Compact X-ray Research Articles

Applicability of Large-Area Single-Photon Counting Detectors Timepix for High-Resolution and High-Contrast X-Ray Imaging of Biological Samples

High-resolution X-ray imaging techniques, usually known as microradiography and micro-computed tomography (CT), have become highly required and frequently used tools for biology, biomedical and preclinical research. State-of-the-art micro-CT scanners are capable of achieving a spatial resolution of few micrometers or even less, thanks to the constant development of compact microfocus X-ray sources together with simultaneous progress in detector technologies. The current standard in X-ray detection is a digital imaging device containing read-out circuitry coupled with a scintillation sensor. Such detectors are available in a variety of different sizes, and are easy to use and relatively affordable. Nevertheless, the mentioned technology suffers from inherent limitations like, for example, undesirable generation of dark current, that compromise the quality of the provided data. This work demonstrates the applicability of Timepix large-area hybrid-pixel photon-counting detectors (PCDs) for high-resolution X-ray imaging in biology research. Photon-counting detection technology provides dark-current-free quantum-counting operation. Therefore, an enhanced contrast-to-noise ratio of the acquired data is achieved. Furthermore, the biased semiconductor sensor achieves almost ideal point-spread function (PSF) resulting in images with high spatial-resolution. Both above-mentioned features make PCDs to be excellent tools for high-resolution X-ray imaging especially for samples with low intrinsic absorption contrast. We evaluated the imaging performance of large-area Timepix detectors compared to a state-of-the-art flat-panel detector dedicated for high-resolution X-ray imaging. The presented data demonstrate the versatility of the used detectors as it covers a wide range of samples from laboratory animals to single-cell marine organisms.

Photon yield of superradiant inverse Compton scattering from microbunched electrons

Compact x-ray sources offering high-brightness radiation for advanced imaging applications are highly desired. We investigate, analytically and numerically, the photon yield of superradiant inverse Compton scattering from microbunched electrons in the linear Thomson regime, using a classical electrodynamics approach. We show that for low electron beam energy, which is generic to inverse Compton sources, the single electron radiation distribution does not match well to collective amplification pattern induced by a density modulated electron beam. Consequently, for head-on scattering from a visible laser, the superradiant yield is limited by the transverse size of typical electron bunches driving Compton sources. However, by simultaneously increasing the electron beam energy and introducing an oblique scattering geometry, the superradiant yield can be increased by orders of magnitude.

Dust scattering halo around the CCO in HESS J1731–347: A detailed analysis

The supernova remnant (SNR) HESS J1731−347 is one of the few objects exhibiting emission up to the TeV energy band and it stands as a prime target for the study of cosmic ray acceleration in SNRs. It also hosts a central compact object (CCO), which is of interest in the context of the ultra-dense matter equation of state in neutron stars. For both types of studies, however, the parameters of the respective models depend crucially on the assumed distance to the object and are affected to a certain extent by the assumed interstellar medium (ISM) properties around the SNR. Here, we report on the first quantitative analysis of the properties of the compact X-ray dust scattering halo that is assumed to be present around the CCO based on Chandra observations of the source. Our findings unambiguously confirm the presence of a compact halo around the CCO, and we show that the observed halo properties are consistent with expectations from independent measurements of the dust distribution along the line of sight and the distance to the source. Although we were not able to significantly improve those constraints, our results are important for future studies of the CCO itself. Indeed, the halo contribution is expected to affect the X-ray spectrum and the derived parameters of the neutron star when observed with moderate angular resolutions. Our results, which offer a quantitative characterization of the halo properties, will be useful in accounting for this effect.

Computational method for the optimization of quasimonoenergetic laser Compton x-ray sources for imaging applications.

The development of compact quasimonoenergetic x-ray radiation sources based on laser Compton scattering (LCS) offers opportunities for novel approaches to medical imaging. However, careful experimental design is required to fully utilize the angle-correlated x-ray spectra produced by LCS sources. Direct simulations of LCS x-ray spectra are computationally expensive and difficult to employ in experimental optimization. In this manuscript, we present a computational method that fully characterizes angle-correlated LCS x-ray spectra at any end point energy within a range defined by three direct simulations. With this approach, subsequent LCS x-ray spectra can be generated with up to 200 times less computational overhead.

The Origin of The Soft X-Ray Excess in the Seyfert 1.5 Galaxy ESO 362-G18

We review the Seyfert 1.5 Galaxy ESO 362-G18 for exploring the origin of the soft X-ray excess. The Warm Corona and Relativistic Reflection models are two main scenarios to interpret the soft X-ray excess in active galactic nuclei at present. We use the simultaneous X-ray observation data of XMM-Newton and NuSTAR on 2016 September 24 to perform spectral analysis in two steps. First, we analyze the time-average spectra by using Warm Corona and Relativistic Reflection models. Moreover, we also explore the Hybrid model, Double Reflection model and Double Warm Corona model. We find that both the Warm Corona and Relativistic Reflection models can interpret the time-average spectra well but cannot be distinguished easily based on the time-averaged spectra fit statistics. Second, we add the rms and covariance spectra to perform the spectral analysis with time-average spectra. The result shows that the warm corona could reproduce all of these spectra well. The hot, optical thin corona and neutral distant reflection will increase their contribution with the temporal frequency, meaning that the corona responsible for X-ray continuum comes from the inner compact X-ray region and the neutral distant reflection is made of some moderate scale neutral clumps.

Low-energy X-ray irradiation: A novel non-thermal microbial inactivation technology.

Over the last several decades, food irradiation technology has been proven neither to reduce the nutritional value of foods more than other preservation technologies, nor to make foods radioactive or dangerous to eat. Furthermore, food irradiation is a non-thermal food processing technology that helps preserve more heat sensitive nutrients than those found in thermally processed foods. Conventional food irradiation technologies, including γ-ray, electron beam and high energy X-ray, have certain limitations and drawbacks, such as involving radioactive isotopes, low penetration ability, and economical unfeasibility, respectively. Owing to the recent developments in instrumentation technology, more compact and cheaper tabletop low-energy X-ray sources have become available. The generation of low-energy X-ray, unlike γ-ray, does not involve radioactive isotopes and the cost is lower than high energy X-ray. Furthermore, low-energy X-ray possesses unique advantages, i.e., high linear energy transfer (LET) value and high relative biological effect (RBE) value. The advantages allow low-energy X-ray irradiation to provide a higher microbial inactivation efficacy than γ-ray and high energy X-ray irradiation. In the last few years, various applications reported in the literature indicate that low-energy X-ray irradiation has a great potential to become an alternative food preservation technique. This chapter discusses the technical advances of low-energy X-ray irradiation, microbial inactivation mechanism, factors influencing its efficiency, current applications, consumer acceptance, and limitations.

Optimization of parameters of a compact soft X-ray source for operation in the wavelength range 2-5 nm

This paper presents a compact source of soft X-ray radiation for operation in the wavelength range of 2-5 nm with a pulse repetition frequency of more than 500 Hz. The source parameters were optimized to reduce the intensity of ablation of the discharge volume wall and obtain the maximum intensity of the spectral lines of multicharged ions C V --- 4 nm and Ar IX --- 4.87 nm. The obtained results can be used in the development of a microscope for the tasks of cell transmission microscopy with nanometer resolution. Keywords: High-voltage pulse generator, Capillary plasma, "Water-window" microscopy.

Matching-based two-color X-ray free-electron laser generation utilizing laser–plasma accelerated electron beam

Abstract Laser–plasma accelerators (LPAs) have great potential to realize a compact X-ray free-electron laser (FEL), which is limited by the beam properties currently. Two-color high-intensity X-ray FEL provides a powerful tool for probing ultrafast dynamic systems. In this paper, we present a simple and feasible method to generate a two-color X-ray FEL pulse based on an LPA beam. In this scheme, time-dependent mismatch along the bunch is generated and manipulated by the designed lattice system, enabling FEL lasing at different wavelength within two undulator sections. The time separation between the two pulses can be precisely adjusted by varying the time-delay chicane. Numerical simulations show that two-color soft X-ray FELs with gigawatt-level peak power and femtosecond duration can be generated, which confirm the validity and feasibility of the scheme.

Design, performance, and utilization of the Low-Energy X-ray Reflectometer at DTU space

A state-of-the-art compact Low-Energy X-ray Reflectometer is in operation at DTU Space and is used to characterize x-ray coatings for the optics of future spaceborne and ground-based telescopes. The reflectometer is housed in a vacuum chamber and operates at 1.487 keV, complimenting an existing 8.048 keV reflectometer. With a microfocus source and plane-parabolic Kirkpatrick–Baez mirrors, the 0.5-mm wide beam is collimated to <0.75 arcmin. An actively cooled 2D CCD yields sample alignment precision of 26 μm in linear position and 0.18 arcmin in angle. A multilayer monochromator provides a peak reflectance of 43.5% and beam purity > 99 % . The reflectometer has a 2θ range of 0 deg to 35 deg and dynamic range up to eight orders of magnitude. Techniques are demonstrated to investigate the sample surface morphology and we show the system’s capability to detect the presence of atmospheric contaminants on coated mirrors.

Radio-Frequency Undulators, Cyclotron Auto Resonance Maser and Free Electron Lasers

We discuss a hybrid Free Electron Laser (FEL) architecture operating with a RF undulator provided by a powerful Cyclotron Auto-Resonance Maser (CARM). We outline the design elements to operate a compact X-ray device. We review the essential aspects of wave undulator FEL theory and of CARM devices.

Demonstration of a compact x-ray free-electron laser using the optical klystron effect

We demonstrate the operation of a compact x-ray free-electron laser (FEL) using the optical klystron mechanism. This effect speeds up the FEL process using the dispersion of magnetic chicanes placed between the undulator modules of the FEL beamline. The demonstration was performed at the soft x-ray beamline of SwissFEL, called Athos, which is, as far as we are aware, the only x-ray FEL to date with magnetic chicanes between every two undulator modules. In our measurements, we show that, compared to standard operation without chicanes, the required undulator length to achieve FEL saturation is reduced between 15% and 30% for radiation wavelengths between 1 and 2 nm. Fully exploiting the optical klystron effect represents an important step toward more compact FEL designs, rendering this key technology more affordable and hence accessible to a larger science community.

Development of a compact x-ray laser in the ‘water window’ at 4.0 nm

A narrow spectral range between 2.3 nm and 4.4 nm wavelengths, the so-called ‘water window’ (WW), provides a unique opportunity for time-resolved imaging of proteins in their natural environment, as water is semi-transparent, while carbon is mostly opaque at these wavelengths. In this work we are presenting experimental developments toward high laser gain in CV ions at 4.03 nm, in a table-top device, and discuss possible application of such an x-ray laser to high-resolution microscopy, as well as generation of attosecond pulses.

Compact X-Ray Tube With Ceramic Vacuum Seal for Portable and Robust Dental Imaging

A major challenge for glass X-ray tube makers is the reduction in the tube size for portable or handheld applications. Size reduction is difficult mainly due to contact size restrictions for glass-to-metal welding. In high-voltage (60-70 kV) portable applications such as dental imaging, a distance of at least 5 mm should be maintained between the anode and the glass envelope to prevent the latter from burnout, which further limits reduction in the tube's diameter. In this study, reduction in the size of a dental X-ray tube by approximately 43% is achieved by replacing the glass envelope with ceramic. Instead of welding, the ceramic body permits the use of brazing, which supports extremely small contact sizes. Additionally, due to the higher dielectric constant of ceramic, even less than 1 mm spacing is permissible between the envelope and the anode, enabling further size reduction. Despite the 43% reduction in size, limiting spatial resolutions of approximately 8 and 7 lines per mm are obtained for the ceramic and glass sealed tubes, respectively. Moreover, the two tubes obtain similar X-ray images of human teeth, verifying the potential of the compact-size ceramic X-ray tube in dental imaging.

Imaging by intensity interferometry of x-ray fluorescence at a compact x-ray free-electron laser

A semiclassical theory of incoherent diffractive imaging is given, based on the Hanbury Brown and Twiss effect when used to image inner-shell x-ray fluorescence from heavy atoms excited by the femtosecond pulses of an x-ray laser. Interference between emission from different atoms is expected when the pulse duration is shorter than the fluorescent lifetime. Simulations for atoms at the vertices of an icosahedral virus capsid are given, and reconstructions are presented based on phasing of the pair correlation function between photons emitted independently from many different atoms at two different detector pixels. The dependence of the pair-correlation function on the fluorescence lifetime relative to the pulse duration of the x-ray free-electron laser (XFEL) is computed, and a simple expression is obtained for the contrast of incoherent diffractive imaging speckles as a function of the XFEL's flux and lifetime. This indicates that compact XFELs, with reduced flux but sub-femtosecond pulses, should be ideally suited to atomic-resolution three-dimensional mapping of heavy atoms in materials science, chemistry, and biology.

Transverse confinement of electron beams in a 2D optical lattice for compact coherent x-ray sources

Compact coherent x-ray sources have been the focus of extensive research efforts over the past decades. As a result, several novel schemes like optical and nano-undulators for generating x-ray emissions in ‘table-top’ setups are proposed, developed, and assessed. Despite the extensive efforts in the past decades, there exists no operational FEL based on optical or electromagnetic undulators. By combining the particle confinement capability of optical cavities with wiggling motion inside an optical undulator, this paper proposes a new concept for making a compact coherent x-ray source. The full-wave solution of first-principle equations based on finite-difference time-domain and particle-in-cell is performed to simulate inverse-Compton scattering (ICS) off both free and confined electrons. It is shown that the strong space-charge effect in a low-energy electron beam (5 MeV) is the main obstacle in acquiring coherent gain through the ICS mechanism with a 10 micrometer laser. Subsequently, it is shown that by confining the electron beam at the field nodes of an optical cavity, the space-charge effect is compensated, and additionally, the ultrahigh charge density enables high FEL-gain at confinement spots. The full-wave numerical simulations predict enhancement of about three orders of magnitude in the radiation efficiency when ICS is carried out with confined electrons compared to free electrons. These theoretical results show promising potential as a new scheme for implementing a compact coherent x-ray source.

A step closer to compact X-ray lasers

A step closer to compact X-ray lasers

Free-electron lasing at 27 nanometres based on a laser wakefield accelerator.

X-ray free-electron lasers can generate intense and coherent radiation at wavelengths down to the sub-ångström region1-5, and have become indispensable tools for applications in structural biology and chemistry, among other disciplines6. Several X-ray free-electron laser facilities are in operation2-5; however, their requirement for large, high-cost, state-of-the-art radio-frequency accelerators has led to great interest in the development of compact and economical accelerators. Laser wakefield accelerators can sustain accelerating gradients more than three orders of magnitude higher than those of radio-frequency accelerators7-10, and are regarded as an attractive option for driving compact X-ray free-electron lasers11. However, the realization of such devices remains a challenge owing to the relatively poor quality of electron beams that are based on a laser wakefield accelerator. Here we present an experimental demonstration of undulator radiation amplification in the exponential-gain regime by using electron beams based on a laser wakefield accelerator. The amplified undulator radiation, which is typically centred at 27 nanometres and has a maximum photon number of around 1010 per shot, yields a maximum radiation energy of about 150 nanojoules. In the third of three undulators in the device, the maximum gain of the radiation power is approximately 100-fold, confirming a successful operation in the exponential-gain regime. Our results constitute a proof-of-principle demonstration of free-electron lasing using a laser wakefield accelerator, and pave the way towards the development of compact X-ray free-electron lasers based on this technology with broad applications.

Influence of Irradiation-driven Winds on the Evolution of Intermediate-mass Black Hole X-ray Binaries

Abstract In young dense clusters, an intermediate-mass black hole (IMBH) may get a companion star via exchange encounters or tidal capture and then evolve toward the IMBH X-ray binary by the Roche lobe overflow. It is generally thought that IMBH X-ray binaries are potential ultraluminous X-ray sources (ULXs); hence, their evolution is very significant. However, the irradiation-driven winds by the strong X-ray flux from the accretion disks around the IMBHs play an important role in determining the evolution of IMBH X-ray binaries and should be considered in the detailed binary evolution simulation. Employing the models with the MESA code, we focus on the influence of irradiation-driven winds on the evolution of IMBH X-ray binaries. Our simulations indicate that a high wind-driving efficiency (f = 0.01 for Z = 0.02, and f = 0.002 for Z = 0.001) substantially shortens the duration in the ULX stage of IMBH X-ray binaries with an intermediate-mass (5 M ⊙) donor star. However, this effect can be ignored for high-mass (10 M ⊙) donor stars. The irradiation effect (f = 0.01 or 0.002) markedly shrinks the initial parameter space of IMBH binaries evolving toward ULXs with high luminosity (L X &gt; 1040 erg s−1) and hyperluminous X-ray sources in the donor-star mass versus orbital period diagram. Furthermore, the irradiation effect results in an efficient angular momentum loss, yielding to IMBH X-ray binaries with relatively close orbits. In our simulated parameter space, about 1% of IMBH binaries would evolve toward compact X-ray sources owing to short initial orbital periods, some of which might be detected as low-frequency gravitational-wave sources.

Near-GeV Electron Beams at a Few Per-Mille Level from a Laser Wakefield Accelerator via Density-Tailored Plasma.

A simple, efficient scheme was developed to obtain near-gigaelectronvolt electron beams with energy spreads of few per-mille level in a single-stage laser wakefield accelerator. Longitudinal plasma density was tailored to control relativistic laser-beam evolution, resulting in injection, dechirping, and a quasi-phase-stable acceleration. With this scheme, electron beams with peak energies of 780-840MeV, rms energy spreads of 2.4‰-4.1‰, charges of 8.5-23.6pC, and rms divergences of 0.1-0.4mrad were experimentally obtained. Quasi-three-dimensional particle-in-cell simulations agreed well with the experimental results. The dechirping strength was estimated to reach up to 11 TeV/mm/m, which is higher than previously obtained results. Such high-quality electron beams will boost the development of compact intense coherent radiation sources and x-ray free-electron lasers.

A compact and efficient angle-resolved X-ray fluorescence spectrometer for elemental depth profiling

An angle resolved X-ray fluorescence spectrometer based on the concept of scanning-free shallow detection with energy-dispersive area detectors is presented. The instrument is characterized with respect to energy resolution, linearity, angular discrimination and repeatability and the necessary data evaluation strategies are presented in detail. As demonstration of its capabilities and showcase for potential applications, two different copper indium gallium (di)selenide (CIGS) absorber layers, typically applied in thin film solar cells, are analyzed. In combination with quantitative (but integral) results for layer composition and layer thickness from a commercial XRF spectrometer, depth profiles of the Ga concentration of both ≈ 2 μm thin samples are obtained. The results of the novel spectrometer compare well with quantitative depth-profiles obtained from glow-discharge optical emission spectrometry. The combination of simplicity, stability and efficiency of the spectrometer concept makes it a potential candidate for industrial applications.Description of compact angle-resolved X-ray fluorescence spectrometer. Exploiting scanning-free grazing emission X-ray fluorescence approach. Energy dispersive charge-coupled device with single-photon detection. Enabling non-destructive, quantitative elemental depth profiling. Depth profiling of nano-structured stratified specimen, here CIGS solar cells.