With the development of economy and science and technology, computer has become an indispensable tool for people to live and work. Entering a new development period, the rapid development of information technology makes the application of computer more and more extensive. Applying computer technology to music teaching in schools has important practical significance for solving the problem that traditional teaching is too theoretical and improving the effect of music teaching. The combination of music teaching and computer music technology in Colleges and universities and the practical application and operation reform of music theory is a qualitative change improvement to the shortcomings of the traditional music teaching mode. At the same time, it can effectively stimulate college students’ interest in learning music and improve the teaching quality. This paper discusses how to apply computer music technology to music teaching in Colleges and universities, aiming to further improve students’ interest in learning and explore more convenient and effective teaching methods and ways for music classroom teaching.