Collateral Effects Research Articles

Integrative Review of Developmental Behavior-Analytic Concepts.

We reviewed five behavior-analytic concepts related to development: behavioral trap, cumulative-hierarchical learning (CHL), basic behavioral repertoire (BBR), pivotal behavior, and behavioral cusp. We searched for terminological variations of the concepts in the CAPES Journals Portal and selected for analysis 31 peer-reviewed articles written in English or Portuguese, published between 1967 and 2021, that contained the search terms in the title, abstract, or keywords and contextualized in the main text. We analysed the conventional usage of the concepts, their conceptual limitations, and the relationships among them, declared or implied, and proposed a conceptual integration of the concepts under a CHL framework, following a path indicated by other authors. We considered BBR, pivotal behavior, and behavioral cusp nonsynonymous concepts of the same logical category, referring to prerequisites for important developmental outcomes and targets of CHL-inspired interventions but defined by different effects on subsequent behavioral development. The three concepts can be conflated in a superset-subset fashion, based on the specificity of their effects: BBR consists of a broad class of behaviors that may affect subsequent learning; the subclass of BBRs characterized by far-reaching collateral effects are classified as pivotal behavior, and the subclass of pivotal behaviors whose potential effects include contact with unprecedented environmental contingencies are classified as behavioral cusps. We propose that behavioral traps be explicitly incorporated in the CHL framework, to emphasize the environmental component of the cumulative-hierarchical learning process. Our formulation seems to organize the conceptual field in a way that respects the conventional use of concepts, preserving their strengths. Regardless of the specific formulation, we believe that integrating the various development-related concepts within a cumulative-hierarchical learning framework can encourage a more proactive integration of findings, questions, and practices informed by each concept, which could lead to the mutual refinement of the corresponding conceptual and methodological frameworks, as well as new research questions and practical applications. In particular, we expect that explicitly incorporating behavioral traps within the CHL framework will provide a useful heuristic model to guide research on how natural environmental contingencies influence the systematic transformation of behavior across the lifespan.

Reversible Myc hypomorphism identifies a key Myc-dependency in early cancer evolution

Germ-line hypomorphism of the pleiotropic transcription factor Myc in mice, either through Myc gene haploinsufficiency or deletion of Myc enhancers, delays onset of various cancers while mice remain viable and exhibit only relatively mild pathologies. Using a genetically engineered mouse model in which Myc expression may be systemically and reversibly hypomorphed at will, we asked whether this resistance to tumour progression is also emplaced when Myc hypomorphism is acutely imposed in adult mice. Indeed, adult Myc hypomorphism profoundly blocked KRasG12D-driven lung and pancreatic cancers, arresting their evolution at the early transition from indolent pre-tumour to invasive cancer. We show that such arrest is due to the incapacity of hypomorphic levels of Myc to drive release of signals that instruct the microenvironmental remodelling necessary to support invasive cancer. The cancer protection afforded by long-term adult imposition of Myc hypomorphism is accompanied by only mild collateral side effects, principally in haematopoiesis, but even these are circumvented if Myc hypomorphism is imposed metronomically whereas potent cancer protection is retained.

Musculoskeletal oncology and thermal ablation: the current and emerging role of interventional radiology.

The role of interventional radiology (IR) is expanding. With new techniques being developed and tested, this radiology subspecialty is taking a step forward in different clinical scenarios, especially in oncology. Musculoskeletal tumoral diseases would definitely benefit from a low-invasive approach that could reduce mortality and morbidity in particular. Thermal ablation through IR has already become important in the palliation and consolidation of bone metastases, oligometastatic disease, local recurrences, and treating specific benign tumors, with a more tailored approach, considering the characteristics of every patient. As image-guided ablation techniques lower their invasiveness and increase their efficacy while the collateral effects and complications decrease, they become more relevant and need to be considered in patient care pathways and clinical management, to improve outcomes. We present a literature review of the different percutaneous and non-invasive image-guided thermal ablation methods that are currently available and that could in the future become relevant to manage musculoskeletal oncologic diseases.

Turning a Novel Janus Electrospun Mat into an Amphiphilic Membrane with High Aromatic Hydrocarbon Adsorption Capacity

Aromatic hydrocarbons in water is one of the collateral effects of the petrochemical industry and represents a serious problem both for their toxicity and environmental contamination. In this work, an innovative amphiphilic membrane was developed capable of rapidly removing hydrocarbons (such as BTEX) present in water under the solubility limit. Firstly, a Janus nanostructured membrane was developed from the deposition of superhydrophobic carbonaceous nanoparticles (CNPs) synthesized by radiofrequency plasma polymerization on a hydrophilic electrospun poly(vinyl alcohol) mat. Secondly, this membrane was turned amphiphilic by UV exposure, allowing water to pass through. The surface properties of the membranes were studied through SEM, contact angle, and FTIR analysis. Dead-end experiments showed that the toluene and xylene selective sorption capacity reached the outstanding adsorption capacity of 647 mg/g and 666 mg/g, respectively, and that the membrane could be reused three times without efficiency loss. Furthermore, swelling of the PVA fibers prevented the liberation of NPs. The selective sorption capacity of the UV-exposed CNPs was explained by studying the interfacial energy relations between the materials at play. This work provides a simple, low-cost, and scalable technique to develop membranes with great potential for water remediation, including the removal of volatile organic compounds from produced water, as well as separating oil-in-water emulsions.

Smart nano-actuators for electrochemical sensing of Metformin in human plasma

Smart artificial nano-actuators were developed using electroactive acrylamide polymer nanoparticles by molecular imprinting. These nanoparticles are receptors that mimic the specificity of antibodies and replace enzymes in traditional biosensors allowing highly sensitive and selective monitoring. Electroactive polymer nanoparticles can be synthesized by the including of ferrocene, which confers signaling functions. These actuators operate by a swelling mechanism in response to a specific electrochemical stimulus. Molecular recognition is based on molecular imprinting and binding of the target molecule. The polymer nanoparticles were computationally designed to bind to Metformin and synthesized by controlled free-radical polymerization. Polymer nanoparticles were incorporated on the surface using screen-printed electrodes. As a result, these nano-actuators allow extremely sensitive monitoring of Metformin in human plasma. Metformin is essential for treating various chronic diseases, and monitoring is necessary to reduce collateral drug side effects. Herein, sensing of Metformin was achieved by differential pulse voltammetry (DPV) in a concentration range between 100 and 2000 pM, with a limit of detection of 9 pM and sensitivity at 31.5 nA pM−1 (0.998) in plasma. No cross-reactivity was observed against potential interferences (Sitagliptin and Paracetamol). This technology can be potentially applied for rapid point-of-care testing as an alternative to laboratory-based techniques, reducing the time and cost of the analysis.

OR26-4 Glucocorticoid Receptor Expression and Signaling During Critical Illness, in Relation to the Duration of Illness and the Systemic Glucocorticoid Availability: A Prospective, Observational, Cross-Sectional Human and a Translational Mouse Study

Abstract Critically ill patients are thought to develop maladaptive glucocorticoid-resistance which convinces many clinicians to administer stress doses of glucocorticoids to overcome this state of glucocorticoid-resistance. However, supportive data arises mainly from whole blood cells. It is currently not known if the observed changes in regulators and markers of glucocorticoid signaling and activity are also present in other cell and tissue types with a role in critical illness. We quantified regulators and markers of glucocorticoid signaling and activity in several cell and tissue types in critically ill humans and animals and in healthy controls. We found that throughout critical illness, glucocorticoid activity appeared suppressed in neutrophils, but upregulated in monocytes and skeletal muscle. Also in vital tissues GRα-signaling was altered in a tissue-specific, largely time-independent manner. Increasing systemic glucocorticoid availability increased glucocorticoid activity in adipose tissue, diaphragm and lung, whereas in immune cells and other tissues regulatory pathways counteracted. These data argue against glucocorticoid-treatable generalized glucocorticoid resistance and rather point towards an adaptive response in each specific cell or tissue type to optimally guide the beneficial actions of glucocorticoids to the tissues that need it while protecting collateral undesirable effects in tissue that are harmed by elevated systemic glucocorticoid availability. Presentation: Monday, June 13, 2022 11:45 a.m. - 12:00 p.m.

Agricultural policies against invasive species generate contrasting outcomes for climate change mitigation and biodiversity conservation.

Direct consequences of biological invasions on biodiversity and the environment have been largely documented. Yet collateral indirect effects mediated by changes in agri-environmental policies aimed at combating invasions remain little explored. Here we assessed the effects of recent changes in water management in rice farming, which are aimed at buffering the impact of the invasive apple snail (Pomacea maculata, Lamarck) on greenhouse gas emissions and diversity of waterbird communities. We used observational data from a 2-year field monitoring (2015-2016) performed at the Ebro Delta regional scale. We found that drying rice fields reduced methane emission rates by 82% (2015) and 51% (2016), thereby reflecting the contribution of rice farming to climate change. However, there was a marked reduction (75% in 2015 and 57% in 2016) in waterbird diversity in dry fields compared with flooded fields, thus suggesting that post-invasion policies might hinder biodiversity conservation. Our results highlight the need for accounting for potential collateral effects during the policy decision-making process to design efficient agricultural management plans that lessen undesirable agri-environmental outcomes.

Optimal Configuration Mitigating Rayleigh-Backscattering-Induced Distortion in Radioastronomic Optical Fiber Systems

In the context of Radioastronomic applications where the Analog Radio-over-Fiber technology is used for the antenna downlink, detrimental nonlinearity effects arise because of the interference between the forward signal generated by the laser and the Rayleigh backscattered one which is re-forwarded by the laser itself toward the photodetector. The adoption of the so called <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dithering</i> technique, which involves the direct modulation of the laser with a sinusoidal tone and takes advantage of the laser chirping phenomenon, has been proved to reduce such Rayleigh Back Scattering - induced nonlinearities. The frequency and the amplitude of the <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dithering tone</i> should both be as low as possible, in order to avoid undesired collateral effects on the received spectrum as well as keep at low levels the global energy consumption. Through a comprehensive analysis of <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dithered</i> Radio over Fiber systems, it is demonstrated that a progressive reduction of the <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dithering tone</i> frequency affects in a peculiar fashion both the chirping characteristics of the field emitted by the laser and the spectrum pattern of the received signal at the fiber end. Accounting for the concurrent effects caused by such phenomena, optimal operating conditions are identified for the implementation of the <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dithering tone</i> technique in radioastronomic systems.

Collaterals and extent of myocardial injury in patients with acute coronary syndromes – an analysis of the prospective SPUM-ACS cohort

Abstract Introduction The impact of collateral circulation in the presence of severe coronary artery disease such as chronic total occlusion (CTO) has been extensively studied, with results despite few discrepancies, supporting an overall benefit on preservation of myocardial tissue and left ventricular ejection fraction (LVEF). However, less is known about the protective effects of collaterals in the context of acute coronary syndromes (ACS). In the current study we sought to analyze the incidence, grade and impact of collateral circulation in a large prospectively recruited cohort of patients presenting with ACS with independent events adjudication. Methods and results 4'546 ACS patients presenting with ACS, enrolled in the prospective Special Program University Medicine ACS (SPUM-ACS) cohort were included. The current analysis showed the presence of a collateralized culprit lesion in 12.9% (n=586) of patients, 84% (n=492) originating from the contralateral side and 16% (n=94) from the ipsilateral side. Of those 64.6% (n=378) were being graded as Rentrop 2 or more. There were no differences in baseline characteristics between the two groups including incidence of diabetes, coronary artery disease, age and gender. However, despite the presence of collaterals graded Rentrop 2 or more, those patients had a significantly lower LVEF mean 48,44% vs 51.6%, p=0.025 and higher creatinine Kinase levels, mean (CK) 981 U/I vs 957 UI, p&amp;lt;0.001 as compared to patients with absent collateral-circulation on admission. Interestingly a sub analysis of the STEMI population showed no significant differences in both LVEF and CK at presentation, while troponin (TNT) plasma levels were significantly lower in patients with collaterals (mean TNT 0.0031 ug/l vs 0.035 ug/l p=0.001). Additionally no differences in cardiovascular mortality, stent thrombosis or MI was seen at one year follow-up. Conclusion The current analysis highlights a possible protective impact of a pre-existing collateral circulation against myocardial injury in the setting of ACS and ST elevation myocardial infarction. However this was not translated into improvement in hard outcomes acutely and up to one year of follow up, but may be important in the long run. Funding Acknowledgement Type of funding sources: Public Institution(s). Main funding source(s): Swiss National Research Foundation - ZurichHeart House

Modelling collateral flow and thrombus permeability during acute ischaemic stroke.

The presence of collaterals and high thrombus permeability are associated with good functional outcomes after an acute ischaemic stroke. We aim to understand the combined effect of the collaterals and thrombus permeability on cerebral blood flow during an acute ischaemic stroke. A cerebral blood flow model including the leptomeningeal collateral circulation is used to simulate cerebral blood flow during an acute ischaemic stroke. The collateral circulation is varied to capture the collateral scores: absent, poor, moderate and good. Measurements of the transit time, void fraction and thrombus length in acute ischaemic stroke patients are used to estimate thrombus permeability. Estimated thrombus permeability ranges between 10^-7 and 10^-4 mm². Measured flow rates through the thrombus are small and the effect of a permeable thrombus on brain perfusion during stroke is small compared with the effect of collaterals. Our simulations suggest that the collaterals are a dominant factor in the resulting infarct volume after a stroke.

EUS-guided radiofrequency ablation of pancreatic/peripancreatic tumors and oligometastatic disease: an observational prospective multicenter study.

Background and study aims Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is an emerging and minimally invasive technique that seems promising for treatment of focal pancreatic and peripancreatic lesions. Our aim was to prospectively evaluate the feasibility, safety, and technical and clinical success of pancreatic and extra-pancreatic EUS-RFA. Patients and methods We prospectively collected clinical and technical data for all patients who underwent EUS-RFA at two Belgian academic centers from June 2018 to February 2022. Feasibility, adverse events (AEs), and follow-up were also assessed. Results Twenty-nine patients were included, accounting for 35 lesions: 10 non-functioning neuroendocrine tumors (29 %), 13 pancreatic insulinomas (37 %), one adenocarcinoma (3 %), and 11 intra-pancreatic and extra-pancreatic metastatic lesions (31 %). Technical success was achieved in 100 % of cases, with a median of three power applications per lesion (interquartile range 2). The majority of patients (59 %) presented no collateral effects, three (10.3 %) developed non-severe acute pancreatitis, and four (14 %) had mild abdominal pain. At 6 months follow-up (n = 25), 36 % of patients showed radiological complete response, 16 % presented a significant partial response and 48 % showed < 50 % decrease in diameter. At 12 months (n = 20), 30 % showed complete necrosis and 15 % > 50 % decrease in diameter. Hypoglycemia related to insulinoma was immediately corrected in all 13 cases, with no recurrence during follow-up. Conclusions EUS-RFA is feasible, safe, and effective for treatment of pancreatic and peripancreatic tumors. Larger and longer multicenter prospective studies are warranted to establish its role in management of focal pancreatic lesions and oligometastatic disease. Symptomatic insulinoma currently represent the best indication.

MicroRNA-4732-3p Is Dysregulated in Breast Cancer Patients with Cardiotoxicity, and Its Therapeutic Delivery Protects the Heart from Doxorubicin-Induced Oxidative Stress in Rats.

Anthracycline-induced cardiotoxicity is the most severe collateral effect of chemotherapy originated by an excess of oxidative stress in cardiomyocytes that leads to cardiac dysfunction. We assessed clinical data from patients with breast cancer receiving anthracyclines and searched for discriminating microRNAs between patients that developed cardiotoxicity (cases) and those that did not (controls), using RNA sequencing and regression analysis. Serum levels of 25 microRNAs were differentially expressed in cases versus controls within the first year after anthracycline treatment, as assessed by three different regression models (elastic net, Robinson and Smyth exact negative binomial test and random forest). MiR-4732-3p was the only microRNA identified in all regression models and was downregulated in patients that experienced cardiotoxicity. MiR-4732-3p was also present in neonatal rat cardiomyocytes and cardiac fibroblasts and was modulated by anthracycline treatment. A miR-4732-3p mimic was cardioprotective in cardiac and fibroblast cultures, following doxorubicin challenge, in terms of cell viability and ROS levels. Notably, administration of the miR-4732-3p mimic in doxorubicin-treated rats preserved cardiac function, normalized weight loss, induced angiogenesis, and decreased apoptosis, interstitial fibrosis and cardiac myofibroblasts. At the molecular level, miR-4732-3p regulated genes of TGFβ and Hippo signaling pathways. Overall, the results indicate that miR-4732-3p is a novel biomarker of cardiotoxicity that has therapeutic potential against anthracycline-induced heart damage.

RNA-targeting CRISPR-Cas systems.

CRISPR-Cas is a widespread adaptive immune system in bacteria and archaea that protects against viral infection by targeting specific invading nucleic acid sequences. Whereas some CRISPR-Cas systems sense and cleave viral DNA, type III and type VI CRISPR-Cas systems sense RNA that results from viral transcription and perhaps invasion by RNA viruses. The sequence-specific detection of viral RNA evokes a cell-wide response that typically involves global damage to halt the infection. How can one make sense of an immune strategy that encompasses broad, collateral effects rather than specific, targeted destruction? In this Review, we summarize the current understanding of RNA-targeting CRISPR-Cas systems. We detail the composition and properties of type III and type VI systems, outline the cellular defence processes that are instigated upon viral RNA sensing and describe the biological rationale behind the broad RNA-activated immune responses as an effective strategy to combat viral infection.

Immunological Modulation and Control of Parasitaemia by Ayahuasca Compounds: Therapeutic Potential for Chagas's Disease.

Ayahuasca is a psychoactive and psychedelic decoct composed mainly of Banisteriopsis caapi and Psychotria viridis plant species. The beverage is rich in alkaloids and it is ritualistically used by several indigenous communities of South America as a natural medicine. There are also reports in the literature indicating the prophylaxis potential of Ayahuasca alkaloids against internal parasites. In the present study, Ayahuasca exhibited moderate in vitro activity against Trypanosoma cruzi trypomastigotes (IC50 95.78 μg/mL) compared to the reference drug benznidazole (IC50 2.03 μg/mL). The β-carboline alkaloid harmine (HRE), isolated from B. caapi, was considered active against the trypomastigotes forms (IC50 6.37), and the tryptamine N, N-dimethyltryptamine (DMT), isolated from P. viridis was also moderately active with IC50 of 21.02 μg/mL. Regarding the in vivo evaluations, no collateral effects were observed. The HRE alone demonstrated the highest trypanocidal activity in a dose-responsive manner (10 and 100 mg/kg). The Ayahuasca and the association between HRE and DMT worsened the parasitaemia, suggesting a modulation of the immunological response during the T. cruzi infection, especially by increasing total Immunoglobulin (IgG) and IgG1 antibody levels. The in silico molecular docking revealed HRE binding with low energy at two sites of the Trypanothione reductase enzyme (TR), which are absent in humans, and thus considered a promissory target for drug discovery. In conclusion, Ayahuasca compounds seem to not be toxic at the concentrations of the in vivo evaluations and can promote trypanocidal effect in multi targets, including control of parasitaemia, immunological modulation and TR enzymatic inhibition, which might benefit the treatments of patients with Chagas' disease. Moreover, the present study also provides scientific information to support the prophylactic potential of Ayahuasca against internal parasites.

In Vitro Mechanisms of Resistance Development to Imipenem-Relebactam in KPC-Producing Klebsiella pneumoniae.

Carbapenem-resistant Enterobacterales, such as KPC-producing Klebsiella pneumoniae, represent a major threat to public health. Novel drug combinations including imipenem-relebactam (IPM-REL) have recently been introduced and have been shown to exhibit excellent activity toward such strains. However, there has recently been reports of the in vivo emergence of IPM-REL resistance in KPC-producing K. pneumoniae. Here, we evaluated, in vitro, the nature of the mutations that lead to IPM-REL resistance in 5 KPC-producing K. pneumoniae strains, including 2 that produce KPC enzymes conferring ceftazidime-avibactam resistance. An in vitro multi-step selection assay was performed and corresponding mutants obtained. Mutations were identified in OmpK36 as well as 2 different mutant derivatives of KPC. Mutant strains exhibited decreased susceptibility to β-lactams, including the carbapenems, and meropenem-vaborbactam (MEM-VAB). Expression of blaKPC gene variants in an Escherichia coli recombinant strain resulted in a concomitant increased susceptibility to carbapenems and decreased susceptibility to CAZ-AVI, and enzymatic assays showed that the inhibitory activity of both AVI and REL was significantly lowered for both KPC mutants compared to parental enzymes. Complementation assays showed that OmpK36 plays a major role in IPM-REL resistance as well resistance to other ß-lactams and β-lactam/ß-lactamase inhibitor combinations. Overall, this study showed that (i) IPM-REL resistant strains can be obtained from CAZ-AVI-susceptible or -resistant KPC producers, (ii) selection of IPM-REL resistance has a collateral effect on MEM-VAB susceptibility - indicative of shared resistance mechanisms, (iii) and mutations in the KPC sequence may be obtained using IPM-REL selection leading to the possibility of vertical and horizontal transfer of this resistance trait.

Pengaruh agunan dan profitabilitas terhadap tingkat hutang perusahaan dimoderasi oleh umur perusahaan

The capital structure is reflected in the ratio of total debt (short-term plus long-term) to total assets. Leverage is a comparison between a company's long-term funding between long-term debt and total assets. The level of debt is important for the company's business continuity, when the company experiences a funding deficit after using its own capital, the company will use debt as a source of funds from outside the company. There are factors that can affect debt levels such as COL, AGE and NPM. This study was conducted to determine the effect of COL and NPM moderated by the age of the company on the level of company debt. The gap theory in this study is that there are differences in results in profitability variables so that researchers are interested in re-examining to see the results. The population of this study used companies in the various industries sector for the 2016-2020 period amounted to 44 companies and the sample obtained was 11 companies using purposive sampling techniques. The analysis in this study used descriptive statistics, then the pituitary test used moderation regression analysis. The results of this study indicate that partially collateral has a negative effect on the level of debt, profitability has no effect on the level of debt, the age of the company strengthens the effect of collateral on the level of debt and the age of the company does not moderating the effect of profitability on debt levels.

Microphysics of early dark energy

Early dark energy (EDE) relies on scalar field dynamics to resolve the Hubble tension, by boosting the pre-recombination length scales and thereby raising the CMB-inferred value of the Hubble constant into agreement with late universe probes. However, the collateral effect of scalar field microphysics on the linear perturbation spectra appears to preclude a fully satisfactory solution. ${H}_{0}$ is not raised without the inclusion of a late universe prior, and the ``${S}_{8}$ tension,'' a discrepancy between early- and late-universe measurements of the structure growth parameter, is exacerbated. What if EDE is not a scalar field? Here, we investigate whether different microphysics, encoded in the constitutive relationships between pressure and energy density fluctuations, can relieve these tensions. We show that EDE with an anisotropic sound speed can soften both the ${H}_{0}$ and ${S}_{8}$ tensions while still providing a quality fit to CMB data. Future observations from the CMB-S4 experiment may be able to distinguish the underlying microphysics at the $4\ensuremath{\sigma}$ level, and thereby test whether a scalar field or some richer physics is at work.

Ionizing protoplanetary discs in pebble collisions

ABSTRACT We introduce collisions of solids as a new and efficient ionization mechanism for gas in protoplanetary discs, which especially operates in the dense midplane of protoplanetary discs. This idea is sparked by laboratory experiments where we found that charge, which is exchanged by grains in mutual collision (tribocharging), is not tied to their surfaces alone. As kind of collateral effect, charges also become entrained into the gas phase, i.e. collisions ionize the protoplanetary disc. Therefore, solids are not only sinks of charges in discs but also sources. A first estimate shows that ionization rates in the midplane at 1 AU in the range of $10^{-19}\!-\!10^{-15}\,{\rm s}^{-1}$ seem feasible depending on the assumption of rather calm or highly turbulent conditions with radial particle pile up.

The Collateral Effects of Antecedent Exercise on Stereotypy and Other Nonstereotypic Behaviors Exhibited by Individuals with Autism Spectrum Disorder: A Systematic Review.

The presence of stereotypy is one of the core features exhibited by individuals diagnosed with autism spectrum disorder (ASD). Stereotypy can interfere with academic engagement and become a major barrier to appropriate education and social development of individuals with ASD. Studies have shown that antecedent physical exercise can produce reductions in stereotypy and positive collateral effects. The purpose of the current systematic review was to examine the collateral effects of antecedent physical exercise on stereotypy and engagement in nonstereotypic behaviors. The findings suggest that individuals with ASD can benefit from incorporating antecedent physical exercise with regard to stereotypy and other positive collateral behaviors. Implications of the results and areas for further research are discussed.

Use of a Feeding Station by Andean Condors in Central Chile

Abstract Organic waste disposals are a valuable food source for vultures. However, some negative collateral effects may result from their use. I documented Andean Condors' (Vultur gryphus) use of a feeding station, which was established in central Chile to reduce risks associated with condors' use of landfills. I also evaluated the changes in that use over time. The feeding station was in place between 2010 and 2016, from July to December, which are the months with the lowest food availability and the highest presence of condors at the landfill. Between 2010 and 2012, the daily maximum abundances were 85, 72, and 82 condors each respective year. In 2013, the daily maximum abundance peaked at 146 condors, but abundance subsequently decreased until 2016, possibly due to the availability of European rabbit (Oryctolagus cuniculus) carcasses associated with an outbreak of myxomatosis. The abundance of the four sex/age classes was highest for immature females, followed by adult females, immature males, and adult males. This contrasts with counts in areas not associated with a predictable source of food, where adult males are the most numerous (Pavez and Estades (2016), Journal of Raptor Research 50:23–32). The high proportion of immature females at the feeding station may reflect a feeding strategy that compensates for their lower social status and foraging effectiveness. Given the current situation in Chile, with the reduction of natural food sources and subsequent increasing use of landfills by condors, it is important to evaluate the use of feeding stations as a management tool during certain times and places.