Due to the project delay, the construction price of the first unit of the two types of third-generation nuclear motor type AP1000 and EPR in China is higher than the local benchmark price of coal. If the delay is not considered, only the first unit factor is considered, the price should be between 0.48-0.49 yuan/kWh. Compared with the construction period and electricity price of solar power generation and wind power, this price still has no advantage. Therefore, the economic efficiency of nuclear power has become a key factor to determine whether nuclear power can occupy a place in the future power market and then get rapid development. In this paper, combined with the construction experience of third-generation nuclear power in China, a comprehensive economic analysis of nuclear power is carried outfrom the design requirements, equipment procurement, construction period, financing channels, operation and maintenance strategies and other factors, so as to provide direction guidance for the economic improvement of the subsequent batch construction of the third-generation nuclear power and the better participation of nuclear power in the power market competition.