The subject of the study is the transformation of the lines of international technological exchange in the context of multiple restrictions from the countries with high technological potential. The purpose of the work is to identify possible ways for further technological cooperation of Russia with countries that are subject to sanctions restrictions in this area. The article rationale is determined by the need for Russia to find new niches and areas of technological exchange with foreign countries. The research methodology includes the use of general scientific methods, namely statistical one, evaluation of empirical data, specification and abstraction, expert assessments, classification, structuring and systematization of objects. The research methodology includes the use of general scientific methods, namely statistical, evaluation of empirical data, concretization and abstraction, expert assessments, classification, structuring and objects arrangement. The article concludes that ensuring the innovative component of the economic growth of the countries around the world through a combination of their own resources and commercial and non-commercial technology exchange is a long-term trend. In the context of growing geopolitical tensions, developed countries have become increasingly active in imposing restrictions on the transfer of technology and high-tech goods. The establishment of new spatial and geographical areas of international technological cooperation has become an inevitable consequence of this situation. An important response for the countries targeted by the sanctions restrictions is the shaping of new vectors of cooperation, including targeting exports and imports of technologies to/from friendly countries, developing non-commercial forms of technological exchange, including scientific contacts, training specialists, and holding business forums. An important response for countries targeted by sanctions restrictions is the formation of new vectors of cooperation, including targeting the export and import of technology to friendly countries, developing non-commercial forms of technological exchange, including scientific contacts, training specialists, and holding business forums. Ensuring the technological sovereignty of Russia and other sanctioned countries is possible by improving the scientific infrastructure and encouraging domestic and foreign investments.