Relying on the first-class construction discipline platform, the field research was conducted on the application-oriented colleges and universities that have opened the intelligent construction major, and the necessity of the establishment of the intelligent building major, talent training, professional construction, practice base construction, and teacher construction were discussed. The new generation of information technology, such as BIM technology, 3D printing, assembly, unmanned aerial vehicles, smart construction site sand tables etc., optimizes and adjusts the training program and curriculum system of civil engineering professionals, and integrates them into the corresponding courses. Combine smart construction site and virtual simulation technology with practical courses to explore the cultivation of innovative talents in application-oriented universities. The exploration of the cultivation of innovative talents in intelligent construction in application-oriented colleges and universities pays more attention to application-oriented training, explores new modes of practical teaching, and constructs a smart construction site simulation practice teaching system and virtual simulation practice teaching project group from practice, so as to provide reference for colleges in the later stage of intelligent construction professional declaration and construction, and application-oriented talent training.