The serious problem of residual film pollution in the arid region of northwestern China has a severe negative impact on both the farmland environment and the benefits of cotton planting. Drip irrigation without mulch (DIWM) has the potential to serve as an effective alternative to mulch drip irrigation and address the issue of residual film pollution. However, there are few studies on how to formulate a rational irrigation regime under DIWM conditions and achieve water savings and productivity gains. Consequently, from 2020 to 2021, we established three DIWM treatments: W4, W6, and W8. None of the treatments were irrigated at the seedling stage, and the irrigation regime was the same for all the treatments at the squaring stage (2 irrigations at an irrigation quota of 45 mm). From the initial flowering stage, the frequency of irrigation was once every 6 d, 8 d, and 12 d for W4, W6, and W8, respectively, and the corresponding total numbers of watering times were 8, 6, and 4, respectively. The irrigation amount was 69 mm at each time point during the flowering and boll-forming stages in all the treatments, and the final irrigation amount was 52.2 mm in W8. The total irrigation amounts were 366 mm, 504 mm and 625.2 mm for W4, W6 and W8, respectively. This study explored the spatiotemporal characteristics of soil moisture via sensors combined with the spatial grid method. Additionally, the growth indices, biomass accumulation, yield components, and water use efficiency (WUE) of cotton were assessed across various treatments. The results revealed that, in 2020 and 2021, the W8 treatment resulted in the highest soil water content (SWC) in the 70–110 cm soil layer and soil water consumption (WC) in the 10–110 cm layer, with the WC in the 10 cm layer being 20 % and 44 % greater than that in W6, respectively. The excessive total irrigation amount (IA) in the W8 treatment led to high vegetative growth of cotton, diminishing the positive impact on yield. Across both years, the WUE observed in the W6 treatment significantly exceeded that of W8, while the seed cotton yield demonstrated only marginal decreases of 5 % and 0.9 % compared with that of W8. The irrigation amount and average WC in the 10–40 cm soil layer were 19 % and 29 % lower in W6 than in W8, respectively, but the economic benefits were only 2 % lower than those in W8. There was a significant positive correlation between the SWC and WC in all the different soil layers, and the effect of the SWC on the WC gradually decreased with increasing soil depth. Overall, the irrigation regime employed in the W6 treatment within the arid zone, devoid of mulch cover, proves to be an effective water-saving strategy, ensuring a consistent cotton yield and enhancing WUE. This study serves as a reference for developing an efficient irrigation system tailored to the DIWM cotton industry in arid zones, contributing to the promotion of green and sustainable agricultural development in this region.