An array of existing active contour models is prone to suffering from the deficiencies of poor anti-noise ability, initialization sensitivity, and slow convergence. In order to handle these problems, a robust hybrid active contour method based on bias correction is proposed in this research paper The energy functional is formulated through incorporating the adaptive edge indicator function and level set formulation driven by bias field correction. The adaptive edge indicator function, which is formulated based on image gradient information, is utilized to detect object boundaries and accelerate the segmentation in the homogeneous region. The level set formulation is constructed based on an improved criterion function, in which bias field information is considered. Specifically, the bias field distribution is approximated through the local mean gray value algorithm as a prior. Moreover, a new regularized function is proposed so as to maintain the stability of curve evolution. The segmentation process is implemented by the optimized energy function and the novel regularized term. Compared to previous active contour models, the modified active contour method can yield more precise, stable, and efficient segmentation results on some challenging images.