Pathogenic variants in the transmembrane sulfate transporter protein SLC26A2 are associated with different phenotypes of inherited chondrodysplasias. As limited data is published from India, in this study we sought to elucidate the molecular basis of... Read More
Computational Biology Research Articles
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Computational biology insights into genotype-clinical phenotype-protein phenotype relationships between novel SLC26A2 variants identified in inherited skeletal dysplasias
- European Journal of Medical Genetics
- VOL. 65
on Oct 1, 2022
DeepRHD: An efficient hybrid feature extraction technique for protein remote homology detection using deep learning strategies
- Computational Biology and Chemistry
- VOL. 100
on Oct 1, 2022
In computational biology, the Protein Remote homology Detection technique (PRHD) has got undeniable significance. It is mostly important for structure and function identification of a protein sequence. The previous years have seen a challenge that la... Read More
Editorial: Recent advances in computational biology
- Chaos, Solitons & Fractals
- VOL. 163
on Oct 1, 2022
Editorial: Recent advances in computational biology.
- Chaos, solitons, and fractals
- VOL. 163
on Oct 1, 2022
The path via pathway-based approaches towards safety assessment: A concise review
- Toxicology and Applied Pharmacology
- VOL. 452
on Oct 1, 2022
For decades, chemical safety assessment has been proposed to shift from animal testing to in vitro testing systems in response to the call for the 3R. In Europe, the answer was to combine various information sources in integrated testing strategies (... Read More
Antifungal activity and molecular mechanisms of mulberrin derivatives against Colletotrichum gloeosporioides for mango storage
- International Journal of Food Microbiology
- VOL. 378
on Oct 1, 2022
In this work, by using high throughput virtual screening and bioactivity assays, this work revealed that three natural compounds, mulberrin (Mul) exhibiting the highest anti-CYP51 activity, isoxanthohumol and (s)-isopsoralen markedly inhibited 14α-de... Read More
Decoding brain memory formation by single-cell RNA sequencing
- Briefings in Bioinformatics
on Sep 24, 2022
Abstract To understand how distinct memories are formed and stored in the brain is an important and fundamental question in neuroscience and computational biology. A population of neurons, termed engram cells, represents the physiologi... Read More
Organizing the bacterial annotation space with amino acid sequence embeddings
- BMC Bioinformatics
- VOL. 23
on Sep 23, 2022
BackgroundDue to the ever-expanding gap between the number of proteins being discovered and their functional characterization, protein function inference remains a fundamental challenge in computational biology. Currently, known protein annotations a... Read More
Feature importance network reveals novel functional relationships between biological features in Arabidopsis thaliana
- Frontiers in Plant Science
- VOL. 13
on Sep 23, 2022
Understanding how the different cellular components are working together to form a living cell requires multidisciplinary approaches combining molecular and computational biology. Machine learning shows great potential in life sciences, as it can fin... Read More
Predicted cellular interactors of the endogenous retrovirus-K protease enzyme
- Frontiers in Virology
- VOL. 2
on Sep 23, 2022
Retroviral proteases are essential enzymes for viral replication and drive changes within the cellular proteome. While several studies have demonstrated that protease (PR) enzymes from exogenous retroviruses cleave cellular proteins and modulate cell... Read More
A pyroptosis-related gene signature predicting survival and tumor immune microenvironment in breast cancer and validation
- BMC Cancer
- VOL. 22
on Sep 22, 2022
BackgroundPyroptosis is a newly discovered form of cell programmed necrosis, but its role and mechanism in cancer cells remain unclear. The aim of this study is to systematically analyze the transcriptional sequencing data of breast cancer (BC) to fi... Read More
SPRoBERTa: protein embedding learning with local fragment modeling
- Briefings in Bioinformatics
on Sep 22, 2022
Abstract Well understanding protein function and structure in computational biology helps in the understanding of human beings. To face the limited proteins that are annotated structurally and functionally, the scientific community emb... Read More
Computational modelling in health and disease: highlights of the 6th annual SysMod meeting
- Bioinformatics
on Sep 22, 2022
Abstract Summary The Community of Special Interest (COSI) in Computational Modelling of Biological Systems (SysMod) brings together interdisciplinary scientists interested in combining data-driven c... Read More
Post-COVID-19 Pandemic Impact Assessment of Bioinformatics and Women Bioinformaticians: A Realm of Possibilities or Gloom-Ridden
- The Open COVID Journal
- VOL. 2
on Sep 21, 2022
COVID-19 has greatly influenced the worldwide scientific community to shift its focus towards computational and multidisciplinary approaches to meet the needs around the world. In contrast, a downfall in women computational biologists was significant... Read More
Deep RNA sequencing of intensive care unit patients with COVID-19
- Scientific Reports
- VOL. 12
on Sep 21, 2022
AbstractCOVID-19 has impacted millions of patients across the world. Molecular testing occurring now identifies the presence of the virus at the sampling site: nasopharynx, nares, or oral cavity. RNA sequencing has the potential to establish both the... Read More
Clustered tree regression to learn protein energy change with mutated amino acid
- Briefings in Bioinformatics
on Sep 17, 2022
Abstract Accurate and effective prediction of mutation-induced protein energy change remains a great challenge and of great interest in computational biology. However, high resource consumption and insufficient structural information o... Read More
Climatic clustering and longitudinal analysis with impacts on food, bioenergy, and pandemics
- Phytobiomes Journal
on Sep 15, 2022
Predicted growth in world population will put unparalleled stress on the need for sustainable energy and global food production, as well as increase the likelihood of future pandemics. In this work, we identify high-resolution environmental zones in... Read More
BDEtools: A MATLAB Package for Boolean Delay Equation Modeling
- Journal of Computational Biology
on Sep 13, 2022
Boolean Delay Equations (BDEs) can simulate surprisingly complex behavior, despite their relative simplicity. In addition to steady-state dynamics, BDEs can also generate periodic and quasiperiodic oscillations, m:n frequency locking, and even chaos.... Read More
Artificial Intelligence Applied to Medical Imaging and Computational Biology
- Applied Sciences
- VOL. 12
on Sep 8, 2022
The Special Issue “Artificial Intelligence Applied to Medical Imaging and Computational Biology” of the Applied Sciences Journal has been curated from February 2021 to May 2022, which covered the state-of-the-art and novel algorithms and applications... Read More
Protein Function Analysis through Machine Learning
- Biomolecules
- VOL. 12
on Sep 6, 2022
Machine learning (ML) has been an important arsenal in computational biology used to elucidate protein function for decades. With the recent burgeoning of novel ML methods and applications, new ML approaches have been incorporated into many areas of ... Read More