The effects of ion irradiation on a giant magnetoimpedance (GMI) have been investigated for a Co-based amorphous ribbon with various kinds of ions such as Xe, Ar, and N. The GMI ratio and M-H loop parameters were used to characterize the samples before and after the ion irradiation. The GMI ratio increased considerably in the ion irradiated samples and the GMI response showed a strong dependence on the irradiated ion species and driving frequencies. It was shown that the ion irradiations lead to a substantial modification of the magnetic properties including a large coercivity and shearing of the in-plane magnetization loops, thus suggesting the reduction of an exchange coupling.