Since there is no cure for dementia, patients often seek complementary and alternative medicine (CAM) therapies to slow down disease progression. While the quality of life (QoL) is an important outcome dimension for dementia, the QoL outcomes of CAM for dementia have not been clear. This study aimed to determine the effect of CAM therapies for the dementia patients in terms of QoL outcomes by conducting systematic review and meta-analyses. A systematic review search in PubMed, CENTRAL, EMBASE, MEDLINE, NCSL, KISS, KMbase, NDSL, RISS and OASIS was performed by June 2017. Search keywords were the following: ‘dementia’, ‘alzheimer’, ‘cognitive impairment’, ‘Chinese’, ‘Korean’, ‘oriental’, ‘herbal’, ‘acupuncture’ and ‘quality of life’. Literature were selected separately by two independent researchers, and the quality of literatures was evaluated using RoB and RoBAN. All quantitative data were synthesized using the Comprehensive Meta-Analysis (CMA) software, version 3.0 For the systematic review, 29 articles (14 RCTs, 13 pre-post trials, and 2 cohort studies) with QoL measures were included. Dementia specific QoL instruments like GQOL-D (n=7) and QOL-AD (n=6) and general instruments of WHOQOL-BREF (n=4) and SF-36 (n=4) were generally reported. In meta-analyses, a combination of two acupuncture intervention researches (electro-acupuncture RCT and pre-post trial), it was found that acupuncture significantly increased standard mean difference (SMD) by 0.384 only at mental component of SF-36. Also various CAM interventions such as multiple training modalities, forest healing and creative story telling were significant in psychological (SMD 0.537, p=.007) and social relationships domain (SMD 0.519, p=.004) of WHOQOL-BREF. This study found that CAM interventions improved QoLs of dementia patients. Therefore, CAM therapies can be considered part of the clinical management of dementia and utilized to assist with pharmacological treatment. Furthermore, if the coverage of health insurance is extended to CAM treatment, the QoL of patients with dementia will be greatly improved.
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