Cobalt Ferrite Nanoparticles Research Articles

Optimization of cobalt ferrite magnetic nanoparticle as a theranostic agent: MRI and hyperthermia.

Magnetic nanoparticles (MNPs) are considered a theranostic agent in MR imaging, playing an effective role in inducing magnetic hyperthermia. Since, high-performance magnetic theranostic agents are characterized by superparamagnetic behavior and high anisotropy, in this study, cobalt ferrite MNPs were optimized and investigated as a theranostic agent. CoFe2O4@Au@dextran particles were synthesized and characterized by DLS, HRTEM, SEM, XRD, FTIR, and VSM methods. After cytotoxicity evaluation, MR imaging parameters (r1, r2 and r2 / r1) were calculated for these nanostructures. Afterward, magnetic hyperthermia at the frequency of 425kHz was applied to calculate specific loss power (SLP). Formation of CoFe2O4@Au@dextran was confirmed by UV-Visible spectrophotometry. On the basis of the relaxometric and hyperthermia induction findings of nanostructures in all stages of synthesis, the CoFe2O4@Au@dextran could produce the highest parameters of r2 and r2/r1 and SLP with values ​​of 389.7, 51.2mM-1s-1, and 2449 W/g, respectively. The formation of multi-core MNPs by dextran coating is expected to improve the magnetic properties of the nanostructure, leading to optimization of theranostic parameters, so that CoFe2O4@Au@dextran NPs can create contrast-enhanced images more than three times the clinical use and require less contrast agent, reducing side effects. Accordingly, CoFe2O4@Au@dextrancan be introduced as a suitable theranostic nanostructurewith optimal efficiency.

Preparation of a 3D printable high-performance GelMA hydrogel loading with magnetic cobalt ferrite nanoparticles.

Osteosarcoma remains a worldwide concern due to the poor effectiveness of available therapies in the clinic. Therefore, it is necessary to find a safe and effective therapy to realize the complete resection of osteosarcoma and reconstruction of the bone defect. Magnetic hyperthermia based on magnetic nanoparticles can kill tumor cells by raising the temperature without causing the side effects of conventional cancer treatments. This research aims to design a high-performance magnetic hydrogel composed of gelatin methacrylate and highly magnetic cobalt ferrite (CFO) nanoparticles for osteosarcoma treatment. Specifically, CFO is surface functionalized with methacrylate groups (MeCFO). The surface modified CFO has good biocompatibility and stable solution dispersion ability. Afterward, MeCFO nanoparticles are incorporated into GelMA to fabricate a three-dimensional (3D) printable MeCFO/GelMA magnetic hydrogel and then photocross-linked by UV radiation. MeCFO/GelMA hydrogel has high porosity and swelling ability, indicating that the hydrogel possesses more space and good hydrophily for cell survival. The rheological results showed that the hydrogel has shear thinning property, which is suitable as a bioprinting ink to produce desired structures by a 3D printer. Furthermore, 50μg/mL MeCFO not only decreases the cell activity of osteosarcoma cells but also promotes the osteogenic differentiation of mBMSCs. The results of the CCK-8 assay and live/dead staining showed that MeCFO/GelMA hydrogel had good cytocompatibility. These results indicated that MeCFO/GelMA hydrogel with potential antitumor and bone reconstruction functions is a promising therapeutic strategy after osteosarcoma resection.

MHD Flow and Heat Transfer of a Ternary Hybrid Ferrofluid Over a Stretching/Shrinking Porous Sheet with the Effects of Brownian Diffusion and Thermophoresis

In this paper, the magnetohydrodynamic (MHD) flow of a ternary hybrid ferrofluid over a stretching/shrinking porous sheet in the presence of radiation and mass transpiration is studied. The ternary hybrid nanofluid is formed by suspending three types of nanoparticles for enhancing heat transfer. The nanoparticles of copper, (Cu) iron oxide (Fe3O4), and cobalt ferrite (CoFe2O4) are suspended in water in this study, producing in the combination Cu-Fe3O4-CoFe2O4-H2O. Brownian motion and thermophoresis are integrated into the ternary hybrid ferrofluid model. Similarity transformations convert the governing partial differential equations into ordinary differential equations. The boundary value problem (BVP) is used in the Maple computer software to solve transformed equations numerically. The computed results for relevant parameters such as velocity profile, temperature profile, skin friction coefficient, local Nusselt and Sherwood numbers are visually shown and explained in detail.

Synthesis of the cobalt ferrite magnetic nanoparticles by sol–gel auto-combustion method in the presence of egg white (albumin)

Synthesis of the cobalt ferrite magnetic nanoparticles by sol–gel auto-combustion method in the presence of egg white (albumin)

Cation trivalent tune of crystalline structure and magnetic properties in coprecipitated cobalt ferrite nanoparticles

CoFe2O4, CoBi0.1Fe1.9O4, CoLa0.1Fe1.9O4, and CoAl0.1Fe1.9O4 nanoparticles were successfully synthesized by the coprecipitation method. After annealing at 700 °C for 5 h, the x-ray Diffractometer results confirm that a single phase of cobalt ferrite-based nanoparticles is obtained, which is suitable for ICDD 22-1086. The addition of Bi3+, La3+ and Al3+ ions to the cobalt ferrite nanoparticles modified the crystallite size and lattice constant. Trivalent metal cation substitution tunes the crystallite size which has also been confirmed by measuring the grains with Scanning Electron Microscope images. In the Far Transform Infra-Red curve, the addition of metal ions (Bi3+, La3+, and Al3+) to cobalt ferrite nanoparticles resulted in absorption peaks at the tetrahedral and octahedral sites without any additional absorption peaks. The VSM results showed that saturation magnetization decreased drastically in the presence of trivalent non-magnetic cations, which confirms the replacement of Fe3+ by trivalent non-magnetic cations. The kOe order of the coercive field was obtained in this experiment. The largest coercive field of the cobalt ferrite nanoparticles was obtained with the addition of La3+ ions, i.e. 3.67 kOe suggest to support both Jahn-Teller effect and strain-induced magnetism.

Synthesis and characterization of nanoparticles of cobalt and nickel ferrites for elimination of hazardous organic dyes from industrial wastewater.

This study presents the results of synthesis and characterization of nanoparticles of cobalt ferrite (CoFe2O4) and nickel ferrite (NiFe2O4) using co-precipitation method followed by application for removal of hazardous organic textile dyes of thiazole yellow G (TYG) and alizarin yellow R (AYR). XRD analysis confirmed formation of cubic spinel structure with average crystallite sizes at 16.07nm and 13.84nm for CoFe2O4 and NiFe2O4, respectively. Field emission scanning electron microscopy (FESEM) analysis showed agglomeration of spherical shape morphology with uniformly distributed Co, Ni, Fe, and O elements. The surface area calculated from Brunauer-Emmett-Teller (BET) analysis was 64 m2/g and 62 m2/g for CoFe2O4 and NiFe2O4, respectively. Vibrating sample magnetometer (VSM) showed super-paramagnetic behavior for all samples with magnetic saturation (Ms) at 7.269 and 6.61emu/g for CoFe2O4 and NiFe2O4, respectively. The adsorption influencing parameters such as pH of solution, quantity of adsorbent, and contact time on dye removal efficiency were thoroughly investigated. Overall, acidic condition of samples with pH at 4 favored the maximum removal efficiency by CoFe2O4 as 98, 97, and 93%, and by NiFe2O4 as 96, 93, and 92%, respectively, for TYG, AYR, and mixture sample. The Langmuir adsorption isotherm model describes the equilibrium of all samples with the best fit of coefficient of determination (R2). The adsorption results fitted well with a pseudo-second-order kinetic model for all samples. The regeneration-reuse ability of adsorbents and cost estimation analysis of the dye removal process suggested that the economic suitability of nano-adsorbents for remediation of textile effluents was favored. The estimated thermodynamic parameters inferred that the removal of organic dyes onto the surface of CoFe2O4 and NiFe2O4 is a spontaneous, favorable, and exothermic physical adsorption process.

Structural, magnetic and antibacterial studies of gadolinium doped cobalt ferrite nanoparticles synthesized at low temperature

In this work structural, magnetic and antimicrobial studies of gadolinium (Gd) doped cobalt ferrite nanopowder samples were synthesised through facile auto-combustion route using citric acid as combustion agent. The pristine nanopowders were sintered at 600 °C. X-ray diffraction (XRD), infrared spectroscopy (IR) measurements indicated the formation of a single spinel phase. The lattice constant gradually increased from 8.3801 Å to 8.3915 Å with increasing Gd concentration. The average crystallite size varied from 54 nm to 42.7 nm. The correlation between the cation distribution from XRD and the magnetic properties is discussed. The substitution of Gd ions significantly reduced the magnetisation from 60.6 to 36.6 emu g−1 and increased the coercivity. Antimicrobial activities of pure and Gd substituted cobalt ferrite are carried out against Gram-positive (Bacillus subtilis) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) and also against fungi strain (Aspergillus niger) pathogens, suggesting that Gd substitution significantly improves the activity of cobalt ferrite nanopowders.

Correction to the paper "Synthesis and magnetic properties of cobalt ferrite nanoparticles formed under hydro and solvothermal condition"

Correction to the paper "Synthesis and magnetic properties of cobalt ferrite nanoparticles formed under hydro and solvothermal condition"

Cobalt ferrite nanoparticles anchored on reduced graphene oxide nanoribbons (0D/1D CoFe2O4/rGONRs) as an efficient catalyst for hydrogen generation via NaBH4 hydrolysis

For better performance of nanoparticles as the heterogeneous catalyst, various materials with a large surface area have been introduced as the substrate. Herein, CoFe2O4 nanoparticles were anchored on carbon nanotubes (CoFe2O4/CNTs) and graphene nanoribbons (CoFe2O4/GONRs) to investigate the influence of substrate in the catalytic performance. These nanocomposites were evaluated in a NaBH4 hydrolysis reaction to produce hydrogen. The results showed that the highest hydrogen volume occurs in the presence of CoFe2O4/GONRs nanocatalyst. Abundant oxygen-based functional groups at the edges of GONRs offered excellent sites for CoFe2O4 nanoparticles and improved catalytic performance. Under optimum conditions (2.0 wt% of NaBH4, 15 mg of catalyst, 2.0 wt% of NaOH), the hydrogen generation rate was found to be 3.7 L g-1min−1 at 35 °C. The activation energy was calculated using the Arrhenius method, equivalent to 31.4 kJ mol−1. Therefore, CoFe2O4/GONRs catalyst can be a novel and efficient candidate for hydrogen production as a clean fuel.

Preparation and characterization of chitosan/polyethylene glycol and cobalt ferrite magnetic-polymeric nanoparticles as resveratrol carriers: preparation, analytical methodology validation and in vitro applicability

ABSTRACT The objective of this research was to produce, characterize and evaluate biological activities of magnetic-polymeric nanoparticles loaded with resveratrol. Magnetic nanoparticles of cobalt ferrite (CoFe2O4), polymeric nanoparticles of chitosan (CS) and polyethylene glycol (PEG), and polymeric-magnetic nanoparticles containing resveratrol (RSV) were developed. An analytical method using UV-VIS spectroscopy was developed and validated for the determination of RSV in the nanoparticles. The samples were analyzed by dynamic light scattering (DLS) for size, polydispersity index (PDI) and zeta potential. The encapsulation efficiency was determined by an indirect method. Antioxidants (ABTS and DPPH) and antibacterial (MIC and CBM) activities were evaluated. The average size of the nanoparticles varied between 184.6 and 276.5 nm. The magnetic-polymeric nanoparticles showed high encapsulation efficiency (EE) (98.75%) with a slow and prolonged release rate of 33.49% in 120 h. Furthermore, three months of storage showed less than 10% of RSV degradation. Its antioxidant activity (AA) was 170.55 mmol TE g−1 (by the ABTS method) and 130.60 mmol TE g−1 (by the DPPH method). The resveratrol-loaded magnetic-polymeric nanoparticles inhibited the growth of four tested bacteria. Their MIC values were less than 52.36 µg mL−1, and the CBM values of the nanoparticles >52.36 µg mL−1.

In-situ preparation of CoFe2O4 nanoparticles on eggshell membrane-activated carbon for microwave absorption

This study explores the potential of using cobalt ferrite (CF) nanoparticles grown in situ on eggshell membranes (ESM) to mitigate the increasing problem of electromagnetic interference (EMI). A simple carbonization process was adopted to synthesize CF nanoparticles on ESM. The study further examines the composites' surface morphology and chemical composition and evaluates their microwave absorption performance (MAP) at X-band frequency. Results showed that the composite of CF and ESM - CESM@CF, exhibited a strong RL peak value of −39.03 mm with an optimal thickness of 1.5 mm. The combination of CF and ESM demonstrates excellent impedance matching and EM wave attenuation. The presence of numerous interfaces, conduction loss from the morphology, interfacial polarisation, and dual influence from both CF and ESM contribute to the high MAP of the composite. CESM@CF composite is projected as an excellent biomass-based nano-composite for EM wave absorption applications.

Reduced Graphene Oxide-Modified Spinel Cobalt Ferrite Nanocomposite: Synthesis, Characterization, and Its Superior Adsorption Performance for Dyes and Heavy Metals.

This work is dedicated to the synthesis, characterization, and adsorption performance of reduced graphene oxide-modified spinel cobalt ferrite nanoparticles. The as-synthesized reduced graphene oxide cobalt ferrite (RGCF) nanocomposite has been characterized using FTIR spectroscopy, FESEM coupled with EDXS, XRD, HRTEM, zeta potential, and vibrating sample magnetometer (VSM) measurements. FESEM proves the particle size in the range of 10 nm. FESEM, EDX, TEM, FTIR, and XPS analyses provide the proof of successful incorporation of rGO sheets with cobalt ferrite nanoparticles. The crystallinity and spinel phase of cobalt ferrite nanoparticles have been shown by XRD results. The saturation magnetization (M s) was measured as 23.62 emu/g, proving the superparamagnetic behavior of RGCF. The adsorption abilities of the synthesized nanocomposite have been tested using cationic crystal violet (CV) and brilliant green (BG) and anionic methyl orange (MO) and Congo red (CR) dyes. The adsorption trend for MO, CR, BG, and As(V) follows RGCF > rGO > CF at neutral pH. Adsorption studies have been accomplished by optimizing parameters like pH (2-8), adsorbent dose (1-3 mg/25 mL), initial concentration (10-200 mg/L), and contact time at constant room temperature (RT). To further investigate the sorption behavior, isotherm, kinetics, and thermodynamic studies have been conducted. Langmuir isotherm and pseudo-second-order kinetic models suited better for the adsorption of dyes and heavy metals. The maximum adsorption capacities (q m) obtained have been found as 1666.7, 1000, 416.6, and 222.2 mg/g for MO, CR, BG, and As, respectively, with operational parameters such as T = 298.15 K; RGCF dose: 1 mg for MO and 1.5 mg each for CR, BG, and As. Thus, the RGCF nanocomposite was found to be an excellent adsorbent for the removal of dyes and heavy metals.

An effective and eco‐friendly sonochemical multicomponent synthesis of trisubstituted imidazoles via modified silica‐coated cobalt ferrite nanoparticles by tungstic acid

This research is providing a method for the synthesis of 2,4,5‐trisubstituted imidazole derivatives based on pursuing the green chemistry principles. Therefore, a one‐pot multicomponent cyclocondensation reaction through aldehyde interaction with ammonium acetate and 1,2‐diketone was carried out in EtOH:H2O solvent under ultrasound irradiation. This protocol was utilized as an eco‐effective synthetic route by applying CoFe2O4@SiO2@(‐CH2)3OWO3H nanocomposite as a nanocatalyst. The stabilized tungstic acid on 3‐chloropropyl anchored to SiO2‐coated CoFe2O4 magnetic nanoparticles was designed, prepared, and applied as a recyclable heterogeneous acid catalyst to attain high product yields and short reaction times. The structure of nanocatalyst was confirmed by using Fourier transform infrared spectroscopy (FT‐IR), X‐ray diffraction (XRD), field emission scanning electron microscopy (FE‐SEM), energy dispersive spectroscopy (EDS), vibrating sample magnetometer (VSM), thermogravimetric analysis (TGA), and Brunauer–Emmett–Teller (BET) techniques, and the obtained organic derivatives were examined through melting point, FT‐IR, and 1H NMR analyses.

Facile fabrication of mesoporous carbon-anchored cobalt ferrite nanoparticles as a heterogeneous activator of peroxymonosulfate for efficient degradation of Congo red.

Herein, mesoporous carbon-anchored cobalt ferrite nanocomposites (nano-CoFe2O4@MC) were fabricated using a hydrothermal method for application as heterogeneous catalysts to activate peroxymonosulfate (PMS), in order to solve the problems of low activation performance and secondary pollution caused by the inter-particle agglomeration, metal ion leaching, and difficult recovery of nano metal catalysts. Analysis techniques such as SEM, TEM, XRD, BET, FTIR, VSM, TGA, and Raman spectroscopy indicated that the prepared nanocomposites have excellent surface properties, structural stability, and magnetic properties. The performance of nano-CoFe2O4@MC for Congo red (CR) degradation was evaluated by comparison with other treatment systems and study of the influence of experimental parameters, including the anchoring ratios, catalyst dosage, PMS concentration, initial pH, CR concentration, coexisting anions, and humic acid. Both radical and nonradical pathways were observed in the activation process of PMS by nano-CoFe2O4@MC. The analysis results of the element composition and ionic state of the catalyst show that the redox cycle of two ion pairs, Co3+/Co2+ and Fe2+/Fe3+, could enhance the multipath electron transfer on the catalyst surface to promote the generation of reactive oxygen species. Identification of the intermediate products revealed CR was transformed into 12 intermediates through two branch pathways in the nano-CoFe2O4@MC/PMS system. After five cycles of use, the catalytic efficiency of the catalyst did not decrease significantly. Nanocomposites with high catalytic performance, stability, recyclability, and a low ion leaching rate have broad application prospects in the treatment of antibiotic wastewater.

Effects of Chromium(III) Ion Doping on Structural, Optical, and Magnetic Properties of Nickel–Cobalt Ferrite Nanoparticle

Chromium(III)-doped nickel–ferrite nanoparticles, with the general formula Ni0.5Co0.5CrxFe2−xO4 (x = 0.0, 0.10, and 0.20), were prepared by the sol–gel method. The prepared samples were sintered at 700°C for 5 hr. The XRD result showed that the prepared samples are in single-phase partially inverse cubic spinel ferrite structures with space group Fd3m. From the XRD characterization, the average crystallite size for all samples decreased from 39.54 to 30.42 nm and the lattice parameters are found to be 0.8324, 0.8320, and 0.8314 nm for x = 0.0, 0.10, and 0.20, respectively. The energy dispersive X-ray (EDX) spectroscopy analysis confirmed the presence of all ions as per the stoichiometric ratios. The vibrating sample magnetometer measurements revealed that the saturation magnetization (Ms), remnant magnetization (Mr), and coercive fields are found to be decreased with increasing concentration of Cr3+ ions. The UV–vis spectroscopy analysis showed that the energy bandgap (Eg) increased with increasing the concentration of Cr3+ ion from 1.61 to 1.96 eV. The Fourier transform infrared spectra show the two main absorption bands at 407–424 cm−1 and 547–588 cm−1 corresponding to stretching vibrations of metal–oxygen in the octahedral and tetrahedral sites, respectively.

Detailed studies on structural, morphological, optical, magnetic and mossbauer properties of Cu-substituted cobalt ferrite nanoparticles

In this research, the effect on the morphology, structure, optic, magnetic and Mossbauer features of Cu2+ doping in Co1−xCuxFe2O4 (x = 0.0–1.0) nanoparticles fabricated using the sol-gel auto-combustion reaction method were investigated. The mainly pure phase structure of Co-spinel was observed in x-ray diffraction (XRD) patterns. The sizes of crystal were observed in between 28.77–36.25 nm. The fundamental vibrational bands of the nanoparticles have been found at 426 and 602 cm−1 wavelengths via the Fourier transform infrared (FT-IR) spectrum. The most of Co2+ ions are located at the A site and that substitution by Cu+2 ions at the octahedral site for x = 0.0, 0.25, and 0.50. for x = 0.75 content, the Mössbauer results show that some Cu2+ ions are present in both A and B sites. Magnetization measurements at room temperature show that Cu2+ substitution into Co-ferrite significantly changes the magnetic quantities such as coercivity field (Hc), remnant (Mr) and saturation magnetization (Ms). Magnetic hysteresis curves obtained at room temperature show well-known S-shaped features for all nanoparticles with Ms values of 51.5–64.4 emu g−1, Mr values of 31–36 emu g−1 and H c values of 429.5–1447.8 Oe.

Green Synthesis of Cobalt Ferrite Nanoparticles: An Emerging Material for Environmental and Biomedical Applications

Research and utilization of nanotechnology are growing exponentially in every aspect of life. The constant growth of applications for magnetic nanoparticles, specifically nanoferrites, attracted many researchers. Among them, nanocobalt ferrite is the most crucial and studied magnetic nanoparticle. Environmentally benign synthetic methods became necessary to minimize environmental and occupational hazards. Green synthesis approaches in science and technology are now widely applied in the synthesis of nanomaterials. Herein, we reviewed recent advances in synthesizing nanocobalt ferrites and their composites using various scientific search engines. Subsequently, various applications were discussed, such as environmental (treatment of water/wastewater, photocatalytic degradation of dyes, and nanosorbent for environmental remediation) and biomedical (nanobiosensors for cancer diagnosis at the primary stage, effective targeted drug delivery, magnetic resonance imaging, hyperthermia, and potential drug candidates against cancer and microbial infections). This review offers comprehensive knowledge on how to choose appropriate natural resources for the green synthesis of nanocobalt ferrite and the benefits of this approach compared to conventional methods.

An Effective Method of Magnetic Hyperthermia Based on the Ferromagnetic Resonance Phenomenon

Nickel and cobalt ferrite nanoparticles have been synthesized using the chemical precipitation method; the nanoparticle sizes were found to be 63 ± 22 and 26 ± 4 nm, respectively. The static hysteresis loops and Mössbauer spectra have been measured. It is shown that cobalt ferrite powders are magnetically harder than nickel ferrite powders. Ferromagnetic resonance (FMR) curves have been studied. It is found that the FMR absorption for cobalt ferrite is observed at room temperature and above. The time dependences of the nanoparticle warm-up under FMR conditions have been measured. The maximum temperature changes for nickel ferrite and cobalt ferrite particles are 8 and 11 K, respectively. Using the example of cobalt ferrite powder, the possibility of effectively heating of particles in the FMR mode in their own field without using a DC magnetic field source is shown. The observed effect can be used in magnetic hyperthermia.

Gamma irradiation mediated production improvement of some myco-fabricated nanoparticles and exploring their wound healing, anti-inflammatory and acetylcholinesterase inhibitory potentials

In the current scenario, scaling up the microbial production of nanoparticles with diverse biological applications is an emerging prospect for NPs’ sustainable industry. Thus, this paper was conducted to develop a suitable applicative process for the myco-fabrication of cobalt-ferrite (CoFeNPs), selenium (SeNPs), and zinc oxide (ZnONPs) nanoparticles. A strain improvement program using gamma irradiation mutagenesis was applied to improve the NPs-producing ability of the fungal strains. The achieved yields of CoFeNPs, SeNPs, and ZnONPs were intensified by a 14.47, 7.85, and 22.25-fold increase from the initial yield following gamma irradiation and isolation of stable mutant strains. The myco-fabricated CoFeNPs, SeNPs, and ZnONPs were then exploited to study their wound healing, and anti-inflammatory. In addition, the acetylcholinesterase inhibition activities of the myco-fabricated NPs were evaluated and analyzed by molecular docking. The obtained results confirmed the promising wound healing, anti-inflammatory, and acetylcholinesterase inhibition potentials of the three types of NPs. Additionally, data from analyzing the interaction of NPs with acetylcholinesterase enzyme by molecular docking were in conformation with the experimental data.

Antibacterial activities of Bi-Ag co-doped cobalt ferrite and their ZnO/Ag nanocomposite/s

Cobalt ferrite was co-doped with bismuth and silver of different concentrations via sol–gel combustion method. Citric acid was used as fuel. The powder product was calcined using an electric furnace at 1000 °C for 4 hrs. X-ray diffraction pattern of co-doped cobalt ferrite nanoparticles (CF-NPs) showed the formation of cubic crystalline structure. Few very small absorption bands were also observed. The crystallite sizes of these materials were ∼ 40 nm to ∼ 60 nm. As calculated using Scherrer’s equation it has been observed that the crystallite size changed with change in doping and co-doping levels. This is a very pertinent observation showing that crystallite size can be controlled through doping and co-doping. Since properties of particles largely depend on the sizes of the particles this also imply that particles of desired properties can be synthesised using this method. The results obtained through X-ray diffraction were further deeply analysed using Rietveld Refinement using FullProf suite. Fourier Transform Infrared (FTIR) Spectroscopic studies confirmed the formation of spinel structures. Few very small absorption bands were also observed in FTIR. Particle sizes as observed using Zeta potential and Particle Size Analyser (ZS) was approximately 675 nm. Field Emission Scanning Electron Microscope (FESEM), Transmission Electron Microscope (TEM) showed that the particles were agglomerated. Composites of co-doped CF-NPs with ZnO/Ag were prepared manually by grinding them in a mortar and pestle. Starch was used as a binder. All these samples including composites showed antibacterial activities. The results revealed that co-doped cobalt ferrite nanoparticles of higher dopant concentration exhibit higher antibacterial activity. These materials can be used in various biomedical applications.