Codonopsis Lanceolata Research Articles

Complete genome sequence of Codonopsis torradovirus A, a novel torradovirus infecting Codonopsis lanceolata in South Korea.

We herein present the complete genome sequence of codonopsis torradovirus A (CoTVA), which was isolated from Codonopsis lanceolata (deodeok) in Gangwon-do, South Korea. The CoTVA genome contains two positive-sense RNA segments, namely RNA1 (6922 nucleotides), which encodes a predicted polyprotein, and RNA2 (4613 nucleotides), which encodes a movement protein and coat proteins (CPs). The proteinase-polymerase (Pro-Pol) and CP amino acid sequences were 75% and 54% identical, respectively, to those of motherwort yellow mosaic virus. Pairwise comparisons of the Pro-Pol and CP sequences revealed that the virus described in this study should be considered a member of a new torradovirus species. Phylogenetic analysis of the Pro-Pol sequence encoded by RNA1 and the CP region encoded by RNA2 indicated that CoTVA is a new member of the genus Torradovirus in the family Secoviridae. CoTVA is the first torradovirus detected in Codonopsis lanceolata.

Selecting marker substances of main producing area of Codonopsis lanceolata in Korea using UPLC-QTOF-MS analysis

더덕(Codonopsis lanceolata)은 주로 한국, 중국 등 동아시아 지역에 재배되고 있으며, 더덕의 뿌리는 기침, 기관지염, 천식, 결핵, 소화 불량의 증상을 치료하기 위한 기능성 식품 및 전통 의학으로 사용되어져 왔다. 보고된 바에 의하면 phenylpropanoids, polyacetylenes, saponins, flavonoids와 같은 다양한 식물 천연물 성분들이 항비만, 항염, 항암, 항산화, 항미생물 활성과 같은 약리학적 작용에 관여한다고 보고되어 있다. MS기반 대사체학 분석을 이용한 주산지의 마커 성분을 선정하는 것은 다른 지역에서 재배된 약용 식물의 안전성뿐만 아니라 화학적 조성과 생물학적 효능의 변화와도 관련이 있기 때문에 부작용 없이 더덕의 유익한 효과만을 보장하는데 중요하다. 본 연구에서는 국내산 더덕의 주산지 특성을 구별하기 위해 UPLC-QTOF-MS를 기반으로 하는 대사체 프로파일링과 다변량 통계분석 기법인 PCA 분석을 수행하여 판별모델을 확립하였다. 그 결과 인제(강원도), 횡성(강원도), 무주(전라북도)의 3개 그룹이 PCA와 loading plot 분석결과 tangshenoside I, lancemaside A, lancemaside G는 더덕 주산지를 구별하기 위한 잠재적 대사체 마커들로 제안하였다.

Inhibitory effect of ethanol extract of Codonopsis lanceolata against oxidative stress and disruption of tight cell junction in NCI-H441 cells after exposure to urban particulate matter

Inhibitory effect of ethanol extract of Codonopsis lanceolata against oxidative stress and disruption of tight cell junction in NCI-H441 cells after exposure to urban particulate matter

Antioxidative and Antimicrobial Effects of Ethanol Extract of Codonopsis lanceolata by Steaming Times

Antioxidative and Antimicrobial Effects of Ethanol Extract of Codonopsis lanceolata by Steaming Times

Various Biological Activities of Extracts from Deodeok (Codonopsis lanceolata Trautv.) Buds

Ji Yeong Kim, Byung Soon Hwang, Su Hyun Kwon, Mi Jang, Gi Chang Kim, Hae Ju Kang, and In Guk Hwang. Journal of the Korean Society of Food Science and Nutrition 2021;50:10-5. https://doi.org/10.3746/jkfn.2021.50.1.10

Effect of extraction solvent on in vitro anti-inflammatory, antioxidant activity, total phenol and flavonoid contents in Codonopsis lanceolata

Many plant products from medicinal herbs are historically important for the treatment and prevention of diseases. Medicinal plants are showing a wide range of activities like antioxidant, anti-inflammatory, and anti-aging. This study was investigated to evaluate the phenolic content, DPPH, ABTS radical scavenging rate, and anti-inflammatory activity from Codonopsis lanceolata (CL) root extract. Total polyphenol and flavonoid content showed the highest amount in 30% EtOH extract of CL and followed by 90 °C hot water extract. The DPPH, ABTS radical scavenging activity was also found that the increase was proportional to the concentration, the highest amount in 30% EtOH extract. Cell viability of RAW 264.7 cell for CL extracts was not significantly changed by extracts up to a concentration of 200 µg/mL, and it was confirmed that the macrophage cell showed little toxicity. LPS-treated experimental group significantly inhibited NO production. The effect of extracts of CL against inflammatory mediators (TNF-α, IL-6, and IL-1β) production showed that the anti-inflammatory activity was most excellent in 30% EtOH. These results suggested that CL extracts tested here have potential anti-inflammatory and antioxidant activity, and these effects are differences depending on the extraction solvent.

Slippery flowers as a mechanism of defence against nectar-thieving ants.

The great diversity of floral characteristics among animal-pollinated plants is commonly understood to be the result of coevolutionary interactions between plants and pollinators. Floral antagonists, such as nectar thieves, also have the potential to exert an influence upon the selection of floral characteristics, but adaptation against floral antagonists has attracted comparatively little attention. We found that the corollas of hornet-pollinated Codonopsis lanceolata (Campanulaceae) and the tepals of bee-pollinated Fritillaria koidzumiana (Liliaceae) are slippery to nectar-thieving ants living in the plant's habitat; because the flowers of both species have exposed nectaries, slippery perianths may function as a defence against nectar-thieving ants. We conducted a behavioural experiment and observed perianth surface microstructure by scanning electron microscopy to investigate the mechanism of slipperiness. Field experiments were conducted to test whether slippery perianths prevent floral entry by ants, and whether ant presence inside flowers affects pollination. Scanning electron microscopy observations indicated that the slippery surfaces were coated with epicuticular wax crystals. The perianths lost their slipperiness when wiped with hexane. Artificial bridging of the slippery surfaces using non-slippery materials allowed ants to enter flowers more frequently. Experimental introduction of live ants to the Codonopsis flowers evicted hornet pollinators and shortened the duration of pollinator visits. However, no statistical differences were found in the fruit or seed sets of flowers with and without ants. Slippery perianths, most probably based on epicuticular wax crystals, prevent floral entry by ants that negatively affect pollinator behaviour. Experimental evidence of floral defence based on slippery surfaces is rare, but such a mode of defence may be widespread amongst flowering plants.

Evaluation of Antioxidant and α-glucosidase Inhibitory Activities of Codonopsisjavanica (Blume) Hook. f. Thoms’ Root Extract

Evaluation of Antioxidant and α-glucosidase Inhibitory Activities of Codonopsisjavanica (Blume) Hook. f. Thoms’ Root Extract

Codonopsis lanceolata Contributes to Ca2+ Homeostasis by Mediating SOCE and PLC/IP3 Pathways in Vascular Endothelial and Smooth Muscle Cells.

Codonopsis lanceolata has been widely used as an anti-inflammatory and anti-lipogenic agent in traditional medicine. Recently, C. lanceolata was reported to prevent hypertension by improving vascular function. This study evaluated the effects of C. lanceolata and its major component lancemaside A on cytosolic calcium concentration in vascular endothelial cells and vascular smooth muscle cells. Cytosolic calcium concentration was measured using fura-2 AM fluorescence. C. lanceolata or lancemaside A increased the cytosolic calcium concentration by releasing Ca2+ from the endoplasmic reticulum and sarcoplasmic reticulum and by Ca2+ entry into endothelial cells and vascular smooth muscle cells from extracellular sources. The C. lanceolata- and lancemaside A-induced cytosolic calcium concentration increases were significantly inhibited by lanthanum, an inhibitor of non-selective cation channels, in both endothelial cells and vascular smooth muscle cells. Moreover, C. lanceolata and lancemaside A significantly inhibited store-operated Ca2+ entry under pathological extracellular Ca2+ levels. In Ca2+-free extracellular fluid, increases in the cytosolic calcium concentration induced by C. lanceolata or lancemaside A were significantly inhibited by U73122, an inhibitor of phospholipase C, and 2-APB, an inositol 1,4,5-trisphosphate receptor antagonist. In addition, dantrolene treatment, which inhibits Ca2+ release through ryanodine receptor channels, also inhibited C. lanceolata- or lancemaside A-induced increases in the cytosolic calcium concentration through the phospholipase C/inositol 1,4,5-trisphosphate pathway. These results suggest that C. lanceolata and lancemaside A increase the cytosolic calcium concentration through the non-selective cation channels and phospholipase C/inositol 1,4,5-trisphosphate pathways under physiological conditions and inhibit store-operated Ca2+ entry under pathological conditions in endothelial cells and vascular smooth muscle cells. C. lanceolata or lancemaside A can protect endothelial cells and vascular smooth muscle cells by maintaining cytosolic calcium concentration homeostasis, suggesting possible applications for these materials in diets for preventing vascular damage.

First Report of Sclerotinia sclerotiorum Causing Sclerotinia Rot on Codonopsis lanceolata in Korea

Lance asiabell or deodeok (Codonopsis lanceolata L.) is native to East Asia such as Korea, China, Japan, and Russia. In Korea, roots of the plant are widely used as a food and medicine because of its high content of beneficial ingredients such as saponin. In May 2018, Sclerotinia rot symptoms on 2-year-old lance asiabell plants were observed in a field in Jeju (33.51° N, 126.84° E), Korea. Symptoms affecting the crown were water-soaked lesions associated with characteristic white cottony mycelia. Secondary symptoms such as wilting and bleaching were also observed on above-ground tissues. The incidence of diseased plants was approximately 10% in the field. Ten sclerotia were collected from the soil around the diseased plants, surface sterilized with 1% NaOCl for 1 min, and then rinsed twice in sterilized distilled water. The sclerotia were placed on water agar and incubated at 20°C for 5 days in the dark. Four isolates were obtained from mycelium grown from each sclerotium and were cultured on potato dextrose agar (PDA) at 20°C for 3 weeks in the dark. All isolates produced irregular and black sclerotia (1.8 to 4.5 mm in size) on a PDA plate. Based on morphological characteristics of mycelia and sclerotia, all isolates were tentatively identified as Sclerotinia sclerotiorum (Kohn 1979). To confirm the morphological identification of all isolates, DNA sequencing of the internal transcribed spacer (ITS) region of rDNA was carried out using ITS1 and ITS4 primer pair (White et al. 1990). The 505-bp products of nucleotide sequences obtained from four isolates (NC18657 to NC18660) were deposited in GenBank with accession numbers MK418968 to MK418971. The ITS region sequences of the four isolates were 100% identical with GenBank reference accession number KF859933 of S. sclerotiorum CBS 499.50. Pathogenicity assays were conducted using two isolates (NC18657 and NC18659) on the lance asiabell seedlings. Five healthy 2-week-old seedlings were inoculated by placing a sclerotium with PDA plug (3 × 3 mm) around the stem. The same number of seedlings were noninoculated controls and received noncolonized PDA plugs. Plants were maintained in the growth chamber at 20 ± 3°C with a 14-h photoperiod. After 4 weeks, all inoculated seedlings wilted. Black irregular sclerotia with white mycelium were observed on the soil surface. No symptoms were observed in the control plants. The fungus was consistently reisolated from the sclerotia formed on the soil surface, thus fulfilling Koch’s postulates. To our knowledge, this is the first report of S. sclerotiorum causing Sclerotinia rot on lance asiabell in Korea. Further studies are needed to develop integrated management of the disease on the host in Korea.

Lancemaside A Isolated from the Root of Codonopsis lanceolata Inhibits Ovarian Cancer Cell Invasion via the Reactive Oxygen Species (ROS)-Mediated p38 Pathway.

Codonopsis lanceolata roots have been widely used in Korean cuisine and traditional medicine. This study aimed to investigate the antimetastatic effects of lancemaside A, a major triterpenoid saponin, isolated from the roots of C. lanceolata, in human ovarian cancer cells. Lancemaside A significantly suppressed the migration and invasion and the expression of matrix metalloproteinases (MMPs)-2 and -9 in ovarian cancer A2780 and SKOV3 cells. Treatment with lancemaside A generated reactive oxygen species (ROS) in ovarian cancer cells. However, treatment with anti-oxidant N-acetyl-L-cysteine (NAC) significantly negated the anti-invasive activity of lancemaside A. Additionally, lancemaside A activated p38 MAP kinase, which is mediated by ROS generation. This is the first study, to our knowledge, to reveal that lancemaside A isolated from the roots of C. lanceolata exerts antimetastatic activity through inhibition of MMP expression and cancer cell invasion via activation of the ROS-mediated p38 pathway.

고구마껍질 주원료인 식물 혼합물의 RAW264.7 대식세포에서 면역활성 증진효과

This study aimed to investigate the immunostimulatory effect of a sweet potato peel-based plant mixture, including Platycodon grandiflorum, Codonopsis lanceolata and corn silk, on RAW264.7 macrophages. We tested the immunostimulatory effect of 12 plant extracts, individually, in terms of nitric oxide (NO) production in RAW264.7 macrophages. NO production of Platycodon grandiflorum, Codonopsis lanceolata, and corn silk extracts (PG, CL, CS) in RAW264.7 macrophages was significantly higher than that of other plant extracts (p<0.05). The cytotoxicity and production of NO and cytokines by PG, CL, CS, and weet potato peel extract (SP) in RAW264.7 macrophages were determined. The production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in PG, CL or CS-treated RAW264.7 macrophages was significantly higher than that of SP-treated ones (p<0.05). Immunostimulatory effect of the extract from plant mixture containing Platycodon grandiflorum, Codonopsis lanceolata, corn silk, and sweet potato peel in the ratio 1:1:0.5:3 (w/w) was significantly higher than that of SP extract alone, and was similar or higher than that of PG, CL, and CS, on RAW264.7 macrophages (p<0.05). Therefore, the extract from plant mixture may be considered as a potential candidate for the development of functional food materials for enhancing immune activity.

Beneficial effects of Codonopsis lanceolata extract on systolic blood pressure levels in prehypertensive adults: A double-blind, randomized controlled trial.

Codonopsis lanceolata (CL) extract was shown to have antihypertensive effects in hypertensive rats. This randomized controlled trial was designed to investigate the ability of CL extract to prevent hypertension (HTN) in prehypertensive subjects. Eighty subjects aged 19-60years with a systolic blood pressure (BP) of 120-139mmHg and a diastolic BP of 80-89mmHg were recruited over 3months. Subjects were randomized 1:1 to a CL group and a placebo (PL) group and administered CL extract and starch, respectively, for 6weeks. (BP) was measured and blood sampled at baseline and at the end of the trial. Relative to baseline, systolic BP was significantly decreased, and catalase activity was significantly increased following CL treatment in both the elevated systolic BP and stage 1 HTN subgroups. In the elevated systolic BP subgroup, serum nitrite concentration relative to baseline was significantly increased in CL compared to PL treated subjects (p=.038). In subjects with stage 1 HTN, high sensitivity C-reactive protein (p=.020) and malondialdehyde (p=.039) showed significantly greater reductions from baseline in the CL than in the PL group. In summary, CL was effective in preventing endothelial dysfunction, inflammation, and lipid peroxidation in prehypertensive subjects, with these effects differing according to baseline systolic BP levels.

Carbon Dioxide Enrichment Combined with Supplemental Light Improve Growth and Quality of Plug Seedlings of Astragalus membranaceus Bunge and Codonopsis lanceolata Benth. et Hook. f.

Astragalus membranaceus Bunge and Codonopsis lanceolata Benth. et Hook. f. are two medicinal species used to remedy inflammation, tumor, and obesity in Eastern medicine. Carbon dioxide (CO2) and supplemental lighting are two methods to enhance the growth, yield, and quality of crops. However, few studies have focused on the synergistic effects of CO2 and the supplemental light source on plug seedlings of medicinal species. In this study, uniform seedlings were grown with no supplemental light (the control) or under one of three supplemental light sources [high pressure sodium (HPS), metal halide (MH), or mixed light-emitting diodes (LEDs)] combined with one of three levels of CO2 (350, 700, or 1050 μmol·mol−1). The supplemental light (100 μmol·m−2·s−1 photosynthetic photon flux density) and CO2 were provided simultaneously from 10:00 pm to 2:00 am every day. The results showed that the supplemental lighting (LEDs, MH, and HPS) greatly improved the seedling quality with greater dry weights (of the shoot, root, and leaf), stem diameter, leaf area, and Dickson’s quality index (DQI) than those of the control in both species. An enriched CO2 at 1050 μmol·mol−1 accelerated the growth and development of plug seedlings, evidenced by the increased root and leaf dry weights, stem diameter, and DQI compared to the those from the other two CO2 enrichment levels. Moreover, LEDs combined with 1050 μmol·mol−1 CO2 not only increased the contents of soluble sugars but also the starch content. However, an enriched CO2 at 700 μmol·mol−1 was more suitable for the accumulation of total phenols and flavonoids. Furthermore, LEDs combined with 700 or 1050 μmol·mol−1 CO2 increased the chlorophyll, quantum yield, and stomatal conductance at daytime and nighttime for A. membranaceus and C. lanceolata, respectively. In conclusion, the data suggest that LEDs combined with CO2 at 1050 μmol·mol−1 is recommended for enhancing the growth and development of plug seedlings of A. membranaceus and C. lanceolata.

Codonopsis lanceolata polysaccharide CLPS alleviates high fat/high sucrose diet-induced insulin resistance via anti-oxidative stress

Polysaccharide has been considered as an important bioactive compound in Codonopsis lanceolata. High fat/high sucrose (HFHS) diet-induced insulin resistance is implicated in multiple metabolic diseases, such as type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD), these metabolic diseases has become epidemic health issue worldwide. In this study, the effect of C. lanceolata polysaccharide (CLPS) on improving insulin sensitivity in chronic HFHS diet-fed mice was investigated. Our data indicates that CLPS significantly reduced fasting blood glucose (FBG), fasting serum insulin (FINS) and insulin resistance index, in parallel with improved glucose and insulin tolerance impaired by HFHS diet. Impaired phosphorylation of PKB/Akt and hyperphosphorylation of IRS-1 at Ser307 were observed in the mice fed with HFHS diet, and those defects were also rescued by CLPS administration. In addition, CLPS caused a significant decrease in the level of malondialdehyde (MDA), and an increase in reduced glutathione (GSH)/oxidised glutathione (GSSG) ratio; concurrent with enhanced expression of antioxidant enzymes including superoxide dismutase (SOD) and catalase (CAT), and activated Nrf2 signaling. In summary, these findings suggest that CLPS ameliorates HFHS diet-induced insulin resistance through activating anti-oxidative signaling pathway, providing new insights into the protective effects of C. lanceolata polysaccharide in metabolic disease.

Manipulating the Difference between the Day and Night Temperatures Can Enhance the Quality of Astragalus membranaceus and Codonopsis lanceolata Plug Seedlings

Astragalus membranaceus Bunge and Codonopsis lanceolata Benth. et Hook. f. are two famous medical species in Korea, China, and Japan, mainly used for treating diseases including cancer, obesity, and inflammation. Manipulation of the difference between the day and night temperatures (DIF) is an efficient horticultural practice to regulate the growth and development of vegetables in a glasshouse. However, little research has focused on how the DIF influences the plug seedling quality of medicinal plants. In this study, uniform plug seedlings were cultivated in three environmentally controlled chambers under an average daily temperature of 20 °C with negative (−10 °C), zero, or positive (+10 °C) DIFs, and the same relative humidity (75%), photoperiod (12 h), and light intensity (150 μmol·m−2·s−1 photosynthetic photon flux density with white LEDs). The results showed that the DIF had a noticeable effect on the growth, development, and morphology of A. membranaceus and C. lanceolata plug seedlings. The positive DIF (+10 °C) significantly increased the biomass (shoot, root, and leaf), stem diameter, and Dickson’s quality index, indicating an enhanced plug seedling quality. Moreover, the contents of primary and secondary metabolites, including soluble sugar, starch, total phenols and flavonoids, were higher with higher DIFs, where the maximum values were found at 0 °C or +10 °C DIF. Furthermore, the increases in the chlorophyll content and stomatal conductance were obtained in a positive DIF, indicating that a positive DIF was favorable to photosynthesis. An analysis of the gene expression showed that a positive DIF (+10 °C) up-regulated the expression of photosynthetic genes, including GBSS, RBCL, and FDX. In conclusion, the results of this study recommend a positive DIF (+10 °C) for enhancing the quality of A. membranaceus and C. lanceolata plug seedlings.

Night Temperature Affects the Growth, Metabolism, and Photosynthetic Gene Expression in Astragalus membranaceus and Codonopsis lanceolata Plug Seedlings.

Astragalus membranaceus and Codonopsis lanceolata are two important medical herbs used in traditional Oriental medicine for preventing cancer, obesity, and inflammation. Night temperature is an important factor that influences the plug seedling quality. However, little research has focused on how the night temperature affects the growth and development of plug seedlings of these two medicinal species. In this study, uniform plug seedlings were cultivated in three environmentally controlled chambers for four weeks under three sets of day/night temperatures (25/10 °C, 25/15 °C, or 25/20 °C), the same relative humidity (75%), photoperiod (12 h), and light intensity (150 μmol·m−2·s−1 PPFD) provided by white LEDs. The results showed that night temperature had a marked influence on the growth and development of both species. The night temperature of 15 °C notably enhanced the quality of plug seedlings evidenced by the increased shoot, root, and leaf dry weights, stem diameter, and Dickson’s quality index. Moreover, a night temperature of 15 °C also stimulated and increased contents of primary and secondary metabolites, including soluble sugar, starch, total phenols and flavonoids. Furthermore, the 15 °C night temperature increased the chlorophyll content and stomatal conductance and decreased the hydrogen peroxide content. Analysis of the gene expression showed that granule-bound starch synthase (GBSS), ribulose bisphosphate carboxylase large chain (RBCL), and ferredoxin (FDX) were up-regulated when the night temperature was 15 °C. Taken together, the results suggested that 15 °C is the optimal night temperature for the growth and development of plug seedlings of A. membranaceus and C. lanceolata.

SK-N-SH 세포에서 도라지, 더덕, 옥수수수염, 가시오가피의 Nitric Oxide에 의한 세포 독성 억제 효과

SK-N-SH 세포에서 도라지, 더덕, 옥수수수염, 가시오가피의 Nitric Oxide에 의한 세포 독성 억제 효과

Lancemaside A from Codonopsis lanceolata prevents hypertension by inhibiting NADPH oxidase 2-mediated MAPK signalling and improving NO bioavailability in rats.

This study investigated whether lancemaside A (LMA) can prevent hypertension and assessed the mechanisms of action of LMA in rats. Hypertension was induced by chronic immobilization stress and nicotine administration. Hypertensive vehicle rats were treated with LMA (1, 20, or 40mg/kg) or nifedipine (10mg/kg) as a positive control daily for 3weeks. In hypertensive vehicle rats, LMA dose-dependently reduced systolic blood pressure. LMA doses of 20 and 40mg/kg reduced the aortic expression of nicotinamide adenine dinucleotide phosphate oxidase (NOX)2 (both P<0.01), and 40mg/kg LMA reduced serum malondialdehyde (P<0.01). Serum nitrite levels were significantly higher in LMA treated rats than in hypertensive vehicle rats, with LMA doses of 20 and 40mg/kg reducing the expression of endothelial nitric oxide synthase in rat aortas (P<0.001 and P<0.01, respectively). LMA also reduced the aortic levels of nuclear factor kappa B and the activation of the three isoforms of mitogen-activated protein kinase (MAPK). Lancemaside A prevents hypertension in rats by inhibiting the activation of MAPK signalling and the impairment in nitric oxide bioavailability due to NOX2-mediated oxidative stress. Thus, LMA may act as a preventive agent for hypertension.

Deodorization Effects and Antibacterial Activity of Codonopsis lanceolata Extract

Purpose: The antioxidant effects and antibacterial effects on 7 types of dermatitis of Codonopsis lanceolata (C. lanceolata ) ethanol and water extracts were investigated to study its potential as an ingredient of antibacterial cosmetics for skin and functional cosmetics for hair by testing its deodorization effects on ammonia. Methods: The total polyphenol and flavonoid contents, electron donating ability, ABTS radical scavenging activity of C. lanceolata extracts were investigated for its antioxidant effects and the antibacterial effects of c. lanceolata extract on 7 different germs causing dermatitis were explored with the paper disc method. In addition, a gas detection method was employed to test the deodorizing effects on ammonia. Results: As a result of the antioxidant effects test, the total polyphenol contents of C. lanceolata ethanol and water extracts were 88.86±1.64 and 76.46±1.23 μg/ mL, respectively, and the total flavonoid contents were measured 78.29±1.13 and 60.02±1.35μg/mL, respectively. As for the 2,2-diphenylpicrylhydrazyl (DPPH) scavenging activity was 78.78% and 62.12%. The test on 2,2'-Azinobis [3-ethylbenzothiazoline-6-sulfonic acid]-diammonium salt (ABTS) radical scavenging activity with was 80.12% and 72.24%. For the 7 dermatitis germs, C. lanceolata ethanol extract and water extract showed antibacterial effects at the concentration of 5 mg/mL. For the deodorization effects of C. lanceolata extract on ammonia, ethanol extract revealed 98% of deodorizing effects after 30 min. Conclusion: C. lanceolata ethanol extract had greater antioxidant effects and antibacterial effects on the 7 dermatitis germs than water extract; with higher deodorizing effects, it is considered suitable for making antibacterial cosmetics for skin and functional products for hair.