ABSTRACT Purpose This study examined word list and connected text oral reading fluency of persons with alexia and aphasia and whether fluency predicts reading comprehension abilities. Method Twelve individuals with chronic alexia and aphasia and twelve neurotypical, age- and education-matched individuals read aloud real and non word reading lists and paragraphs to elicit measures of fluency. Participants answered comprehension questions following the paragraphs. Descriptive statistics, independent samples t-tests, and multiple linear regression were used to analyze fluency and comprehension. Results Neurotypical adults read significantly more fluently than persons with alexia and aphasia for word lists and paragraphs. For both participant groups, comprehension was not found to be significantly influenced by oral non word list fluency, oral real word list fluency, or oral paragraph reading fluency. Conclusions Though results are interpreted with caution due to study limitations, the study provides an initial framework for characterizing fluency and comprehension of oral single word list and oral paragraph reading in persons with alexia and aphasia. Clinical implications include caution with use of list reading for assessing reading ability, as well as the need for better assessments for diagnosing alexia.