Column Size Research Articles

Method Development and Validation of Stability-Indicating HPLC-UV Method for Determination of 5 -Fluorouracil

Introduction: In the realm of pharmaceutical analysis, the development and validation of a High-Performance Liquid Chromatography with Ultraviolet Detection (HPLC-UV) method for the precise determination of 5-FU stand as a crucial endeavor. Methods: This study outlines the systematic process of method development, optimization, and subsequent validation to ensure the reliability and applicability of the method in pharmaceutical quality control. Method optimization included the selection of an appropriate stationary phase, mobile phase composition, and chromatographic conditions to achieve optimum resolution, sensi-tivity, and run time. Results: A speedy, simple, and dependable HPLC technique for quantifying 5-FU on a C18 (250 4.6 mm, 5m particle size) column with solvent A included 10 mM phosphate buffer with pH 3.0 and solvent B with acetonitrile as the mobile phase. At 250 nm, the effluent was measured. Fur-ther, 5-FU had a retention time of 1.698 minutes. Conclusion: According to ICH criteria, the devised technique was validated for precision, accu-racy, linearity range, robustness, and ruggedness.

Dynamic responses of thin-walled FRP-concrete-steel tubular wind turbine tower under horizontal impact loading: Experimental study and FE modelling

Thin-walled FRP-concrete-steel tubular towers (TW-FCSTs), composed of an outer FRP tube, an inner hollow steel tube, and an interlayer of concrete, represent a novel type of wind turbine tower with promising application prospects. Given their potential risks to potential vehicle or vessel collisions, this study investigates the dynamic responses of five cantilevered TW-FCSTs using a horizontal impact device. These TW-FCSTs possess significantly large void ratios (i.e., φ=0.73or0.82) and practical large column sizes (i.e., Dc = 300 mm, Hc = 1500 mm). The experimental programme of this paper investigates several key parameters, including FRP thickness, steel thickness, and void ratio of TW-FCSTs, as well as the velocity and numbers of impact loading. Experimental findings demonstrate the following insights: (1) cantilevered TW-FCSTs exhibit an overall flexural failure mode after the horizontal impact loading; (2) the increase in steel thickness or FRP thickness contributes to greater energy dissipation and reduced localized dent deformation; (3) the higher void ratio results in more pronounced localized dent deformation and less overall deformation in specimens; (4) the proportion of energy dissipation caused by localized dent deformation increased with impact velocity, signifying more severe localized dent deformation at higher impact velocities. The utilization of FE models in LS-DYNA effectively simulates the dynamic performance of cantilevered TW-FCSTs, offering reliable predictions. Parametric studies were conducted to analyze influences of impact mass, impact height, concrete strength, and steel yield strength.

Thermal performance analysis of supporting column ultra-thin vapor chamber with graded microgroove

To analyze the thermal behavior of a graded microgroove ultra-thin vapor chamber with supporting column, a three-dimensional steady-state numerical model coupled with graded capillary force network, which involves hydraulic and heat transfer on hydraulic and heat transfer performance on ultra-thin vapor chamber with different supporting column sizes. This model considers the influence of supporting column with varying diameters and intervals on liquid flow and temperature distribution, as well as the effects of a graded capillary force network on heat transfer limit of ultra-thin vapor chamber. The numerical results show that the additional heat transfer provided by the central support column causes an outward shift in the saturation temperature of vapor, creating a new liquid reflux path at the condensation surface. The accuracy of the model is verified by the preparation of ultra-thin vapor chamber with a graded microgroove a graded microgroove. Compared with the experimental results on conventional microgrooves, graded microgrooves can improve the heat transfer limit by 29.3%. According to the theoretical analysis model, the graded capillary force network can effectively resist incremental increases in vapor pressure drop, enhancing the efficiency of gas–liquid circulation of ultra-thin vapor chamber.

STABILITY INDICATING ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF AMLODIPINE AND LOSARTAN POTASSIUM BY UPLC

A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Amlodipine and Losartan Potassium, in its pure form as well as in tablet dosage form. Chromatography was carried out on Acquity BEH-shield RP18 UPLC column (3.0 mm × 100) mm, particle size Column using a mixture of Acetonitrile and Acetate buffer (pH-4.3) (35:65% v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 238nm. The retention time of the Amlodipine and Losartan Potassium was found to be 2.179, 3.610 ±0.02min respectively. The method produce linear responses in the concentration range of 20-60µg/ml of Amlodipine and 10-30µg/ml of Losartan Potassium respectively. The method precision for the determination of assay was below 2.0% RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.

Phytochemical profiling and characterization of flavonoid derivatives from propolis sample and investigation of cytotoxic and antiprotozoal activities

Recently, the growth of consumer demand for functional foods with potential nutritional and health benefits led to rapid growth of analytical tools for profiling of bioactive metabolites and assure quality. Bee propolis is one of the most important bee products owing to its myriad health value. As a gummy exudate produced in beehives after harvesting from different plant species, bee propolis contains bioactive secondary metabolites. The current study aims to profiling the chemical composition of propolis samples from Nigeria using HPLC–UV-ELSD and with the aid of NMR-based analysis for assignment of metabolites classes abundant in Nigerian propolis. Red Nigerian propolis samples were subjected to phytochemical analysis using HPLC–UV-ELSD and NMR. Further chromatographic separation of promising fractions was performed by column chromatography and size exclusion chromatography. Screening of the antitrypanosomal and cytotoxic activities against Trypanosoma brucei and human leukemia cell lines (U937), respectively, was performed. The performance of LC–MS permitted identification of the different components from which 13 compound were identified and allowed combination of fractions to afford 9 fractions from which two isoflavonoids were isolated and identified using 1D and 2D NMR analysis with MS as isosativan and Medicarpin. Red Nigerian propolis crude extract showed the highest inhibitory activity at 6.5 µg/ml compared to moderate activity for the isolated compounds with MIC of 7.6 µg/ml and 12.1 µg/ml for medicarpin and isosativan, respectively. Moreover, the fraction RN-6 from the total extract showed the potent cytotoxic effect with IC50 = 26.5 µg/ml compared to standard diminazen which showed IC50 = 29.5 µg/ml.

Numerical modeling of the punching shear behavior of biaxially loaded RC footings

In this study, the punching shear behavior of footings under biaxial eccentric loads is numerically investigated. Load eccentricities usually encountered in practice were primarily investigated on flat slabs, whereby the research on footings is still limited. Since the structural behavior of thick footings is significantly different compared to that of thin ones due to fracture mechanics, further investigations are required. To gain a deep understanding of the punching shear behavior of footings under biaxial eccentric loads, a numerical investigation was conducted. A finite element model was developed and validated against multiple experimental results in terms of load-deflection behavior and crack patterns. The validated model was then employed to examine the effect of different biaxial load eccentricities, different shear spans to effective depth ratios, column sizes, and column shapes. Finally, the numerical results were used for analyzing the design approach of the latest version of Eurocode 2 (FprEC2-2023). The numerical results showed a gradual transition between a fully developed punching shear cone to a partially formed cone without shear crack formation on the less loaded side with increasing load eccentricities. Additionally, larger load eccentricities lead to significantly increased rotation of the footing accompanied by a reduction of the punching shear capacity. A more pronounced influence of the effect of unbalanced moments on the punching shear capacity was identified in footings with a larger shear span to effective depth ratio. Furthermore, the effect of column size was more pronounced in small shear spans under concentric loads, while the effect was greater in footings with a larger shear span to depth ratio under eccentric loads. However, the beneficial effect of a larger column size was more pronounced for eccentric loads compared to concentric loading. Overall, the results indicate a good agreement with the design approach of Eurocode (FprEC2) for square columns. However, in some cases, the prediction was underestimated. Modified approaches from the literature for considering the effect of load eccentricity were found to address the underestimated cases safely. The results of this study demonstrated the applicability of the new design approaches for eccentric punching shear in footings under biaxial eccentric loads.

Development of a Computer-Aided Algorithm to Determine the Floor Wise Column Size for Multi-storey Base-Isolated RC Frame Buildings

Development of a Computer-Aided Algorithm to Determine the Floor Wise Column Size for Multi-storey Base-Isolated RC Frame Buildings

Axial compression performance of rubberized concrete-filled steel tubular stub columns after fire exposure: Experimental investigation and calculation models

Rubberized concrete (RuC) has emerged as a promising eco-friendly solution for structural elements, offering improved energy dissipation, damping characteristics, and ductility. Incorporating rubber particles into concrete-filled steel tubular (CFST) columns presents an environmentally conscious alternative for various structural applications. However, understanding its performance post-fire is crucial for safe design application, an area currently lacking comprehensive research. This study investigates the structural behavior of sixteen axially loaded circular RuCFST columns after exposure to fire. The columns, with diameters of 219 mm and 377 mm, are filled with normal concrete and RuC, containing 5 %, 15 %, and 30 % replacement of natural fine and coarse aggregate with rubber particles. Following ISO-834 fire standards, the specimens undergo elevated temperatures and subsequent application of compressive axial loads to determine their post-fire behavior. Analysis includes examination of failure modes, temperature-time relationships, axial load-deformation curves, and strain and stress development in the columns. Microstructural analysis using scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS) is conducted to study internal morphology before and after exposure to high temperatures. Results indicate non-uniform and nonlinear distributions of maximum temperatures across cross-sections, with historical temperature affecting residual capacity more significantly with increased rubber content and decreased column size. Load-bearing capacities decrease by up to 30 % and 22 % for small and large RuCFST columns, respectively, after exposure to fire. Residual axial stiffness also declines, with reductions of nearly 55 % and 42 % for small and large columns, respectively. In contrast, ductility improves in fire-exposed specimens, with columns having a 30 % rubber replacement ratio showing the highest enhancement. A novel method for calculating post-fire residual load capacity based on the average historical maximum temperature is introduced, demonstrating high accuracy and offering a valuable tool for assessing and reinforcing RuCFST columns after fire exposure.

A fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis.

Extracellular vesicles (EVs) carry diverse biomolecules derived from their parental cells, making their components excellent biomarker candidates. However, purifying EVs is a major hurdle in biomarker discovery since current methods require large amounts of samples, are time-consuming and typically have poor reproducibility. Here we describe a simple, fast, and sensitive EV fractionation method using size exclusion chromatography (SEC) on a fast protein liquid chromatography (FPLC) system. Our method uses a Superose 6 Increase 5/150, which has a bed volume of 2.9mL. The FPLC system and small column size enable reproducible separation of only 50µL of human plasma in 15min.To demonstrate the utility of our method, we used longitudinal samples from a group of individuals who underwent intense exercise. A total of 838 proteins were identified, of which, 261 were previously characterized as EV proteins, including classical markers, such as cluster of differentiation (CD)9 and CD81. Quantitative analysis showed low technical variability with correlation coefficients greater than 0.9 between replicates. The analysis captured differences in relevant EV proteins involved in response to physical activity.Our method enables fast and sensitive fractionation of plasma EVs with low variability, which will facilitate biomarker studies in large clinical cohorts.

A different strategy to reduce energy consumption for designing heterogeneous decanter-assisted advanced pressure-swing distillation process

In this work, we aim to explore the feasibility of integrating two strategies, i.e., (1) introducing a small quantity of solvent as a makeup stream and (2) employing a decanter, to develop an energy-efficient pressure swing distillation process for ternary azeotropic separation. The addition of a minor amount of solvent aims to facilitate the transition of the feed composition from outside the liquid–liquid equilibrium region to within it. This transition could enable the use of a decanter, thereby promoting a more energy-efficient separation process with reduced reliance on pressure-driven mechanisms. A systematic approach was proposed to explore this concept, involving the different thermodynamic features for conceptual design followed by process optimization and process evaluation. This approach was exemplified using a mixture containing chloroform, ethanol, and water. Two solvent and decanter-assisted triple-column pressure-swing azeotropic distillation (SD-TCPSAD) process were developed and evaluated against the conventional triple-column pressure swing distillation in terms of economic, energy, and environmental performance. Among the three configurations, SD-TCPSAD I exhibited the most favorable outcomes, achieving a 61 %, 69 %, and 69 % improvement in economic, energy, and environmental impact. These improvements were primarily attributed to the utilization of smaller column sizes, the utilization of different heating utilities, and a substantial decrease in overall energy consumption.

Mechanical and tribological properties of Ti1-xZrxB2 coatings deposited by magnetron sputtering on hot work steel

Low fracture toughness is a common problem encountered by many researchers in the application of pure TiB2 coatings. To improve their properties, a convenient and useful method is the use of doping, so this study proposes the deposition of TiB2 enriched with Zr on a steel substrate. The objective of the research was to investigate the impact of Zr addition to TiB2 coatings on both their mechanical and tribological properties. Four coatings with varying compositions (pure TiB2; TiB2 doped with 3, 6, and 10 at.% Zr) were deposited using magnetron sputtering from TiB2 and Zr targets. The coating structures were analyzed by means of X-ray diffraction (XRD), transmission electron microscopy (TEM), and atomic force microscopy (AFM). Nanoindentation, scratch test, and ball-on-disk test were used to determine the mechanical and tribological properties. In most cases, only two factors have a significant impact on the mechanical and tribological properties of the Zr-doped coating. Firstly, a change in the preferred orientation of the coating from (102)(111) to (100) results in increased hardness and wear resistance. Secondly, a reduction in crystallite and column size enhances ductility and fracture toughness by impeding or altering the direction of crack propagation. Based on the study, one can conclude that the optimal Ti1-xZrxB2 properties were obtained for 6 at.% Zr content.

Study and Analysis of Seismic Performance of RC Structures with Various Building Classes and Orientations

In the framework of this project, an attempt was made to find out the influence of the shape, size and direction of the rectangular columns of the construction plan on the general stiffness and seismic response of the building suffering from the earthquake. A multistory RC building is modeled using ETABS software with different column shapes (square and rectangular), column sizes (different cross-sectional area at building height), and column orientations to determine the effect of each on the stiffness and seismic response of the building. . . The analytical results of each model were compared in terms of base movement, overburden displacement, layer deflection and time period. Keywords –Moment resisting System, Lateral Loads, ETABS, Seismic response etc

Residual stress depth profiles self-developed in cathodic arc deposited Ti-Al-N coatings prepared at different constant substrate bias values

Ti-Al-N coatings were prepared by cathodic arc deposition on Inconel 718 substrates at different values of constant substrate bias voltage, aiming to produce samples with different self-developed residual stress (RS) depth profiles through the thickness of the coatings. RS profile measurements and structural characterization were performed on a laboratory-scale x-ray diffraction system (x-ray energy of 8 keV) and in a synchrotron x-ray radiation facility (x-ray energy of 15 keV). Mechanical testing to obtain hardness and Young’s modulus values was performed by instrumented nanoindentation. The results indicate higher compressive RS at the film/substrate interface that decays to lower compressive stress or mild tensile stress at the film surface. Surface hardness and the compressive RS value of the coating increase with larger values of the substrate bias voltage. By comparing the stress characterization done on a laboratory scale and at the synchrotron facility, one observes a generally good agreement, indicating that these analyses may be conducted at a smaller scale and with less costly equipment, and still maintain a reliable precision. The work presents and reviews in detail the methodology of the RS depth-profile analysis. The highest hardness of 31.1 GPa and near-substrate compressive RS around −10 GPa were obtained for a bias of −100 V. Transmission electron microscopy results indicate that regions with higher compressive stresses are found to have smaller columns and denser structure, while portions of the same sample with mild compressive or tensile stresses present larger column size and are richer in hexagonal phases. The findings demonstrate the complex interplay between stress, microstructure, and ultimately mechanical properties in industrially produced Ti-Al-N coatings and indicate that any successful strategy to mitigate stress development should consider the inhomogeneous self-developed stress gradients present even in coatings deposited under constant and controlled conditions.

QbD Approach to Method Development, Validation and Degradation Profiling of Antifungal Drugs by RP-HPLC

For the simultaneous estimation of Itraconazole (ITZ) and Terbinafine hydrochloride (TBF HCl) in tablet dosage form, a simple, novel, cost effective and rapid RP-HPLC method was developed. Method development becomes quick, accurate, sensitive, and robust by using quality by design (QbD). RP-HPLC was performed using a C18 (agilent, 4.6 x 250mm, 5µm particle size) column. Methanol and 0.05% OPA (pH 3.5) was used as mobile phase in 84:16 ratio. The analysis was conducted in gradient mode with a flow rate of 0.95mL/min. Detection wavelength was set at 270nm. Retention time for TBF and ITZ was at 2.93 and 6.96min, respectively. The accuracy, precision, repeatability, linearity, LOD, LOQ and robustness parameters have been validated as per the ICH Q2 (R1) guideline: Validation of analytical procedures–text and methodology. Values for LOD and LOQ were found to be 0.131 and 0.398µg/mL and 0.350 and 1.061µg/mL respectively for ITZ and TBF HCl. Thus, the technique can be employed for regular QC analysis of bulk ITZ and TBF HCl and their pharmaceutical formulations. Degradative stress conditions like acid, base, neutral, oxidation applied and degradations were studied.

Excel as an optimization tool applied to multicomponent distillation column sizing

The unit operation of distillation is a method of significant importance for industrial separation processes, as it enables the fractionation of a mixture based on the differences in volatility among its components. Considering that a typical initial mixture generally contains three or more products of interest, studies aimed at optimizing multicomponent distillation, although scarce in the literature, are increasingly imperative to ensure efficiency and reduce operational and energy costs associated with the process. Since sizing multicomponent distillation columns using the Fenske-Underwood and Gilliland (FUG) and Kirkbride methods involves extensive and complex calculations to obtain operational parameters, the objective of this study was to develop a computational method using Microsoft Excel® software to make them more practical and enhance the accuracy of the results obtained. The functionality of the developed spreadsheet was verified through the resolution of an example of application, both manually and electronically. In both cases, the results obtained were identical, but with significantly lower time consumption and probability of error by the electronic method, demonstrating its potential for use in academic and industrial settings.

Cost optimization of tall buildings having tube composite columns using social spider algorithm

SummaryThis study aims to develop an algorithmic approach to obtain optimum designs for tall buildings having composite columns and investigate the material cost advantages of these buildings over steel structures. The social spider optimization (SSO) algorithm, a new meta‐heuristic optimization method that has shown promising results in optimizing frame structures, was used to obtain the optimum designs. Concrete‐filled steel tube sections were chosen for composite columns. To define the optimization problem, we considered the material cost of the structure as the objective function, the size of columns (strength, deflection, drift, and geometric limitations) as the constraint functions, and ready steel sections as the design variables. We tested eight different frame structures of varying heights and irregularities to analyze how cost varied according to these parameters. Our results demonstrate that composite columns are a more cost‐effective option than steel structures, even for buildings that are not considered high rises. We found that the difference in cost between the two types of structures increases with building height and irregularity. Additionally, our optimization algorithm was unable to find feasible designs for steel structures taller than 180 m using ready steel profiles.

Assessing embodied carbon of flat slab buildings – An ANN-integrated optimization methodology

Currently, there is a scarcity of studies that comprehensively address all structural components in the building's overall environmental performance. Although mathematical optimization has shown its great effectiveness, the prevailing iterative design approach continues hindering the simultaneous optimization of building structural performance and its sustainability. This research aims to address this gap by introducing an innovative optimization framework that integrates optimization concepts into the design process using Artificial Neural Networks (ANNs). The proposed framework includes a carbon-optimization problem for flat slab buildings, which is validated with manual designs, and a surrogate modelling stage employing ANNs to predict optimal design solutions. The best network demonstrates remarkable predictive power, yielding minimal errors and high fitness (>0.96) for all variables, except slab thickness. Sensitivity analysis identifies the building's height and dimensions as the most influential factors on the slab reinforcement, column reinforcement, and carbon footprint. While span length and slab concrete strength greatly impact slab and drop depths, column size is primarily controlled by span length and building's height. This research not only provides crucial insights into sustainable design solutions but also paves a clear pathway towards achieving decarbonization and cleaner production across the entire building sector.

Evolution and diversity of biomineralized columnar architecture in early Cambrian phosphatic-shelled brachiopods

Biologically-controlled mineralization producing organic-inorganic composites (hard skeletons) by metazoan biomineralizers has been an evolutionary innovation since the earliest Cambrian. Among them, linguliform brachiopods are one of the key invertebrates that secrete calcium phosphate minerals to build their shells. One of the most distinct shell structures is the organo-phosphatic cylindrical column exclusive to phosphatic-shelled brachiopods, including both crown and stem groups. However, the complexity, diversity, and biomineralization processes of these microscopic columns are far from clear in brachiopod ancestors. Here, exquisitely well-preserved columnar shell ultrastructures are reported for the first time in the earliest eoobolids Latusobolus xiaoyangbaensis gen. et sp. nov. and Eoobolus acutulus sp. nov. from the Cambrian Series 2 Shuijingtuo Formation of South China. The hierarchical shell architectures, epithelial cell moulds, and the shape and size of cylindrical columns are scrutinised in these new species. Their calcium phosphate-based biomineralized shells are mainly composed of stacked sandwich columnar units. The secretion and construction of the stacked sandwich model of columnar architecture, which played a significant role in the evolution of linguliforms, is highly biologically controlled and organic-matrix mediated. Furthermore, a continuous transformation of anatomic features resulting from the growth of diverse columnar shells is revealed between Eoobolidae, Lingulellotretidae, and Acrotretida, shedding new light on the evolutionary growth and adaptive innovation of biomineralized columnar architecture among early phosphatic-shelled brachiopods during the Cambrian explosion.

Evolution and diversity of biomineralized columnar architecture in early Cambrian phosphatic-shelled brachiopods.

Biologically-controlled mineralization producing organic-inorganic composites (hard skeletons) by metazoan biomineralizers has been an evolutionary innovation since the earliest Cambrian. Among them, linguliform brachiopods are one of the key invertebrates that secrete calcium phosphate minerals to build their shells. One of the most distinct shell structures is the organo-phosphatic cylindrical column exclusive to phosphatic-shelled brachiopods, including both crown and stem groups. However, the complexity, diversity, and biomineralization processes of these microscopic columns are far from clear in brachiopod ancestors. Here, exquisitely well-preserved columnar shell ultrastructures are reported for the first time in the earliest eoobolids Latusobolus xiaoyangbaensis gen. et sp. nov. and Eoobolus acutulus sp. nov. from the Cambrian Series 2 Shuijingtuo Formation of South China. The hierarchical shell architectures, epithelial cell moulds, and the shape and size of cylindrical columns are scrutinised in these new species. Their calcium phosphate-based biomineralized shells are mainly composed of stacked sandwich columnar units. The secretion and construction of the stacked sandwich model of columnar architecture, which played a significant role in the evolution of linguliforms, is highly biologically controlled and organic-matrix mediated. Furthermore, a continuous transformation of anatomic features resulting from the growth of diverse columnar shells is revealed between Eoobolidae, Lingulellotretidae, and Acrotretida, shedding new light on the evolutionary growth and adaptive innovation of biomineralized columnar architecture among early phosphatic-shelled brachiopods during the Cambrian explosion.

Dynamic responses of concrete-filled steel tubes impacted horizontally by a rigid vehicle: Experimental study and numerical modelling

Concrete-filled steel tubes (CFSTs), composed of an outer tube made of steel as the confining material and an inner concrete core, have been popularly utilised as high-rise building columns and urban bridge piers owing to their superior structural behaviour. Since the invention of CFSTs, their mechanical performance under static and seismic loading conditions have been extensively studied, while the investigation on their dynamic behaviour under impact loading is relatively limited. Of these limited studies about CFSTs under impact loading conditions, most experiments were completed using a drop-hammer testing facility or a pendulum-hammer testing device. Against this background, this study investigated six large CFSTs being impacted horizontally by a rigid vehicle to analysis their dynamic response. All specimens were vertically placed with the bottom pedestal fixed on the lab floor and the top end free. The main parameters of these CFSTs included the impact velocity (i.e., vi = 3.16–7.18 m/s), the CFST section size (i.e., D = 180–300 mm), as well as the CFST column height (i.e., hc = 1500–2100 mm). Test results revealed that, (1) all CFSTs experienced a bending-dominant failure when impacted horizontally by a rigid vehicle; (2) the impact velocity had a positive correlative trend with the peak impact force Fpeak and the peak lateral displacement δpeak of the CFST column; (3) a larger section size of the CFST column resulted in a higher flexural stiffness and a larger flexural capacity, thus leading to a higher Fpeak, a smaller time duration T and a smaller δpeak; (4) the column height would affect the inertial response of the CFST column; a larger column height led to a larger Fpeak caused by the larger inertia effect of the CFST segment above the impact point. Finite-element model was established on the platform of LS-DYNA to simulate these CFSTs under horizontal impact loading, which was able to predict both impact force–time history curves and lateral displacement–time history curves with reasonably accuracy.