Total synthesis of (+)-kalkitoxinElectronic supplementary information (ESI) available: experimental procedures and spectroscopic data. See http://www.rsc.org/suppdata/cc/b3/b306124h/

Abstract

The neurotoxic lipopeptide (+)-kalkitoxin was synthesized by a route which employed asymmetric organocopper conjugate addition followed by in situ enolate alkylation to install the anti,anti-1,2,4-trimethyl relationship of the toxin; the synthesis of kalkitoxin required sixteen steps and proceeded in 3% overall yield.