The article considers the driving forces and factors that have a significant impact on the dynamics of trade relations between the Altai Krai and other regions. An assessment is made of the degree of trade's closeness and economic ties between the Altai Krai and other Russian regions, a detailed analysis of their role and place in the exchange of goods with the Altai Krai in 1990-2020 is carried out. The analysis was carried out in two main perspectives of interregional trade — import and export of products, taking into account its commodity structure on the example of two time periods: in the period 2001-2016, as well as in the modern period 2017-2020. The conclusion is made about the importance of demand for the products of Altai manufacturers from the regions of Russia as the most important driver of growth in agriculture and industry. A long-term stable trend of the predominance of imports of industrial and technical products into the region and exports of consumer goods from the region has been revealed. It is proved that the Altai Krai is extremely important for the development of production in a number of Russian regions, despiteits sales market's narrowness and limited domestic demand. The main periods in the development of trade and interregional economic relations, which differ significantly in intensity, are identified. The dynamics of interregional commodity exchange of the region, which occurred under the influence of shifts in its sectoral structure and the structure of domestic demand, is revealed. The features of interregional integration processes in the tradesphere in different chronological periods are revealed and characterized.