In the realm of Electronics and Computer engineering, achieving optimal performance of circuits amidst escalating complexity poses significant challenges. Traditional manual optimization techniques are often inadequate to navigate the intricacies of modern electronic systems. This paper advocates for the adoption of machine learning-driven optimization as a transformative approach to smart circuit design. By leveraging machine learning algorithms, engineers can systematically explore the expansive design space, discern complex relationships between circuit parameters and performance metrics, and ultimately enhance the efficiency and effectiveness of electronic circuits. This paper comprehensively reviews the application of machine learning techniques in circuit design optimization. Supervised learning algorithms such as neural networks, support vector machines, and decision trees enable the modeling of intricate interdependencies within electronic circuits. Unsupervised learning techniques, including clustering and dimensionality reduction, facilitate efficient exploration of the design landscape by identifying patterns and correlations. Additionally, reinforcement learning algorithms offer an autonomous approach to circuit optimization through iterative learning and refinement. Real-world applications of machine learning-driven optimization in electronics and computer engineering span various domains, including power-efficient integrated circuits, signal processing algorithm optimization, and layout optimization for enhanced performance and reliability. Moreover, machine learning techniques play a crucial role in mitigating variability in semiconductor manufacturing processes, ensuring robustness and reliability of electronic systems in the face of uncertainties. Despite the promising potential of machine learning in circuit design optimization, challenges such as dataset acquisition, model interpretability, and scalability to complex circuits persist. Addressing these challenges requires innovative research endeavors, including the development of hybrid optimization techniques and novel hardware architectures. DOI: https://doi.org/10.52783/tjjpt.v45.i02.6339