As a new chiral auxiliary, a 2,2,6,6-tetramethyl-3,5-heptanediol (TMHDdiol) derivative has been developed. The chiral auxiliary is an acyclic, but strongly conformationally biased, molecule. Conjugate addition of lithium N-benzyl-N-(trimethylsilyl)amide (LSA) to the enoates having a TMHD auxiliary proceeded with high diasteroselectivities to give β-amino esters in high yields, although the use of conventional auxilliaries such as-8-phenylmethyl and oxazolidone resulted in low diasteroselectivity. Organocopper conjugate addition to TMHD crotonate, heptanoate, and cinnamate produced high diastereoselectivities, and Diels-Alder reaction of TMHD acrylate with cyclopentadiene in the presence of TiCl 4 afforded an endo adduct exclusively with high diasteroselectivity. The addition of LSA proceeded via an s-cis conformation of enoates, but the organocopper addition in the presence of BF 3 .OEt 2 and the Diels-Alder reaction in the presence of TiCl 4 proceeded through an s-trans form