly in affluent societies such as the European Union, the increasing consumption of unhealthy fruits and vegetables and carcinogenic residues are constantly on the agenda. Reducing aflatoxin levels in dried foods to below health risk levels, eliminating them from food and ensuring access to healthy food are essential for food safety and human health. In this study, the impact of food safety practices in fruit and vegetable trade between the European Union and Türkiye was examined using mandarins, one of Türkiye’s main fresh fruit and vegetable exports, and the European Union Rapid Alert System for Food and Feed (RASFF) notifications for food and feed for the period between 2019 and 2022. The reasons for these notifications and the requests made in this context were examined and a TOWS analysis matrix was created based on the findings obtained. In conclusion, residue and aflatoxin inspections should be included in traceability activities in Türkiye. Producers need to be informed to ensure the effectiveness of inspections. It is crucial to provide adequate support to producers to improve storage conditions for perishable and dry products and to encourage the use of the latest production techniques. It is of great importance to raise awareness of these techniques among producers. Thus, the European Union can be an alternative market to the Russian Federation, which is Türkiye’s largest trading partner.

The safety and use of perioperative dexamethasone in the perioperative management of primary sporadic supratentorial meningiomas.

Despite the lack of prospective evidence for the perioperative use of dexamethasone in meningioma surgery, its use is well established in the daily routine of several centers. The present study evaluates the effect of dexamethasone on postoperative complications, peritumoral T2/FLAIR hyperintensity, and progression-free survival in patients with supratentorial meningiomas undergoing resection. A total of 148 patients who underwent resection of a primary sporadic supratentorial meningioma at the authors' institution between 2018 and 2020 were included in this retrospective cohort. Safety criteria were side effects of dexamethasone (e.g. hyperglycemia), surgical morbidities, length of stay, and mortality. The individual Karnofsky Performance Scales (KPS) were evaluated regarding the individual development and the delta of KPS at 3- and 12-months compared to baseline KPS was calculated. Longitudinal assessment of the peritumoral T2-/FLAIR hyperintensity changes was performed. The use of both pre- and postoperative dexamethasone did not influence the incidence rates of wound infections, infarctions, postoperative seizures, pulmonary embolism, postoperative hemorrhage, mortality, length of stay, new-onset hyperglycemia and new neurological deficits. Perioperative Dexamethasone use was associated with an improved Karnofsky performance development at 3- (delta of KPS 3.3 vs. -1.9, p=0.001) and 12-months (delta of KPS 3.8 vs. -1.1, p=0.008) compared to the preoperative Karnofsky performance status. Multivariable analysis revealed that perioperative dexamethasone use enhances the KPS improvement (OR: 3.65, 95% CI: 1.01-13.18, p=0.048). Persistent peritumoral T2/FLAIR hyperintensity changes were observed in 35 cases of 70 patients with available follow-up images and a baseline edema (50.0%). Perioperative dexamethasone use enhanced the reduction of the preoperative peritumoral T2-/FLAIR hyperintensity changes (mean reduction of maximum diameter: 1.8 cm vs. 1.1 cm, p=0.023). Perioperative dexamethasone use was independently associated with a lower risk for persistent peritumoral T2-/FLAIR hyperintensity changes (OR: 3.77, 95% CI: 1.05-13.54, p=0.042) The perioperative use of dexamethasone did not influence the progression-free survival time in Simpson grade I or II resected WHO grade 1 meningiomas (log-rank test: p=0.27). Perioperative dexamethasone use seems to be safe in surgery for primary supratentorial meningiomas. Dexamethasone use might enhance the functionality by reducing postoperative peritumoral T2-/FLAIR hyperintensities. These findings highlight the need for prospective data.

Phase 1 study of safety and tolerability of an oral contraceptive containing low-dose ethinyl oestradiol combined with glecaprevir/pibrentasvir treatment in healthy premenopausal women.

Glecaprevir/pibrentasvir (GLE/PIB) is an approved guideline-recommended chronic hepatitis C virus infection treatment. GLE/PIB coadministration with ethinyl oestradiol (EE) is not recommended in current labels owing to a Phase 1 study observing Grade ≥2 alanine aminotransferase (ALT) elevation in 2 out of 12 healthy women cotreated for 11 days with GLE/PIB and oral contraceptive (OC) containing 35 μg/250 μg EE/norgestimate. No Grade ≥2 elevation was observed with low-dose (20 μg) EE (n = 14). This Phase 1 study examined safety/tolerability of GLE/PIB coadministered with an OC containing low-dose EE using a larger sample size and longer treatment duration. Healthy premenopausal women were treated with EE/levonorgestrel alone (20/100 μg, Cycles 1-2), followed by coadministration with GLE/PIB (300/120 mg; Cycles 3-4). A safety criterion of special interest was a confirmed Grade ≥2 ALT elevation (>3× upper normal limit). Adverse events (AEs) and study drugs concentrations were examined. Of 85 enrolled women, 72 initiated combined GLE/PIB + EE/levonorgestrel treatment, 66 completed the study and 19 discontinued prematurely (non-safety reason, n = 16; AE [deemed unelated to GLE/PIB], n = 3). No participant met the safety criterion of special interest of confirmed Grade ≥2 ALT elevation. No serious/Grade ≥3 AEs were reported. Study drug concentrations were within the expected ranges. GLE/PIB in combination with an OC containing low-dose EE was generally well tolerated with no confirmed Grade ≥2 ALT elevation and no evidence of drug-induced liver injury. No pattern to the reported AEs and no new safety issues were identified. This was a Phase 1 study of healthy volunteers, not a registered clinical trial.

Assessment of urban waterlogging-induced road traffic safety risk and identification of its driving factors: A case study of Beijing

Due to the increasing number of urban waterlogging events, systematic risk assessment and cause exploration are needed to ensure the safety of people's lives and property on roads. In this paper, the urban waterlogging-induced road traffic safety risk (UWRTSR) in the central part of Beijing was assessed and its driving factors were investigated. We obtained the simulation data of road inundation for five rainstorm return periods (5-year, 10-year, 20-year, 50-year and 100-year) through the InfoWorks ICM hydrodynamic model. Then, the safety risk levels of pedestrians and vehicles are evaluated with safety criteria formulas and standards, and the driving factors are identified by the Geodetector model. The results show that the proportion of the total length of road sections at different risk levels for pedestrians, stationary vehicles and moving vehicles increased with increasing rainstorm return period, while for the same road section, the risk level for pedestrians or vehicles may increase due to a higher intensity rainstorm event. The results of subsequent driving factor analysis show that slope, terrain ruggedness index (TRI) and LS factor were the top three single-factor explanatory powers, with the joint effect of slope and rain pipe capacity (RPC) possessing the largest explanatory power. It is found that a high level UWRTSR is to be generated in road sections with low drain network specifications and high slope gradients. Our research may help smooth emergency resource management, road network construction and reconstruction to mitigate the waterlogging risk.

The current status of zirconium alloys fuel cladding

Properties such as corrosion and radiation resistance of zirconium alloys fuel claddings for nuclear reactors and ways to improve them are considered. The need to ensure high radiation and corrosion resistance and reliability of fuel claddings for the safe operation of pressurized water reactors of NPPs under operating conditions is substantiated. The use of sponge zirconium as the base of the alloys provides safety criteria under LOCA conditions. Optimization of the Fe content in the Zr-1%Nb alloy leads to increased corrosion resistance in the coolant and resistance to radiation growth during irradiation.

Methodology for Selecting Optimal Routes for the Transportation of Dangerous Goods in Conditions of Risk Uncertainty

Abstract * A risk situation is a type of uncertainty situation where events are likely to occur. In other words, risk is an estimated probability, and uncertainty is something that cannot be quantified. The greater the uncertainty when making a decision, the greater the degree of risk. The investigation is devoted to the development of a unified methodology for selecting optimal (from the proposed alternatives) routes for transporting dangerous goods (any of the 9 standard classes) by road. A model for determining two groups of risk components for transporting dangerous goods on separate routes is proposed, namely: parameters of risks of probability of occurrence of emergency situations and parameters that affect the risks of complexity of eliminating their possible consequences. This opened up opportunities for correct selection of criteria when forming a multi-criteria optimization problem of transportation. Mathematical algorithms for a comprehensive solution of the multi-criteria optimization problem of routing dangerous goods transportation are developed using the classical criteria of Laplace, Wald, Savage, and Hurwitz. To confirm the legal capacity of the proposed approach and mathematical apparatus, the optimal route for transportation of cylinders with technical gases through the transport network of Lutsk was calculated. Possible alternative transportation routes have been identified and safety criteria have been formalized for two groups of risk components

Data-Based In-Cylinder Pressure Model with Cyclic Variations for Combustion Control: An RCCI Engine Application

Cylinder-pressure-based control is a key enabler for advanced pre-mixed combustion concepts. In addition to guaranteeing robust and safe operation, it allows for cylinder pressure and heat release shaping. This requires fast control-oriented combustion models. Over the years, mean-value models have been proposed that can predict combustion metrics (e.g., gross indicated mean effective pressure (IMEPg), or the crank angle where 50% of the total heat is released (CA50)) or models that predict the full in-cylinder pressure. However, these models are not able to capture cycle-to-cycle variations. The inclusion of the cycle-to-cycle variations is important in the control design for combustion concepts, like reactivity-controlled compression ignition, that can suffer from large cycle-to-cycle variations. In this study, the in-cylinder pressure and cycle-to-cycle variations are modelled using a data-based approach. The in-cylinder conditions and fuel settings are the inputs to the model. The model combines principal component decomposition and Gaussian process regression. A detailed study is performed on the effects of the different hyperparameters and kernel choices. The approach is applicable to any combustion concept, but is most valuable for advance combustion concepts with large cycle-to-cycle variation. The potential of the proposed approach is successfully demonstrated for a reactivity-controlled compression ignition engine running on diesel and E85. The average prediction error of the mean in-cylinder pressure over a complete combustion cycle is 0.051 bar and of the corresponding mean cycle-to-cycle variation is 0.24 bar2. This principal-component-decomposition-based approach is an important step towards in-cylinder pressure shaping. The use of Gaussian process regression provides important information on cycle-to-cycle variation and provides next-cycle control information on safety and performance criteria.

Vibration reduction effect of retaining pile structure under the action of damping hole—A case study

In the context of mitigating the impact of blasting-induced seismic waves on excavation processes and reducing the vibrational load on retaining pile structures, this study examines the influence of predetermined damping hole parameters on the damping effect. It also evaluates the protective efficacy of damping holes on retaining pile structures. Leveraging the foundation pit project at the Julong Avenue Station of Wuhan Metro Line 7 as a reference, on-site blasting construction was monitored to obtain vibration velocities at the top of the retaining pile structure. A numerical calculation model for blasting in the foundation pit was established using LS-DYNA software, and its reliability was verified through the integration of on-site monitoring data at the top of the retaining pile. Multiple damping hole excavation schemes were devised, and their effects on the damping effectiveness were analyzed with respect to various parameters. Safety criteria for the stability of the retaining pile structure were proposed based on the ultimate tensile stress criterion, ultimate shear stress criterion, and Mohr’s criterion. Under the optimized scheme, the dynamic response characteristics of the retaining pile structure were analyzed, and the practical application effects on-site were observed. The research findings indicate that the depth, spacing, and number of damping holes have a significant impact on the damping effect. The safety criterion for the vibrational velocity of the retaining pile structure during blasting is determined to be 26.10 cm/s. Under the optimized scheme, the vibrational velocities at various monitoring points on the retaining pile structure all fall within the safe range, with a maximum reduction rate of 30.9%.

Optimal configuration of distributed energy storage considering intending island recovery in faulty distribution networks

With the rapid development of distributed generation, represented by photovoltaic power, the access of a large number of distributed generation poses threats to the security and reliable operation of islanded distribution networks. However, relying on the distributed energy storage system can stabilize the island power supply, which can effectively improve the reliability of the island distribution network. To this end, under the premise of knowing photovoltaic output and load forecast curve, this paper proposes a distributed energy storage optimization configuration method in the active islanding operation mode of multi-source distribution network, which satisfies the “N-1″ safety criterion. First, this paper establishes an optimization configuration model for distributed energy storage with multiple objectives, including minimizing the load shedding in the non-fault loss of power zone, the initial investment cost of distributed energy storage, the node voltage deviation and the system frequency offset. Then, aiming at the islanded power flow calculation process mentioned above, an improved trust region algorithm is proposed, and integrating this method with the harmony search algorithm and ”N-1″ safety criterion solves the model. Finally, the IEEE 33-node distribution system is used to test the performance of the proposed algorithm. The results show that the proposed improved trust region algorithm has the advantages of fast convergence speed and short time-consumption compared with the traditional trust region algorithm. And the proposed optimization configuration scheme for distributed energy storage can satisfy the “N-1″ safety criterion of the distribution network under different fault scenarios.

Recommendations for topical antimicrobial therapy of inflammatory diseases of the middle ear based on the results of evidence-based clinical study

Introduction. In conditions of widespread resistance of pathogens to traditional antimicrobial drugs, active attention is paid to the development of topical antimicrobial drugs for the effective treatment of inflammatory pathology of the middle ear.Aim. To study the efficacy and safety of a new dosage form of the drug Dioxydin® (2.5 mg/ml ear drops) in the treatment of patients with acute purulent otitis media and exacerbation of chronic purulent otitis media in comparison with ear drops containing 0.3% ciprofloxacin solution.Materials and methods. A multicenter randomized comparative clinical trial included adults with acute purulent otitis media or exacerbation of chronic purulent otitis media and during 6 face-to-face visits (days 1st, 3rd, 6th, 9th, as well as a therapy completion visit and a follow-up visit), the effect of drugs was evaluated according to examination, otoscopy, microbiological and audiometric examinations. Safety was assessed by the frequency of adverse events and the results of blood, urine tests and vital signs.Results. The achievement of the primary criteria was evaluated among 164 participants randomized into 2 groups: the proportion of patients with no indications for systemic antibacterial therapy at Visit 2 and with no ear pain at Visit 4, Dioxydin® ear drops had no less effectiveness than the comparison drug (64.6 and 89.9% versus 68.3 and 87.3%, respectively). In terms of the frequency of elimination of the pathogen and improvement of air conduction, the compared drugs also had no statistically significant differences, and according to some secondary criteria, Dioxydin® significantly exceeded 0.3% ciprofloxacin solution (the proportion of patients with a pronounced decrease in pain and congestion in the ear, as well as hyperemia of the eardrum). According to the safety criteria, the compared drugs had no significant differences.Conclusions. The results of the study confirmed the high efficacy and safety of Dioxydin® ear drops in the treatment of otitis media in adults.

Concordance of Blood Glucose and CGM During a Pilot Trial of Automated Insulin Delivery in Type 1 Diabetes Pregnancies.

Customized and standard automated insulin delivery (AID) systems for use in pregnancies of women with preexisting type 1 diabetes (T1D) are being developed and tested to achieve pregnancy appropriate continuous glucose monitoring (CGM) targets. Guidance on the use of CGM for treatment decisions during pregnancy in the United States is limited. Ten pregnant women with preexisting T1D participated in a trial evaluating at-home use of a pregnancy-specific AID system. Seven-point self-monitoring of blood glucose (SMBG) was compared to the closest sensor glucose (Dexcom G6 CGM) value biweekly to assess safety and reliability based on the 20%/20 mg/dL criteria. All participants completed the study with 7 participants satisfying the safety and reliability criteria with a mean absolute relative difference of 10.3%. Three participants did not fulfill the criteria, mainly because the frequency of SMBG did not meet the requirements. Dexcom G6 CGM is safe and accurate in the real-world setting for use in pregnant women with preexisting T1D with reduced SMBG testing as part of a pregnancy-specific AID system.

Abstract CT081: A phase 1/2 study investigating the safety and efficacy of autologous TAC T cells in subjects with unresectable, locally advanced, or metastatic claudin 18.2+ solid tumors

Abstract Background: CLDN18.2 is a tight junction protein found in differentiated gastric epithelial cells, which can become abnormally or ectopically expressed in a number of solid tumor indications. This exposure profile illustrates the potential of CLDN18.2 as a candidate for targeted therapy. To date, there are no approved therapeutic agents directed against this target. The T cell antigen coupler (TAC) technology is an approach to modifying T cells ex vivo, which allows recognition and cytotoxicity of tumor cells by co-opting the natural T cell receptor. TAC T cells demonstrate a safer profile than chimeric antigen receptor T cells. TAC01-CLDN18.2 is an autologous T-cell product comprising T cells expressing CLDN18.2 TAC. Methods: This is a first-in-human study (NCT05862324) to investigate the safety and preliminary anti-tumor activity of TAC01-CLDN18.2 in CLDN18.2+/HER2- solid tumors. Subjects will undergo leukapheresis and may receive bridging anticancer therapy, if deemed necessary by the Investigator, during cell manufacturing. Prior to TAC01-CLDN18.2 infusion, subjects will undergo low-intensity lymphodepletion chemotherapy. In Phase I dose escalation, TAC01-CLDN18.2 will be administered at increasing doses (Cohorts 1-3) in adult subjects after ≥2 lines of therapy using the classic 3+3 dose escalation study design. Subjects with pancreatic ductal adenocarcinoma (PDAC) may have been treated with 1 line of prior therapy. CLDN18.2 expression levels will be determined centrally using a clinical trial assay validated across relevant indications. Dose limiting toxicities will be assessed up to 28 days from TAC01-CLDN18.2 infusion. A second dose may be administered, according to preidentified clinical and safety criteria. In Phase II, dose expansion groups will further evaluate the efficacy, safety, and pharmacokinetics of the optimal TAC01-CLDN18.2 dose, with the option of redosing. Indications will include gastric and esophageal adenocarcinoma (group A), PDAC (group B) and ovarian and non-small cell lung cancer (group C) in subjects after ≥2 and <4 lines of prior therapy (subjects with PDAC may have been exposed to 1 therapy). Definitions of eligible CLDN18.2 expression levels will be based on retrospective analysis of data from Phase 1 in association with clinical efficacy. A Simon 2-stage design will be used to enroll ≤57 subjects in Group A and ≤22 subjects in Group C. Group B will be exploratory and will enroll ≤10 subjects with an opportunity of cohort enrichment based on clinical efficacy data. The first patient was enrolled in December and continues to participate in the trial. Citation Format: Ecaterina E. Dumbrava, Daniel Olson, Samuel Saibil, Davendra P. Sohal, Syma Iqbal, Alejandro Urgelles, Maria Apostolopoulou, Amy Mueller, Kara Moss, Deyaa Adib, Ben Schlecter. A phase 1/2 study investigating the safety and efficacy of autologous TAC T cells in subjects with unresectable, locally advanced, or metastatic claudin 18.2+ solid tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr CT081.

МЕТОДОЛОГИЯ ПРИНЯТИЯ ОПТИМАЛЬНЫХ РЕШЕНИЙ ПО УПРАВЛЕНИЮ ЖИЗНЕННЫМ ЦИКЛОМ ОБЪЕКТА КАПИТАЛЬНОГО СТРОИТЕЛЬСТВА С УЧЕТОМ КРИТЕРИЯ ПЫЛЕВОГО ЗАГРЯЗНЕНИЯ АТМОСФЕРНОГО ВОЗДУХА

Abstract. The existing approaches to decision-making in construction have two significant drawbacks. Firstly, they allow us to calculate the effectiveness of the options under consideration only for the object construction phase, without giving an idea of the decisions effectiveness taken at other life cycle stages. Secondly, the absence of an environmental safety criterion for a particular technology in the model reduces its universality and the adequacy of the decisions taken.
 The article proposes a new approach to management decision-making in construction as to the management of a capital construction object life cycle. A methodology has been developed for making optimal decisions on life cycle management, taking into account the criterion of atmospheric air dust pollution. In order to build the methodology, a block diagram of the formation of dust emissions into the atmosphere from temporary pollution sources at various stages was developed. The dust pollution values for works performed at various life cycle stages of a capital construction object were obtained experimentally. Based on the data obtained, the values of the given optimization criterion are determined for choosing the optimal solution for life cycle management, taking into account the criterion of atmospheric air dust pollution.
 Unlike the existing ones, the developed methodology allows, firstly, to calculate the effectiveness of the options under consideration not only for the construction stage, but also for the entire object life cycle. Secondly, the model introduces a criterion of environmental safety of the control solutions under consideration, quantified by the degree of dust pollution of atmospheric air.
 Subject of research: The processes of atmospheric air dust pollution when performing work at various stages of the capital construction object life cycle. 
 Materials and methods: Theoretical and experimental methods for determining the concentration of dust pollution using the Ecologist program, based on the results of field dust pollution measurements and aerosol dispersed composition analysis.
 Results: A methodology for making optimal decisions on managing the capital construction object life cycle has been developed, including 5 stages.
 1. Identification of work types that cause atmospheric air dust pollution.
 2. Determination of fine dust concentration from each type of work.
 3. Determination of the atmospheric air pollution indicator total value for the implementation of all control solutions (technologies) variants and for all capital construction object life cycle stages according to the proposed model.
 4. Determination of given optimization criterion values for the implementation of all control solutions (technologies) variants and for all life cycle stages according to the proposed expression.
 5. Selection of the control solution (technology) with the lowest given optimization criterion value.
 Conclusions: As a result of theoretical and practical research, a methodology has been created that allows, firstly, to calculate the effectiveness of the options under consideration not only for the construction stage, but also for the entire object life cycle. Secondly, the model introduces a criterion of environmental safety of the control solutions under consideration, quantified by the atmospheric air dust pollution degree.

Integrating GIS and BIM with MCDM for infrastructure planning: a comprehensive framework

PurposePresent study aimed to integrate Geographic Information Systems (GIS) and Building Information Modeling (BIM) in conjunction with multicriteria decision-making (MCDM) to enhance infrastructure investment planning.Design/methodology/approachThis analysis combines GIS databases with BIM simulations for a novel highway project. Around 150 potential alternatives were simulated, narrowed to 25 more effective routes and 3 options underwent in-depth analysis using PROMETHEE method for decision-making, based on environmental, cost and safety criteria, allowing for comprehensive cross-perspective comparisons.FindingsA comprehensive framework proposed was validated through a case study. Demonstrating its adaptability with customizable parameters. It aids decision-making, cost estimation, environmental impact analysis and outcome prediction. Considering these critical factors, this study holds the potential to advance new techniques for assessment and planning railways, power lines, gas and water.Research limitations/implicationsThe study acknowledges limitations in GIS data quality, particularly in underdeveloped areas or regions with limited technology access. It also overlooks other pertinent variables, like social, economic, political and cultural issues. Thus, conclusions from these simulations may not entirely represent reality or diverse potential scenarios.Practical implicationsThe proposed method automates decision-making, reducing subjectivity, aids in selecting effective alternatives and considers environmental criteria to mitigate negative impacts. Additionally, it minimizes costs and risks while demonstrating adaptability for assessing diverse infrastructures.Originality/valueBy integrating GIS and BIM data to support a MCDM workflow, this study proposes to fill the existing research gap in decision-making prioritization and mitigate subjective biases.

Методические подходы к расчету показателей риска аварий при обосновании безопасности размещения магистральных газопроводов в пределах пятой подзоны приаэродромной территории

The issues of safe allocation of hazardous production facilities, particularly trunk gas pipelines and gas supply facilities, as well as the application of a risk-oriented approach with the substantiation of such allocation, are currently at the top of the agenda. The article continues the earlier published studies dedicated to the review of quantitative and qualitative approaches to the risk analysis of the field, the determination of acceptable risk criteria with the substantiation of safe allocation of trunk gas pipelines and gas supply facilities within the fifth subzone of the aerodrome environs. The study provides general relations for the calculation of risk indices; the final calculated indices are the individual risks of fatalities among passengers and crewmembers as well as the annual number of fatalities on aircraft as a result of accidents at hazardous production facilities per 1 million persons of passenger traffic. The suggested approach takes into account several aviation-specific factors; i.e., aircraft flights at variable heights, complex configuration of take-off and landing, several available routes of approach to the airport (departure from the airport), and random allocation of hazardous production facilities adjacent to the aerodrome. A methodology and algorithm to use the introduced general relations have been provided, for which lists of input data and basic assumptions have been composed. The assumptions enable the conversion of general relations into simple algebraic expressions. Safety criteria and methodological approaches to determine their actual values, as suggested by the authors, enable linking the field of industrial safety and the field of aircraft flight safety and primarily aim at the reduction of uncertainties associated with problems of risk-oriented approach with the substantiation of allocation of trunk gas pipelines within the fifth subzone of the aerodrome environs. The vectors of further improvement of the methodology have been proposed.

Research on Design and Analysis of Multi-Story Building by using AutoCAD and STAAD-Pro

“The population of India is the second highest in the world as per the 2022 report” [1]. In order to live well, there is an increasing demand for adequate infrastructure. People are migrating from rural to urban regions. Problems will rise due to the high population in urban areas. Due to a lack of available land for construction in metropolitan areas, high-rise building structures are becoming more necessary to address the population density issue. High-rise structures are in high demand, and their construction must be completed without compromising any of the three criteria of cost, timeliness, and safety. AutoCAD design software enables the production of both 2D and 3D drawings for use in constructing multi-story buildings. This study aims to utilize the software package STAAD-Pro to analyze and design a multi-story building, following the production of 2D and 3D drawings using AutoCAD. STAAD-Pro offers a far quicker method of structural analysis and planning for the likelihood of the fewest faults. The design involves load calculations and analyzing the whole structure by STAAD Pro. “The method used in STAAD Pro analysis is Limit State Design followed by Indian Standard Codes. The loads considered for designing the building are dead loads, live loads, and Wind loads. For analyzing a multi-storied building, one has to consider all the possible loadings and see that the structure is safe against all possible loading conditions” [2]. The aim of this study is to analyze the structural behavior of the building and ensure that it meets the necessary design standards and codes. To remain competitive in the constantly expanding market, it is crucial for structural engineers to optimize their time management. This study highlights the importance of using advanced software tools in the design and analysis of complex structures to ensure their safety and stability.

Feasibility, safety, and adherence of a remote physical and cognitive exercise protocol for older women.

Population aging and the consequences of social distancing after the COVID-19 pandemic make it relevant to investigate the feasibility of remote interventions and their potential effects on averting functional decline. (1) To investigate the feasibility, safety, and adherence of a remote protocol involving physical and cognitive exercises for older women with normal cognition; (2) to examine its effects on cognitive and well-being variables. Twenty-nine women (age ≥ 60 years old) were randomized into experimental group (EG; n = 15) and control group (CG; n = 14). The EG performed a 40-minute session of cognitive and physical exercises, and CG performed a 20-minute stretching session. Both groups performed 20 sessions via videoconference and 20 on YouTube twice a week. The Mini-Mental State Examination, Verbal Fluency Test, Digit Span (direct an inverse order), Geriatric Depression Scale (GDS), and Well-being Index (WHO-5) were applied in pre- and post-interventions by phone. Overall adherence was 82.25% in EG and 74.29% in CG. The occurrence of adverse events (mild muscle pain) was 33.3% in EG and 21.4% in CG. The EG improved verbal fluency and attention (p ≤ 0.05); both groups had improved depressive symptoms. The present study met the pre-established criteria for feasibility, safety, and adherence to the remote exercise protocol among older women. The results suggest that a combined protocol has more significant potential to improve cognitive function. Both interventions were beneficial in improving the subjective perception of well-being.

Moving from ethnic exclusions to cultural safety: how is athlete ethnicity discussed in research on menstrual health in sports? A scoping review

ObjectiveThis study aims to investigate how athlete ethnicity is discussed in the inclusion and exclusion criteria, methodology, findings, and conclusions of research focused on menstrual health in sports science and...