Conventional Ion Source Research Articles

Quasi-Simultaneous Identification of Polar and Neutral Lipids in Mass Spectrometry by kHz Switching of Electrospray and Plasma Ionization.

The identification of polar and neutral lipid species as biomarkers in complex biological samples is a key task in clinical and life sciences. Electrospray and plasma-based ionization techniques are necessary to cover the full range of lipidomes, owing to their limited molecular polarity ranges. However, combining both to generate hybrid spectra is difficult without averaging spectra, as electrospray and plasma sources operate under vastly different conditions. Their electric fields also interfere, resulting in a mutual destabilization of the ionization processes. Herein, a heated nanoelectrospray is combined with a flexible microtube plasma using a rapid (kHz range) switching process (heated nESI-sFμTP) to generate quasi-simultaneous ionization. This approach loads the ion trap with polar and less-polar ions during each injection cycle, generating hybrid spectra without averaging it. The performance of the quasi-simultaneous approach is investigated in positive ion mode, comparing it with conventional ion sources through the analysis of complex lipid liver and heart samples. While no improvements are observed in negative ion mode, the novel quasi-simultaneous approach shows great potential for analyzing complex samples in positive ion mode. The combined heated nESI-sFμTP exceeds the molecular polarity range of individual sources, offering excellent ionization efficiency and MS2 capabilities.

Multi-filament ion source for uniform ion beam generation

Ion beams are employed in various fields such as semiconductor manufacturing, surface modification and material science. The uniformity of ion beams is crucial in many applications, but conventional ion sources that use a single filament often limit the uniformity and intensity of the ion beam. This paper presents a study that aims to optimize a multi-filament ion source to enhance the uniformity of ion beams. The study includes a detailed explanation of the ion source components and design, methods for measuring ion beam uniformity with its experimental design, followed by results, analysis, discussions and conclusions, completed by suggestions for future research directions. The experimental results demonstrate that the use of a multi-filament ion source improves ion beam uniformity compared to a single-filament ion source. An optimal design for the ion source components and new approaches for improving ion beam uniformity are described. The study’s results provide important information for improving ion beam uniformity and offer a technical basis for providing high-quality products and services in various industries.

Developing a penning ionization gauge ion source with a filament for a compact ion microbeam system

We present the development of a penning ionization gauge ion source with a filament (F-PIG) for producing submicron ion beams in a compact ion microbeam system. The conventional penning ionization gauge ion source (PIG) represents a viable choice for microbeam system due to its compact size and low power consumption. However, directly utilizing a PIG for generating submicron ion beam poses challenges, primarily from significant energy spread, causing substantial aberrations. Considering this, this study proposes a solving the generation of low-voltage discharge plasma, achieved using low-energy electrons from a filament by focusing on the development of F-PIG for this purpose. Experimental results demonstrate that the F-PIG exhibits considerable promise an ion source to forming submicron beam within a compact ion microbeams system. These findings indicate that F-PIG can effectively reduce the width of the beam energy spread, making it a valuable asset for microbeam applications.

Gas mixing and double frequency operation of the permanent magnet quadrupole minimum-B electron cyclotron resonance ion source CUBE-ECRIS

CUBE-ECRIS is a recently commissioned permanent magnet electron cyclotron resonance (ECR) ion source developed at the university of Jyväskylä accelerator laboratory. The special features of the new ion source design include an unconventional quadrupole minimum-B magnetic field structure and a slit beam extraction system necessitated by the line-shaped plasma loss fluxes. Gas mixing and double frequency operation are widely used methods to optimize high charge state ion production of conventional ECR ion sources. The work presented here demonstrates the applicability of these methods for boosting the high charge state beam currents of argon, krypton and xenon extracted from CUBE-ECRIS. Oxygen and helium were used as mixing gases and microwave frequencies between 10 and 11 GHz were used for single and double frequency operation. Gas mixing has a strong impact on the high charge state beam currents. For example, the highest observed charge state increased from 15+ to 19+ for krypton and from 16+ to 23+ for xenon with oxygen gas mixing. Double frequency operation provides an additional performance improvement, for example the currents of argon 9+ and 11+ beams, produced with gas mixing, increased 30% and 100% in double frequency operation at the same total power.

Optimizing 40Ar/39Ar analyses using an Isotopx NGX-600 mass spectrometer

40Ar/39Ar geochronology relies on magnetic sector mass spectrometers to determine relative isotopic abundances. Ongoing technological developments within noble gas mass spectrometers over the last decade have led to analysis of increasingly smaller samples and higher precision, but also result in more complex data correction and interpretation. We describe a new multi-collector noble gas spectrometer, the Isotopx NGX-600, that is configured to optimize 40Ar/39Ar measurements. The NGX-600 is equipped with 9 Faraday collectors and one ion counting electron multiplier. Each Faraday is equipped with Isotopx ATONA® amplifier technology, enabling measurements spanning a dynamic range of amplified beam current from below 10−16 A to above 10−9 A. The performance of the NGX-600 is evaluated using both a conventional Nier-type ion source, and a next generation low temperature ion source, which allows for trap current variation from 200 μA to 1000 μA. We have performed over 3000 analyses of atmospheric argon to: (1) assess optimal measurement and integration times for blanks, baselines, and air aliquots of various ion intensities, (2) quantify the sensitivity via measurements of first principles 40Ar/39Ar standards, (3) compare the sensitivity between the conventional and new low temperature Nier-type ion sources, and (4) evaluate corrections associated with inter-Faraday biases, instrumental mass bias, and Faraday-multiplier gain. In addition to optimization experiments, we report a comparative analysis of both single crystal fusion and incremental heating data from Quaternary volcanic rocks obtained using both the 5-collector Nu Instruments Noblesse and the NGX-600 spectrometers.

Improved Uranium Particle Analysis by SIMS using O3 - Primary Ions.

We have investigated the use of negative molecular oxygen primary ion beams (i.e., O2 - and O3 -) to determine the benefits of using such beams for uranium particle SIMS analyses. Typically, O- is the most practical negative primary ion species from the conventional duoplasmatron ion source for both age dating and uranium isotopic analysis of particles. Newer RF plasma ion sources make it possible to use O2 - and O3 - due to higher brightness and primary ion fluence, and the increased abundance of molecular species in the plasma relative to the duoplasmatron. We have determined that by using an O3 - beam, the ionization yield can be increased by a factor of approximately two over an O- beam, up to 4.7%, a substantial improvement that positively impacts measurement precision and detection limits. We also investigated the effect of the molecular oxygen beams on uranium isotope mass fractionation and the Th/U relative sensitivity factor for SIMS analyses in comparison to O- beams. We found that O3 - reduced instrumental mass fractionation and matrix/substrate effects relative to the other negative ion beams. Particle measurements using O3 - were improved compared to conventional O- beam analyses due to higher yields, smaller corrections, and reduced substrate effects.

Mapping of azimuthal B-fields in Z-pinch plasmas using Z-pinch-driven ion deflectometry

B-field measurements are crucial for the study of high-temperature and high-energy-density plasmas. A successful diagnostic method, ion deflectometry (radiography), is commonly employed to measure MGauss magnetic fields in laser-produced plasmas. It is based on the detection of multi-MeV ions, which are deflected in B-fields and measure their path integral. Until now, protons accelerated via laser–target interactions from a point-like source have been utilized for the study of Z-pinch plasmas. In this paper, we present the results of the first Z-pinch-driven ion deflectometry experiments using MeV deuterium beams accelerated within a hybrid gas-puff Z-pinch plasma on the GIT-12 pulse power generator. In our experimental setup, an inserted fiducial deflectometry grid (D-grid) separates the imploding plasma into two regions of the deuteron source and the studied azimuthal B-fields. The D-grid is backlighted by accelerated ions, and its shadow imprinted into the deuteron beams demonstrates ion deflections. In contrast to the employment of the conventional point-like ion source, in our configuration, the ions are emitted from the extensive and divergent source inside the Z-pinch. Instead of having the point ion source, deflected ions are selected via a point projection by a pinhole camera before their detection. Radial distribution of path-integrated B-fields near the axis (within a 15 mm radius) is obtained by analysis of experimental images (deflectograms). Moreover, we present a 2D topological map of local azimuthal B-fields B(r,z) via numerical retrieval of the experimental deflectogram.

Plasma plume expansion with pulsed electron neutralization

Electrons neutralizing the ion beam from a gridded ion source are typically provided by an external cathode. This cathode emits a continuous current that ensures quasi-neutrality of the plume, and current balance of the ion source. A new type of neutralization scheme has recently been identified in the context of radio-frequency (RF) biased ion sources, where instead of a continuous electron current, the plume is neutralized by electron pulses emitted from the same plasma source as the ion beam itself. In contrast to conventional gridded ion sources, experiments have shown that pulsed neutralization produces hot electrons with a strongly anisotropic energy distribution in the plume. By making use of a two-dimensional particle-in-cell (PIC) simulation, we analyze the pulsed neutralization and plasma expansion to understand the fundamental plume physics in these systems, and perform a direct comparison with the expansion observed in typical DC systems. Electron trapping in the near-field plume region is found to be critical for ensuring quasi-neutrality, and the plume potential is observed to be higher than the downstream acceleration grid potential to prevent excessive electron backstreaming into the plasma source. This potential difference results in the formation of high-energy electron beams that generate collective plume oscillations with frequencies above the applied RF frequency. A detailed parametric study is performed to investigate the influence of the pulse frequency, emission current, and capacitance between the source and outer surrounding boundaries. In particular, the pulse frequency and emission current have a significant effect on the resulting plume potential, and the effectiveness of the resulting ion beam neutralization.

A Hollow-Cathode Ion Source in Glow Discharge Mass Spectrometry

The paper proposes a new glow discharge ion source based on a hollow cathode. The proposed source produces a denser plasma than the previously used glow discharge sources. It is shown experimentally that the maximum rate of cathode sputtering of a conducting solid sample in a hollow cathode ~25 mm in diameter is achieved when the sample has the shape of a rod with a diameter of 2–4 mm and a length of 10–15 mm and is placed along the axis of the cathode cavity. If a cover with a hole is placed on the cathode cavity, a plasma bunch is formed near the hole (a “plasma plug”), which resists the flow of argon from the hollow cathode. The pressure in the discharge chamber decreases, and the glow discharge is concentrated in the cathode cavity. This results in a decrease in the background level in the glow discharge source by approximately two orders of magnitude. The mechanism of formation and extraction of ions from a glow discharge ion source is considered. The ions formed in the glow discharge plasma form two oppositely directed ion flows in the source, one of them with an ion energy of 100 eV or higher. These ions, accelerating in the region of the cathode potential drop, are directed to the cathode, bombard the analyzed sample, and spray it. The second flow of low-energy ions is drawn from the same region of negative luminescence and is transported in the opposite direction, that is, to the surface of the discharge chamber-anode due to ambipolar diffusion. These ions are extracted from a hole in the anode chamber of a conventional ion source by an accelerating voltage and used for mass spectral analysis. The use of a hollow cathode with a plasma plug, the effect of ambipolar diffusion, and a modified Pierce lens makes it possible to increase the luminosity of the glow discharge source by more than one order of magnitude.

Direct ion-beam deposition of Ag nanoparticles using a solid-state silver ion source

Ion beam technology has shown itself worth to be an efficient method to produce nanoparticles embedded in dielectrics for photoelectronic devices. However, direct ion-beam deposition of nanoparticles (NPs) on the surface of dielectrics is rarely reported because the conventional metal ion source runs into difficulties to generate low energy (<10 keV) ion-beams. Herein, Ag NPs are directly deposited on the surface of Si substrates using the recently developed solid electrolyte ion source (SEIS), which possesses advantages of compactness, simple working conditions, and ability of emitting ion-beam at an energy of few keV. The composition, morphology and size of the synthesized Ag NPs are studied. Precise control of the NPs size including in-plane diameter and height is achieved by a modulation of the ion implantation dose. Localized maskless deposition of metal films on semiconductor surface is also expected using the SEIS device.

Effects of the Transverse Instability and Wave Breaking on the Laser-Driven Thin Foil Acceleration

Acceleration of ultrathin foils by the laser radiation pressure promises a compact alternative to the conventional ion sources. Among the challenges on the way to practical realization, one fundamental is a strong transverse plasma instability, which develops density perturbations and breaks the acceleration. In this Letter, we develop a theoretical model supported by three-dimensional numerical simulations to explain the transverse instability growth from noise to wave breaking and its crucial effect on stopping the acceleration. The wave-broken nonlinear mode triggers rapid stochastic heating that finally explodes the target. Possible paths to mitigate this problem for getting efficient ion acceleration are discussed.

Acoustic Droplet Ejection and Open Port Interface for Rapid Analysis of Metabolic Stability Assays

In vitro absorption, distribution, metabolism and elimination (ADME) assays are widely used for profiling compounds in pharmaceutical drug discovery programs. Many compounds are screened in metabolic stability assays, using liver microsomes as a model of intrinsic hepatic clearance. Analysis of metabolic stability assays has relied on high throughput LC-MS/MS techniques to keep up with automated assays and compound profiling needs. An experimental alternative to sample analysis via fast chromatography employs an open port interface (OPI) which dilutes and directs acoustically-ejected droplets from microtiter plates to a conventional electrospray ion source for ionization and introduction into a mass spectrometer. Metabolic stability assays of 37 commercial drug compounds using in human, dog, rat and mouse liver microsomes (LMs), were analyzed by LC-MS/MS and an experimental breadboard version of an ADE-OPI-MS/MS system. Results from the experiments comparing intrinsic clearance (CLint) generated with ADE-OPI-MS/MS vs fast LC-MS/MS for all compounds showed ≥86% of CLint values were within a factor of two with R2 ≥ 0.86 using 25 nL and 5 nL sample ejection volumes on the ADE-OPI-MS/MS instrument. Throughput with the experimental ADE-OPI-MS/MS system used in this study was more than ten-fold faster than analysis by the fast LC-MS/MS at 1.3 s/sample versus 17.2 s/sample, respectively.

Temperature-programmed capillary high-performance liquid chromatography with atmospheric pressure chemical ionization mass spectrometry for analysis of fatty acid methyl esters.

A new capillary high-performance liquid chromatography method with atmospheric pressure chemical ionization mass spectrometry was developed for the analysis of fatty acid methyl esters and long-chain alcohols. The chromatographic separation was achieved using a Zorbax SB-C18 HPLC column (0.3 × 150mm, 3.5μm) with a mobile phase composed of acetonitrile and formic acid and delivered isocratically at a flow rate of 10μL/min. The column temperature was programmed simply, using a common column oven. Good reproducibility of the temperature profile and retention times were achieved. The temperature programming during the isocratic high-performance liquid chromatography run had a similar effect as a solvent gradient; it reduced retention times of later eluting analytes and improved their detection limits. Two atmospheric pressure chemical ionization sources of the mass spectrometry detector were compared: an enclosed conventional ion source and an in-house made ion source with a glass microchip nebulizer. The enclosed source provided better detectability of saturated fatty acid methyl esters and made it possible to determine the double bond positions using acetonitrile-related adducts, while the open chip-based source provided better analytical figures of merit for unsaturated fatty acid methyl esters. Temperature-programmed capillary high-performance liquid chromatography is a promising method for analyzing neutral lipids in lipidomics and other applications.

Novel Approaches for Intensifying Negative C60 Ion Beams Using Conventional Ion Sources Installed on a Tandem Accelerator

We developed novel methods for producing negative C60 ion beams at the accelerator facility Takasaki Ion Accelerators for Advanced Radiation Application (TIARA) to increase the current intensity of swift C60 ion beams accelerated to the MeV energy region using a tandem accelerator. We produced negative C60 ion beams with an intensity of 1.3 µA, which is several tens of thousands of times greater than the intensity of beams produced using conventional methods based on the Cs sputtering process. These beams were obtained by temporarily adding an ionization function based on electron attachment to an existing ion source that is widely used in tandem accelerators. The high-intensity swift C60 ion beams can be made available relatively easily to institutes that have tandem accelerators and ion sources of the type used at TIARA because there is no need to change existing ion sources or install new ones.

Neutron generator based on intense lithium beam driver.

We are proposing a compact neutron generator based on a Li beam driver. The proposed neutron generator comprises a laser ion source, a radio-frequency quadrupole linear accelerator (RFQ linac), a drift tube linac, and a target containing protons. In the generator, the lithium ion is used as a projectile instead of protons to utilize the kinematic focusing technique. The technique enables us to enhance the neutron flux without increasing the beam energy, which is important to develop a clean compact neutron generator. Moreover, the combination of a laser ion source and a RFQ linac with the direct plasma injection scheme will provide several tens of mA of a fully ionized lithium beam, which is much higher than that of conventional heavy ion sources comparable with proton drivers. Neutrons are generated by the nuclear reaction of the lithium ions and protons in the beam target. In this paper, we reported the current status of the development. For RFQ, we designed the RFQ rods to accelerate 40 mA of 7Li3+. We fabricated and installed the rods into a cavity, and, as a first test, accelerated 10 mA of C6+ successfully.

Design and Construction the RF Ion Source for Compact Accelerator with 30 keV Energy

In constructing the low energy accelerator for plant modification the most important part is the ion source. In the conventional cold cathodes and hot filament ion source methods the filament continuously burns out over time, has a shorter lifespan and requires venting of the ion source to atmosphere. Henceforth the Radio frequency (RF) antenna ion source or “non-thermionic ion source” with 13.6 MHz was used in the accelerator as well as it being easy to generate varie the plasma souce and stability. This ion source can produce a particle beam of about ~30 to 40 mA current. The ion particle was extracted by the first zero voltage extraction rod electrode method focusing the ion beam of 0-30 kV with the second rod electrode after which the third rod electrode has zero voltage. In calculating and designing this system via the Simion8.0 Program, the result showed that the Ar+ ion beam with 30 keV can be focused with 1 cm diameter beam at the distance of 10 cm of the drift space.

Axial Ring-Cusp Hybrid (ARCH) plasma discharge: an approach to highly efficient miniature-scale ion sources

The miniaturization of conventional direct-current ion sources is predominantly restricted by efficiency limitations associated with the increased surface area-to-volume ratio of smaller-scale discharge chambers—reducing the effective confinement length of the high-energy ‘primary’ electrons that is necessary for efficient plasma generation. The Axial Ring-Cusp Hybrid (ARCH) plasma discharge addresses this scaling limitation by using a new approach that combines magnetic and electrostatic confinement to decouple the primary and plasma electrons loss mechanisms. Simulated ion thruster performance measurements show that the ARCH discharge may be capable of achieving a discharge loss and a propellant mass utilization of 175 eV/ion and 0.87, respectively. These estimates are supported by full internal maps of the plasma properties, including the electron energy distribution function, inside the discharge chamber. The measurements show highly effective confinement of the primary electrons, high average plasma electron temperatures of ∼5 eV, and low plasma sheath potential relative to the anode—attributes generally found only in efficient conventional-scale discharges with good overall plasma confinement. As such, the new ARCH discharge design approach may allow miniature ion thrusters to achieve the performance and efficiency levels similar to those of highly efficient conventional ion thrusters.

Detection of explosives using negative ion mobility spectrometry in air based on dopant-assisted thermal ionization

The ionization source is an essential component of most explosive detectors based on negative ion mobility spectrometry. Conventional ion sources suffer from such inherent limitations as special safety regulations on radioactive sources or generating interfering ions (for non-radioactive sources) such as corona discharge operating in the air. In this study, a new negative ion source is introduced for ion mobility spectrometry that is based on thermal ionization and operates in the air, applicable to explosives detection. Our system consists of a heating filament powered by an isolated power supply connected to negative high voltage. The ionization is assisted by doping chlorinated compounds in the gas phase using chlorinated hydrocarbons in contact with the heating element to yield Cl− reactant ions. Several chlorinated hydrocarbons are evaluated as the reagent chemicals for providing Cl- reactant ions, of which CCl4 is identified as the best ionizing reagent. The ion source is evaluated by recording the ion mobility spectra of common explosives, including TNT, RDX, and PETN in the air. A detection limit of 150 pg is obtained for TNT. Compared to other ionization sources, the new source is found to be low-cost, simple, and long-lived, making it suited to portable explosives detection devices.

Secondary ion formation during electronic and nuclear sputtering of germanium

Abstract Using a time-of-flight mass spectrometer attached to the UNILAC beamline located at the GSI Helmholtz Centre for Heavy Ion Research, we investigate the formation of secondary ions sputtered from a germanium surface under irradiation by swift heavy ions (SHI) such as 5 MeV/u Au by simultaneously recording the mass spectra of the ejected secondary ions and their neutral counterparts. In these experiments, the sputtered neutral material is post-ionized via single photon absorption from a pulsed, intensive VUV laser. After post-ionization, the instrument cannot distinguish between secondary ions and post-ionized neutrals, so that both signals can be directly compared in order to investigate the ionization probability of different sputtered species. In order to facilitate an in-situ comparison with typical nuclear sputtering conditions, the system is also equipped with a conventional rare gas ion source delivering a 5 keV argon ion beam. For a dynamically sputter cleaned surface, it is found that the ionization probability of Ge atoms and Gen clusters ejected under electronic sputtering conditions is by more than an order of magnitude higher than that measured for keV sputtered particles. In addition, the mass spectra obtained under SHI irradiation show prominent signals of GenOm clusters, which are predominantly detected as positive or negative secondary ions. From the m-distribution for a given Ge nuclearity n, one can deduce that the sputtered material must originate from a germanium oxide matrix with approximate GeO stoichiometry, probably due to residual native oxide patches even at the dynamically cleaned surface. The results clearly demonstrate a fundamental difference between the ejection and ionization mechanisms in both cases, which is interpreted in terms of corresponding model calculations.

Ion emission properties of indium nanowires grown on anodic aluminum oxide template

Indium (In) nanowires were synthesized on self-ordered hexagonal porous anodic aluminum oxide (AAO) template by electrodepositing In2(SO4)3 in the pores of AAO template. In nanowires obtained are very straight and have uniform-diameter about 45 nm. The ion emission properties of In nanowires were investigated. The onset field of ion emission is observed at about 1.6 V/μm, which is much lower than that for a conventional liquid metal ion source (LMIS) consisting of a sharpened metal needle. The I-E curves follow nearly a linear relationship with a slope of about 6.0 μA/(V/μm), indicating a conventional ion emission phenomenon in LMIS. It is proposed that the unique geometry of nanowires may be the reason for their advantages in LMIS.