Concurrent Patterns Research Articles

Expressiveness of concurrent intensionality

The expressiveness of communication primitives has been explored in a common framework based on the π-calculus by considering four features: synchronism (asynchronous vs synchronous), arity (monadic vs polyadic data), communication medium (shared dataspaces vs channel-based), and pattern-matching (binding to a name vs testing name equality). Here pattern-matching is generalised to account for terms with internal structure such as in recent calculi like Spi calculi, Concurrent Pattern Calculus and Psi calculi. This paper explores intensionality, a feature that extends pattern-matching to allow communication primitives to interact by also matching on the structure of terms. By means of possibility/impossibility of encodings, this paper shows that intensionality alone can encode synchronism, arity, communication-medium, and pattern-matching, yet no combination of these without intensionality can encode any intensional language. Further, some languages may also be non-linear, where two inputs must be equal to allow interaction. This paper also explores all the relations between linear and non-linear variations of the above languages.

Concurrent Wnt pathway component expression in breast and colorectal cancer

Wnt signaling pathway regulates important cell functions such as proliferation and migration and is frequently deregulated in colorectal and breast cancer. Thus, it constitutes an attractive therapeutic target with many drugs being investigated in clinical trials. Eighty-two breast and 102 colorectal carcinomas were analyzed for: relative mRNA expression levels of Wnt pathway components namely Wnt3 ligand, Frizzled 7 receptor and LEF1 transcriptional factor, their concurrent expression patterns and their correlation with clinicopathological features. Regarding breast carcinomas, increased relative mRNA expression levels of WNT3 were found in 54 % of cases whereas decreased relative mRNA expression levels were observed in FZD7 and LEF1 in 82 % and 43 % of cases, respectively. Expression levels of WNT3 were significantly correlated with tumour grade (p = 0.021) in breast cancer. As far as colorectal carcinomas are concerned, increased relative mRNA expression levels of WNT3, FZD7 and LEF1 were found in 60 %, 37 % and 48 % of cases respectively. A statistically significant correlation emerged between LEF1expression levels and pT-category (p = 0.027), suggesting a possible association with tumour aggressiveness in colorectal carcinomas. Statistically significant linear correlations were observed between the expression of WNT3/LEF1 (R = 0.233, p = 0.035) and FZD7/LEF1 (R = 0.359, p = 0.001) in breast carcinomas as well as in colorectal carcinomas (R = 0.536, p < 0.01 and R = 0.210, p = 0.034) respectively. Our results demonstrate a possible clinical significance of Wnt pathway gene expression levels in both tumour types. The distinct expression patterns and simultaneous expression of the investigated genes underscore the complexity of this pathway in breast and colorectal carcinogenesis and highlights the necessity of patient selection with regard to the effectiveness of Wnt pathway inhibitors.

Individual and joint trajectories of change in bone, lean mass and physical performance in older men

BackgroundDeclines in bone, muscle and physical performance are associated with adverse health outcomes in older adults. However, few studies have described concurrent age-related patterns of change in these factors. The purpose of this study was to characterize change in four properties of muscle, physical performance, and bone in a prospective cohort study of older men.MethodsUsing repeated longitudinal data from up to four visits across 6.9 years from up to 4681 men (mean age at baseline 72.7 yrs. ±5.3) participating in the Osteoporotic Fractures in Men (MrOS) Study, we used group-based trajectory models (PROC TRAJ in SAS) to identify age-related patterns of change in four properties of muscle, physical performance, and bone: total hip bone mineral (BMD) density (g/m2) and appendicular lean mass/ht2 (kg/m2), by DXA; grip strength (kg), by hand dynamometry; and walking speed (m/s), by usual walking pace over 6 m. We also described joint trajectories in all pair-wise combinations of these measures. Mean posterior probabilities of placement in each trajectory (or joint membership in latent groups) were used to assess internal reliability of the model. The number of trajectories for each individual factor was limited to three, to ensure that the pair-wise determination of joint trajectories would yield a tractable number of groups as well as model fit considerations.ResultsThe patterns of change identified were generally similar for all measures, with three district groups declining over time at roughly similar rates; joint trajectories revealed similar patterns with no cross-over or convergence between groups. Mean posterior probabilities for all trajectories were similar and consistently above 0.8 indicating reasonable model fit to the data.ConclusionsOur description of trajectories of change with age in bone mineral density, grip strength, walking speed and appendicular lean mass found that groups identified by these methods appeared to have little crossover or convergence of change with age, even when considering joint trajectories of change in these factors.

Beyond the "self" in self-regulation: Family interaction modulates situational self-control by adolescent drug users.

Prevailing views of adolescent self-regulation (ASR) as a relatively stable disposition or skill that an individual possesses in various degrees stand in contrast to a complementary, situational perspective from family systems theory casting ASR as intertwined with ongoing family processes and malleable depending on interpersonal interactions. Using observational data from a large, ethnically diverse sample of substance-using adolescents (N = 458), the current study examines the social context of ASR across 3 increasingly conflictual family interaction tasks. Coders rated ASR and 3 concurrent family interaction patterns: enmeshment, conflict avoidance, and negative affect. ASR declined across the 3 tasks, and independent of this systematic change, family-level negative affect in the first task exerted a strong lagged statistical effect on subsequent declines in ASR. The findings are consistent with family systems theory in both the context-dependent nature of ASR behavior and the modulating role of family interaction. In addition to its well-established dispositional properties, ASR may be of interest as a context-specific and potentially modifiable dependent variable. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

HSR20-086: Concurrent Chemoradiation Treatment Patterns for Stage III Non-Small Cell Lung Cancer in Veterans

HSR20-086: Concurrent Chemoradiation Treatment Patterns for Stage III Non-Small Cell Lung Cancer in Veterans

An interactive web-based geovisual analytics platform for co-clustering spatio-temporal data

Clustering methods are useful in analyzing patterns from big spatio-temporal data. However, previous studies typically rely on traditional clustering methods to explore spatial or temporal patterns. Co-clustering methods allow the concurrent analysis of spatial and temporal patterns by identifying location- and timestamp-clusters at the same time. By combining co-clustering with coordinated multiple views (CMV) in an interactive geovisual analytics platform, we facilitate the exploratory co-clustering analysis of spatio-temporal data and the results. Further enhanced by Web 2.0 standards, our geovisual analytics platform ease the access to co-clustering analysis from any web browser. More specifically, our platform allows users to upload data and to visually explore it using interactive CMV to help the selection of co-clustering parameters. Our platform also allows users to run co-clustering and to visually and interactively explore the results. To illustrate the use of our platform, we analyze Dutch annual average temperature for 28 stations from 1992 to 2011. Results show that our platform not only helps to get a better understanding of the dataset but also to choose the co-clustering parameters. Our platform helps to interpret the co-clustering results too, and it supports the extraction and exploration of complex patterns buried in the data. In the era of big data, our web-based platform enables the exploration of concurrent spatio-temporal patterns from large datasets by combing both computer power and human interpretative capabilities.

A clinicopathological pattern of cutaneous tuberculosis and HIV concurrence in western Rajasthan.

Cutaneous tuberculosis (TB) forms a small subset of extrapulmonary TB and continues to be a significant diagnostic dilemma in routine practice. The present study is an attempt to find the incidence, clinical spectrum, and histopathological features of cutaneous TB in western Rajasthan. The relation of cutaneous TB with the human immunodeficiency virus (HIV) was also assessed. A total of 40 cases of newly diagnosed patients of cutaneous TB attending the dermatology outpatient department over a period of 1 year were included in the study. A detailed clinical examination and investigations including histopathological examination were carried out. The overall incidence of cutaneous TB was 0.025% (40 of 160,000 outpatients). HIV concurrence was 5% (2 cases) of all cutaneous TB cases. The most common variants were scrofuloderma (40%), lupus vulgaris (30%), TB verrucosa cutis (8%), orificial TB (2%), and lichen scrofulosorum (2%). Males suffered more than females (2.07:1) and all patients belonged to lower socioeconomic class. The Mantoux test was positive in 65% of cases. Extracutaneous involvement occurred in 17 (42.50%) cases. Characteristic well-defined tuberculoid granulomas were seen in 60% of cases, whereas 40% of cases showed nonspecific changes. : This study provides the epidemiological data of cutaneous TB in western Rajasthan, identifies the clinicohistopathological pattern, and calls the attention of the health-care professionals that they should improve the propaedeutics of neglected and underdiagnosed cases of cutaneous TB that is prevalent in the lower socioeconomic group. Due to the varied clinical presentations, physician awareness and a high index of suspicion are necessary to diagnose cutaneous forms of TB.

Cluster and simultaneity of modifiable risk factors for cardiovascular diseases in adolescents of Southeast Brazil

Abstract Aim: This study aimed to evaluate the cluster of the five major modifiable risk factors for cardiovascular diseases (CVD) and their associated factors and to identify patterns of concurrency of modifiable obesogenic risk factors associated with overweight in Brazilian adolescents. Methods: A survey was conducted (2015) with 1,055 (boys, n = 475; girls, n = 580) high school (public and private schools) adolescents (14-20 years old) in a medium-sized city in Southeast Brazil. The observed prevalence ratio (O) for the expected (E) risk factors (smoking, alcohol, insufficient physical activity, sedentary behavior, and poor diet) greater than one (O/E > 1) was considered as a cluster. We use multinomial and binary logistic regressions (stratified by sex) in the analyzes. Results: Almost 30% of adolescents had three or more risk factors (no factor = 5.4%). The five risk factors tended to cluster in boys (O/E = 2.5; 95% CI = 1.6-3.5). In both sexes, smoking and alcohol consumption persisted in O/E > 1 ratio. Conclusions: Boys showed a consistent pattern of association for risk factors. Overweight was associated with pairs of obesogenic risk factors in both sexes. The results indicate the need for health interventions that consider the cluster and the simultaneity of risk factors for CVD among Brazilian youth.

Preschoolers’ broad mathematics experiences with parents during play

The current study broadens our understanding of preschoolers’ early math experiences with parents, recognizing that math knowledge and experiences are inclusive of numeracy as well as non-numeracy domains. Parents and preschoolers (N = 45) were observed exploring three domains of early mathematics knowledge (i.e., number, space, and pattern) during play in three activities (playing cards, building with blocks, and stringing beads, all with activity suggestions). Children were administered a broad math and numeracy measure and individual measures of spatial and patterning skills concurrently and 7 months later. Dyads explored math broadly across most activities but emphasized number more than space or patterning. In addition, there was more overall math exploration during card and bead play than during block play, with the greatest parent support during card play. Parent support was not linked to children’s skills, although children’s exploration of space and patterns related moderately to their concurrent spatial and pattern skills. Overall, parents and young children explored a variety of early math domains in guided play contexts, with an emphasis on numeracy. Future work should aim to increase the breadth and rigor of individual concepts that parents and preschoolers explore during play.

What happens to the ocean surface gravity waves when ENSO and MJO phases combine during the extended boreal winter?

The safety of vulnerable coastal and offshore infrastructures requires an in-depth understanding of wave variability and climate drivers. We investigate the association of significant wave height (Hs) and peak wave period (Tp) with the co-occurrence of El Nino–Southern Oscillation (ENSO) and the Madden–Julian Oscillation (MJO) at the global scale. We calculate composites of daily anomalies in modelled Hs, Tp, and surface wind for periods of ENSO–MJO phase combinations. Calculations spanned November–March seasons over the period 1979–2018. Wave anomalies are widespread across the world’s oceans, with remarkable strength during several ENSO–MJO phase combinations, demonstrating strong tropic–tropic and tropic-extratropic teleconnections. Positive Hs anomalies are strongest in the Pacific Ocean during El Nino–MJO phase 8, in the Atlantic Ocean during ENSO-neutral-MJO phase 3, and in the Indian Ocean during ENSO-neutral-MJO phase 4. Positive Tp anomalies are strongest in the Pacific Ocean during La Nina–MJO phase 8, in the Atlantic Ocean during El Nino–MJO phase 1, and in the Indian Ocean during El Nino–MJO phase 8. In the Southern Ocean, the strongest Hs anomalies occur during El Nino–MJO phase 8, whereas in the Maritime Continent, they appear during ENSO-neutral-MJO phases 5–6. Despite previous studies finding low correlations of ENSO indices with wave parameters in the North Atlantic, our results suggest that ENSO-related conditions play a significant role in the area when combined with certain MJO-related conditions. This study also reveals that the wave anomalies associated with ENSO–MJO phase combinations can be twice as strong as those found in previous work, related only to the MJO. Therefore, considering multiple concurrent climate patterns in the analysis of wave anomalies is essential to developing more reliable coastal management plans.

OmicsARules: a R package for integration of multi-omics datasets via association rules mining

BackgroundThe improvements of high throughput technologies have produced large amounts of multi-omics experiments datasets. Initial analysis of these data has revealed many concurrent gene alterations within single dataset or/and among multiple omics datasets. Although powerful bioinformatics pipelines have been developed to store, manipulate and analyze these data, few explicitly find and assess the recurrent co-occurring aberrations across multiple regulation levels.ResultsHere, we introduced a novel R-package (called OmicsARules) to identify the concerted changes among genes under association rules mining framework. OmicsARules embedded a new rule-interestingness measure, Lamda3, to evaluate the associated pattern and prioritize the most biologically meaningful gene associations.As demonstrated with DNA methlylation and RNA-seq datasets from breast invasive carcinoma (BRCA), esophageal carcinoma (ESCA) and lung adenocarcinoma (LUAD), Lamda3 achieved better biological significance over other rule-ranking measures. Furthermore, OmicsARules can illustrate the mechanistic connections between methlylation and transcription, based on combined omics dataset. OmicsARules is available as a free and open-source R package.ConclusionsOmicsARules searches for concurrent patterns among frequently altered genes, thus provides a new dimension for exploring single or multiple omics data across sequencing platforms.

LPM: A Systematic Methodology for Concurrent Data Access Pattern Optimization from a Matching Perspective

As applications become increasingly data intensive, conventional computing systems become increasingly inefficient due to data access performance bottlenecks. While intensive efforts have been made in developing new memory technologies and in designing special purpose machines, there is a lack of solutions for evaluating and utilizing recent hardware advancements to address the memory-wall problem in a systematic way. In this study, we present the memory Layered Performance Matching (LPM) methodology to provide a systematic approach for data access performance optimization. LPM uniquely presents and utilizes the data access concurrency, in addition to data access locality, in a memory hierarchical system. The LPM methodology consists of models and algorithms, and is supported with a series of analytic results for its correctness. The rationale of LPM is to reduce the overall data access delay through the matching of data request rate and data supply rate at each layer of a memory hierarchy, with a balanced consideration of data locality, data concurrency, and latency hiding of data flow. Extensive experimentations on both physical platforms and software simulators confirm our theoretical findings, and they show that the LPM approach can be applied in diverse computing platforms and can effectively guide performance optimization of memory systems.

Synthesis of concurrent multibeam and conical beam antenna arrays

An approach is presented to synthesize linear and planar antenna arrays to have concurrent multibeam radiation patterns as well as desired sidelobe levels. This approach is based on zeros perturbation of the pattern of linear arrays. Multibeam planar arrays are synthesized by both multiplying and transforming multibeam linear arrays. Besides, planar arrays having conical or ring type beam are synthesized by applying a special transformation to dual-beam linear arrays. Some examples are brought to verify the effectiveness of the proposed approach for both linear and planar arrays.

Correlates of concurrent partnerships and patterns of condom use among men who have sex with men and transgender women in Peru.

BackgroundIn Peru, there is an ongoing high-incidence HIV epidemic among men who have sex with men (MSM) and transgender women (TW). Sexual concurrency, or having sex with a partner in between two acts of sex with another partner, may be a key factor in onward HIV transmission. In this study, we quantify concurrency, evaluate factors associated with concurrency, and assess condom use with concurrent partners among MSM and TW in Peru.MethodsWe conducted a secondary analysis of data from the 2011 Peruvian Biobehavioral Survey. Pearson’s Chi-squared test was used to identify individual-level characteristics associated with concurrency. We estimated the association between participant characteristics, concurrent partnerships, partnership type (stable vs. non-stable), and CLAI within the context of concurrent partnerships using multivariate and repeated-measure Poisson regression.Results3-month cumulative prevalence of concurrency was higher among TW compared to MSM (30.7% vs 25.2%, p = 0.014). Among those with concurrent stable and non-stable partners, 45% used condoms with both partners (95% CI: 40%-50%) and 30% preferentially had CLAI with the stable partner only (95%CI: 26%-35%). Factors associated with CLAI within the context of concurrent partnerships varied between MSM and TW.ConclusionsAlthough concurrency is common among TW and MSM in Peru, patterns of concurrency and differential condom use may vary between TW and MSM. Future research may explore differential condom use with stable and non-stable partners to better understand behavioral factors that may alter vulnerability to HIV in TW compared to MSM.

Longitudinal study of Mycobacterium avium ssp. paratuberculosis fecal shedding patterns and concurrent serological patterns in naturally infected dairy cattle

Mycobacterium avium ssp. paratuberculosis (MAP) is the etiological agent of paratuberculosis, a disease that affects ruminants worldwide. Despite global interest in the control of this disease, gaps exist in our knowledge of fecal shedding patterns and concurrent serological patterns. This longitudinal study in dairy cattle herds with high MAP seroprevalence in France aimed at accurately describing fecal shedding patterns over 1 year; relating those shedding patterns to individual animal characteristics (age, breed, parity); and exploring the association between fecal shedding patterns and serological patterns. To describe temporal fecal shedding patterns and continuity of shedding, along with the standard quantitative PCR (qPCR) threshold cycle we used a cutoff value that related to low or nonculturable fecal shedding. We also defined a threshold cycle indicative of shedding in high quantities to describe infection progression patterns. Twenty-one herds completed the study, and 782 cows were tested 4 times each. We obtained 4 sets of paired fecal qPCR and serum ELISA results from 757 cows. Although we targeted highly likely infectious animals, we found a large diversity of shedding patterns, as well as high variability between herds in the proportion of animals showing a given pattern. The fecal qPCR results of almost 20% of the final study sample were positioned at least once in the range that indicated low or nonculturable fecal shedding (between the adjusted and the standard cutoff value). Although these animals would typically be classified as non-shedders, they could be important to infection dynamics on the farm. Animals that shed at least twice consecutively and animals that shed in high quantities rarely reverted to negativity. Repeated fecal qPCR can be used to detect temporal fecal shedding traits, and the decision to cull an animal could practically be based on temporal, semiquantitative results. Overall, we found a mismatch between fecal shedding and ELISA seropositivity (637 animals were ELISA-negative 4 times, but only 13% of those animals were qPCR-negative 4 times). We found that having more than 2 ELISA-positive samples was strongly related to persistent and continuous shedding. We suggest that although serological testing is much less sensitive than qPCR, it can also be used, particularly over the course of multiple testing events, to identify animals that are most likely to contribute to the contamination of the farm environment.

Evaluating the Importance of the Concurrent Methylation Pattern of the DAPK1 Gene and the Quantification of Human Papillomavirus as a Diagnostic Biomarker in Cervical

Evaluating the Importance of the Concurrent Methylation Pattern of the DAPK1 Gene and the Quantification of Human Papillomavirus as a Diagnostic Biomarker in Cervical

163-OR: Sensitivity Analysis of Alternate Definitions of Multiple Islet Autoantibody Positivity

The development of multiple islet autoantibodies (IA) predicts progression to type 1 diabetes (T1D), and forms the basis of current staging of T1D. However, age at seroconversion, persistence of IA, and frequency of sampling influence the determination of multiple IA status. Individual IA may appear at different timepoints and fluctuate. This analysis aims to understand how differences in the stringency of multiple IA status definition impact risk estimates of progression to stage 3 T1D. We combined data from three birth-cohort studies (N=18,537): DAISY (U.S.), DiPiS (Sweden) and DIPP (Finland), defining four groups by IA positivity pattern and accounting for variability in persistence and timing in concurrent and sequential patterns of IAA, IA2A, and GADA. Subjects were placed exclusively in their most stringent IA group. Cumulative incidence of progression to T1D was estimated by survival analysis and log-rank test, which showed group differences (p&amp;lt;0.0001). T1D risk 15 years after seroconversion [95% CI] increased according to increasing stringency of the definition: Single IA/Persistent 10% [6%, 14%], multiple IA/Any 17% [3%, 29%], multiple IA/Same Visit 40% [17%, 57%], and multiple IA/Persistent 74% [69%, 77%]. Enhanced understanding of the characteristics of IA patterns can better inform recruitment for intervention studies and improve communication of risk during pre-symptomatic T1D screening. Disclosure B. Liu: None. M. Ghalwash: None. V. Anand: None. E. Koski: None. K. Ng: None. J.L. Dunne: None. M. Lundgren: None. H. Elding Larsson: None. W. Hagopian: Research Support; Self; Novo Nordisk A/S. R. Veijola: None. B.I. Frohnert: None. Funding JDRF

A Versatile Triangular Patch Array for Wideband Frequency Alteration With Concurrent Circular Polarization and Pattern Reconfigurability

This paper focuses on the design with experimental verification of a circular polarization (CP) and pattern reconfigurable triangular patch array simultaneously operating at various tunable frequencies. The resonant frequency of the antenna can be altered from 1.97 to 2.54 GHz (25.3% tunable bandwidth) by varying the capacitance values from 4.27 to 1.15 pF of the six varactors fixed between the annular slots on the three triangular patches. A wideband phase shifting network with switching capability is also designed which facilitates the antenna to operate it in both types of CP and pattern reconfigurable modes at each frequency. The antenna is tested in receiving mode and it shows a maximum realized gain of 3.1 dBc when operated in any of the CP mode and 1.45 dB for pattern reconfigurability mode. It has a very wideband axial ratio (AR) value (<3 dB) at each reconfigured frequency and also covers the entire frequency agility bandwidth. Investigation confirms that the antenna produces circularly polarized radiation pattern with minimum AR beamwidth of 24° at all frequency bands for both types of CP radiation. It is also observed that the antenna pattern can be rotated at 120° angle in the complete azimuth plane with a wide 3 dB beamwidth of ±45° at its operating frequencies. The multifaceted reconfiguring ability of the antenna enables it to serve many futuristic communication system requirements such as supporting multiple radios and maintaining signal quality in diverse climatic conditions.

A latent class analysis of the past-30-day substance use patterns among lifetime cocaine users: Findings from a community sample in North Central Florida

ObjectivesCocaine use is increasing and many cocaine users engage in polysubstance use. Within polysubstance use, relationships among use of individual substances are necessarily complex. To address this complexity, we used latent class analysis (LCA) to identify patterns of polysubstance use among lifetime cocaine users and examine associations among these patterns, demographics, and risk profiles. MethodsMembers of HealthStreet, an ongoing community engagement program, were asked about lifetime and past 30-day use of cocaine, alcohol, tobacco, marijuana, and prescription medications, mental health conditions, recent Emergency Department (ED) visits and demographics. LCA was used to identify classes of past 30-day polysubstance use among individuals who endorsed lifetime cocaine use. Multinomial logistic regression identified factors associated with these classes. ResultsAmong 1797 lifetime cocaine users, a five-class LCA model was identified: 1) past 30-day tobacco use only (45%), 2) past 30-day alcohol, marijuana and tobacco use (31%), 3) past 30-day tobacco, prescription opioid and sedative use (13%), 4) past 30-day cocaine, alcohol, marijuana and tobacco use (9%), 5) past 30-day cocaine and multiple polysubstance use (2%). Demographics, ED visits and mental health conditions were associated with class membership. ConclusionsApproximately 11% of lifetime cocaine users used cocaine in the past 30 days with two different concurrent substance use patterns. Prescription medication (opioids and sedatives) and complex polysubstance use patterns were stronger indicators of negative outcomes than current cocaine use. Cocaine was not used frequently with other stimulants. In addition to polysubstance use, prescription medication use should be targeted for intervention among lifetime cocaine users.

Criterion Validity of the Early Communication Indicator for Infants and Toddlers

The Early Communication Indicator (ECI) is a progress monitoring measure designed to support intervention decisions of the home visitors and early educators who serve infants and toddlers. The present study sought to add to the criterion validity claims of the ECI in a large sample of children using measures of language and preliteracy not previously investigated. Early Head Start service providers administered and scored ECIs quarterly for infants and toddlers in their caseload as part of standard services. In addition, a battery of language and early literacy criterion tests were administered by researchers when children were 12, 24, 36, and 48 months of age. Analyses of this longitudinal data then examined concurrent and predictive correlational patterns. Results indicated that children grew in communicative proficiency with age, and weak to moderately strong patterns of relationship emerged that differed by ECI scale, age, and criterion measure. The strongest positive patterns of relationships were between Single Words and Multiple Words and the criterion at older ages. Gestures and Vocalizations established a pattern of negative relationships to the criterion measures. Implications for research and practice are discussed.