Abstract. The article discusses issues of a comprehensive rehabilitation approach for patients with melanoma when treated with immunotherapy. By focusing on innovative treatments, the study highlights the need to integrate nutritional support, physical therapy, magnetic therapy and psychological support to improve quality of life and enhance the effectiveness of immunotherapy regimens. Purpose. The study aims to evaluate the impact of a multidisciplinary rehabilitation program on improving physiological functions, psychoemotional well-being and the impact on the overall antitumor response, which together can improve the quality of life of patients with melanoma. Materials and methods. The study included 135 patients diagnosed with melanoma who received a course of immunotherapy. In the study group (the main group), a complex of rehabilitation techniques was used (magnetic therapy, physical therapy, nutritional support, psychological support), while in the control group, patients did not undergo an accompanying comprehensive rehabilitation program. Treatment effectiveness was assessed in accordance with iRECIST 1.1 criteria. To assess the quality of life, the Russian version of the EORTC QLQ-C30 questionnaire was used. The severity of adverse events was assessed according to CTCAE 5.0 criteria. Results. Patients from the main group who received comprehensive rehabilitation support along with immunotherapy showed an improvement in their general physical condition and a decrease in the intensity of some side effects of treatment. Patients in the control group who received only standard immunotherapy also showed changes in their health status, but these changes were less pronounced compared to the main group. Adverse events during treatment occurred in 55 % of patients in the main group and in 74 % in the control group. Patients in the main group noted an improvement in quality of life by 25 %, while in patients in the control group this figure was 12 %. An 18 % improvement in general condition was noted by patients in the main group, while patients in the control group noted an 8 % improvement in general condition. Conclusion. Implementation of a multidisciplinary rehabilitation approach, including nutritional support, physical therapy exercises, magnetic therapy, and psychological support, demonstrates significant improvements in symptom management and quality of life in melanoma patients undergoing immunotherapy.