The influence of applying ultrasonic waves on cure kinetic parameters of unsaturated polyester resin (UP) reinforced with Cloisite 10A nanoparticles (10A) via non-isothermal differential scanning calorimetry has been studied. Advanced integral isoconversional method was used to study the influence of sonication on activation energy, pre-exponential factor and reaction model in terms of conversion degree. Furthermore, the kinetic parameters of Vyazovkin and Sbirrazzuoli diffusion factor (VS diffusion factor) and Kamal equations were obtained. The results proved that by applying ultrasound the dominance of the diffusion phenomenon shifted to lower conversion degrees. XRD and TEM tests were performed on samples containing nanoclay before and after the application of ultrasonic waves. The results showed that the application of ultrasonic waves had no significant effect on the intercalation and exfoliation of nanoclay platelets. Ultrasound breaks down agglomerates and thus more styrene adsorbs by nanoclay platelets. It was observed that in the final stage of the cure reaction, the sonication has a great effect on the activation energy and reduces it dramatically. Finally, the influence of sonication on optimal cure cycle of thin composite parts was investigated. The results showed that the application of ultrasonic waves increased the crosslinking reaction rate of the unsaturated polyester resin and decreased the optimum cure cycle time.