Channel Complex Research Articles

A reduced complexity rate-matching and channel interleaver/de-interleaver for 5G NR

Rate matching and channel interleavers play a pivotal role in code rate adaptation and minimizing burst errors in communication systems. The data and control channels in the Fifth generation (5G) New Radio (NR) employs distinct channel interleavers/de-interleavers for reducing bit error rate. However, the independent implementation results in a substantial increase in silicon cost. To address this challenge, hardware sharing is pivotal for optimizing resource utilization and improving overall system performance. This study introduces a rate-matching architecture and a simple algorithm for the creation of a new Shared-Resource Channel interleaver/De-interleaver (SRC) architecture. The proposed work ensures low complexity tailored for both data and control channels within the 5G NR framework by incorporating the hardware sharing technique. The proposed SRC architecture, synthesized on the Virtex-7 Field Programmable Gate Array (FPGA), showcases noteworthy advancements over existing 5G NR interleaver architecture, achieving a notable 23% reduction in resource utilization. Through implementation using the Qflow Compiler in 45 nm CMOS technology, the ASIC synthesis of the proposed design demonstrates a substantial decrease in hardware complexity and area by 44.6% and 43%, respectively. Furthermore, the proposed architecture exhibits a 19.2% reduction in power consumption compared to its existing counterpart in 5G NR. The proposed integrated design demonstrates a remarkable resource efficiency by occupying nearly half the resources compared to individual implementations.

WITHDRAWN: Ip3r-Grp75-Vdac and Relevant Ca2+ Signaling Regulate Dietary Palmitic Acid-Induced De Novo Lipogenesis by Mitochondria-Associated ER Membrane (MAM) Recruiting Seipin in Yellow Catfish

BackgroundThe mitochondria-associated endoplasmic reticulum membrane (MAM) is the central hub for endoplasmic reticulum and mitochondria functional communication. It plays a crucial role in hepatic lipid homeostasis. However, even though MAM has been acknowledged to be rich in enzymes that contribute to lipid biosynthesis, no study has yet investigated the exact role of MAM on hepatic neutral lipid synthesis. ObjectivesTo address these gaps, this study investigated the systemic control mechanisms of MAM on neutral lipids synthesis by recruiting seipin, focusing on the role of the inositol trisphosphate receptor-1,4,5(Ip3r)-75 kDa glucose-regulated protein (Grp75)-voltage-dependent anion channel (Vdac) complex and their relevant Ca2+ signaling in this process. MethodsTo this end, a model animal for lipid metabolism, yellow catfish (Pelteobagrus fulvidraco), were fed 6 different diets containing a range of palmitic acid (PA) concentrations from 0–150 g/kg in vivo for 10 wk. In vitro, experiments were also conducted to intercept the MAM-mediated Ca2+ signaling in isolated hepatocytes by transfecting them with si-mitochondrial calcium uniporter (mcu). Because mcu was placed in the inner mitochondrial membrane (IMM), si-mcu cannot disrupt MAM’s structural integrity. Results1. Hepatocellular MAM subproteome analysis indicated excessive dietary PA intake enhanced hepatic MAM structure joined by activating Ip3r-Grp75-Vdac complexes. 2. Dietary PA intake induced hepatic neutral lipid accumulation through MAM recruiting Seipin, which activated lipid droplet biogenesis. Our findings also revealed a previously unidentified mechanism whereby MAM-recruited seipin and controlled hepatic lipid homeostasis, depending on Ip3r-Grp75-Vdac-controlled Ca2+ signaling and not only MAM’s structural integrity. ConclusionsThese results offer a novel insight into the MAM-recruited seipin in controlling hepatic lipid synthesis in a MAM structural integrity-dependent and Ca2+ signaling-dependent manner, highlighting the critical contribution of MAM in maintaining hepatic neutral lipid homeostasis.

An improved CFD particulate fouling simulation method: The local fouling method

In most of the modern and developed industries, water is used as heat transfer fluid. However, the accumulation of many precipitates and suspended solids in some locations results in particulate fouling on the surface of heat exchangers. To anticipate the particulate fouling deposition at the specific location of the heat exchanger channel, an improved CFD particulate fouling model is proposed in this study, namely, the local fouling method. The method is applied to study the heat transfer surfaces of smooth and complex channels along with their particulate fouling deposition process. The results illustrate that the modeled fouling resistance of the two channels is in good agreement with the published experimental data. The average value of local fouling resistance obtained by the local method can substitute the integral fouling resistance obtained by the integral method. In addition, the fouling resistance data obtained by the local method approach has a stronger correlation with the experimental data as compared to that obtained by the existing integral method. And the local method may be applied to obtain local fouling information for both smooth and complex channels heat transfer surfaces.

Peristaltic transport of magnetized Williamson hybrid nanofluid in a complex wavy channel with various shape features

Peristaltic transport of magnetized Williamson hybrid nanofluid in a complex wavy channel with various shape features

Biological activity of a benzene sulfonamide on perfusion pressure and coronary resistance using an isolated rat heart model

There are studies which indicate that some sulfonamide derivatives can produce changes in the cardiovascular system; however, their biological activity on perfusion presure and coronary resistance is not clear. The aim of this research was to evaluate the effect exerted by benzenesulfonamide, and their derivatives (2,5-dichloro- N-(4-nitro-phenyl)-benzene-sulfonamide, 2-hydrazino-carbonyl-benzenesulfonamide, 4-(2-amino-ethyl)-benze- ne-sulfonamide, and 4-[3-(4-nitro-phenyl)-ureido]-benzene- sulfonamide) on perfusion pressure and coronary reistance. To evaluate the biological activity of benzenesulfonamide and their derivatives on perfusion pressure and coronary reistance an isolated rat heart model was used. Furthermore, theoretical interaction of 4-(2-amino-ethyl)-benzenesul- fonamide with Calcium channel surface was determined using 6jp5 protein, nifedipine, amlodipine, verapamil and BayK 8644 as theoretical tools in a DockingServer program. The Results showed that 4-(2-amino-ethyl)-ben- zenesulfonamide decreased perfusion pressure and coronary resistance compared to benzenesulfonamide, 2,5-dichloro- N-(4-nitro-phenyl)-benzene-sulfonamide, 2-hydrazinocar- bonyl-benze-nesulfonamide, 4-[3-(4-nitro-phenyl)-ureido]- benenesulfonamide and the control conditions. Besides, theoretical data suggest that 4-(2-aminoethyl)benzenesulfo- namide could interact with aminoacid residues such as Glu614 and Ala320 involved in 6jp5 protein surface. This phenomenon could result in an ligand-Calcium channel complex formation to produce a decrease in perfusion pressure and vascular resistance. It is noteworthy that biological and experimental models used in this study is an invaluable research tool for investigating questions across the spectrum of physiologic functions of cardiovascular system such as perfusion pressure and coronary resistance

Modulation format recognition in a UVLC system based on an ultra-lightweight model with communication-informed knowledge distillation

Modulation format recognition (MFR) is a key technology for adaptive optical systems, but it faces significant challenges in underwater visible light communication (UVLC) due to the complex channel environment. Recent advances in deep learning have enabled remarkable achievements in image recognition, owing to the powerful feature extraction of neural networks (NN). However, the high computational complexity of NN limits their practicality in UVLC systems. This paper proposes a communication-informed knowledge distillation (CIKD) method that achieves high-precision and low-latency MFR with an ultra-lightweight student model. The student model consists of only one linear dense layer under a communication-informed auxiliary system and is trained under the guidance of a high-complexity and high-precision teacher model. The MFR task involves eight modulation formats: PAM4, QPSK, 8QAM-CIR, 8QAM-DIA, 16QAM, 16APSK, 32QAM, and 32APSK. Experimental results show that the student model based on CIKD can achieve comparable accuracy to the teacher model. After knowledge transfer, the prediction accuracy of the student model can be increased by up to 87%. Besides, it is worth noting that CIKD’s inference accuracy can reach up to 100%. Moreover, the parameters constituting the student model in CIKD correspond to merely 18% of the parameters found in the teacher model, which facilitates the hardware deployment and online data processing of MFR algorithms in UVLC systems.

Design and construction of a helium cooling experimental loop

The helium cooling tritium breeding blanket and helium cooling divertor, which produce tritium or heat, are important components in Chinese Fusion Engineering Test Reactor (CFETR) design. The helium cooling system, which function is similar to the primary loop of Pressurized Water Reactor (PWR), is designed to extract energy from blankets and divertors. These helium cooling components have many complex internal flow channels to extract high thermal load. They also have to withstand electromagnetic force, thermal stress and coolant pressure, etc. Therefore, out-of-pile experiments must be carried out as far as possible to verify the design. Under CFETR project support, a helium cooling experiment loop is built to carry out the thermo-hydraulic experiments for these components and to accumulate experience of helium cooling system. According to the cooling requirements of blanket, the loop test section operating parameters are flow rate 2.5kg/s, temperature 550°C and pressure 12MPa. During preliminary commissioning, these parameters have been reached. A high heat flux testing facility will connect to this loop for future experiments.

Abstract 762: The combination of EPA and naproxen suppresses colon tumorigenesis via altering the TME, and promoting epithelial maturation in cancerous crypts

Abstract Introduction: Colorectal cancer (CRC) is a leading cause of cancer-associated mortality. Our recent study in Pirc rats revealed that the combination of eicosapentaenoic acid and sodium naproxen exhibited additive tumor protection. While the results from this preclinical study were impressive, showing tumor suppression in excess of 95%, potential mechanisms underlying this tumor protection remain unclear. The purpose of this study was to determine the transcriptomic changes resulting in the tumor suppression afforded by the combination of EPA and naproxen supplementation in the diet. Methods: Six week-old Pirc rats were fed either a control AIN-93G diet, or AIN-93G diet supplemented with 2% EPA combined with 200 ppm naproxen, for a total of 20 weeks. Global transcriptomic analysis was performed using RNA sequencing (RNA-Seq) of colon tumors and tumor-adjacent normal tissue from 26-week-old Pirc rats. 100-bp paired-end sequencing was performed on an Illumina NovaSeq to a depth of 25 million reads per sample. Reads were trimmed with Trimmomatic-v0.39, and reads were mapped to the mRatBN7.2.105 rat reference genome using HISAT2. Differentially expressed genes were calculated using DESeq2, and gene set enrichment analysis (GSEA) were performed using Rstudio. Results: DESeq2 identified 809 differentially expressed genes (DEGs, 2-fold change > 1, FDR < 0.05) between large tumors from AIN-93G fed rats versus suppressed tumors from rats fed the combination of EPA and naproxen (490 up-regulated, 319 down-regulated). GSEA analysis revealed activation of inflammatory pathways including IL-17 signaling, JAK-STAT signaling, complement activation, cytokine signaling, ribosome biogenesis, and cell cycle were enriched in untreated control. In contrast, suppressed tumors from animals supplemented with EPA and naproxen were enriched in pathways including negative regulation of Wnt signaling, cell fate specification, ion channel complexes, and nutrient absorption. Furthermore, suppressed tumors shared significant GSEA pathway overlap with normal tissue, leading us to believe the combination of EPA and naproxen may be preventing tumorigenesis in part by maintaining cells in a differentiated state. Conclusion and Future directions: Inflammation plays a key role in tumorigenesis and promoting cancer stem cell niches in tumors. According to our analysis, the combination of EPA and naproxen attenuated cancer-associated inflammation and reduced proliferation in part by augmenting tumor differentiation. Future studies will utilize single-nuclei RNA-Seq (snRNA-Seq) to determine at a single cell resolution the transcriptomic changes of epithelial and stromal populations within the TME. This work was supported by National Cancer Institute task order 75N91019F00132. Citation Format: Ryan Beach, Michael Martinez, Vignesh Gunasekharan, Daniel W. Rosenberg. The combination of EPA and naproxen suppresses colon tumorigenesis via altering the TME, and promoting epithelial maturation in cancerous crypts [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 762.

Remote control of fluid motion in a channel by acoustic holography

A new method for manipulating fluid movement using sound waves is presented in this paper. The method relies on acoustic streaming near the free surface of the fluid in a channel with an open top. The sound waves are modulated in phase using acoustic phase holography, which creates a periodic phase pattern from 0 to 2π along a straight path on a target plane. The paper also describes an experimental design to study the main factors influencing the method, such as frequency, number of phase patterns in the path, and sound pressure amplitude. The paper shows that phase pitch and voltage significantly affects fluid speed and that there is a good match between the theoretical and experimental results. Furthermore, the article reports additional experiments with different channel shapes to demonstrate the versatility of the method in controlling fluid motion. The highest fluid speed observed was 0.4 mm/s at a frequency of 1300 kHz and a phase pitch of 5. The paper also investigates the effect of changing the frequency on reversing the flow direction in a U-shaped channel, both experimentally and theoretically. The paper concludes that this method could be a suitable alternative to other acoustic devices for inducing fluid motion because of its simple and flexible design, fabrication, accuracy, and ability to handle complex channels.

Measurements and Simulations of the Flow Distribution in a Down-Scaled Multiple Outlet Spillway with Complex Channel

Measurements of mass flow through a three-outlet spillway modeled after a scaled-down spillway were conducted. The inlet and channel leading up to the outlets were placed to lead the water toward the outlet at an angle. With this, measurements of the water level at three locations were recorded by magnetostrictive sensors. The volumetric flow rates for each individual outlet were recorded separately to study the differences between them. Additionally, Acoustic Doppler Velocimetry was used to measure water velocities close to the outlets. The conditions changed were the inlet volume flow rate and the flow distribution was measured at 90, 100, 110, and 200 L per second. Differences between the outlets were mostly within the error margin of the instruments used in the experiments with larger differences shown for the 200 L test. The results produced together with a CAD model of the setup can be used for verification of CFD methods. A simulation with the k-epsilon turbulence model is included and compared to earlier experiments and the new experimental results. Larger differences are seen in the new experiments. Differing inlet conditions are assumed as the principal cause for the differences seen.

Relay-node Selection Method Based on Weighted Strategy for 3D Scenario in Internet of Vehicles

<p>In recent years, Internet of Vehicles (IoV), as a supporting technology for Intelligent Transportation System (ITS), is flourishing with the emergence and development of new technologies such as edge computing, 5G communication, and Artificial Intelligence (AI). However, the more complexity of wireless channels and vehicle distribution in 3D scenario brings a great challenge for relay-node selection in ITS. In this paper, we focus on how to alleviate the problem that the decline of two-hop distance and two-hop connection probability caused by the relative fading of inter-layer communication radius in 3D scenario with Vehicle-to-Vehicle (V2V) communication. To face this challenge, we develop a Relay-node Selection method based on Weighted Strategy for Overpass scenario (RSWSO). The simulation results show that RSWSO achieves improvement in two-hop distance, and an increase of up to 11.2% in terms of two-hop connection probability.</p> <p> </p>

Postsynaptic β1spectrin maintains Na+ channels at the neuromuscular junction.

Spectrins function together with actin as obligatory subunits of the submembranous cytoskeleton. Spectrins maintain cell shape, resist mechanical forces, and stabilize ion channel and transporter protein complexes through binding to scaffolding proteins. Recently, pathogenic variants of SPTBN4 (β4spectrin) were reported to cause both neuropathy and myopathy. Although the role of β4spectrin in neurons is mostly understood, its function in skeletal muscle, another excitable tissue subject to large forces, is unknown. Here, using a muscle specific β4spectrin conditional knockout mouse, we show that β4spectrin does not contribute to muscle function. In addition, we show β4spectrin is not present in muscle, indicating the previously reported myopathy associated with pathogenic SPTBN4 variants is neurogenic in origin. More broadly, we show that α2, β1 and β2spectrins are found in skeletal muscle, with α2 and β1spectrins being enriched at the postsynaptic neuromuscular junction (NMJ). Surprisingly, using muscle specific conditional knockout mice, we show that loss of α2 and β2spectrins had no effect on muscle health, function or the enrichment of β1spectrin at the NMJ. Muscle specific deletion of β1spectrin also had no effect on muscle health, but, with increasing age, resulted in the loss of clustered NMJ Na+ channels. Together, our results suggest that muscle β1spectrin functions independently of an associated α spectrin to maintain Na+ channel clustering at the postsynaptic NMJ. Furthermore, despite repeated exposure to strong forces and in contrast to neurons, muscles do not require spectrin cytoskeletons to maintain cell shape or integrity. KEY POINTS: The myopathy found in pathogenic human SPTBN4 variants (where SPTBN4 is the gene encoding β4spectrin) is neurogenic in origin. β1spectrin plays essential roles in maintaining the density of neuromuscular junction Nav1.4 Na+ channels. By contrast to the canonical view of spectrin organization and function, we show that β1spectrin can function independently of an associated α spectrin. Despite the large mechanical forces experienced by muscle, we show that spectrins are not required for muscle cell integrity. This is in stark contrast to red blood cells and the axons of neurons.

Modulation of potassium channels by transmembrane auxiliary subunits via voltage-sensing domains.

Voltage-gated K+ (KV ) and Ca2+ -activated K+ (KCa ) channels are essential proteins for membrane repolarization in excitable cells. They also play important physiological roles in non-excitable cells. Their diverse physiological functions are in part the result of their auxiliary subunits. Auxiliary subunits can alter the expression level, voltage dependence, activation/deactivation kinetics, and inactivation properties of the bound channel. KV and KCa channels are activated by membrane depolarization through the voltage-sensing domain (VSD), so modulation of KV and KCa channels through the VSD is reasonable. Recent cryo-EM structures of the KV or KCa channel complex with auxiliary subunits are shedding light on how these subunits bind to and modulate the VSD. In this review, we will discuss four examples of auxiliary subunits that bind directly to the VSD of KV or KCa channels: KCNQ1-KCNE3, Kv4-DPP6, Slo1-β4, and Slo1-γ1. Interestingly, their binding sites are all different. We also present some examples of how functionally critical binding sites can be determined by introducing mutations. These structure-guided approaches would be effective in understanding how VSD-bound auxiliary subunits modulate ion channels.

“An Overview On Biological Behavior Of Benzotriazole: Synthesis And Docking Study On Its Versatile Biological Activities”

The practice of medicinal chemistry is devoted to the discovery and development of new chemical agents for treating diseases. Triazoles are obtained by a slight modification of azole ring and similar or improved activities as well as fewer adverse effects are reported for triazole derivatives several advantages are the notable attraction for using benzotriazole moiety-dependent methodologies, in my research work I synthesized various derivatives of n-(1h-benzotriazol-6-yl)-benzamide from Benzene 1,2,4-triamine and benzoic acid with high yield and the synthesized derivatives characterized by FT-IR spectrum, H1 NMR spectrum, and mass spectrum data of synthesized derivatives compounds of benzotriazole Scheme analysis proves that resultant compounds n-(1h-benzotriazol-6-yl)-benzamide derivatives. The molecular docking studies validated the outcome results from the anti-inflammatory and antiarthritic agents and signifies the potential of these derivatives as crystal structure of C-terminus of voltage-gated sodium channel in complex (PDB ID:4DCK) and COX 2 Inhibitor (PDB ID:1CX2) inhibitors. So, these compounds can be modified further for the development of new anti-inflammatory and antiarthritic agents. This study strongly suggests that most of molecules synthesized in this study may indeed be promising drug candidates with interesting pharmacological profile and most of these derivatives could be a fruitful for further development of better anti-inflammatory and antiarthritic activity.

Protocols of data collection networks based on IEEE 802.15.4 radio channels in complexes for the protection of underground metal structures from electrochemical corrosion

Radio communication systems in telemetry and telemechanics systems of active electrochemical protection of underground metal structures are considered. The requirements for radio exchange systems for data collection networks from remote control and measuring points of cathodic protection stations are formulated. The analysis of the applicability of known exchange protocols based on the specifications of the IEEE 802.15.4 standard and its software add-ons for such networks is carried out and the need for the development of specialized network and channel layer protocols is justified. The results of the development of specialized network protocols of the application, network and channel levels that implement data exchange modes required for the collection networks under consideration while minimizing energy consumption are presented.

System‐Wide Effects of Local Bed Disturbance on the Morphological Evolution of a Bifurcating Channel Network

AbstractDeltaic channel networks are important conduits for water and material supplies to the fluvial and coastal communities. However, increasing human interventions in river deltas have altered the topology and geometry of channel networks as well as their long‐term evolution. While the morphological evolution of a single channel has received extensive studies, the system‐wide morphological responses of channel networks to local disturbances remain largely unclear. Here we investigate the morphological responses of a bifurcating channel network subject to local disturbance of channel deepening due to dredging and sand mining through idealized simulations, and further compare the results with the reference scenarios of a single channel and theoretical analysis of the phase plane. The results show that the infilling of the local deepening is associated with the erosion of the entire branch, which also causes system‐wide effects on the siltation of the other branch. The morphological responses of the bifurcating channel network consist of a relatively short stage for the infilling of the local deepening followed by a relatively long stage for recovering the equilibrium configuration of the river bifurcation. The system‐wide effects of the local disturbance arise from the altered water surface slope and water partitioning downstream of the bifurcation due to the local deepening. Also, the prolonged recovery of the equilibrium configuration is consistent with theoretical analysis, which reveals a slow evolution of the bifurcation when approaching the equilibrium. Our results can help understand the long‐term morphological responses of large‐scale complex channel networks and inform water managements under increasing human interventions.

The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction

Mechanotransduction is the process by which a mechanical force, such as touch, is converted into an electrical signal. Transmembrane channel-like (TMC) proteins are an evolutionarily conserved family of membrane proteins whose function has been linked to a variety of mechanosensory processes, including hearing and balance sensation in vertebrates and locomotion in Drosophila. TMC1 and TMC2 are components of ion channel complexes, but the molecular features that tune these complexes to diverse mechanical stimuli are unknown. Caenorhabditis elegans express two TMC homologs, TMC-1 and TMC-2, both of which are the likely pore-forming subunits of mechanosensitive ion channels but differ in their expression pattern and functional role in the worm. Here, we present the single-particle cryo-electron microscopy structure of the native TMC-2 complex isolated from C. elegans. The complex is composed of two copies of the pore-forming TMC-2 subunit, the calcium and integrin binding protein CALM-1 and the transmembrane inner ear protein TMIE. Comparison of the TMC-2 complex to the recently published cryo-EM structure of the C. elegans TMC-1 complex highlights conserved protein-lipid interactions, as well as a π-helical structural motif in the pore-forming helices, that together suggest a mechanism for TMC-mediated mechanosensory transduction.

Underwater-Acoustic-OFDM Channel Estimation Based on Deep Learning and Data Augmentation

In UnderWater-Acoustic-Orthogonal-Frequency-Division-Multiplexing-(UWA-OFDM) communication, the traditional interpolated channel estimation method produces error codes, due to the small number of user pilots, uneven distribution, and complex channel characteristics. In this paper, we propose a novel UWA-channel-estimation method based on Deep Learning (DL). First, based on a small number of channel samples, we used the CWGAN-GP model to generate enhanced classified underwater-acoustic channel samples to have semantic similarity to the real samples and also to present the diversity of the samples. After obtaining the channel sample, the pilot estimation matrix was processed in a similar image way. Here, we extracted the channel features by constructing a convolutional network structure similar to U-Net, weakening the impact of feature information loss. A Channel-Attention-Denoising-(CAD) module was also designed, to further optimize the reconstructed channel information. The simulation results verified the superiority of the proposed algorithm, in terms of Mean Square Error (MSE) and Bit-Error Rate (BER) compared to the existing Least-Squares-(LS), Deep-Neural-Network-(DNN), and ChannelNet algorithms.

A Gas-Steamed Route to Mesoporous Open Metal-Organic Framework Cages Enhancing Flame Retardancy and Smoke Suppression of Polyurea.

Up to now, metal-organic frameworks (MOFs) with open nanostructures have shown outstanding capabilities in trapping smoke particles compared to the original MOFs. However, only a few MOF-based strategies have been reported to synthesize hierarchical porous cages thus far, which are mainly restricted to environmentally unfriendly wet-chemical liquid methods. Herein, as a proof-of-concept, a gas-steamed metal-organic framework approach was designed to fabricate a series of cheeselike open cages with hierarchical porosity. Briefly, zeolitic imidazolate framework-67 (ZIF-67) and phytic acid were employed as precursor and etchant, respectively. Abandoning the conventional wet-chemical method, the coordination bond of ZIF-67 was cleaved by acidic steam, forming an open framework with a high specific surface area and a hierarchical porous structure. The universality of this method was also confirmed by the selection of different etchants. Impressively, they also show outstanding fume-toxic adsorption capability and labyrinth effects based on abundant and complex porous channels. At only 5 wt % loading, Co3O4@open ZIF-67 cage-2 (Co3O4@OZC-2) imparted polyurea (PUA) composites with a 21.2% limiting oxygen index, and the peak of heat release rate, total heat release, and total smoke production were reduced by around 37.5, 25.5, and 40.4%, respectively, compared to neat PUA. This work will shed light on the advanced structural design of polymer composites with high fire safety, especially smoke suppression performance, so as to obtain more feasible applications.

Modulation of KCNQ1/KCNE channel complexes by intracellular zinc

Modulation of KCNQ1/KCNE channel complexes by intracellular zinc