Conversion Factor Research Articles

Experimental study on creep-fatigue damage of hot central plant recycling asphalt mixture containing high RAP

The objective of this study is to delve into the nonlinear damage evolution mechanism of hot central plant recycling asphalt mixture under the influence of creep-fatigue interaction. A predictive model for lifespan, considering the interaction of temperature and load, was developed. Dynamic creep tests were conducted at different temperatures to assess the creep effect of the asphalt mixture under actual road temperature conditions. The investigation began by acknowledging the material's viscoelastic properties, thereby deriving the loss compliance value - a key indicator of temperature effects - using an equivalent conversion factor and a viscoelastic mechanics model. This allowed for the incorporation of creep behavior into the load system. Furthermore, to analyze the nonlinear damage mechanism and fatigue prediction mechanism, direct tensile fatigue tests were performed at different temperatures and different stress levels. The fatigue damage evolution law of hot central plant recycling asphalt mixture containing high RAP considering the creep effect was revealed, and the fatigue life evaluation method under the combined action of temperature and stress level was proposed. The results show that the fitting degree of the time-temperature conversion equation and the viscoelastic mechanics model to the test data is more than 0.9, and the derived loss compliance value better captures the creep effect. Based on the nonlinear creep-fatigue damage model, the damage law of high-RAP hot central plant recycling asphalt mixture was identified. The optimized fatigue life prediction model fully considers the combined effect of temperature and stress level and analyzes the influence parameters of the real state of pavement fatigue. The prediction accuracy is within the requirements of engineering applications. The model's predictive accuracy meets the criteria for engineering applications, enhancing the multifaceted damage coupling analysis approach for hot central plant recycling asphalt mixture and predict the service life of recycled pavements under complex conditions, establishing a groundwork for the prediction and assessment of long-lasting recycled pavements.

Modeling Fallout from Nuclear Weapon Detonations: Efficient Activity and Dose Calculation of Radionuclides and Their Progeny.

The purpose of this paper is to present a practical method for quick determination of potential radiological doses and contaminations by fallout from nuclear detonations, or other releases, that includes the contributions from all nuclides. We precalculate individual (total) activities of all radionuclides from any initial cocktail and all their ingrowing progeny at a set of pinpoints in time with a logarithmic time-spacing. This is combined with the set of dose conversion factors (DCC) for any exposure pathway to obtain a time-dependent cocktail for the whole release as if it is one substance. An atmospheric dispersion model then provides the thinning coefficient of the released material to give local concentrations and dose rates. Progeny ingrowth is illustrated for pure 238 U and for a nuclear reactor that has been shut down. Efficient dose assessment is demonstrated for fallout from nuclear detonations and compared with the traditional approach of preselecting nuclides for specific endpoints and periods-of-interest. The compound cocktail DCC reduces the assessment of contaminations and potential dose-effects from fallout after a nuclear detonation to (the atmospheric dispersion of) only one tracer substance, representing any cocktail of nuclides and their progeny. This removes the need to follow all separate nuclides or an endpoint-specific preselection of "most important nuclides." As the cocktail DCCs can be precalculated and the atmospheric dispersion of only one tracer substance has to be modelled, our method is fast. The model for calculating cocktail DCCs is freely available, easily coupled to any regular atmospheric dispersion model, and therefore ready for operational use by others.

The Effect of Mineral Composition on the Correlation between Point Load Index with the Uniaxial Compressive Strength of Sulfate Rocks and their Point Loading Deformation

Point load test is a common, inexpensive and fast test for the indirect achievement of compressive or tensile strength of the rocks in the laboratory and the field. In this research, by conducting uniaxial compression test (UCT), axial (APLT), and diametral (DPLT) point load tests on gathered sulfate rock blocks from the Gachsaran Formation outcrops at the four under-construction reservoir dam sites in Iran, investigate the effect of mineral composition on the relationships between point load index, the uniaxial compressive strength (UCS) and their point load deformation. Regarding that, firstly by creating a correlation between axial (APLI) and diametral (DPLI) point load index and UCS, relationships for each specific mineral composition were provided. Secondly, by comparing the reliability of the APLT and DPLT results in predicting UCS, the conversion factors of the APLI and DPLI to the UCS were calculated. Thirdly, the effect of unique or multiple sampling locations in the analysis results was compared, and finally, for the first time, the deformation of loading points in point load tests was investigated. The results of this study confirmed that by variation of mineral composition of sulfate rocks, the relationships between APLI and DPLI, and UCS, conversion factors as well as loading points deformation patterns during point load tests are changed significantly, and the results of APLT and DPLT can be used to predict UCS with the same reliability in dry and saturated conditions.

AAPM WGTG51 Report 385: Addendum to the AAPM's TG-51 protocol for clinical reference dosimetry of high-energy electron beams.

An Addendum to the AAPM's TG-51 protocol for the determination of absorbed dose to water is presented for electron beams with energies between 4MeV and 22MeV ( ). This updated formalism allows simplified calibration procedures, including the use of calibrated cylindrical ionization chambers in all electron beams without the use of a gradient correction. New data are provided for electron beams based on Monte Carlo simulations. Implementation guidance is provided. Components of the uncertainty budget in determining absorbed dose to water at the reference depth are discussed. Specifications for a reference-class chamber in electron beams include chamber stability, settling, ion recombination behavior, and polarity dependence. Progress in electron beam reference dosimetry is reviewed. Although this report introduces some major changes (e.g., gradient corrections are implicitly included in the electron beam quality conversion factors), they serve to simplify the calibration procedure. Results for absorbed dose per linac monitor unit are expected to be up to approximately 2% higher using this Addendum compared to using the original TG-51protocol.

Elemental Impurities in Gelatine Capsules: Human Health Risk Assessment

INTRODUCTION. This work continues the authors’ earlier study on gelatine capsule contamination with elemental impurities, which resulted in proposing a list of elements for standardisation. To ensure the safe use of medicinal products in this dosage form, it is necessary to develop criteria for the quantitative assessment of potential human health risks associated with elemental impurities in gelatine capsule shells.AIM. This study aimed to determine the permitted daily concentration (PDC) limits for elemental impurities in gelatine capsules from a risk-based pharmaceutical quality control perspective.MATERIALS AND METHODS. The authors analysed their previous experimental data, the relevant Russian State Standard (GOST), the requirements of the State Pharmacopoeia of the Russian Federation and leading world pharmacopoeias (USA, UK, EU, China, Japan, and India), and the scientific literature published from 1980 to 2023 on the content of elemental impurities (Al, As, Cd, Cu, Cr, Cr, Fe, Hg, Mn, Pb, and Zn) in gelatine capsule shells and medical gelatine.RESULTS. When standardising the content of elemental impurities in gelatine capsule shells, it is necessary to consider not only the toxicity of impurities but also their potential to compromise the quality of gelatine. Complexing elements (Cd, Cu, Hg, Cr, and Zn) can affect the quality of gelatine at subtoxic concentrations. For Cd, Cu, and Hg, the authors recommended using the PDC limits specified in GOST 23058-89 Gelatine. Raw materials for the medical industry. Specifications. For Cr and Zn, the authors recommended adhering to the PDC limits specified in the State Pharmacopoeia of the Russian Federation, edition XIV, Monograph 2.1.0099.18 Gelatine. Lead affects the quality of gelatine at concentrations above the toxicity threshold, and arsenic does not cause clustering of gelatine molecules. For Pb and As, the authors recommended using the PDC limits specified in the State Pharmacopoeia of the Russian Federation, edition XV, General Monograph 1.1.0040 Elemental impurities. The authors proposed a conversion factor to account for the complexing potential of Al when limiting its content in gelatine capsule shells. The authors recommended assessing the risks to human health associated with Mn intake with gelatine capsule shells indirectly by listing total heavy metals as a quality attribute to be controlled at the level of medical gelatine. The content of Fe should also be standardised at the raw material level.CONCLUSIONS. The content of elemental impurities in gelatine capsule shells should not exceed the following limits: 45 µg/g for Al, 1.5 µg/g for As, 0.03 µg/g for Cd, 10 µg/g for Cr, 15 µg/g for Cu, 0.05 µg/g for Hg, 0.5 µg/g for Pb, and 30 µg/g for Zn. The standardisation of these elements in gelatine capsule shells will prevent negative effects on the human body and shell quality.

Comparison of quantitative detection of BCR::ABL1 p210 transcript levels: a multicenter study

Objective: To assess the capability of seven reference medical laboratories to detect BCR::ABL1 p210 transcription levels and to compare the results among those laboratories. Methods: The interlaboratory comparison was carried out in two stages. The samples were prepared by the reference laboratory. The quantitative values of BCR::ABL1 p210 of the comparison samples covered 0.001%-0.01%, 0.01%-0.1%, 0.1%-1%, 1%-10% and>10% in each stage. Real-time quantitative PCR (RT-PCR) and dPCR (digital PCR) were used to examine the samples. The conversion factor (CF) was calculated and validated for each laboratory. Results: In the RT-PCR comparison, one laboratory was failed to detect BCR::ABL1 p210 in fourteen samples at the first stage. The results of the other six laboratories were qualified with the bias <±1.2 folds (-0.133-0.338) and 95% limits of agreement within ±5 folds (upper limit 0.147-0.785, lower limit -0.770--0.109), and the corresponding CF values were calculated and validated. In the dPCR comparison, one laboratory did not report results at the second stage. The results of the other six laboratories were qualified with the bias <±1.2 folds (-0.026-0.267) and 95% limits of agreement within±5 folds (upper limit 0.084-0.991, lower limit -0.669--0.135), and the corresponding CF values were calculated and validated. The samples with BCR::ABL1 p210 quantitative values of 0.01%-0.1%, 0.1%-1%, 1%-10% and >10% could be detected by both RT-PCR and qPCR. When the quantitative value of BCR::ABL1 p210 was 0.001%-0.01%, the detection rate of dPCR was higher than that of RT-PCR (85.56% vs. 68.00%). Conclusions: A good consistency is present among various laboratories. The quantitative value of BCR::ABL1 p210 is comparable among laboratories as shown by the CF value conversion. For quantitative detection of BCR::ABL1 p210 deep molecular reaction, dPCR has a higher positive detection rate and more advantages than RT-PCR. To ensure the accuracy and reproducibility of the BCR::ABL1 p210 test, it is imperative for every laboratory to enhance their daily quality control practices.

Research regarding the influence of size on the compressive strength of spontaneous combustion coal gangue concrete utilizing the diffusion model

This passage employs the U2-Net model to segment images of spontaneous combustion gangue coarse aggregate (SCGCA) concrete cross-section and randomly placed aggregate library. These methods are used to construct the dataset and subsequently establish and train the diffusion model. Based on this model, a two-dimensional micro-mechanical model of SCGCA concrete was constructed, accurately reproducing the distribution, grading, and shape of the aggregate in the concrete. The size effect of SCGCA concrete is analyzed through experimentation and numerical simulation of two-dimensional micro-models. The findings of the study reveal that the dimension conversion factors for the 100 mm and 200 mm cubic specimens are 0.92 and 1.12 respectively, which demonstrates the evident size effect of SCGCA concrete. The remarkable coherence between the empirical results and the computational simulation results serves as a powerful validation of the durability and efficacy of the model delineated in this paper. In accordance with the theory of Bažant's size effect, this paper elucidates the size effect law of uniaxial compressive strength in SCGCA concrete models ignited spontaneously at different dimensions.

Conversion from the frequency of chromosome translocations in T-lymphocytes to the bone marrow dose in the long-term period after internal 89,90 Sr exposure

Cytogenetic Fluorescence In Situ Hybridization studies, that allow assessing the frequency of stable chromosome aberrations in circulating T lymphocytes, are commonly used in retrospective dosimetry in cases of uniform whole-body exposure. In the event of 89,90Sr exposure, interpretation of cytogenetic data is challenging, especially if blood sampling occurs long after the start of exposure. The weighted average dose to T-lymphocytes at the time of donor blood sampling in the long-term period after exposure to 89,90Sr does not coincide with the red bone marrow dose. Previously, we developed a model that allows us to estimate the weighted average doses to T-lymphocytes upon 89,90Sr ingress into the body of people belonging to various age groups. In this study, the modeling results were used to estimate the conversion factors from the frequency of translocations to the red bone marrow dose, which is important for assessing radiobiological effects associated with hematological diseases. The objective of our study is to estimate numerically the conversion factors (Brbm) from the dose to lymphocytes to the dose to red bone marrow for various scenarios of 89,90Sr ingestion depending on age, sex, and time after the start of exposure. The following scenarios are considered: single, uniform chronic for six months, uniform chronic for 1-5 years, non-uniform intake for 5 years (simulates the dynamics of intake in the Techa riverside settlements in 1950-1954). As a result, it has been found that the Brbm values significantly depend on the age at the time of 89,90Sr intake. The older the person is at the start of exposure, the more the cytogenetic dose differs (it is significantly lower) from the dose to the red bone marrow. We can say that the cytogenetic dose corresponds to the red bone marrow dose only in newborns and infants. This is due to the age-related dynamics of T-cell populations. Sex does not have a significant effect on Brbm. The effect of the 89,90Sr intake duration on Brbm is the most pronounced for 15-year-old adolescents. For them, the difference in Brbm values for a single and chronic 5-year ingress reaches 13%. Non-uniform intake of 90Sr over several years does not have a significant effect on Brbm and can be modelled by a uniform intake of the same duration.

Simultaneous X-ray and optical variability of M dwarfs observed with eROSITA and TESS

M-dwarf stars are the most numerous stars in the Galaxy, and are highly magnetically active. They exhibit bursts of radiation and matter, called flares and coronal mass ejections which have the potential to strongly affect the habitability of their planets. We investigate variability through simultaneous optical and X-ray observations, forming the largest statistical sample of M dwarfs observed in this way so far. Such simultaneous observations at different wavelengths, which correspond to emissions from different layers of the stellar atmosphere, are required to constrain the flare frequency and energetics and to understand the physics of flares. We used light curves from the extended ROentgen Survey with an Imaging Telescope Array (eROSITA) on board the Russian Spektrum-Roentgen-Gamma mission (SRG) and the Transiting Exoplanet Survey Satellite (TESS) for a sample of M dwarfs observed simultaneously with both instruments. Specifically, we identified 256 M dwarfs in the TESS Southern Continuous Viewing Zone (SCVZ), which corresponds to a sky area of 452.39 ($ deg^2 $), with simultaneous TESS and eROSITA detection. For this work, we selected the $25$ X-ray brightest or most X-ray variable stars. We used photometric data from Gaia and 2MASS to obtain stellar parameters such as distances, colours, masses, radii, and bolometric luminosities. X-ray fluxes and luminosities were determined from observed eROSITA count rates using appropriate rate-to-flux conversion factors. We defined and examined various variability diagnostics in both wavebands and how these parameters are related to each other. Our stars are nearby (mostly within $ 100$\,pc ), rotating fast rot &lt; 9$\,d), and display a high optical flare frequency, as expected from the selection of particularly X-ray-active objects. The optical duty cycle -- defined as the fraction of observing time in which the stars were in a high activity state -- is well correlated with the optical flare rate and was therefore used as proxy for optical variability. The X-ray and optical duty cycles are positively correlated, and there is a trend of faster rotators tending to have higher X-ray and optical variability. For stars with many X-ray flaring events, the chances of these events being found together with optical flares are high. A quantitative variability study of individual flares in the X-ray light curves is severely affected by data gaps due to the low (4\,h) cadence during the eROSITA all-sky survey. To mitigate this, we made use of the optical flares observed with TESS combined with knowledge accumulated from solar flares to put additional constraints on the peak flux and timing of X-ray events. With this method we could perform an exponential fit to X-ray light curves in the aftermath of an optical flare, and we find that the energies for these X-ray flares are well correlated with the corresponding optical flare energy. We also found two peculiar flaring events with uncharacteristically long duration and high energies observed in both their X-ray and optical light curves. Despite the substantial uncertainties associated with our analysis, which are mostly related to the poor sampling of the eROSITA light curves, our results showcase in an exemplary way the relevance of simultaneous all-sky surveys in different wavebands for obtaining unprecedented quantitative information on stellar variability.

Molecular gas scaling relations for local star-forming galaxies in the low-M* regime

We derived molecular gas fractions (fmol = Mmol/M*) and depletion times (τmol = Mmol/SFR) for 353 galaxies representative of the local star-forming population with 108.5 M⊙ &lt; M* &lt; 1010.5 M⊙ drawn from the ALLSMOG and xCOLDGASS surveys of CO(2−1) and CO(1−0) line emission. By adding constraints from low-mass galaxies and upper limits for CO non-detections, we find the median molecular gas fraction of the local star-forming population to be constant at log fmol = −0.99−0.19+0.22, challenging previous reports of increased molecular gas fractions in low-mass galaxies. Above M* ∼ 1010.5 M⊙, we find the fmol versus M* relation to be sensitive to the selection criteria for star-forming galaxies. We tested the robustness of our results against different prescriptions for the CO-to-H2 conversion factor and different selection criteria for star-forming galaxies. The depletion timescale τmol weakly depends on M*, following a power law with a best-fit slope of 0.16 ± 0.03. This suggests that small variations in specific star formation rate (sSFR = SFR/M*) across the local main sequence of star-forming galaxies with M* &lt; 1010.5 M⊙ are mainly driven by differences in the efficiency of converting the available molecular gas into stars. We tested these results against a possible dependence of fmol and τmol on the surrounding (group) environment of the targets by splitting them into centrals, satellites, and isolated galaxies, and find no significant variation between these populations. We conclude that the group environment is unlikely to have a large systematic effect on the molecular gas content of star-forming galaxies in the local Universe.

Study of Adding Different Levels of Aqueous Extract of Cloves to Water and Its Effect on the Productive Traits of Broilers

This experiment was conducted in the poultry field belonging to the Agricultural Research and Experimentation Station at the College of Agriculture / Karbala for the period from 10/6/2022 until 11/9/20123. The current study aimed to demonstrate the effect of using different levels of aqueous extract of clove powder added to drinking water and its effect on some productive traits of broiler chickens. A cage with dimensions of 1.5 x 1 m, with 30 chicks for each treatment, with three replicates of the treatment (10 chicks for each replicate), and with four treatments, namely T1, the control treatment without any addition. As for treatments T2, T3, and T4, aqueous extract of clove powder was added to it in three concentrations (10, 20, and 30). ml/liter of drinking water, respectively. The results of the experiment indicated a significant improvement (p≤0.05) in the productive characteristics of the clove powder aqueous extract treatments. Treatment T4 (30 ml/liter of drinking water) witnessed a significant improvement (p≤0.05) in body weight and weight gain and an increase in the food conversion factor with a decrease Significant (p≤0.05) in the percentage of deaths, compared to the control treatment.

Compressive Strengths of Cube vs. Cored Specimens of Cement Stabilized Rammed Earth Compared with ANOVA

Cement-stabilized rammed earth (CSRE) is a variation of the traditional rammed earth building material, which has been used since ancient times, strengthened by the addition of a stabilizer in the form of Portland cement. This article compares the compressive strength of CSRE determined from specimens cored from structural walls and those molded in the laboratory. Both types of specimens underwent a 120-day curing period. The tests were conducted on specimens with various grain sizes and cement content. An analysis of variance (ANOVA) was performed on the obtained results to determine whether it is possible to establish a conversion factor between the compressive strength values obtained from laboratory-molded cubic samples and those from cored samples extracted from the CSRE structure. The study revealed that the compressive strength of CSRE increases significantly over the curing period, with substantial strength gains observed up to 120 days. The results indicated no statistically significant difference in the mean unconfined compressive strength (UCS) between cubic and cored specimens for certain mixtures, suggesting that a shape coefficient factor may not be necessary for calculating CSRE compressive strength in laboratory settings. However, for other mixtures, normal distribution was not confirmed. These findings have implications for the standardization and practical application of CSRE in construction, highlighting the need for longer curing periods to achieve optimal strength and the potential to simplify testing protocols.

Safety of Acheta domesticus powder as a Novel food pursuant to Regulation (EU) 2015/2283.

Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on Acheta (A.) domesticus powder as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The main components of the NF are protein, fat and dietary fibre (chitin). The Panel notes that the concentration of contaminants in the NF depends on the occurrence levels of these substances in the insect feed. The Panel further notes that there are no safety concerns regarding the stability of the NF if the NF complies with the proposed specification limits during its entire shelf-life. The NF has a high protein content, although the true protein content is overestimated when using the nitrogen-to-protein conversion factor of 6.25 due to the presence of non-protein nitrogen from chitin. The applicant proposed to use the NF as food ingredient in a number of food products. The target population proposed by the applicant is the general population. Considering the composition of the NF and the proposed conditions of use, the consumption of the NF is not nutritionally disadvantageous. The panel notes that no safety concerns arise from the toxicological information of A. domesticus. The panel considers that the consumption of the NF might trigger primary sensitisation to A. domesticus proteins and may cause allergic reactions in subjects allergic to crustaceans, mites and molluscs. Additionally, allergens from the feed may end up in the NF. The panel concludes that the NF is safe under the proposed uses and use levels.

Absolute Method for Measuring Environmental Radioactive Materials Using Imaging Plates

Abstract We had previously developed a measurement method using an imaging plate (IP) to evaluate and address surface contamination caused by the release of radioactive materials during the Fukushima nuclear accident. The measurement units for the surface contamination density were in relative values [described as relative luminescence levels measured in luminescence arbitrary units (LAU)], but the evaluation was required in absolute values, such as Bq cm−2, to enable appropriate control of exposure doses. This study establishes a method for converting the IP measurements of surface contamination density due to environmental radioactivity into absolute values. Soil contaminated with radioactive materials from the Fukushima nuclear accident was collected to create a working reference material (WRM). The conversion coefficient for surface contamination density was calculated using the WRM values measured with an IP and high-purity germanium detectors. The IP measurement values were converted into the surface contamination density using the conversion coefficient. The WRM values measured with the IP and high-purity germanium detectors were 324.1 LAU and 32.22 ± 2.27 Bq cm−2, respectively. The surface contamination density conversion factor was calculated as 0.0994. The surface contamination density on the roof of the Tsukuba City facility was re-evaluated using the conversion factor. The average value of 29,972 Bq m−2 matched the amount of radioactive material fallen in Tsukuba City. By standardizing the measurement conditions for surface contamination when using IPs, we successfully quantified the surface contamination density with an accuracy comparable to that of conventional methods. This method is expected to make a significant contribution to efficient radiation safety management.

Duty of candour and clinically significant accidental or unintended exposures: revisiting the definition of moderate harm for patient safety incidents involving ionizing radiation.

To explore a quantitative interpretation of the term 'moderate harm' as applied to the triggering of the duty of candour associated with clinically significant accidental and unintended exposures to ionizing radiation. Current definitions of 'moderate harm' were matched to the lay descriptions of disease and injury states used in the calculation of detriment as disability-adjusted life years (DALY) by the World Health Organization, to obtain a value of detriment associated with 'moderate harm'. Published conversion factors between effective dose and DALY were used to calculate the effective dose associated with the same detriment. The DALY loss associated with a moderate harm incident is estimated as 0.0216 years. This corresponds to the detriment resulting from exposure to ionizing radiation of 21 mSv. An effective dose of 21 mSv relates to a probability of induced cancer of 0.0012. The results obtained closely match existing guidance although the method used is completely different. It is concluded that there is no evidence to change the existing guidance on the triggering of DoC in radiation incidents. An alternative approach to linking 'moderate harm' and radiation detriment has reinforced existing guidance.

An artificial intelligence-designed predictive calculator of conversion from minimally invasive to open colectomy in colon cancer

Minimally invasive surgery is safe and effective in colorectal cancer. Conversion to open surgery may be associated with adverse effects on treatment outcomes. This study aimed to assess risk factors of conversion from minimally invasive to open colectomy for colon cancer and impact of conversion on short-term and survival outcomes. This case–control study included colon cancer patients undergoing minimally invasive colectomy from the National Cancer Database (2015–2019). Logistic regression analyses were conducted to determine independent predictors of conversion from laparoscopic and robotic colectomy to open surgery. 26,546 patients (mean age: 66.9 ± 13.1 years) were included. Laparoscopic and robotic colectomies were performed in 79.1% and 20.9% of patients, respectively, with a 10.6% conversion rate. Independent predictors of conversion were male sex (OR: 1.19, p = 0.014), left-sided cancer (OR: 1.35, p < 0.001), tumor size (OR: 1, p = 0.047), stage II (OR: 1.25, p = 0.007) and stage III (OR: 1.47, p < 0.001) disease, undifferentiated carcinomas (OR: 1.93, p = 0.002), subtotal (OR: 1.25, p = 0.011) and total (OR: 2.06, p < 0.001) colectomy, resection of contiguous organs (OR: 1.9, p < 0.001), and robotic colectomy (OR: 0.501, p < 0.001). Conversion was associated with higher 30- and 90-day mortality and unplanned readmission, longer hospital stay, and shorter overall survival (59.8 vs 65.3 months, p < 0.001). Male patients, patients with bulky, high-grade, advanced-stage, and left-sided colon cancers, and patients undergoing extended resections are at increased risk of conversion from minimally invasive to open colectomy. The robotic platform was associated with reduced odds of conversion. However, surgeons’ technical skills and criteria for conversion could not be assessed.

Generation and autocorrelation traces investigation of Nyquist pulse sequences

We propose a novel approach for generating Nyquist pulse sequences using a dual parallel Mach-Zehnder modulator (DPMZM) and a phase modulator (PM). The generated Nyquist pulse sequence achieves a repetition frequency of 10 GHz and a full width at half maximum (FWHM) of 4.22 ps. The time-domain waveforms of these sequences are retrieved using the phase and intensity from cross-correlation and spectrum only (PICASO) method. Further investigation into the autocorrelation traces reveals a pulse width conversion factor of approximately 0.75 between the Nyquist pulse sequences and their autocorrelation traces. Our work offers an alternative approach to generating and measuring Nyquist pulse sequences.

Toxicological evaluation of Alpinia oxyphylla-derived molecule (PD-00105): In vitro genotoxicity studies and 90-day oral toxicity study in rats

PD-00105 corresponds to a compound initially identified in the fruit of Alpinia oxyphylla Miq., obtained by chemical synthesis and proposed to be use in dietary supplements for its potential neuroprotective properties. The aim of this study was to perform a toxicological evaluation of PD-00105 in accordance with the testing strategy recommended by food regulatory authorities. All studies were conducted in accordance with Good Laboratory Practice (GLP), and followed the Organization for Economic Co-operation and Development (OECD) test guidelines for chemicals. Studies included a bacterial reverse mutation test, one in vitro micronucleus test in mammalian cells, and a repeated dose 90-day oral toxicity study. No sign of toxicity was observed in the two genotoxicity tests. The test item induced a significant liver and kidney toxicity at high doses (50 and 100 mg/kg BW/day), highlighted by significant increases in liver and kidney absolute and relative weights, associated with histopathological findings and concomitant changes in hematology and clinical chemistry. Increases in alanine aminotransferase, alkaline phosphatase, total protein, albumin, globulin, cholesterol, LDL, and HDL have been measured in these two groups. However, findings observed in the low-dose group (10 mg/kg BW/day) were considered as minimal and non-adverse, and were limited to an increase in liver weight in males and in kidneys weight in females, without concomitant changes in blood chemistry. The No Observed Adverse Effect Level (NOAEL) of PD-00105 was established as 10 mg/kg BW/day under the conditions of this study. This study substantiates the use of PD-00105 in dietary supplements at doses of 10 mg/day, taking into account a safety margin factor for dose conversion to humans.

The Roadmap of a Cash Dupont Analysis and Its Impact on Stock Valuation Strategy

It is a common belief that capital intensive corporations are associated with relatively low profit margins. They operate in environments where it may be a struggle to keep returns in excess of their capital costs. This further implies a possible decline in stock value because of these lower margins. This paper extends the financial literature on the effects of capital intensity on firm performance through the introduction of the Cash DuPont Model in conjunction with a Monte Carlo Simulation. The model’s use of the free cash flow to equity (FCFE), cash conversion factor (CCF), and resulting Cash ROE ultimately leads to the determination of the fair price to book value multiple. All of these data metrics are blended into a process of stock price valuation that explains both the possibility and probability of the mispricing of a stock. The results reveal that a capital-intensive firm can show undervalued tendencies despite low profit margins.

Carbon footprint of tonsillectomy

Background and purposeHealthcare is responsible for 5.4% of greenhouse gas emissions in the UK. Emissions in surgery is a relatively unexplored area; in particular, this hasn't yet been looked at as a whole in ENT in the UK. The purpose of the study was to quantify the amount of greenhouse gas (GHG) emission from a tonsillectomy and assess the proportion of each source's contribution. MethodsOperational data from tonsillectomies performed at a large university teaching hospital in the UK were gathered and converted to global warming potential using established conversion factors and data from existing healthcare-focused carbon footprint studies. The domains considered were waste, pharmaceuticals, surgical instrument decontamination, transportation, consumables use and utilities. This study used a process-based carbon footprint approach based on the “Greenhouse Gas Protocol: Product Life Cycle Accounting and Reporting Standard”. Main findingsThe carbon footprint of a typical case was 41 kgCO2e which is equivalent to driving a car for approximately 150 miles. Consumables were responsible for 17% of this; 14% came from transport, 5.4% from decontamination, 4.8% from pharmaceuticals and 4% from waste. However, the largest GHG was from utilities, of which heating, ventilation and air conditioning was the overwhelming contributor. ConclusionsWhile the largest sources of GHG emissions require hospital-wide initiatives, there are aspects of consumables and waste streams we can improve on in ENT surgery. These include the use of disposable vs reusable instruments as well as increased availability and use of recycling waste streams in theatres. Additionally, this study provides a template that can be applied to other ENT procedures.