This paper presents a Neural Network (NN) approach for displacement analysis with applications in modelling the seismic response of the UK’s Advanced Gas Cooled Reactors (AGRs). A quarter sized physical model of a reactor core was developed at the University of Bristol to provide experimental validation to the existing numerical models that support the seismic resilience assessments of the AGRs. The physical model outputs include displacement and acceleration datasets of considerable size and complexity, collected for a range of seismic inputs and postulated component damage scenarios. Rich sets of displacement data were employed in training two NN models that can predict displacement at user-defined locations in the core physical model and can map the correlation between the component relative displacements. Understanding component displacements is particularly important, as such displacements may affect the channel shapes and can cause local and general distortion of the core. This paper presents the development, testing and performance of the NN models. The NNs yield predictions that compare well with the experimentally obtained parameters. As more experimental test data become available, the NN’s prediction capability will benefit from accumulated training. In the future, the NNs will be incorporated into a multi-layered framework for dynamic response prediction and analysis.