In this paper, an intra-panel interface with a clock embedded differential signaling for TFT-LCD systems is proposed. The proposed interface reduces the number of signal lines between the timing controller and the column drivers in a TFT-LCD panel by adopting the embedded clock scheme. The protocol of the proposed interface provides a delay-locked loop (DLL)-based clock recovery scheme for the receiver. The timing controller and the column driver integrated with the proposed interface are fabricated in 0.13- μm CMOS process technology and 0.18-μm high voltage CMOS process technology, respectively. The proposed interface is verified on a 47-inch Full High-Definition (FHD) (1920RGBt1080) TFT-LCD panel with 8-bit RGB and 120-Hz driving technology. The maximum data rate per differential pair was measured to be as high as 2.0 Gb/s in a wafer test.