Thе publication has been prepared with the support of the "RUDN University Program 5-100". Nowadays a high prevalence of the secondary detection of allergic dermatitis is observed due to severe ecological and social conditions, excessive use of genetically modified food, unhealthy and irrational nutrition, stress, etc. Based on the above mentioned, we set out the goal to specify the epidemiological statistics of etiologic factors in patients with atopic dermatitis in Western Georgia. The study involved 89 patients (aged 18-70, 38 females and 51 males). With complaints of allergic rash on the skin, they came to the National Institute of Allergology, Asthma and Clinical Immunology of the Georgian Academy of Sciences (Tskaltubo, Georgia). Based on anamnesis and clinical investigations the patients were primarily diagnosed with possible atopic dermatitis of unknown etiology. In order to verify the diagnosis and determine the contributing factors, following laboratory tests have been conducted: to detect allergenization degree in the serum of the patients the total IgE level and specific IgE concentration was measured by advanced automated system "Immuno CAP 100". Analysis of the obtained results showed the increased level of total IgE only in 41 (46%) patients among 89. In allergodiagnostic tests the specific IgE positive results were found only in 25 (28%) patients, especially to the following allergens: weeds (Wx2) – ambrosia, plantain, clasp/tarragon, atriplex – in 5 (5,6%) on average; tree dust (Tx9) - alder, lactarius piperatus, nuts, oak, willow - 6 (6,7%); and cereals (Gx1) - festuca pratensis, lolium temulentum, timoti grass, poa - 2 (2,2%); Mx2 -Penicillium notatum, Cladosporium herbarum, Aspergillus fumigatus, Candida albicans, Alternaria alternate- 16 (17,9%) was revealed. Positive Helicobacter pylori test was accepted in 37 (41, 5%) patients. Laboratory diagnosis on helminthes has shown high epidemic prevalence and strong correlation with allergenization: toxokara - 21 (23.5%), ascarida - 6 (6,7%), lamblia - 2 (2,2%) patients; The changes in the hormonal effect of thyroid gland was revealed in 5 (5,6%) patients only. Combination of several etiological factors was found including Helicobacter and Toxocariasis, specific markers of allergenization and Toxocariasis, etc. Such combinations resulted in further exacerbation of the clinical course of the disease. Targeted therapy demonstrated high clinical efficacy. The research confirms the necessity of performing the study of epidemic data and statistics. Relevant updated and renewable recommendations support the targeted prevention and effective outcome-oriented approaches. The above is undoubtedly the key issue and the particularly acute task of modern medicine.